{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:24:54Z","timestamp":1791591894503,"version":"4.3.4"},"reference-count":33,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10846","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T06:48:56Z","timestamp":1574405336000},"source":"Crossref","is-referenced-by-count":2,"title":["The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament"],"prefix":"10.3892","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing 100053, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing 100021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing 100191, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing 100191, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing 100053, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing 100053, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"key20200713234339_b1-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jocn.2015.07.027","article-title":"Mid- to long-term outcomes of posterior decompression with instrumented fusion for thoracic ossification of the posterior longitudinal ligament","volume":"27","author":"Koda","year":"2016","journal-title":"J Clin Neurosci"},{"key":"key20200713234339_b2-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1016\/j.spinee.2015.08.060","article-title":"A circumferential decompression-based surgical strategy for multilevel ossification of thoracic posterior longitudinal ligament","volume":"15","author":"Hu","year":"2015","journal-title":"Spine J"},{"key":"key20200713234339_b3-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.wneu.2018.01.099","article-title":"Local spinal cord decompression through a full endoscopic percutaneous transcorporeal approach for cervicothoracic ossification of the posterior longitudinal ligament at the T1-T2 level","volume":"112","author":"Kong","year":"2018","journal-title":"World Neurosurg"},{"key":"key20200713234339_b4-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1007\/s00586-015-4097-5","article-title":"A systematic review of complications in thoracic spine surgery for ossification of the posterior longitudinal ligament","volume":"26","author":"Xu","year":"2017","journal-title":"Eur Spine J"},{"key":"key20200713234339_b5-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/os.12331","article-title":"Treatment for thoracic ossification of posterior longitudinal ligament with posterior circumferential decompression","volume":"9","author":"Xu","year":"2017","journal-title":"Orthop Surg"},{"key":"key20200713234339_b6-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3340\/jkns.2017.0404.017","article-title":"Minimally invasive anterior decompression technique without instrumented fusion for huge ossification of the posterior longitudinal ligament in the thoracic spine: Technical note and literature review","volume":"60","author":"Yu","year":"2017","journal-title":"J Korean Neurosurg Soc"},{"key":"key20200713234339_b7-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13018-016-0489-4","article-title":"Treatment for thoracic ossification of posterior longitudinal ligament with posterior circumferential decompression: Complications and managements","volume":"11","author":"Yang","year":"2016","journal-title":"J Orthop Surg Res"},{"key":"key20200713234339_b8-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"E1356","DOI":"10.1097\/BRS.0000000000001622","article-title":"Outcomes of surgical treatment for thoracic myelopathy: A Single-institutional study of 73 patients","volume":"41","author":"Onishi","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"key20200713234339_b9-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"E1389","DOI":"10.1097\/BRS.0000000000002703","article-title":"Perioperative complications after surgery for thoracic ossification of posterior longitudinal ligament-nationwide multicenter prospective study","volume":"43","author":"Imagama","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"key":"key20200713234339_b10-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"21580","DOI":"10.1038\/srep21580","article-title":"Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713234339_b11-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"127","DOI":"10.11005\/jbm.2014.21.2.127","article-title":"Genetics of ossification of the posterior longitudinal ligament of the spine: A Mini Review","volume":"21","author":"Ikegawa","year":"2014","journal-title":"J Bone Meta"},{"key":"key20200713234339_b12-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2183\/pjab.90.405","article-title":"Genomic study of ossification of the posterior longitudinal ligament of the spine","volume":"90","author":"Ikegawa","year":"2014","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"key20200713234339_b13-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000438625","article-title":"Connexin 43 affects osteogenic differentiation of the posterior longitudinal ligament cells via regulation of ERK activity by stabilizing Runx2 in ossification","volume":"38","author":"Yang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"key20200713234339_b14-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ajhg.2016.05.018","article-title":"Identification and functional characterization of RSPO2 as a susceptibility gene for ossification of the posterior longitudinal ligament of the spine","volume":"99","author":"Nakajima","year":"2016","journal-title":"Am J Hum Genet"},{"key":"key20200713234339_b15-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.4238\/2014.March.17.7","article-title":"Whole exome sequencing implicates PTCH1 and COL17A1 genes in ossification of the posterior longitudinal ligament of the cervical spine in Chinese patients","volume":"13","author":"Wei","year":"2014","journal-title":"Genet Mol Res"},{"key":"key20200713234339_b16-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/ng.3045","article-title":"A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine","volume":"46","author":"Nakajima","year":"2014","journal-title":"Nat Genet"},{"key":"key20200713234339_b17-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13018-014-0103-6","article-title":"Association between single nucleotide polymorphism of IL15RA gene with susceptibility to ossification of the posterior longitudinal ligament of the spine","volume":"9","author":"Guo","year":"2014","journal-title":"J Orthop Surg Res"},{"key":"key20200713234339_b18-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.4238\/2013.October.18.3","article-title":"Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients","volume":"12","author":"He","year":"2013","journal-title":"Genet Mol Res"},{"key":"key20200713234339_b19-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/jor.21586","article-title":"A new haplotype in BMP4 implicated in ossification of the posterior longitudinal ligament (OPLL) in a Chinese population","volume":"30","author":"Ren","year":"2012","journal-title":"J Orthop Res"},{"key":"key20200713234339_b20-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"e40587","DOI":"10.1371\/journal.pone.0040587","article-title":"Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population","volume":"7","author":"Ren","year":"2012","journal-title":"PLoS One"},{"key":"key20200713234339_b21-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3340\/jkns.2011.49.1.8","article-title":"Association of toll-like receptor 5 gene polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine in Korean population","volume":"49","author":"Chung","year":"2011","journal-title":"J Korean Neurosurg Soc"},{"key":"key20200713234339_b22-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1007\/s11999-010-1511-5","article-title":"RUNX2 polymorphisms associated with OPLL and OLF in the Han population","volume":"468","author":"Liu","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"key20200713234339_b23-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12883-019-1263-0","article-title":"COL6A1 mutation leading to Bethlem myopathy with recurrent hematuria: A case report","volume":"19","author":"Bao","year":"2019","journal-title":"BMC Neurol"},{"key":"key20200713234339_b24-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"26962","DOI":"10.1038\/srep26962","article-title":"Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713234339_b25-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1097\/BRS.0b013e31815b761c","article-title":"COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament","volume":"32","author":"Kong","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"key20200713234339_b26-mmr-21-01-0191","first-page":"2557","article-title":"Identification of susceptibility loci for thoracic ossification of the posterior longitudinal ligament by whole-genome sequencing","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713234339_b27-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13018-018-0817-y","article-title":"Association of IL17RC and COL6A1 genetic polymorphisms with susceptibility to ossification of the thoracic posterior longitudinal ligament in Chinese patients","volume":"13","author":"Wang","year":"2018","journal-title":"J Orthop Surg Res"},{"key":"key20200713234339_b28-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1086\/378593","article-title":"Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine","volume":"73","author":"Tanaka","year":"2003","journal-title":"Am J Hum Genet"},{"key":"key20200713234339_b29-mmr-21-01-0191","first-page":"2005","article-title":"Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament","volume":"43","author":"Wang","year":"2019","journal-title":"Int J Mol Med"},{"key":"key20200713234339_b30-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713234339_b31-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3389\/fnmol.2017.00337","article-title":"Collagen VI Null mice as a model for early onset muscle decline in aging","volume":"10","author":"Capitanio","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"key20200713234339_b32-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00441-016-2385-y","article-title":"Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis","volume":"364","author":"Izu","year":"2016","journal-title":"Cell Tissue Res"},{"key":"key20200713234339_b33-mmr-21-01-0191","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuroscience.2011.03.057","article-title":"Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt\/Phosphatidylinositol 3-kinase signaling pathway","volume":"183","author":"Cheng","year":"2011","journal-title":"Neuroscience"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:38:49Z","timestamp":1594687129000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":33,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10846","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]}}}