{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:17:06Z","timestamp":1776338226701,"version":"3.51.2"},"reference-count":31,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.3892\/ol.2015.2845","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T07:29:32Z","timestamp":1420442972000},"page":"1470-1474","source":"Crossref","is-referenced-by-count":7,"title":["Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma"],"prefix":"10.3892","volume":"9","author":[{"given":"GUOWU","family":"XU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAI","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XING","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JINXIANG","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANFEN","family":"CHAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUNYI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"key20180108102626_b1-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1016\/j.crad.2014.01.005","article-title":"Imaging of thymus in myasthenia gravis: from thymic hyperplasia to thymic tumor","volume":"65","author":"Priola","year":"2014","journal-title":"Clin Radiol"},{"key":"key20180108102626_b2-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fonc.2013.00332","article-title":"Surgical approaches for stage IVA thymic epithelial tumors","volume":"3","author":"Shapiro","year":"2014","journal-title":"Front Oncol"},{"issue":"10 Suppl 4","key":"key20180108102626_b3-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"S260","DOI":"10.1097\/JTO.0b013e3181f1f62d","article-title":"Epidemiology of thymoma and associated malignancies","volume":"5","author":"Engels","year":"2010","journal-title":"J Thorac Oncol"},{"key":"key20180108102626_b4-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ejcts.2009.01.014","article-title":"Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment","volume":"35","author":"Lucchi","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"key":"key20180108102626_b5-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1245\/s10434-011-1896-8","article-title":"Different characteristics of thymomas with and without myasthenia gravis","volume":"19","author":"Yu","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"key20180108102626_b6-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3892\/ol.2014.2090","article-title":"Expression and polymorphisms of T cell immunoglobulin domain and mucin domain protein-1 in thymoma with or without myasthenia gravis","volume":"8","author":"Zheng","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180108102626_b7-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/01926230600865549","article-title":"Normal structure, function and histology of the thymus","volume":"34","author":"Pearse","year":"2006","journal-title":"Toxicol Pathol"},{"key":"key20180108102626_b8-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-3083.2012.02703.x","article-title":"T helper type 17 cells expand in patients with myasthenia-associated thymoma","volume":"76","author":"Wang","year":"2012","journal-title":"Scand J Immunol"},{"key":"key20180108102626_b9-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"404053","DOI":"10.1155\/2013\/404053","article-title":"Recent advance in genetic predisposition of myasthenia gravis","volume":"2013","author":"Zagoriti","year":"2013","journal-title":"Biomed Res Int"},{"key":"key20180108102626_b10-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.7754\/Clin.Lab.2012.120916","article-title":"Expression and clinical significance of protein tyrosine phosphatase nonreceptor 22 in resected thymoma","volume":"59","author":"Zheng","year":"2013","journal-title":"Clin Lab"},{"key":"key20180108102626_b11-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"415","author":"Monney","year":"2002","journal-title":"Nature"},{"key":"key20180108102626_b12-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"key":"key20180108102626_b13-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.coi.2006.09.009","article-title":"TIM-3 in autoimmunity","volume":"18","author":"Anderson","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"key20180108102626_b14-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni988","article-title":"Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance","volume":"4","author":"Sabatos","year":"2003","journal-title":"Nat Immunol"},{"key":"key20180108102626_b15-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fimmu.2012.00418","article-title":"TIM-3 as a molecular switch for tumor escape from innate immunity","volume":"3","author":"Mattei","year":"2013","journal-title":"Front Immunol"},{"key":"key20180108102626_b16-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.20100637","article-title":"Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients","volume":"207","author":"Fourcade","year":"2010","journal-title":"J Exp Med"},{"key":"key20180108102626_b17-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1172\/JCI46102","article-title":"Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients","volume":"121","author":"Baitsch","year":"2011","journal-title":"J Clin Inverst"},{"key":"key20180108102626_b18-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1084\/jem.20100643","article-title":"Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity","volume":"207","author":"Sakuishi","year":"2010","journal-title":"J Exp Med"},{"key":"key20180108102626_b19-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1182\/blood-2010-10-310425","article-title":"Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia","volume":"117","author":"Zhou","year":"2011","journal-title":"Blood"},{"key":"key20180108102626_b20-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/425576a","article-title":"Immunology: hepatitis A virus link to atopic disease","volume":"425","author":"Mclntire","year":"2003","journal-title":"Nature"},{"key":"key20180108102626_b21-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1477-7827-11-104","article-title":"The relationship between polymorphisms in the promoter region of Tim-3 and unexplained recurrent spontaneous abortion in Han Chinese women","volume":"11","author":"Shen","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"key20180108102626_b22-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3892\/ol.2013.1410","article-title":"TIM-3 expression in human osteosarcoma: Correlation with the expression of epithelial-mesenchymal transition-specific biomarkers","volume":"6","author":"Shang","year":"2013","journal-title":"Oncol Lett"},{"key":"key20180108102626_b23-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.0105-2896.2010.00903.x","article-title":"TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity","volume":"235","author":"Freeman","year":"2010","journal-title":"Immunol Rev"},{"key":"key20180108102626_b24-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.20060210","article-title":"Dysregulated T cell expression of TIM3 in multiple sclerosis","volume":"203","author":"Koguchi","year":"2006","journal-title":"J Exp Med"},{"key":"key20180108102626_b25-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.molmed.2005.06.008","article-title":"The TIM gene family regulates autoimmune and allergic diseases","volume":"11","author":"Meyers","year":"2005","journal-title":"Trends Mol Med"},{"key":"key20180108102626_b26-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1744-313X.2011.01046.x","article-title":"The -1541C>T and +4259G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population","volume":"38","author":"Xu","year":"2011","journal-title":"Int J Immunogenet"},{"key":"key20180108102626_b27-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.7314\/APJCP.2013.14.6.3897","article-title":"Prognostic value of T cell immunoglobulin mucin-3 in prostate cancer","volume":"14","author":"Piao","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180108102626_b28-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"e53834","DOI":"10.1371\/journal.pone.0053834","article-title":"Tim-3 expression in cervical cancer promotes tumor metastasis","volume":"8","author":"Cao","year":"2013","journal-title":"PLoS One"},{"key":"key20180108102626_b29-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1089\/dna.2012.1625","article-title":"T-cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and renal cell carcinoma","volume":"31","author":"Cai","year":"2012","journal-title":"DNA Cell Biol"},{"key":"key20180108102626_b30-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1007\/s11033-012-1862-y","article-title":"T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer","volume":"39","author":"Tong","year":"2012","journal-title":"Mol Biol Rep"},{"key":"key20180108102626_b31-ol-09-03-1470","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/ni.2396","article-title":"Tumor immunity times out: TIM-3 and HMGB1","volume":"13","author":"Tang","year":"2012","journal-title":"Nat Immunol"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2015.2845\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T02:36:40Z","timestamp":1566182200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2015.2845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,5]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,1,5]]},"published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.3892\/ol.2015.2845"],"URL":"https:\/\/doi.org\/10.3892\/ol.2015.2845","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,5]]}}}