{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:00:44Z","timestamp":1772575244386,"version":"3.50.1"},"reference-count":27,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/ol.2016.4975","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T08:47:41Z","timestamp":1470646061000},"page":"2511-2516","source":"Crossref","is-referenced-by-count":3,"title":["Hepatocellular carcinoma stem cell-like cells are enriched following low-dose 5-fluorouracil chemotherapy"],"prefix":"10.3892","volume":"12","author":[{"given":"Yongqiang","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangwen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junren","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"key20180108110738_b1-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3748\/wjg.v21.i5.1414","article-title":"Association between spp. infections and hepatobiliary malignancies: A review","volume":"21","author":"Segura-Lopez","year":"2015","journal-title":"World J Gastroenterol"},{"key":"key20180108110738_b2-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/ng.2291","article-title":"Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators","volume":"44","author":"Fujimoto","year":"2012","journal-title":"Nat Genet"},{"key":"key20180108110738_b3-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clcc.2014.11.002","article-title":"A review of the evolution of systemic chemotherapy in the management of colorectal cancer","volume":"14","author":"Gustavsson","year":"2015","journal-title":"Clin Colorectal Cancer"},{"key":"key20180108110738_b4-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3892\/mmr.2014.2906","article-title":"Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating \u03b2-catenin and cyclin D1 expression","volume":"11","author":"Wang","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108110738_b5-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"e0115686","DOI":"10.1371\/journal.pone.0115686","article-title":"Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes","volume":"10","author":"Focaccetti","year":"2015","journal-title":"PLoS One"},{"key":"key20180108110738_b6-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3748\/wjg.v9.i4.635","article-title":"Preventive treatments for recurrence after curative resection of hepatocellular carcinoma-a literature review of randomized control trials","volume":"9","author":"Sun","year":"2003","journal-title":"World J Gastroenterol"},{"key":"key20180108110738_b7-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.18632\/oncotarget.2462","article-title":"Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer","volume":"6","author":"Kumar","year":"2015","journal-title":"Oncotarget"},{"key":"key20180108110738_b8-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-12-24","article-title":"Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden","volume":"12","author":"Abubaker","year":"2013","journal-title":"Mol Cancer"},{"key":"key20180108110738_b9-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1158\/1541-7786.MCR-08-0035","article-title":"Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations","volume":"6","author":"Ma","year":"2008","journal-title":"Mol Cancer Res"},{"key":"key20180108110738_b10-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3892\/ijo.2015.2844","article-title":"Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases","volume":"46","author":"Jing","year":"2015","journal-title":"Int J Oncol"},{"key":"key20180108110738_b11-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1101\/gad.1897010","article-title":"Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer","volume":"24","author":"Oliver","year":"2010","journal-title":"Genes Dev"},{"key":"key20180108110738_b12-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/hep.21227","article-title":"Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties","volume":"44","author":"Chiba","year":"2006","journal-title":"Hepatology"},{"key":"key20180108110738_b13-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"e11456","DOI":"10.1371\/journal.pone.0011456","article-title":"Characterization of side populations in HNSCC: Highly invasive, chemoresistant and abnormal Wnt signaling","volume":"5","author":"Song","year":"2010","journal-title":"PLoS One"},{"key":"key20180108110738_b14-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1002\/jcb.23199","article-title":"Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile","volume":"112","author":"Latifi","year":"2011","journal-title":"J Cell Biochem"},{"key":"key20180108110738_b15-ol-0-0-4975","first-page":"312","article-title":"Detection of putative stem cells markers, CD44\/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas","volume":"40","author":"Mannelli","year":"2015","journal-title":"A preliminary immunohistochemical and in vitro study. Clin Otolaryngol"},{"key":"key20180108110738_b16-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CGM.S11286","article-title":"Wound healing and cancer stem cells: Inflammation as a driver of treatment resistance in breast cancer","volume":"8","author":"Arnold","year":"2015","journal-title":"Cancer Growth Metastasis"},{"key":"key20180108110738_b17-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"284","DOI":"10.7150\/ijbs.10248","article-title":"5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cells","volume":"11","author":"Xu","year":"2015","journal-title":"Int J Biol Sci"},{"key":"key20180108110738_b18-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00005-015-0330-5","article-title":"CD133-positive cells from non-small cell lung cancer show distinct sensitivity to cisplatin and afatinib","volume":"63","author":"Alama","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"key20180108110738_b19-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.3892\/mmr.2015.3291","article-title":"Side population cells and drug resistance in breast cancer","volume":"11","author":"Wang","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108110738_b20-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1476-4598-13-213","article-title":"ABCG2, a novel antigen to sort luminal progenitors of BRCA1-breast cancer cells","volume":"13","author":"Leccia","year":"2014","journal-title":"Mol Cancer"},{"key":"key20180108110738_b21-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/pros.22867","article-title":"Differential expression of stem cell markers and ABCG2 in recurrent prostate cancer","volume":"74","author":"Guzel","year":"2014","journal-title":"Prostate"},{"key":"key20180108110738_b22-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s004410050005","article-title":"Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland epithelium","volume":"299","author":"Feuerhake","year":"2000","journal-title":"Cell Tissue Res"},{"key":"key20180108110738_b23-ol-0-0-4975","first-page":"1220","article-title":"EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways","volume":"5","author":"Lv","year":"2012","journal-title":"Mol Med Rep"},{"key":"key20180108110738_b24-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1476-4598-12-159","article-title":"The roles of FOXM1 in pancreatic stem cells and carcinogenesis","volume":"12","author":"Quan","year":"2013","journal-title":"Mol Cancer"},{"key":"key20180108110738_b25-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s13058-014-0436-4","article-title":"The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells","volume":"16","author":"Bergamaschi","year":"2014","journal-title":"Breast Cancer Res"},{"key":"key20180108110738_b26-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"e34329","DOI":"10.1371\/journal.pone.0034329","article-title":"FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma","volume":"7","author":"Teh","year":"2012","journal-title":"PLoS One"},{"key":"key20180108110738_b27-ol-0-0-4975","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/hep.27093","article-title":"Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma","volume":"60","author":"Yamashita","year":"2014","journal-title":"Hepatology"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2016.4975\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T14:54:08Z","timestamp":1515423248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2016.4975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,8]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/ol.2016.4975"],"URL":"https:\/\/doi.org\/10.3892\/ol.2016.4975","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]}}}