{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:31:54Z","timestamp":1774974714745,"version":"3.50.1"},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10874","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T11:18:20Z","timestamp":1575976700000},"source":"Crossref","is-referenced-by-count":3,"title":["Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A"],"prefix":"10.3892","author":[{"given":"Jia'nan","family":"Lan","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zibiao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifa","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"key20200713234442_b1-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1111\/j.1600-6143.2011.03587.x","article-title":"Major challenges limiting liver transplantation in the United States","volume":"11","author":"Wertheim","year":"2011","journal-title":"Am J Transplant"},{"key":"key20200713234442_b2-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1111\/tri.13358","article-title":"2018 annual report of the European Liver Transplant Registry (ELTR)-50-year evolution of liver transplantation","volume":"31","author":"Adam","year":"2018","journal-title":"Transpl Int"},{"key":"key20200713234442_b3-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1097\/01.ta.0000235995.86162.d2","article-title":"Hemodynamic and oxygen transport patterns after head trauma and brain death: Implications for management of the organ donor","volume":"63","author":"Belzberg","year":"2007","journal-title":"J Trauma"},{"key":"key20200713234442_b4-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.mce.2015.05.009","article-title":"Exendin-4 protects rat islets against loss of viability and function induced by brain death","volume":"412","author":"Carlessi","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"key20200713234442_b5-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1016\/j.transproceed.2014.04.016","article-title":"Brain death is associated with endoplasmic reticulum stress and apoptosis in rat liver","volume":"46","author":"Cao","year":"2014","journal-title":"Transplant Proc"},{"key":"key20200713234442_b6-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1224.e1","DOI":"10.1016\/j.cell.2017.11.005","article-title":"SnapShot: Functions of endoplasmic reticulum membrane contact sites","volume":"171","author":"Salvador-Gallego","year":"2017","journal-title":"Cell"},{"key":"key20200713234442_b7-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1083\/jcb.201110131","article-title":"The impact of the unfolded protein response on human disease","volume":"197","author":"Wang","year":"2012","journal-title":"J Cell Biol"},{"key":"key20200713234442_b8-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key20200713234442_b9-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/bj3530417","article-title":"Protein phosphatase 2A: A highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling","volume":"353","author":"Janssens","year":"2001","journal-title":"Biochem J"},{"key":"key20200713234442_b10-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1093\/carcin\/bgl009","article-title":"Dihydroxyphenylethanol induces apoptosis by activating serine\/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells","volume":"27","author":"Guichard","year":"2006","journal-title":"Carcinogenesis"},{"key":"key20200713234442_b11-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/hep.21611","article-title":"Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A","volume":"46","author":"Christen","year":"2007","journal-title":"Hepatology"},{"key":"key20200713234442_b12-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"ra7","DOI":"10.1126\/scisignal.2000514","article-title":"A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta-cells","volume":"3","author":"Qiu","year":"2010","journal-title":"Sci Signal"},{"key":"key20200713234442_b13-mmr-21-02-0567","article-title":"National Research Council: Guide for the care and use of laboratory animals","year":"2011","edition":"8th"},{"key":"key20200713234442_b14-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/00007890-200002150-00020","article-title":"A model of gradual onset brain death for transplant-associated studies in rats","volume":"69","author":"Pratschke","year":"2000","journal-title":"Transplantation"},{"key":"key20200713234442_b15-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1055\/s-0035-1547532","article-title":"Brain death guidelines explained","volume":"35","author":"Wijdicks","year":"2015","journal-title":"Semin Neurol"},{"key":"key20200713234442_b16-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1097\/01.TP.0000080983.14161.95","article-title":"Brain death induces apoptosis in donor liver of the rat","volume":"76","author":"Van Der Hoeven","year":"2003","journal-title":"Transplantation"},{"key":"key20200713234442_b17-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.transproceed.2014.10.012","article-title":"C\/EBP homologous protein-mediated endoplasmic reticulum stress-related renal apoptosis is involved in rats with brain death","volume":"47","author":"Cao","year":"2015","journal-title":"Transplant Proc"},{"key":"key20200713234442_b18-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/0092-8674(89)90058-5","article-title":"KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP\/GRP78 gene","volume":"57","author":"Rose","year":"1989","journal-title":"Cell"},{"key":"key20200713234442_b19-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1158\/1535-7163.MCT-15-0774","article-title":"Expression of GRP78, master regulator of the unfolded protein response, increases chemoresistance in pancreatic ductal adenocarcinoma","volume":"15","author":"Gifford","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20200713234442_b20-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S1534-5807(03)00022-4","article-title":"A time-dependent phase shift in the mammalian unfolded protein response","volume":"4","author":"Yoshida","year":"2003","journal-title":"Dev Cell"},{"key":"key20200713234442_b21-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","article-title":"The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress","volume":"35","author":"Lee","year":"2005","journal-title":"Methods"},{"key":"key20200713234442_b22-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.bbrc.2016.03.002","article-title":"Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT\/mitochondrial apoptotic pathway","volume":"474","author":"Xie","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713234442_b23-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4149\/319_151002N513","article-title":"Prognostic significance of GRP78\/BiP expression in patients with Stage III\/IV hypopharyngeal squamous cell carcinoma","volume":"63","author":"Kaira","year":"2016","journal-title":"Neoplasma"},{"key":"key20200713234442_b24-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"NatRev Mol Cell Biol"},{"key":"key20200713234442_b25-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"35227","DOI":"10.1074\/jbc.M111.233502","article-title":"Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1","volume":"286","author":"Morishima","year":"2011","journal-title":"J Biol Chem"},{"key":"key20200713234442_b26-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.dld.2014.05.013","article-title":"Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease","volume":"46","author":"Negroni","year":"2014","journal-title":"Dig Liver Dis"},{"key":"key20200713234442_b27-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1177\/0022034514525199","article-title":"Transcriptional factor ATF6 is involved in odontoblastic differentiation","volume":"93","author":"Kim","year":"2014","journal-title":"J Dent Res"},{"key":"key20200713234442_b28-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrd3976","article-title":"Targeting the unfolded protein response in disease","volume":"12","author":"Hetz","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"key20200713234442_b29-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S0168-8278(03)00029-1","article-title":"Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis","volume":"38","author":"Shuda","year":"2003","journal-title":"J Hepatol"},{"key":"key20200713234442_b30-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1038\/onc.2012.264","article-title":"IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments","volume":"32","author":"Grkovic","year":"2013","journal-title":"Oncogene"},{"key":"key20200713234442_b31-mmr-21-02-0567","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1128\/JVI.73.1.839-842.1999","article-title":"Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens","volume":"73","author":"Ruediger","year":"1999","journal-title":"J Virol"},{"key":"key20200713234442_b32-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.molcel.2009.02.015","article-title":"From promiscuity to precision: Protein phosphatases get a makeover","volume":"33","author":"Virshup","year":"2009","journal-title":"Mol Cell"},{"key":"key20200713234442_b33-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.canlet.2013.02.036","article-title":"Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer","volume":"335","author":"Seshacharyulu","year":"2013","journal-title":"Cancer Lett"},{"key":"key20200713234442_b34-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"20296","DOI":"10.1074\/jbc.274.29.20296","article-title":"Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A","volume":"274","author":"Ruvolo","year":"1999","journal-title":"J Biol Chem"},{"key":"key20200713234442_b35-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejphar.2010.08.020","article-title":"3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK\/JNK pathway","volume":"648","author":"Chang","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"key20200713234442_b36-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.neurobiolaging.2010.01.016","article-title":"I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis","volume":"33","author":"Liu","year":"2012","journal-title":"Neurobiol Aging"},{"key":"key20200713234442_b37-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/bj2750233","article-title":"Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases","volume":"275","author":"Takai","year":"1991","journal-title":"Biochem J"},{"key":"key20200713234442_b38-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"key20200713234442_b39-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3109\/10715769609088022","article-title":"The oxidative inactivation of sarcoplasmic reticulum Ca(2+)-ATPase by peroxynitrite","volume":"24","author":"Viner","year":"1996","journal-title":"Free Radic Res"},{"key":"key20200713234442_b40-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s11892-013-0370-3","article-title":"Diabetes and infections-hepatitis C: Is there type 2 diabetes excess in hepatitis C infection?","volume":"13","author":"Naing","year":"2013","journal-title":"Curr Diab Rep"},{"key":"key20200713234442_b41-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s12035-015-9640-1","article-title":"Phosphatase 2A inhibition affects endoplasmic reticulum and mitochondria homeostasis via cytoskeletal alterations in brain endothelial cells","volume":"54","author":"Pl\u00e1cido","year":"2017","journal-title":"Mol Neurobiol"},{"key":"key20200713234442_b42-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.freeradbiomed.2014.01.009","article-title":"Disulfide stress: A novel type of oxidative stress in acute pancreatitis","volume":"70","author":"Moreno","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"key20200713234442_b43-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"e337","DOI":"10.1038\/cddis.2012.79","article-title":"Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress","volume":"28","author":"Tay","year":"2012","journal-title":"Cell Death Dis"},{"key":"key20200713234442_b44-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.1093\/emboj\/18.19.5252","article-title":"Cathepsin D targeted by acid sphingomyelinase-derived ceramide","volume":"18","author":"Heinrich","year":"1999","journal-title":"EMBO J"},{"key":"key20200713234442_b45-mmr-21-02-0567","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/alcalc\/agv119","article-title":"The role of ceramide in the pathogenesis of alcoholic liver disease","volume":"51","author":"Yang","year":"2016","journal-title":"Alcohol Alcohol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:39:49Z","timestamp":1594687189000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10874","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,10]]}}}