{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:58:14Z","timestamp":1787896694241,"version":"build-2784847793"},"reference-count":46,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/ol.2016.4927","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T06:52:53Z","timestamp":1470034373000},"page":"3004-3012","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative detection of TUSC3 promoter methylation -a potential biomarker for prognosis in lung cancer"],"prefix":"10.3892","volume":"12","author":[{"given":"Uta","family":"Duppel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Woenckhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Merk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Dietmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"key20180108110641_b1-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00761-010-1853-3","article-title":"Lung cancer","volume":"16","author":"Adamietz","year":"2010","journal-title":"Onkologe"},{"key":"key20180108110641_b2-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N Engl J Med"},{"key":"key20180108110641_b3-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1158\/1078-0432.CCR-07-2033","article-title":"Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung","volume":"14","author":"Licchesi","year":"2008","journal-title":"Clin Cancer Res"},{"key":"key20180108110641_b4-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.lungcan.2007.05.011","article-title":"Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers","volume":"58","author":"Yanagawa","year":"2007","journal-title":"Lung Cancer"},{"key":"key20180108110641_b5-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/1055-9965.EPI-07-2518","article-title":"DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients","volume":"17","author":"Feng","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20180108110641_b6-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/mc.20697","article-title":"Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure","volume":"50","author":"Ali","year":"2011","journal-title":"Mol Carcinog"},{"key":"key20180108110641_b7-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1200\/JCO.2004.10.077","article-title":"Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer","volume":"22","author":"Kim","year":"2004","journal-title":"J Clin Oncol"},{"key":"key20180108110641_b8-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1158\/1078-0432.CCR-10-3436","article-title":"An epigenetic marker panel for detection of lung cancer using cell-free serum DNA","volume":"17","author":"Begum","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key20180108110641_b9-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1158\/1078-0432.CCR-11-3049","article-title":"Defining a gene promoter methylation signature in sputum for lung cancer risk assessment","volume":"18","author":"Leng","year":"2012","journal-title":"Clin Cancer Res"},{"key":"key20180108110641_b10-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.lungcan.2011.03.002","article-title":"Promoter methylation of BRMS1 correlates with smoking history and poor survival in non-small cell lung cancer patients","volume":"74","author":"Yang","year":"2011","journal-title":"Lung Cancer"},{"key":"key20180108110641_b11-ol-0-0-4927","first-page":"2061","article-title":"Aberrant gene promoter methylation in sputum from individuals exposed to smoky coal emissions","volume":"28","author":"Liu","year":"2008","journal-title":"Anticancer Res"},{"key":"key20180108110641_b12-ol-0-0-4927","first-page":"223","article-title":"Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: Associations with clinical outcome","volume":"9","author":"Brabender","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20180108110641_b13-ol-0-0-4927","first-page":"363","article-title":"Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer","volume":"29","author":"DeJong","year":"2009","journal-title":"Anticancer Res"},{"key":"key20180108110641_b14-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s00432-009-0614-4","article-title":"RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China","volume":"135","author":"Lin","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180108110641_b15-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/cncr.20144","article-title":"Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma","volume":"100","author":"Maruyama","year":"2004","journal-title":"Cancer"},{"key":"key20180108110641_b16-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1158\/1078-0432.CCR-04-2378","article-title":"Methylation profiling of archived non-small cell lung cancer: A promising prognostic system","volume":"11","author":"Safar","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180108110641_b17-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.10787","article-title":"Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer","volume":"103","author":"Toyooka","year":"2003","journal-title":"Int J Cancer"},{"key":"key20180108110641_b18-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"12353","DOI":"10.1073\/pnas.0700153104","article-title":"Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers","volume":"104","author":"Jin","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108110641_b19-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/j.gastro.2008.09.063","article-title":"Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression","volume":"136","author":"Ohta","year":"2009","journal-title":"Gastroenterology"},{"key":"key20180108110641_b20-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jhep.2010.06.036","article-title":"Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer","volume":"54","author":"Calvisi","year":"2011","journal-title":"J Hepatol"},{"key":"key20180108110641_b21-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/ijc.25459","article-title":"Reduced expression of RAS protein activator like-1 in gastric cancer","volume":"128","author":"Seto","year":"2011","journal-title":"Int J Cancer"},{"key":"key20180108110641_b22-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1038\/sj.onc.1209634","article-title":"Involvement of programmed cell death 4 in transforming growth factor-betal-induced apoptosis in human hepatocellular carcinoma","volume":"25","author":"Zhang","year":"2006","journal-title":"Oncogene"},{"key":"key20180108110641_b23-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/path.1378","article-title":"Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis","volume":"200","author":"Chen","year":"2003","journal-title":"J Pathol"},{"key":"key20180108110641_b24-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/path.2039","article-title":"Smoking and cancer-related gene expression in bronchial epithelium an non-small-cell lung cancers","volume":"210","author":"Woenckhaus","year":"2006","journal-title":"J Pathol"},{"key":"key20180108110641_b25-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/onc.2011.376","article-title":"Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells","volume":"31","author":"Dawson","year":"2012","journal-title":"Oncogene"},{"key":"key20180108110641_b26-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/1471-2407-10-428","article-title":"Downregulation of metastasis suppressor 1 (MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer","volume":"10","author":"Liu","year":"2010","journal-title":"BMC Cancer"},{"key":"key20180108110641_b27-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1479-5876-9-95","article-title":"The impact of metastasis suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance","volume":"9","author":"Xie","year":"2011","journal-title":"J Transl Med"},{"key":"key20180108110641_b28-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1158\/2159-8290.CD-11-0267","article-title":"miR-23a promotes the transition from indolent to invasive colorectal cancer","volume":"2","author":"Jahid","year":"2012","journal-title":"Cancer Discov"},{"key":"key20180108110641_b29-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S1556-0864(15)31624-5","article-title":"Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers","volume":"1","author":"Lam","year":"2006","journal-title":"J Thorac Oncol"},{"key":"key20180108110641_b30-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/geno.1996.0321","article-title":"Physical mapping of chromosome 8p22 markers and their homozygous deletion in a metastatic prostate cancer","volume":"35","author":"Bova","year":"1996","journal-title":"Genomics"},{"key":"key20180108110641_b31-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/cncr.27850","article-title":"Methylation status of TUSC3 is a prognostic factor in ovarian cancer","volume":"119","author":"Pils","year":"2013","journal-title":"Cancer"},{"key":"key20180108110641_b32-ol-0-0-4927","first-page":"5489","article-title":"Aging and DNA methylation in colorectal mucosa and cancer","volume":"58","author":"Ahuja","year":"1998","journal-title":"Cancer Res"},{"key":"key20180108110641_b33-ol-0-0-4927","first-page":"327","article-title":"Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas","volume":"29","author":"Guerv\u00f2s","year":"2007","journal-title":"Cell Oncol"},{"key":"key20180108110641_b34-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00277-004-0969-1","article-title":"Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis","volume":"84","author":"Scholz","year":"2005","journal-title":"Ann Hematol"},{"key":"key20180108110641_b35-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1023\/B:MBIL.0000008351.36435.d6","article-title":"Methylation profile of several tumor suppressor genes in non-small-cell lung cancer","volume":"37","author":"Zemlyakova","year":"2003","journal-title":"Mol Biol"},{"key":"key20180108110641_b36-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/labinvest.2008.100","article-title":"MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples","volume":"88","author":"Bettstetter","year":"2008","journal-title":"Lab Invest"},{"key":"key20180108110641_b37-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.lungcan.2008.12.001","article-title":"DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components","volume":"65","author":"Kubo","year":"2009","journal-title":"Lung Cancer"},{"key":"key20180108110641_b38-ol-0-0-4927","first-page":"239","article-title":"Quantitative promoter hypermethylation analysis of RASSF1A in lung cancer: Comparison with methylation-specific PCR technique and clinical significance","volume":"5","author":"Lee","year":"2012","journal-title":"Mol Med Rep"},{"key":"key20180108110641_b39-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1093\/nar\/gkn113","article-title":"Sensitive melting analysis after real time-methylation specific PCR (SMART-MSP): High-throughput and probe-free quantitative DNA methylation detection","volume":"36","author":"Kristensen","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"key20180108110641_b40-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00292-007-0929-3","article-title":"Quantitative methylation-specific PCR for the diagnosis of lung cancer","volume":"28","author":"Grote","year":"2007","journal-title":"Pathologe"},{"key":"key20180108110641_b41-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00432-011-1140-8","article-title":"PDCD4 expression inversely correlated with miR-21 levels in gastric cancers","volume":"138","author":"Cao","year":"2012","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180108110641_b42-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/ijc.22106","article-title":"The expression of metastasis suppressor MIM\/MTSS1 is regulated by DNA methylation","volume":"119","author":"Utikal","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180108110641_b43-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/onc.2011.411","article-title":"MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma","volume":"31","author":"Fan","year":"2012","journal-title":"Oncogene"},{"key":"key20180108110641_b44-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/BSR20110045","article-title":"Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: Evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators","volume":"32","author":"Leupold","year":"2012","journal-title":"Biosci Rep"},{"key":"key20180108110641_b45-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ajhg.2008.03.018","article-title":"A defekt in the TUSC3 gene is associated with autosomal recessive mental retardation","volume":"82","author":"Garshasbi","year":"2008","journal-title":"Am J Hum Genet"},{"key":"key20180108110641_b46-ol-0-0-4927","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1098-2264(199901)24:1<42::AID-GCC6>3.0.CO;2-F","article-title":"High-density screen of human tumor cell lines for homozygous deletions of loci on chromosome arm 8p","volume":"24","author":"Levy","year":"1999","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2016.4927\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T14:52:48Z","timestamp":1515423168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2016.4927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,1]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/ol.2016.4927"],"URL":"https:\/\/doi.org\/10.3892\/ol.2016.4927","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]}}}