{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:27:48Z","timestamp":1789954068195,"version":"4.0.1"},"reference-count":17,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.3892\/ol.2017.5732","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T12:45:24Z","timestamp":1486989924000},"page":"2316-2322","source":"Crossref","is-referenced-by-count":37,"title":["Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma"],"prefix":"10.3892","volume":"13","author":[{"given":"Huajie","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"key20180108112650_b1-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cld.2015.01.001","article-title":"Global epidemiology of hepatocellular carcinoma: An emphasis on demographic and regional variability","volume":"19","author":"McGlynn","year":"2015","journal-title":"Clin Liver Dis"},{"key":"key20180108112650_b2-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"837420","DOI":"10.1155\/2014\/837420","article-title":"Human umbilical cord perivascular cells exhibited enhanced migration capacity towards hepatocellular carcinoma in comparison with bone marrow mesenchymal stromal cells: A role for autocrine motility factor receptor","volume":"2014","author":"Bayo","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20180108112650_b3-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmch.2014.11.002","article-title":"Recent advances in cancer therapeutics","volume":"54","author":"Chessum","year":"2015","journal-title":"Prog Med Chem"},{"key":"key20180108112650_b4-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrc1411","article-title":"Biologically active sphingolipids in cancer pathogenesis and treatment","volume":"4","author":"Ogretmen","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"key20180108112650_b5-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1096\/fj.08-117572","article-title":"Role of sphingosine kinase 1 in colon carcinogenesis","volume":"23","author":"Kawamori","year":"2009","journal-title":"FASEB J"},{"key":"key20180108112650_b6-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1042\/BST20110602","article-title":"Sphingosine 1-phosphate signaling in cancer","volume":"40","author":"Pyne","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"key20180108112650_b7-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.20040559","article-title":"Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signaling","volume":"201","author":"Pitson","year":"2005","journal-title":"J Exp Med"},{"key":"key20180108112650_b8-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/10409238.2011.597737","article-title":"Still benched on its way to the bedside: Sphingosine kinase 1 as an emerging target in cancer chemotherapy","volume":"46","author":"Gault","year":"2011","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"key20180108112650_b9-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000318173","article-title":"The expression of sphingosine kinase-1 in head and neck carcinoma","volume":"192","author":"Facchinetti","year":"2010","journal-title":"Cells Tissues Organs"},{"key":"key20180108112650_b10-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1158\/1078-0432.CCR-08-1158","article-title":"Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients","volume":"15","author":"Li","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key20180108112650_b11-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1369\/jhc.4A6606.2005","article-title":"Immunohistochemistry distribution of sphingosine kinase 1 in normal and tumor lung tissues","volume":"53","author":"Johnson","year":"2005","journal-title":"J Histochem Cytochem"},{"key":"key20180108112650_b12-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer","volume":"10","author":"Pyne","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"key20180108112650_b13-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genoma-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"key":"key20180108112650_b14-ol-0-0-5732","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"key20180108112650_b15-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00384-012-1510-y","article-title":"Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2\/9 and uPA via MAPK pathways","volume":"27","author":"Liu","year":"2012","journal-title":"Int J Colorectal Dis"},{"key":"key20180108112650_b16-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3892\/mco.2013.119","article-title":"Tumor markers for hepatocellular carcinoma","volume":"1","author":"Zhao","year":"2013","journal-title":"Mol Clin Oncol"},{"key":"key20180108112650_b17-ol-0-0-5732","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3892\/mmr.2016.5474","article-title":"The effect of LOXL2 in hepatocellular carcinoma","volume":"14","author":"Wu","year":"2016","journal-title":"Mol Med Rep"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2017.5732\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T15:39:23Z","timestamp":1515425963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.5732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,13]]},"published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.3892\/ol.2017.5732"],"URL":"https:\/\/doi.org\/10.3892\/ol.2017.5732","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,13]]}}}