{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:17:33Z","timestamp":1763727453236},"reference-count":53,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.9954","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T08:29:57Z","timestamp":1550132997000},"source":"Crossref","is-referenced-by-count":10,"title":["Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally\u2011induced diabetes mellitus"],"prefix":"10.3892","author":[{"given":"Yu\u2011Han","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2011Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery and Development, Kunming Pharmaceutical Corporation, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2011Yi","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Morphological Laboratory, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2011Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2011Hao","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2011Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2011Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2011Yu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration and Neurorehabilitation, Department of Neurosurgery of The Affiliated Hospital, Qingdao University, Qingdao, Shandong 266071, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Research Center, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2011Ying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"key20200713232235_b1-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"4080364","DOI":"10.1155\/2017\/4080364","article-title":"MicroRNAs and cardiovascular disease in diabetes mellitus","volume":"2017","author":"Ding","year":"2017","journal-title":"Biomed Res Int"},{"key":"key20200713232235_b2-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0166-2236(00)01656-8","article-title":"Cognition and synaptic plasticity in diabetes mellitus","volume":"23","author":"Gispen","year":"2000","journal-title":"Trends Neurosci"},{"key":"key20200713232235_b3-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"249031","DOI":"10.1155\/2014\/249031","article-title":"Neuromodulatory effects of hesperidin in mitigating oxidative stress in streptozotocin induced diabetes","volume":"2014","author":"Ashafaq","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20200713232235_b4-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1042\/CS20171432","article-title":"Endoplasmic reticulum stress\/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice","volume":"132","author":"Kong","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"key20200713232235_b5-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2017.11.015","article-title":"Diabetes mellitus and Alzheimer's disease: GSK-3\u03b2 as a potential link","volume":"339","author":"Zhang","year":"2018","journal-title":"Behav Brain Res"},{"key":"key20200713232235_b6-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1080\/15548627.2017.1320467","article-title":"Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia","volume":"13","author":"Li","year":"2017","journal-title":"Autophagy"},{"key":"key20200713232235_b7-mmr-19-04-3114","first-page":"294","article-title":"Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K\/Akt pathway","volume":"43","author":"Zhong","year":"2019","journal-title":"Int J Mol Med"},{"key":"key20200713232235_b8-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","article-title":"Trk receptors: Roles in neuronal signal transduction","volume":"72","author":"Huang","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"key20200713232235_b9-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1254\/jphs.91.267","article-title":"Brain-derived neurotrophic factor\/TrkB signaling in memory processes","volume":"91","author":"Yamada","year":"2003","journal-title":"J Pharmacol Sci"},{"key":"key20200713232235_b10-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: Roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"key20200713232235_b11-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell Calcium"},{"key":"key20200713232235_b12-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1007\/s12031-014-0398-0","article-title":"P38 MAPK inhibition protects against glutamate neurotoxicity and modifies NMDA and AMPA receptor subunit expression","volume":"55","author":"Rivera-Cervantes","year":"2015","journal-title":"J Mol Neurosci"},{"key":"key20200713232235_b13-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0006-8993(97)01052-4","article-title":"BDNF potentiates spontaneous Ca2+ oscillations in cultured hippocampal neurons","volume":"778","author":"Sakai","year":"1997","journal-title":"Brain Res"},{"key":"key20200713232235_b14-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cbi.2012.11.024","article-title":"NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: Ameliorating effects of curcumin","volume":"201","author":"Jayanarayanan","year":"2013","journal-title":"Chem Biol Interact"},{"key":"key20200713232235_b15-mmr-19-04-3114","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1742-2094-9-275","article-title":"L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: The \u2018collusion\u2019 hypothesis for increased extracellular L-glutamate concentration in neuroinflammation","volume":"9","author":"Junpei","year":"2012","journal-title":"J Neuroinflammation"},{"key":"key20200713232235_b16-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"6220","DOI":"10.3748\/wjg.v23.i34.6220","article-title":"Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats","volume":"23","author":"Li","year":"2017","journal-title":"World J Gastroenterol"},{"key":"key20200713232235_b17-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"E1990","DOI":"10.3390\/ijms18091990","article-title":"The role of ERK signaling in experimental autoimmune encephalomyelitis","volume":"18","author":"Birkner","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20200713232235_b18-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1128\/MCB.05424-11","article-title":"Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation","volume":"31","author":"Plotnikov","year":"2011","journal-title":"Mol Cell Biol"},{"key":"key20200713232235_b19-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12031-013-0157-7","article-title":"Glutamate excitotoxicity activates the MAPK\/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo","volume":"52","author":"Ortu\u00f1o-Sahag\u00fan","year":"2014","journal-title":"J Mol Neurosci"},{"key":"key20200713232235_b20-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrn3469","article-title":"Corticostriatal connectivity and its role in disease","volume":"14","author":"Shepherd","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"key20200713232235_b21-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"e1005395","DOI":"10.1371\/journal.pcbi.1005395","article-title":"Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome","volume":"13","author":"Caligiore","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"key20200713232235_b22-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.neuroimage.2006.08.056","article-title":"Temporal dynamics of basal ganglia response and connectivity during verbal working memory","volume":"34","author":"Chang","year":"2007","journal-title":"Neuroimage"},{"key":"key20200713232235_b23-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.1523\/JNEUROSCI.4181-14.2015","article-title":"The simple act of choosing influences declarative memory","volume":"35","author":"Murty","year":"2015","journal-title":"J Neurosci"},{"key":"key20200713232235_b24-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.2337\/dc14-0016","article-title":"Ventral striatum, but not cortical volume loss, is related to cognitive dysfunction in type 1 diabetic patients with and without microangiopathy","volume":"37","author":"van Duinkerken","year":"2014","journal-title":"Diabetes Care"},{"key":"key20200713232235_b25-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu Rev Neurosci"},{"key":"key20200713232235_b26-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fnbeh.2015.00071","article-title":"Conditional targeting of medium spiny neurons in the striatal matrix","volume":"9","author":"Reinius","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"key20200713232235_b27-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/jnc.12926","article-title":"BDNF and Huntingtin protein modifications by manganese: Implications for striatal medium spiny neuron pathology in manganese neurotoxicity","volume":"131","author":"Stansfield","year":"2014","journal-title":"J Neurochem"},{"key":"key20200713232235_b28-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3109\/01677063.2014.892486","article-title":"Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95","volume":"28","author":"Zhang","year":"2014","journal-title":"J Neurogenet"},{"key":"key20200713232235_b29-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fphar.2018.00024","article-title":"A review on central nervous system effects of gastrodin","volume":"9","author":"Liu","year":"2018","journal-title":"Front Pharmacol"},{"key":"key20200713232235_b30-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.aca.2007.03.035","article-title":"Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat","volume":"590","author":"Lin","year":"2007","journal-title":"Anal Chim Acta"},{"key":"key20200713232235_b31-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jep.2016.06.057","article-title":"The rhizome of Gastrodia elata Blume-an ethnopharmacological review","volume":"189","author":"Zhan","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"key20200713232235_b32-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/BF02979066","article-title":"Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells","volume":"22","author":"Lee","year":"1999","journal-title":"Arch Pharm Res"},{"key":"key20200713232235_b33-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainres.2012.09.010","article-title":"Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1\/2-Nrf2 pathway","volume":"1482","author":"Zhao","year":"2012","journal-title":"Brain Res"},{"key":"key20200713232235_b34-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"309261","DOI":"10.1155\/2015\/309261","article-title":"Neuropharmacological potential of Gastrodia elata Blume and its components","volume":"2015","author":"Jang","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713232235_b35-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1600-0404.2007.00928.x","article-title":"Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats","volume":"117","author":"Zhang","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"key20200713232235_b36-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0006-8993(02)02887-1","article-title":"Hippocampal neuronal apoptosis in type 1 diabetes","volume":"946","author":"Li","year":"2002","journal-title":"Brain Res"},{"key":"key20200713232235_b37-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/2008-7802.178531","article-title":"The effect of diabetes mellitus on apoptosis in hippocampus: Cellular and molecular aspects","volume":"7","author":"Sadeghi","year":"2016","journal-title":"Int J Prev Med"},{"key":"key20200713232235_b38-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1124\/jpet.106.107367","article-title":"A death-promoting role for extracellular signal-regulated kinase","volume":"319","author":"Zhuang","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713232235_b39-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"11975","DOI":"10.1073\/pnas.95.20.11975","article-title":"Inhibition of the p44\/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity","volume":"95","author":"Murray","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713232235_b40-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1242\/jcs.02837","article-title":"Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death","volume":"119","author":"Choi","year":"2006","journal-title":"J Cell Sci"},{"key":"key20200713232235_b41-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1046\/j.1471-4159.2002.01075.x","article-title":"Neuronal-induced and glutamate-dependent activation of glial glutamate transporter function","volume":"82","author":"Poitry-Yamate","year":"2010","journal-title":"J Neurochem"},{"key":"key20200713232235_b42-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"12200","DOI":"10.1074\/jbc.275.16.12200","article-title":"Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures","volume":"275","author":"Stanciu","year":"2000","journal-title":"J Biol Chem"},{"key":"key20200713232235_b43-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10495-006-4065-y","article-title":"Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death","volume":"11","author":"Cagnol","year":"2006","journal-title":"Apoptosis"},{"key":"key20200713232235_b44-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1471-4159.2004.02744.x","article-title":"Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron\/glia mesencephalic cultures","volume":"91","author":"de Bernardo","year":"2004","journal-title":"J Neurochem"},{"key":"key20200713232235_b45-mmr-19-04-3114","first-page":"7827","article-title":"Knockdown of peroxiredoxin V increases glutamateinduced apoptosis in HT22 hippocampal neuron cells","volume":"17","author":"Shen","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713232235_b46-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0006-8993(94)91857-0","article-title":"NT-3 and BDNF protect CNS neurons against metabolic\/excitotoxic insults","volume":"640","author":"Cheng","year":"1994","journal-title":"Brain Res"},{"key":"key20200713232235_b47-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0028-3908(02)00043-6","article-title":"Neurotrophins induce BDNF expression through the glutamate receptor pathway in neocortical neurons","volume":"42","author":"Xiong","year":"2002","journal-title":"Neuropharmacology"},{"key":"key20200713232235_b48-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/sj.cdd.4401662","article-title":"Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways","volume":"12","author":"Almeida","year":"2005","journal-title":"Cell Death Differ"},{"key":"key20200713232235_b49-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1046\/j.1471-4159.2003.01599.x","article-title":"BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB","volume":"84","author":"Hu","year":"2003","journal-title":"J Neurochem"},{"key":"key20200713232235_b50-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/science.7725105","article-title":"Potentiated necrosis of cultured cortical neurons by neurotrophins","volume":"268","author":"Koh","year":"1995","journal-title":"Science"},{"key":"key20200713232235_b51-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1006\/exnr.1999.7242","article-title":"Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity","volume":"161","author":"Glazner","year":"2000","journal-title":"Exp Neurol"},{"key":"key20200713232235_b52-mmr-19-04-3114","doi-asserted-by":"publisher","first-page":"9459","DOI":"10.1523\/JNEUROSCI.19-21-09459.1999","article-title":"Growth factors and taurine protect against excitotoxicity by stabilizing calcium homeostasis and energy metabolism","volume":"19","author":"El","year":"1999","journal-title":"J Neurosci"},{"key":"key20200713232235_b53-mmr-19-04-3114","first-page":"37","article-title":"Effects of gastrodin on apoptotic factors of cerebral cortex neuron in epileptic rats","volume":"32","author":"Bian","year":"2016","journal-title":"Chin J Neuroanat"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T21:29:37Z","timestamp":1662931777000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.9954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":53,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.9954","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,14]]}}}