{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T14:35:32Z","timestamp":1720622132809},"reference-count":36,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2020.10974","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T08:10:45Z","timestamp":1580803845000},"source":"Crossref","is-referenced-by-count":4,"title":["HER4 promotes the progression of colorectal cancer by promoting epithelial\u2011mesenchymal transition"],"prefix":"10.3892","author":[{"given":"Xiaojing","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huien","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxin","family":"Li","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Fifth Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wujie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"key20200713234759_b1-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"key20200713234759_b2-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S1470-2045(05)70422-8","article-title":"Increasing incidence of colorectal cancer in Asia: Implications for screening","volume":"6","author":"Sung","year":"2005","journal-title":"Lancet Oncol"},{"key":"key20200713234759_b3-mmr-21-04-1779","first-page":"11","article-title":"Molecular and pathogenetic aspects of tumor budding in colorectal cancer","volume":"2","author":"Dawson","year":"2015","journal-title":"Front Med (Lausanne)"},{"key":"key20200713234759_b4-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.phrs.2013.11.002","article-title":"The ErbB\/HER family of protein-tyrosine kinases and cancer","volume":"79","author":"Roskoski","year":"2014","journal-title":"Pharmacol Res"},{"key":"key20200713234759_b5-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/sj.bjc.6605473","article-title":"Prognostic effect of activated EGFR expression in human colon carcinomas: Comparison with EGFR status","volume":"102","author":"Rego","year":"2010","journal-title":"Br J Cancer"},{"key":"key20200713234759_b6-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0016-5085(97)70120-3","article-title":"The expression of p185(HER-2\/neu) correlates with the stage of disease and survival in colorectal cancer","volume":"112","author":"Kapitanovi\u0107","year":"1997","journal-title":"Gastroenterology"},{"key":"key20200713234759_b7-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1186\/1471-2407-14-863","article-title":"Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer","volume":"14","author":"Mitsui","year":"2014","journal-title":"BMC Cancer"},{"key":"key20200713234759_b8-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/1471-2407-13-437","article-title":"The prognostic value of Her4 receptor isoform expression in triple-negative and Her2 positive breast cancer patients","volume":"13","author":"Machleidt","year":"2013","journal-title":"BMC Cancer"},{"key":"key20200713234759_b9-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3892\/ijo.2015.3108","article-title":"HER4 tumor expression in breast cancer patients randomized to treatment with or without tamoxifen","volume":"47","author":"G\u00f6thlin","year":"2015","journal-title":"Int J Oncol"},{"key":"key20200713234759_b10-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/CMR.0000000000000040","article-title":"HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma","volume":"24","author":"Nielsen","year":"2014","journal-title":"Melanoma Res"},{"key":"key20200713234759_b11-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/j.bbadis.2018.03.008","article-title":"HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1","volume":"1864","author":"Wang","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"key20200713234759_b12-mmr-21-04-1779","first-page":"6629","article-title":"HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer","volume":"15","author":"Guo","year":"2018","journal-title":"Oncol Lett"},{"key":"key20200713234759_b13-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex networks orchestrate epithelial-mesenchymal transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713234759_b14-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/978-1-4615-2592-9_12","article-title":"Modulations of the epithelial phenotype during embryogenesis and cancer progression","volume":"71","author":"Savagner","year":"1994","journal-title":"Cancer Treat Res"},{"key":"key20200713234759_b15-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/nm.3336","article-title":"The epigenetics of epithelial-mesenchymal plasticity in cancer","volume":"19","author":"Tam","year":"2013","journal-title":"Nat Med"},{"issue":"pii","key":"key20200713234759_b16-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"E171","DOI":"10.3390\/cancers9120171","article-title":"Regulation of EMT in colorectal cancer: A culprit in metastasis","volume":"9","author":"Vu","year":"2017","journal-title":"Cancers (Basel)"},{"key":"key20200713234759_b17-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1200\/JCO.1999.17.7.1983","article-title":"Specificity of HercepTest in determining HER-2\/neu status of breast cancers using the United States Food and Drug Administration-approved scoring system","volume":"17","author":"Jacobs","year":"1999","journal-title":"J Clin Oncol"},{"key":"key20200713234759_b18-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/carcin\/bgv049","article-title":"ERBB4 is over-expressed in human colon cancer and enhances cellular transformation","volume":"36","author":"Williams","year":"2015","journal-title":"Carcinogenesis"},{"key":"key20200713234759_b19-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ccell.2017.11.018","article-title":"Genomic and epigenomic profiling of high-risk intestinal metaplasia reveals molecular determinants of progression to gastric cancer","volume":"33","author":"Huang","year":"2018","journal-title":"Cancer Cell"},{"key":"key20200713234759_b20-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12885-019-5509-4","article-title":"Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion","volume":"19","author":"Tiwari","year":"2019","journal-title":"BMC Cancer"},{"key":"key20200713234759_b21-mmr-21-04-1779","first-page":"1489","article-title":"ErbB 1\u20134 expression alterations in primary colorectal cancers and their corresponding metastases","volume":"29","author":"Ljuslinder","year":"2009","journal-title":"Anticancer Res"},{"key":"key20200713234759_b22-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00384-009-0702-6","article-title":"ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery","volume":"24","author":"Baiocchi","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"key20200713234759_b23-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-2407-6-46","article-title":"Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas","volume":"6","author":"Kountourakis","year":"2006","journal-title":"BMC Cancer"},{"key":"key20200713234759_b24-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"6073","DOI":"10.1158\/0008-5472.CAN-18-0136","article-title":"HER2\/EGFR-AKT signaling switches TGF-\u03b2 from inhibiting cell proliferation to promoting cell migration in breast cancer","volume":"78","author":"Huang","year":"2018","journal-title":"Cancer Res"},{"key":"key20200713234759_b25-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1471-2407-8-129","article-title":"Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways","volume":"8","author":"Siddiqa","year":"2008","journal-title":"BMC Cancer"},{"key":"key20200713234759_b26-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"5456","DOI":"10.1128\/MCB.00012-10","article-title":"Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3","volume":"30","author":"B\u00e9guelin","year":"2010","journal-title":"Mol Cell Biol"},{"key":"key20200713234759_b27-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"840","DOI":"10.2174\/156800910793357970","article-title":"Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas","volume":"10","author":"Lo","year":"2010","journal-title":"Curr Cancer Drug Targets"},{"key":"key20200713234759_b28-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0959-8049(02)00004-7","article-title":"Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery","volume":"38","author":"Lee","year":"2002","journal-title":"Eur J Cancer"},{"issue":"pii","key":"key20200713234759_b29-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"E243","DOI":"10.3390\/cancers10080243","article-title":"Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response","volume":"10","author":"Donoghue","year":"2018","journal-title":"Cancers (Basel)"},{"key":"key20200713234759_b30-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1038\/s41388-018-0204-5","article-title":"The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition","volume":"37","author":"Shi","year":"2018","journal-title":"Oncogene"},{"key":"key20200713234759_b31-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10637-018-0684-8","article-title":"Advanced development of ErbB family-targeted therapies in osteosarcoma treatment","volume":"37","author":"Wang","year":"2019","journal-title":"Invest New Drugs"},{"key":"key20200713234759_b32-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.4143\/crt.2017.487","article-title":"Ligand-independent epidermal growth factor receptor overexpression correlates with poor prognosis in colorectal cancer","volume":"50","author":"Yun","year":"2018","journal-title":"Cancer Res Treat"},{"key":"key20200713234759_b33-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrc3447","article-title":"Regulatory networks defining EMT during cancer initiation and progression","volume":"13","author":"De Craene","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"key20200713234759_b34-mmr-21-04-1779","doi-asserted-by":"publisher","first-page":"77","DOI":"10.21037\/sci.2016.10.12","article-title":"E-cadherin adhesion-mediated Wnt activation for mesoderm specification in human embryonic stem cells needs a soft mattress","volume":"3","author":"Sulaiman","year":"2016","journal-title":"Stem Cell Investig"},{"key":"key20200713234759_b35-mmr-21-04-1779","doi-asserted-by":"crossref","first-page":"45725","DOI":"10.18632\/oncotarget.17392","article-title":"MiR-551b regulates epithelial-mesenchymal transition and metastasis of gastric cancer by inhibiting ERBB4 expression","volume":"8","author":"Song","year":"2017","journal-title":"Oncotarget"},{"key":"key20200713234759_b36-mmr-21-04-1779","first-page":"5934","article-title":"Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma","volume":"14","author":"Chen","year":"2017","journal-title":"Oncol Lett"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:42:15Z","timestamp":1594687335000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2020.10974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":36,"URL":"https:\/\/doi.org\/10.3892\/mmr.2020.10974","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]}}}