{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:39:37Z","timestamp":1770352777961,"version":"3.49.0"},"reference-count":32,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.3892\/ol.2014.2637","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T07:14:58Z","timestamp":1414134898000},"page":"15-24","source":"Crossref","is-referenced-by-count":15,"title":["Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression"],"prefix":"10.3892","volume":"9","author":[{"given":"JUNJI","family":"MA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUNLI","family":"SHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DONGQIANG","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIJUAN","family":"CHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENBIN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FANGFANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOYU","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUIQING","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"key20180108103557_b1-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00114.2010","article-title":"Recent advances in the regulation of cholangiocarcinoma growth","volume":"299","author":"Francis","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20180108103557_b2-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/jso.23028","article-title":"Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part I: diagnosis-clinical staging and pathology","volume":"106","author":"de Marsh","year":"2012","journal-title":"J Surg Oncol"},{"key":"key20180108103557_b3-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3109\/00365521.2011.589472","article-title":"Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany","volume":"46","author":"von Hahn","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"key20180108103557_b4-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.dld.2010.01.005","article-title":"Clinical implications of novel aspects of biliary pathophysiology","volume":"42","author":"Marzioni","year":"2010","journal-title":"Dig Liver Dis"},{"key":"key20180108103557_b5-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11864-013-0237-5","article-title":"Current therapy and future directions in biliary tract malignancies","volume":"14","author":"Ciombor","year":"2013","journal-title":"Curr Treat Options Oncol"},{"key":"key20180108103557_b6-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/43686","article-title":"Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP","volume":"401","author":"Yeung","year":"1999","journal-title":"Nature"},{"key":"key20180108103557_b7-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"7207","DOI":"10.1128\/MCB.21.21.7207-7217.2001","article-title":"Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation","volume":"21","author":"Yeung","year":"2001","journal-title":"Mol Cell Biol"},{"key":"key20180108103557_b8-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"23407","DOI":"10.1074\/jbc.M112.363812","article-title":"Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2","volume":"287","author":"Deiss","year":"2012","journal-title":"J Biol Chem"},{"key":"key20180108103557_b9-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"17515","DOI":"10.1074\/jbc.M313816200","article-title":"RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis","volume":"279","author":"Chatterjee","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180108103557_b10-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAT.0b013e32835817e8","article-title":"Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker","volume":"44","author":"Moon","year":"2012","journal-title":"Pathology"},{"key":"key20180108103557_b11-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1038\/emboj.2011.312","article-title":"Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer","volume":"30","author":"Yun","year":"2011","journal-title":"EMBO J"},{"key":"key20180108103557_b12-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.canlet.2010.08.012","article-title":"Raf kinase inhibitor protein suppresses nuclear factor-\u03baB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression","volume":"299","author":"Beshir","year":"2010","journal-title":"Cancer Lett"},{"key":"key20180108103557_b13-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1478-3231.2009.01981.x","article-title":"Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells","volume":"29","author":"Ma","year":"2009","journal-title":"Liver Int"},{"key":"key20180108103557_b14-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3892\/or.2013.2464","article-title":"Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression","volume":"30","author":"Zhao","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180108103557_b15-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10585-012-9470-8","article-title":"RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases","volume":"29","author":"Birner","year":"2012","journal-title":"Clin Exp Metastasis"},{"key":"key20180108103557_b16-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.idc.2010.07.006","article-title":"Cholangiocarcinoma: new insights into disease pathogenesis and biology","volume":"24","author":"Braconi","year":"2010","journal-title":"Infect Dis Clin North Am"},{"key":"key20180108103557_b17-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1245\/s10434-008-0180-z","article-title":"A proposed staging system for intrahepatic cholangiocarcinoma","volume":"16","author":"Nathan","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"key20180108103557_b18-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1477-2574.2010.00271.x","article-title":"Comparison of the prognostic accuracy of the sixth and seventh editions of the TNM classification for intrahepatic cholangiocarcinoma","volume":"13","author":"Ribero","year":"2011","journal-title":"HPB (Oxford)"},{"key":"key20180108103557_b19-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nature02158","article-title":"Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2","volume":"426","author":"Lorenz","year":"2003","journal-title":"Nature"},{"key":"key20180108103557_b20-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"23407","DOI":"10.1074\/jbc.M112.363812","article-title":"Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2","volume":"287","author":"Deiss","year":"2012","journal-title":"J Biol Chem"},{"key":"key20180108103557_b21-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10555-012-9365-9","article-title":"Raf kinase inhibitor protein (RKIP) in cancer","volume":"31","author":"Escara-Wilke","year":"2012","journal-title":"Cancer Metastasis Rev"},{"key":"key20180108103557_b22-ol-09-01-0015","first-page":"901","article-title":"The expression of cytokeratins 7, 19, and 20 in primary and metastatic carcinomas of the liver","volume":"9","author":"Maeda","year":"1996","journal-title":"Mod Pathol"},{"key":"key20180108103557_b23-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00428-011-1174-y","article-title":"Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater","volume":"460","author":"Kim","year":"2012","journal-title":"Virchows Arch"},{"key":"key20180108103557_b24-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/jcp.24335","article-title":"RKIP: much more than Raf kinase inhibitory protein","volume":"228","author":"Al-Mulla","year":"2013","journal-title":"J Cell Physiol"},{"key":"key20180108103557_b25-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/modpathol.3800549","article-title":"Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas","volume":"19","author":"L\u00f3di","year":"2006","journal-title":"Mod Pathol"},{"key":"key20180108103557_b26-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3748\/wjg.v18.i3.244","article-title":"High level of urokinase plasminogen activator contributes to cholangiocarcinoma invasion and metastasis","volume":"18","author":"Thummarati","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key20180108103557_b27-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"W1129","DOI":"10.2214\/AJR.11.6420","article-title":"Radiofrequency ablation of hepatic metastases after curative resection of extrahepatic cholangiocarcinoma","volume":"197","author":"Park","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"key20180108103557_b28-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.3892\/or.2013.2304","article-title":"Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC\/p-ERK\/MMP-2\/MMP-9","volume":"29","author":"Wang","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180108103557_b29-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-230X-9-30","article-title":"Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy","volume":"9","author":"Leelawat","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"key20180108103557_b30-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/13651820510042246a","article-title":"A matrix metalloproteinase inhibitor to treat unresectable cholangiocarcinoma","volume":"7","author":"French","year":"2005","journal-title":"HPB (Oxford)"},{"key":"key20180108103557_b31-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1572-0241.2003.04025.x","article-title":"Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma","volume":"99","author":"Jo Chae","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"key20180108103557_b32-ol-09-01-0015","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/hep.22838","article-title":"MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3","volume":"49","author":"Selaru","year":"2009","journal-title":"Hepatology"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2014.2637\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T08:37:40Z","timestamp":1515400660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2014.2637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,10,24]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.3892\/ol.2014.2637"],"URL":"https:\/\/doi.org\/10.3892\/ol.2014.2637","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}