{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:21:41Z","timestamp":1782958901951,"version":"3.54.5"},"reference-count":42,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Rep"],"DOI":"10.3892\/mmr.2024.13249","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T12:14:44Z","timestamp":1716207284000},"source":"Crossref","is-referenced-by-count":2,"title":["Oroxylin A inhibits inflammatory cytokines in periodontitis via HO\u20111"],"prefix":"10.3892","volume":"30","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Miao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Mei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, The Af\ufb01liated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"key20240611105634_b1-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"116163","DOI":"10.1016\/j.carbpol.2020.116163","article-title":"The effect of doxycycline-containing chitosan\/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease","volume":"237","author":"Xu","year":"2020","journal-title":"Carbohydr Polym"},{"key":"key20240611105634_b2-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/prd.12258","article-title":"Focal infection of periodontal origin","volume":"79","author":"Slots","year":"2019","journal-title":"Periodontol 2000"},{"key":"key20240611105634_b3-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol 2000"},{"key":"key20240611105634_b4-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1600-051X.2008.01260.x","article-title":"Antimicrobial therapy in periodontitis: The use of systemic antimicrobials against the subgingival biofilm","volume":"35","author":"Herrera","year":"2008","journal-title":"J Clin Periodontol"},{"key":"key20240611105634_b5-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/prd.12201","article-title":"Nonsurgical and surgical treatment of periodontitis: How many options for one disease?","volume":"75","author":"Graziani","year":"2017","journal-title":"Periodontology 2000"},{"key":"key20240611105634_b6-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/jcpe.13264","article-title":"Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis","volume":"47","author":"Teughels","year":"2020","journal-title":"J Clin Periodontol"},{"key":"key20240611105634_b7-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jpba.2018.10.028","article-title":"Comparative two-dimensional HepG2 and L02\/cell membrane chromatography\/C18\/time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix","volume":"164","author":"Gu","year":"2019","journal-title":"J Pharm Biomed Anal"},{"key":"key20240611105634_b8-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.biopha.2017.10.140","article-title":"Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs","volume":"97","author":"Jin","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"key20240611105634_b9-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.intimp.2016.10.011","article-title":"Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2","volume":"40","author":"Li","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"key20240611105634_b10-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1080\/14786419.2016.1244193","article-title":"Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells","volume":"31","author":"Han","year":"2017","journal-title":"Nat Prod Res"},{"key":"key20240611105634_b11-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"110917","DOI":"10.1016\/j.biopha.2020.110917","article-title":"The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review","volume":"133","author":"Liao","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"key20240611105634_b12-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1167\/iovs.61.6.51","article-title":"Perillaldehyde ameliorates aspergillus fumigatus keratitis by activating the Nrf2\/HO-1 signaling pathway and inhibiting dectin-1-mediated inflammation","volume":"61","author":"Fan","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20240611105634_b13-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3390\/antiox11030555","article-title":"Heme oxygenase-1: An anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders","volume":"11","author":"Ryter","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"key20240611105634_b14-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.3390\/molecules26072092","article-title":"Simultaneous quantitative analysis of ginsenosides isolated from the fruit of Panax ginseng C.A. Meyer and regulation of HO-1 expression through EGFR signaling has anti-inflammatory and osteogenic induction effects in HPDL cells","volume":"26","author":"Kim","year":"2021","journal-title":"Molecules"},{"key":"key20240611105634_b15-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"12861","DOI":"10.1038\/s41598-023-39853-5","article-title":"Ixeris dentata and lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway","volume":"13","author":"Lee","year":"2023","journal-title":"Sci Rep"},{"key":"key20240611105634_b16-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1007\/s00784-021-04143-9","article-title":"Molecular docking study and antireabsorptive activity of a semi-synthetic coumarin derivative from Platymiscium floribundum in the ligature-induced periodontitis in rats: The involvement of heme oxygenase-1","volume":"26","author":"Fran\u00e7a","year":"2022","journal-title":"Clin Oral Investig"},{"key":"key20240611105634_b17-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1096\/fj.11-196279","article-title":"Diabetes aggravates periodontitis by limiting repair through enhanced inflammation","volume":"26","author":"Pacios","year":"2012","journal-title":"FASEB J"},{"key":"key20240611105634_b18-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"104514","DOI":"10.1016\/j.archoralbio.2019.104514","article-title":"Doxycycline inhibits NAcht Leucine-rich repeat protein 3 inflammasome activation and interleukin-1\u03b2 production induced by porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts","volume":"107","author":"Xu","year":"2019","journal-title":"Arch Oral Biol"},{"key":"key20240611105634_b19-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.peptides.2017.05.003","article-title":"Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro","volume":"93","author":"Park","year":"2017","journal-title":"Peptides"},{"key":"key20240611105634_b20-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"e0176432","DOI":"10.1371\/journal.pone.0176432","article-title":"Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1","volume":"12","author":"Kwak","year":"2017","journal-title":"PLoS One"},{"key":"key20240611105634_b21-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"105617","DOI":"10.1016\/j.phrs.2021.105617","article-title":"A multi-herb-combined remedy to overcome hyper-inflammatory response by reprogramming transcription factor profile and shaping monocyte subsets","volume":"169","author":"De","year":"2021","journal-title":"Pharmacol Res"},{"key":"key20240611105634_b22-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12964-019-0324-8","article-title":"Blockade of glycolysis-dependent contraction by Oroxylin A via inhibition of lactate dehydrogenase-a in hepatic stellate cells","volume":"17","author":"Wang","year":"2019","journal-title":"Cell Commun Signal"},{"key":"key20240611105634_b23-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cbi.2018.02.025","article-title":"Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha","volume":"285","author":"Jin","year":"2018","journal-title":"Chem Biol Interact"},{"key":"key20240611105634_b24-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"4874","DOI":"10.1167\/iovs.11-8968","article-title":"Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts","volume":"53","author":"Tang","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20240611105634_b25-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2353\/ajpath.2007.060469","article-title":"Molecular pathology in the lungs of severe acute respiratory syndrome patients","volume":"170","author":"Ye","year":"2007","journal-title":"Am J Pathol"},{"key":"key20240611105634_b26-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"L1006","DOI":"10.1152\/ajplung.00015.2014","article-title":"Matrix metalloproteinase-9 activates TGF-\u03b2 and stimulates fibroblast contraction of collagen gels","volume":"306","author":"Kobayashi","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20240611105634_b27-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"6254","DOI":"10.3390\/ijms20246254","article-title":"Prostaglandin E2\/EP signaling in the tumor microenvironment of colorectal cancer","volume":"20","author":"Mizuno","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20240611105634_b28-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.clim.2006.01.016","article-title":"Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases","volume":"119","author":"Park","year":"2006","journal-title":"Clin Immunol"},{"key":"key20240611105634_b29-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/jcpe.12164","article-title":"Salivary IL-1\u03b2 and PGE2 as biomarkers of periodontal status, before and after periodontal treatment","volume":"40","author":"S\u00e1nchez","year":"2013","journal-title":"J Clin Periodontol"},{"key":"key20240611105634_b30-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"615486","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of bone resorption in periodontitis","volume":"2015","author":"Hienz","year":"2015","journal-title":"J Immunol Res"},{"key":"key20240611105634_b31-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1034\/j.1600-051X.1999.260807.x","article-title":"Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis","volume":"26","author":"Jin","year":"1999","journal-title":"J Clin Periodontol"},{"key":"key20240611105634_b32-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: Evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"key20240611105634_b33-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: The conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol Rev"},{"key":"key20240611105634_b34-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"15621","DOI":"10.1074\/jbc.M113.520510","article-title":"Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-\u03b1 and interleukin-1\u03b2 but suppresses that by interleukin-17A: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain","volume":"289","author":"Akiyama","year":"2014","journal-title":"J Biol Chem"},{"key":"key20240611105634_b35-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"108124","DOI":"10.1016\/j.celrep.2020.108124","article-title":"OPG production matters where it happened","volume":"32","author":"Tsukasaki","year":"2020","journal-title":"Cell Rep"},{"key":"key20240611105634_b36-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"108052","DOI":"10.1016\/j.celrep.2020.108052","article-title":"Local production of osteoprotegerin by osteoblasts suppresses bone resorption","volume":"32","author":"Cawley","year":"2020","journal-title":"Cell Rep"},{"key":"key20240611105634_b37-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"636","DOI":"10.5483\/BMBRep.2015.48.11.112","article-title":"N-acetyl cysteine inhibits H2O2-mediated reduction in the mineralization of MC3T3-E1 cells by down-regulating Nrf2\/HO-1 pathway","volume":"48","author":"Lee","year":"2015","journal-title":"BMB Rep"},{"key":"key20240611105634_b38-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1021\/acs.jafc.5b05157","article-title":"Glabridin alleviates the toxic effects of methylglyoxal on osteoblastic MC3T3-E1 cells by increasing expression of the glyoxalase system and Nrf2\/HO-1 signaling and protecting mitochondrial function","volume":"64","author":"Choi","year":"2016","journal-title":"J Agric Food Chem"},{"key":"key20240611105634_b39-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s10787-023-01391-x","article-title":"Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-\u03b1 and COX-2","volume":"32","author":"Nazar","year":"2024","journal-title":"Inflammopharmacology"},{"key":"key20240611105634_b40-mmr-30-1-13249","first-page":"541","article-title":"The temporal expression and localization of extracellular matrix metalloproteinase inducer (EMMPRIN) during the development of periodontitis in an animal model","volume":"45","author":"Liu","year":"2010","journal-title":"J Periodontal Res"},{"key":"key20240611105634_b41-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1039\/D0FO02159H","article-title":"Oroxylin A attenuates osteoarthritis progression by dual inhibition of cell inflammation and hypertrophy","volume":"12","author":"Chen","year":"2021","journal-title":"Food Funct"},{"key":"key20240611105634_b42-mmr-30-1-13249","doi-asserted-by":"publisher","first-page":"106123","DOI":"10.1016\/j.intimp.2019.106123","article-title":"Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice","volume":"80","author":"Huang","year":"2020","journal-title":"Int Immunopharmacol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T07:56:42Z","timestamp":1718092602000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2024.13249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,20]]}},"URL":"https:\/\/doi.org\/10.3892\/mmr.2024.13249","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"article-number":"126"}}