{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:42:24Z","timestamp":1782549744003,"version":"3.54.5"},"reference-count":48,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Rep"],"DOI":"10.3892\/mmr.2020.11092","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T07:18:50Z","timestamp":1587712730000},"page":"219-226","source":"Crossref","is-referenced-by-count":12,"title":["Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL\u20111\u03b2 and the SGK1\u2011NFAT2 signaling pathway"],"prefix":"10.3892","volume":"22","author":[{"given":"Wang","family":"Kai","sequence":"first","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Ping\u2011Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amend","family":"Bastian","sequence":"additional","affiliation":[{"name":"Department of Urology, University of T\u00fcbingen, D\u201172070 T\u00fcbingen, Baden\u2011W\u00fcrttemberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stenzl","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Department of Urology, University of T\u00fcbingen, D\u201172070 T\u00fcbingen, Baden\u2011W\u00fcrttemberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Sha\u2011Sha","sequence":"additional","affiliation":[{"name":"Central Laboratory, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Zunyi Medical University, Guiyang, Guizhou 563000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"key20200713235057_b1-mmr-22-01-0219","first-page":"NC01","article-title":"Experience with uroflowmetry in evaluation of lower urinary tract symptoms in patients with benign prostatic hyperplasia","volume":"8","author":"Singla","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"key20200713235057_b2-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.juro.2015.12.068","article-title":"The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction","volume":"195","author":"Hughes","year":"2016","journal-title":"J Urol"},{"key":"key20200713235057_b3-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.juro.2010.04.075","article-title":"The physiological significance of p27(KIP1) expression in detrusor function","volume":"184","author":"Niederhoff","year":"2010","journal-title":"J Urol"},{"key":"key20200713235057_b4-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/nau.22721","article-title":"The inflammatory cytokine IL-1\u03b2 is involved in bladder remodeling after bladder outlet obstruction in mice","volume":"35","author":"Kanno","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b5-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1159\/000485358","article-title":"Protective Effects of Antimuscarinics on the Bladder Remodeling After Bladder Outlet Obstruction","volume":"44","author":"Liu","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key20200713235057_b6-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1080\/03008880410015156","article-title":"Role of angiogenesis in bladder response to partial outlet obstruction","volume":"215","author":"Levin","year":"2004","journal-title":"Scand J Urol Nephrol Suppl"},{"key":"key20200713235057_b7-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1096\/fj.201600760R","article-title":"Involvement of serum glucocorticoid-regulated kinase 1 in reproductive success","volume":"31","author":"Lou","year":"2017","journal-title":"FASEB J"},{"key":"key20200713235057_b8-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15698\/cst2019.01.170","article-title":"Serum- and glucocorticoid-inducible kinase 1 and the response to cell stress","volume":"3","author":"Lang","year":"2018","journal-title":"Cell Stress"},{"key":"key20200713235057_b9-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.juro.2012.03.112","article-title":"Simulated bladder pressure stimulates human bladder smooth muscle cell proliferation via the PI3K\/SGK1 signaling pathway","volume":"188","author":"Chen","year":"2012","journal-title":"J Urol"},{"key":"key20200713235057_b10-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.yexcr.2013.01.007","article-title":"NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression","volume":"319","author":"Li","year":"2013","journal-title":"Exp Cell Res"},{"key":"key20200713235057_b11-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"104290","DOI":"10.1016\/j.yexmp.2019.104290","article-title":"High expression of NFAT2 contributes to carboplatin resistance in lung cancer","volume":"110","author":"Liu","year":"2019","journal-title":"Exp Mol Pathol"},{"key":"key20200713235057_b12-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1073\/pnas.1409290112","article-title":"Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity","volume":"112","author":"Vaeth","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713235057_b13-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.yexcr.2017.11.010","article-title":"Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin-Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma","volume":"362","author":"Ram","year":"2018","journal-title":"Exp Cell Res"},{"key":"key20200713235057_b14-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1177\/0954411911408663","article-title":"Correlation between intravesical pressure and prostatic obstruction grade using computational fluid dynamics in benign prostatic hyperplasia","volume":"225","author":"Lee","year":"2011","journal-title":"Proc Inst Mech Eng H"},{"key":"key20200713235057_b15-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/iju.13471","article-title":"Benefits and limitations of animal models in partial bladder outlet obstruction for translational research","volume":"25","author":"Kitta","year":"2018","journal-title":"Int J Urol"},{"key":"key20200713235057_b16-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1097\/01.ju.0000133561.32285.23","article-title":"Protective effect of an oral endothelin converting enzyme inhibitor on rat detrusor function after outlet obstruction","volume":"172","author":"Schr\u00f6der","year":"2004","journal-title":"J Urol"},{"key":"key20200713235057_b17-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"835","DOI":"10.4111\/kju.2011.52.12.835","article-title":"Early sequential changes in bladder function after partial bladder outlet obstruction in awake sprague-dawley rats: Focus on the decompensated bladder","volume":"52","author":"Kang","year":"2011","journal-title":"Korean J Urol"},{"key":"key20200713235057_b18-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1464-410X.2007.07129.x","article-title":"Damage to the bladder neck alters autonomous activity and its sensitivity to cholinergic agonists","volume":"100","author":"de Jongh","year":"2007","journal-title":"BJU Int"},{"key":"key20200713235057_b19-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1002\/nau.23427","article-title":"Suture causing urethral meatus stricture: A novel animal model of partial bladder outlet obstruction","volume":"37","author":"Chen","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b20-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12894-018-0329-4","article-title":"Progressive bladder remodeling due to bladder outlet obstruction: A systematic review of morphological and molecular evidences in humans","volume":"18","author":"Fusco","year":"2018","journal-title":"BMC Urol"},{"key":"key20200713235057_b21-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/nau.23104","article-title":"Hydrostatic pressure and muscarinic receptors are involved in the release of inflammatory cytokines in human bladder smooth muscle cells","volume":"36","author":"Liang","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b22-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/1535370216669837","article-title":"MicroRNA 4323 induces human bladder smooth muscle cell proliferationunder cyclic hydrodynamic pressure by activation of erk1\/2signaling pathway. Exp. Biol. Med","volume":"242","author":"Sun","year":"2017","journal-title":"(Maywood),"},{"key":"key20200713235057_b23-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1464-410X.2007.06919.x","article-title":"An alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate glutamate-receptor antagonist can inhibit premicturition contractions in rats with bladder outlet obstruction","volume":"100","author":"Kitta","year":"2007","journal-title":"BJU Int"},{"key":"key20200713235057_b24-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/j.1464-410X.2010.09445.x","article-title":"Bladder outlet obstruction: Progression from inflammation to fibrosis","volume":"106","author":"Metcalfe","year":"2010","journal-title":"BJU Int"},{"key":"key20200713235057_b25-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0022-5347(17)54449-3","article-title":"Prognostic value of urodynamic testing in myelodysplastic patients","volume":"126","author":"McGuire","year":"1981","journal-title":"J Urol"},{"key":"key20200713235057_b26-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/nau.10084","article-title":"Urodynamic evaluation of the human bladder response to an increase in outlet resistance","volume":"21","author":"Engel","year":"2002","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b27-mmr-22-01-0219","doi-asserted-by":"crossref","first-page":"127","DOI":"10.33549\/physiolres.932506","article-title":"Cyclic hydrodynamic pressure induced proliferation of bladder smooth muscle cells via integrin alpha5 and FAK","volume":"63","author":"Wei","year":"2014","journal-title":"Physiol Res"},{"key":"key20200713235057_b28-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"33042","DOI":"10.1038\/srep33042","article-title":"MiR 3180-5p promotes proliferation in human bladder smooth muscle cell by targeting PODN under hydrodynamic pressure","volume":"6","author":"Sun","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713235057_b29-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/1535370216669837","article-title":"MicroRNA 4323 induces human bladder smooth muscle cell proliferation under cyclic hydrodynamic pressure by activation of erk1\/2 signaling pathway","volume":"242","author":"Sun","year":"2017","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20200713235057_b30-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/2090598X.2019.1660071","article-title":"Non-invasive evaluation of bladder outlet obstruction in benign prostatic hyperplasia: A clinical correlation study","volume":"17","author":"Reddy","year":"2019","journal-title":"Arab J Urol"},{"key":"key20200713235057_b31-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1074\/jbc.M109.063727","article-title":"Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling","volume":"285","author":"Karpurapu","year":"2010","journal-title":"J Biol Chem"},{"key":"key20200713235057_b32-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1039\/C7MT00305F","article-title":"Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+\/NFAT2 and NF-\u03baB pathways via ERK\/MAPK in a human uroepithelial cell line","volume":"10","author":"Liu","year":"2018","journal-title":"Metallomics"},{"key":"key20200713235057_b33-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1365-2184.2010.00707.x","article-title":"Chromatin-bound PCNA as S-phase marker in mononuclear blood cells of patients with acute lymphoblastic leukaemia or multiple myeloma","volume":"43","author":"Z\u00f6lzer","year":"2010","journal-title":"Cell Prolif"},{"key":"key20200713235057_b34-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.crvi.2019.03.002","article-title":"Transcription factor p53 regulates healthy human ovarian cells function","volume":"342","author":"Sirotkin","year":"2019","journal-title":"C R Biol"},{"key":"key20200713235057_b35-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.aju.2014.03.003","article-title":"Factors determining the amount of residual urine in men with bladder outlet obstruction: Could it be a predictor for bladder contractility?","volume":"12","author":"Elmissiry","year":"2014","journal-title":"Arab J Urol"},{"key":"key20200713235057_b36-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1002\/nau.24076","article-title":"Do functional changes occur in the bladder due to bladder outlet obstruction? - ICI-RS 2018","volume":"38","author":"Bosch","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b37-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physiolgenomics.90291.2008","article-title":"Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis","volume":"36","author":"Yang","year":"2008","journal-title":"Physiol Genomics"},{"key":"key20200713235057_b38-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3389\/fimmu.2018.01197","article-title":"Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis","volume":"9","author":"Guo","year":"2018","journal-title":"Front Immunol"},{"key":"key20200713235057_b39-mmr-22-01-0219","first-page":"153","article-title":"Inflammasome and Oral Diseases","volume":"108","author":"Bullon","year":"2018","journal-title":"Exp Suppl"},{"key":"key20200713235057_b40-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s00345-013-1027-1","article-title":"Bladder outlet obstruction in men with acute urinary retention: An urodynamic study","volume":"31","author":"Rom","year":"2013","journal-title":"World J Urol"},{"key":"key20200713235057_b41-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"F1007","DOI":"10.1152\/ajprenal.00107.2007","article-title":"Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells","volume":"293","author":"Imamura","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200713235057_b42-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1002\/nau.23418","article-title":"Collagen content in the bladder of men with LUTS undergoing open prostatectomy: A pilot study","volume":"37","author":"Averbeck","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"key20200713235057_b43-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"E391","DOI":"10.1111\/j.1464-410X.2012.11740.x","article-title":"Imbalance between matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) contributes to bladder compliance changes in rabbits with partial bladder outlet obstruction (PBOO)","volume":"112","author":"Yang","year":"2013","journal-title":"BJU Int"},{"key":"key20200713235057_b44-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.prnil.2017.01.008","article-title":"Increased detrusor collagen is associated with detrusor overactivity and decreased bladder compliance in men with benign prostatic obstruction","volume":"5","author":"Bellucci","year":"2017","journal-title":"Prostate Int"},{"key":"key20200713235057_b45-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1016\/S0022-5347(05)64226-7","article-title":"Alterations in the molecular determinants of bladder compliance at hydrostatic pressures less than 40 cm. H2O","volume":"168","author":"Backhaus","year":"2002","journal-title":"J Urol"},{"key":"key20200713235057_b46-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00345-016-1993-1","article-title":"Simulated physiological stretch increases expression of extracellular matrix proteins in human bladder smooth muscle cells via integrin \u03b14\/\u03b1v-FAK-ERK1\/2 signaling pathway","volume":"35","author":"Chen","year":"2017","journal-title":"World J Urol"},{"key":"key20200713235057_b47-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1097\/00005392-200004000-00083","article-title":"Correlation between the structure and function of the rabbit urinary bladder following partial outlet obstruction","volume":"163","author":"Gosling","year":"2000","journal-title":"J Urol"},{"key":"key20200713235057_b48-mmr-22-01-0219","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1097\/01.ju.0000091810.33953.13","article-title":"Collagen directly stimulates bladder smooth muscle cell growth in vitro: Regulation by extracellular regulated mitogen activated protein kinase","volume":"170","author":"Herz","year":"2003","journal-title":"J Urol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T20:09:32Z","timestamp":1615406972000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2020.11092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,24]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,4,24]]}},"URL":"https:\/\/doi.org\/10.3892\/mmr.2020.11092","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,24]]}}}