{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:49:52Z","timestamp":1771631392643,"version":"3.50.1"},"reference-count":33,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2020.10966","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T12:59:08Z","timestamp":1580216348000},"source":"Crossref","is-referenced-by-count":10,"title":["Mechanism of the hypoxia inducible factor 1\/hypoxic response element pathway in rat myocardial ischemia\/diazoxide post\u2011conditioning"],"prefix":"10.3892","author":[{"given":"Jin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"key20200713234720_b1-mmr-21-03-1527","first-page":"68","article-title":"Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog","volume":"70","author":"Jennings","year":"1960","journal-title":"Arch Pathol"},{"key":"key20200713234720_b2-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/cvr\/cvs131","article-title":"Cardioprotection during cardiac surgery","volume":"94","author":"Hausenloy","year":"2012","journal-title":"Cardiovasc Res"},{"key":"key20200713234720_b3-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1093\/cvr\/cvy039","article-title":"Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase","volume":"114","author":"Frankenreiter","year":"2018","journal-title":"Cardiovasc Res"},{"key":"key20200713234720_b4-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11010-017-2958-4","article-title":"Angiotensin (1\u20137) facilitates cardioprotection of ischemic preconditioning on ischemia-reperfusion-challenged rat heart","volume":"430","author":"Pachauri","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"key20200713234720_b5-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"C380","DOI":"10.1152\/ajpcell.00310.2017","article-title":"The role of microRNA-1 targeting of MAPK3 in myocardial ischemia-reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K\/Akt pathway","volume":"315","author":"Hao","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20200713234720_b6-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000487490","article-title":"\u03c9-3 polyunsaturated fatty acid postconditioning protects the isolated perfused rat heart from ischemia-reperfusion injury","volume":"8","author":"Zhang","year":"2018","journal-title":"Cardiorenal Med"},{"key":"key20200713234720_b7-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejphar.2016.03.027","article-title":"Pinacidil-postconditioning is equivalent to ischemic postconditioning in defeating cardiac ischemia-reperfusion injury in rat","volume":"780","author":"Yang","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"key20200713234720_b8-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.phrs.2016.09.006","article-title":"The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia\/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress","volume":"113","author":"Testai","year":"2016","journal-title":"Pharmacol Res"},{"key":"key20200713234720_b9-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"e003714","DOI":"10.1161\/JAHA.116.003714","article-title":"Allogeneic mesenchymal stromal cells overexpressing mutant human hypoxia-inducible factor 1-\u03b1 (HIF1-\u03b1) in an ovine model of acute myocardial infarction","volume":"5","author":"Hnatiuk","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"key20200713234720_b10-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00395-009-0044-0","article-title":"Attenuation of myocardial injury by postconditioning: Role of hypoxia inducible factor-1alpha","volume":"105","author":"Zhao","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"key20200713234720_b11-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"e107832","DOI":"10.1371\/journal.pone.0107832","article-title":"HIF-1\u03b1 signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury","volume":"9","author":"Si","year":"2014","journal-title":"PLoS One"},{"key":"key20200713234720_b12-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12576-012-0206-y","article-title":"Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts","volume":"62","author":"Jin","year":"2012","journal-title":"J Physiol Sci"},{"key":"key20200713234720_b13-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00395-013-0371-z","article-title":"Diazoxide postconditioning induces mitochondrial protein S-nitrosylation and a redox-sensitive mitochondrial phosphorylation\/translocation of RISK elements: No role for SAFE","volume":"108","author":"Penna","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"key20200713234720_b14-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1152\/physrev.00027.2009","article-title":"Muscle KATP channels: Recent insights to energy sensing and myoprotection","volume":"90","author":"Flagg","year":"2010","journal-title":"Physiol Rev"},{"key":"key20200713234720_b15-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s11517-015-1270-2","article-title":"Isolated heart models: Cardiovascular system studies and technological advances","volume":"53","author":"Olejnickova","year":"2015","journal-title":"Med Biol Eng Comput"},{"key":"key20200713234720_b16-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0022-5223(19)37950-4","article-title":"Ultrastructural and cytochemical correlates of myocardial protection by cardiac hypothermia in man","volume":"79","author":"Flameng","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key20200713234720_b17-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713234720_b18-mmr-21-03-1527","first-page":"4415","article-title":"Sevoflurane postconditioning improves myocardial mitochondrial respiratory function and reduces myocardial ischemia-reperfusion injury by up-regulating HIF-1","volume":"8","author":"Yang","year":"2016","journal-title":"Am J Transl Res"},{"key":"key20200713234720_b19-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1161\/CIRCULATIONAHA.107.758516","article-title":"Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning","volume":"118","author":"Eckle","year":"2008","journal-title":"Circulation"},{"key":"key20200713234720_b20-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pharmthera.2012.07.005","article-title":"Hypoxia-inducible factor as a therapeutic target for cardioprotection","volume":"136","author":"Ong","year":"2012","journal-title":"Pharmacol Ther"},{"key":"key20200713234720_b21-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/cvr\/cvr229","article-title":"Ultrasound molecular imaging of angiogenesis induced by mutant forms of hypoxia-inducible factor-1\u03b1","volume":"92","author":"Xie","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key20200713234720_b22-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20051996","article-title":"Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation","volume":"397","author":"Tian","year":"2006","journal-title":"Biochem J"},{"key":"key20200713234720_b23-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/aps.2010.132","article-title":"Hypoxia inducible factor 1 (HIF-1) and cardioprotection","volume":"31","author":"Tekin","year":"2010","journal-title":"Acta Pharmacol Sin"},{"key":"key20200713234720_b24-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"549412","DOI":"10.1155\/2015\/549412","article-title":"Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: Applications and therapies","volume":"2015","author":"Zimna","year":"2015","journal-title":"Biomed Res Int"},{"key":"key20200713234720_b25-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.surg.2011.06.006","article-title":"Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1\u03b1 and VEGF production and improves functional recovery after acute ischemia\/reperfusion","volume":"150","author":"Poynter","year":"2011","journal-title":"Surgery"},{"key":"key20200713234720_b26-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/abbs\/gmt132","article-title":"Up-regulation of hypoxia-inducible factor-1alpha enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats","volume":"46","author":"Li","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713234720_b27-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/abbs\/gmp063","article-title":"Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia\/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation","volume":"41","author":"Zhao","year":"2009","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713234720_b28-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1399-6576.2011.02577.x","article-title":"Neutrophil inhibition contributes to cardioprotection by postconditioning","volume":"56","author":"Granfeldt","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"key":"key20200713234720_b29-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"e1297","DOI":"10.1038\/cddis.2014.267","article-title":"Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia\/reperfusion","volume":"5","author":"Wang","year":"2014","journal-title":"Cell Death Dis"},{"key":"key20200713234720_b30-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1124\/pr.107.06002","article-title":"Interaction of cardiovascular risk factors with myocardial ischemia\/reperfusion injury, preconditioning, and postconditioning","volume":"59","author":"Ferdinandy","year":"2007","journal-title":"Pharmacol Rev"},{"key":"key20200713234720_b31-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1475-2840-11-28","article-title":"High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: Role of mitochondrial KATP channels","volume":"11","author":"Ichinomiya","year":"2012","journal-title":"Cardiovasc Diabetol"},{"key":"key20200713234720_b32-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"H2067","DOI":"10.1152\/ajpheart.00272.2006","article-title":"Opening mitoKATP increases superoxide generation from complex I of the electron transport chain","volume":"291","author":"Andrukhiv","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713234720_b33-mmr-21-03-1527","doi-asserted-by":"publisher","first-page":"33185","DOI":"10.1074\/jbc.M109.054221","article-title":"Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt\/protein kinase C\/histone deacetylase pathway","volume":"284","author":"Koshikawa","year":"2009","journal-title":"J Biol Chem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:41:55Z","timestamp":1594687315000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2020.10966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":33,"URL":"https:\/\/doi.org\/10.3892\/mmr.2020.10966","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]}}}