{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:33:04Z","timestamp":1792204384825,"version":"4.4.0"},"reference-count":23,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.3892\/ol.2015.3054","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T11:07:56Z","timestamp":1426676876000},"page":"2193-2198","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of recombinant adenoviral human p53 gene in the treatment of lung cancer-mediated pleural effusion"],"prefix":"10.3892","volume":"9","author":[{"given":"KUN-LIN","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUN","family":"KANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PENG","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LI","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU-BO","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HENG-YI","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YONG","family":"HE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015]]},"reference":[{"key":"key20180103213941_b1-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"ii32","DOI":"10.1136\/thx.2010.136994","article-title":"BTS Pleural Disease Guideline Group: Management of a malignant pleural effusion: British Thoracic Society pleural disease guideline 2010","volume":"65","author":"Roberts","year":"2010","journal-title":"Thorax"},{"key":"key20180103213941_b2-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/bjc.1996.444","article-title":"How should cancer presenting as a malignant pleural effusion be managed?","volume":"74","author":"Bonnefoi","year":"1996","journal-title":"Br J Cancer"},{"key":"key20180103213941_b3-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1378\/chest.128.3.1431","article-title":"Clinical efficacy and safety of thoracoscopic talc pleurodesis in malignant pleural effusions","volume":"128","author":"Kolschmann","year":"2005","journal-title":"Chest"},{"key":"key20180103213941_b4-ol-0-0-3054","first-page":"1324","article-title":"Clinical research on recombinant human Ad-p53 injection combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer","volume":"28","author":"Zhao","year":"2009","journal-title":"Ai Zheng"},{"key":"key20180103213941_b5-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.3892\/or.2013.2349","article-title":"Intrapleural combination therapy with bevacizumab and cisplatin for non-small cell lung cancer-mediated malignant pleural effusion","volume":"29","author":"Du","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180103213941_b6-ol-0-0-3054","first-page":"490","volume-title":"Medical Molecular Biology","author":"Liu","year":"2000","edition":"1st"},{"key":"key20180103213941_b7-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1038\/sj.onc.1206434","article-title":"Hypoxia attenuates the p53 response to celluar damage","volume":"22","author":"Achison","year":"2003","journal-title":"Oncogene"},{"key":"key20180103213941_b8-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"589vi","DOI":"10.1016\/S1055-3207(02)00021-2","article-title":"Gene therapy for head and neck cancer","volume":"11","author":"Frank","year":"2002","journal-title":"Surg Oncol Clin N Am"},{"key":"key20180103213941_b9-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tips.2004.02.009","article-title":"p53: 25 years after its discovery","volume":"25","author":"Hofseth","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"key20180103213941_b10-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1054\/bjoc.2001.2128","article-title":"Activation and activities of the p53 tumor suppressor protein","volume":"85","author":"B\u00e1lint","year":"2001","journal-title":"J Br Cancer"},{"key":"key20180103213941_b11-ol-0-0-3054","first-page":"2","article-title":"Intrgen advexin therapy halts tumor growth in advanced esophageal cancer patients","volume":"6","author":"Frank","year":"2003","journal-title":"J News Release"},{"key":"key20180103213941_b12-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1055-3207(02)00028-5","article-title":"Clinical update of Ad-p53 gene therapy for lung cancer","volume":"11","author":"Swisher","year":"2002","journal-title":"Surg Oncol Clin N Am"},{"key":"key20180103213941_b13-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0889-8588(03)00144-8","article-title":"Gene replacement therapy for non-small-cell lung cancer: a review","volume":"18","author":"Roth","year":"2004","journal-title":"Hematol Oncol Clin North Am"},{"key":"key20180103213941_b14-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1177\/147323000803600614","article-title":"Advanced malignant pleural or peritoneal effusion in patients treated with recombinant adenovirus p53 injection plus cisplatin","volume":"36","author":"Dong","year":"2008","journal-title":"J Int Med Res"},{"key":"key20180103213941_b15-ol-0-0-3054","first-page":"153","article-title":"Efficacy of recombinant adenoviral human p53 gene in treatment of malignant pleural or peritoneal effusions background","volume":"16","author":"Zhang","year":"2013","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"key20180103213941_b16-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am J Clin Oncol"},{"key":"key20180103213941_b17-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1593\/neo.13142","article-title":"Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents","volume":"15","author":"Zhang","year":"2013","journal-title":"Neoplasia"},{"key":"key20180103213941_b18-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1200\/JCO.2000.18.3.609","article-title":"Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer","volume":"18","author":"Nemunaitis","year":"2000","journal-title":"J Clin Oncol"},{"key":"key20180103213941_b19-ol-0-0-3054","first-page":"93","article-title":"Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy","volume":"9","author":"Swisher","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20180103213941_b20-ol-0-0-3054","first-page":"206","article-title":"Clinical trial for the treatment of advanced lung cancer by intratumoral injection of rAd p53","volume":"14","author":"Weng","year":"2004","journal-title":"Shenzhen Zhong Xi Yi Jie He Za Zhi"},{"key":"key20180103213941_b21-ol-0-0-3054","first-page":"125","article-title":"Combination therapy with recombinant adenovirus-p53 injection (rAd-p53) via transcatheter hepatic arterial chemoembolization for advanced hepatic carcinoma","volume":"13","author":"Guan","year":"2005","journal-title":"World Chin J Digestology"},{"key":"key20180103213941_b22-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1089\/hum.2005.16.1016","article-title":"Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers","volume":"16","author":"Peng","year":"2005","journal-title":"Human Gene Ther"},{"key":"key20180103213941_b23-ol-0-0-3054","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.1091362","article-title":"Mono- versus polyubiquitination: differential control of p53 fate by Mdm2","volume":"302","author":"Li","year":"2003","journal-title":"Science"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2015.3054\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T05:59:19Z","timestamp":1515045559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2015.3054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015]]},"published-print":{"date-parts":[[2015]]}},"alternative-id":["10.3892\/ol.2015.3054"],"URL":"https:\/\/doi.org\/10.3892\/ol.2015.3054","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}