{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:23:38Z","timestamp":1775856218678,"version":"3.50.1"},"reference-count":42,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.3892\/ol.2017.5997","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T08:53:57Z","timestamp":1491382437000},"page":"4533-4539","source":"Crossref","is-referenced-by-count":3,"title":["Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes"],"prefix":"10.3892","volume":"13","author":[{"given":"Jianfu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"key20180108113736_b1-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The prevalence of pituitary adenomas","volume":"101","author":"Ezzat","year":"2004","journal-title":"Cancer"},{"key":"key20180108113736_b2-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/jcp.56.8.561","article-title":"Best Practice No 172: Pituitary gland pathology","volume":"56","author":"Ironside","year":"2003","journal-title":"J Clin Pathol"},{"key":"key20180108113736_b3-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01402074","article-title":"Functional classification of pituitary adenomas","volume":"52","author":"Scanarini","year":"1980","journal-title":"Acta Neurochir (Wien)"},{"key":"key20180108113736_b4-ol-0-0-5997","first-page":"S123","article-title":"Recent clinical and pathophysiological advances in non-functioning pituitary adenomas","volume":"71","author":"Korbonits","year":"2009","journal-title":"Horm Res"},{"key":"key20180108113736_b5-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11102-006-0412-9","article-title":"Clinically non-functioning pituitary adenoma","volume":"9","author":"Jaffe","year":"2006","journal-title":"Pituitary"},{"key":"key20180108113736_b6-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","article-title":"High prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium","volume":"91","author":"Daly","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108113736_b7-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.beem.2009.05.005","article-title":"Non-functioning pituitary adenomas","volume":"23","author":"Greenman","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key20180108113736_b8-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-8794-3-13","article-title":"Signaling pathway networks mined from human pituitary adenoma proteomics data","volume":"3","author":"Zhan","year":"2010","journal-title":"BMC Med Genomics"},{"key":"key20180108113736_b9-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/cc.9.1.10346","article-title":"Ligand-driven activation of the notch pathway in T-ALL and solid tumors: Why Not(ch)?","volume":"9","author":"Indraccolo","year":"2010","journal-title":"Cell Cycle"},{"key":"key20180108113736_b10-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrendo.2011.40","article-title":"Pathogenesis of pituitary tumors","volume":"7","author":"Melmed","year":"2011","journal-title":"Nature Rev Endocrinol"},{"key":"key20180108113736_b11-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jcp.20542","article-title":"Physiology and pathology of notch signalling system","volume":"207","author":"Bianchi","year":"2006","journal-title":"J Cell Physiol"},{"key":"key20180108113736_b12-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1242\/dev.01074","article-title":"Notch signaling: Control of cell communication and cell fate","volume":"131","author":"Lai","year":"2004","journal-title":"Development"},{"key":"key20180108113736_b13-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: Cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"key20180108113736_b14-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.12.12.1751","article-title":"LIN-12\/Notch signaling: Lessons from worms and flies","volume":"12","author":"Greenwald","year":"1998","journal-title":"Genes Dev"},{"key":"key20180108113736_b15-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.7716513","article-title":"Notch signaling","volume":"268","author":"Artavanis-Tsakonas","year":"1995","journal-title":"Science"},{"key":"key20180108113736_b16-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1158\/0008-5472.CAN-05-0884","article-title":"Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses","volume":"65","author":"Moreno","year":"2005","journal-title":"Cancer Res"},{"key":"key20180108113736_b17-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jocn.2011.07.029","article-title":"Overexpression of the Notch3 receptor in non-functioning pituitary tumours","volume":"19","author":"Miao","year":"2012","journal-title":"J Clin Neurosci"},{"key":"key20180108113736_b18-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3892\/ol.2013.1113","article-title":"Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas","volume":"5","author":"Lu","year":"2013","journal-title":"Oncol Lett"},{"key":"key20180108113736_b19-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108113736_b20-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/138945010791170860","article-title":"The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness","volume":"11","author":"Wang","year":"2010","journal-title":"Curr Drug Targets"},{"key":"key20180108113736_b21-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1593\/neo.81008","article-title":"Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types","volume":"11","author":"Hu","year":"2009","journal-title":"Neoplasia"},{"key":"key20180108113736_b22-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.gde.2006.12.001","article-title":"The multifaceted role of Notch in cancer","volume":"17","author":"Roy","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"key20180108113736_b23-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm754","article-title":"Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells","volume":"8","author":"Weijzen","year":"2002","journal-title":"Nat Med"},{"key":"key20180108113736_b24-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.canlet.2011.03.012","article-title":"Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells","volume":"307","author":"Bao","year":"2011","journal-title":"Cancer Lett"},{"key":"key20180108113736_b25-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1158\/0008-5472.CAN-07-1229","article-title":"Oxygen concentration determines the biological effects of Notch-1 signaling in adenocarcinoma of the lung","volume":"67","author":"Chen","year":"2007","journal-title":"Cancer Res"},{"key":"key20180108113736_b26-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1007\/s00018-007-7164-1","article-title":"Notch and cancer: A double-edged sword","volume":"64","author":"Koch","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"key20180108113736_b27-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbrc.2007.02.130","article-title":"Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma","volume":"356","author":"Gao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108113736_b28-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1158\/0008-5472.CAN-04-1890","article-title":"Expression of Notch-1 and its ligands, Delta-Like-1 and Jagged-1, is critical for glioma cell survival and proliferation","volume":"65","author":"Purow","year":"2005","journal-title":"Cancer Res"},{"key":"key20180108113736_b29-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1038\/sj.onc.1208865","article-title":"Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma","volume":"24","author":"Somasundaram","year":"2005","journal-title":"Oncogene"},{"key":"key20180108113736_b30-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3892\/ijo.2013.1778","article-title":"Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma","volume":"42","author":"Maemura","year":"2013","journal-title":"Int J Oncol"},{"key":"key20180108113736_b31-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/hmg\/ddq529","article-title":"Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis","volume":"20","author":"Chapman","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key20180108113736_b32-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1002\/dvdy.21296","article-title":"Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects","volume":"236","author":"Loomes","year":"2007","journal-title":"Dev Dyn"},{"key":"key20180108113736_b33-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1158\/0008-5472.CAN-05-1208","article-title":"Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function","volume":"65","author":"Patel","year":"2005","journal-title":"Cancer Res"},{"key":"key20180108113736_b34-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1432-0436.2001.690207.x","article-title":"Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis","volume":"69","author":"Mailhos","year":"2001","journal-title":"Differentiation"},{"key":"key20180108113736_b35-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1158\/0008-5472.CAN-07-0969","article-title":"Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res"},{"key":"key20180108113736_b36-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1186\/1471-2407-10-641","article-title":"Combination of Dll4\/Notch and Ephrin-B2\/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis","volume":"10","author":"Djokovic","year":"2010","journal-title":"BMC Cancer"},{"key":"key20180108113736_b37-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1161\/CIRCRESAHA.110.221663","article-title":"Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia","volume":"107","author":"Al","year":"2010","journal-title":"Circ Res"},{"key":"key20180108113736_b38-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood-2005-03-1000","article-title":"Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function","volume":"107","author":"Williams","year":"2006","journal-title":"Blood"},{"key":"key20180108113736_b39-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gde.2003.11.004","article-title":"Multiple niches for Notch in cancer: Context is everything","volume":"14","author":"Weng","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"key20180108113736_b40-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature05571","article-title":"Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis","volume":"445","author":"Hellstr\u00f6m","year":"2007","journal-title":"Nature"},{"key":"key20180108113736_b41-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: A simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180108113736_b42-ol-0-0-5997","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1083\/jcb.200503113","article-title":"The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands","volume":"170","author":"Ladi","year":"2005","journal-title":"J Cell Biol"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol.2017.5997\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T16:20:34Z","timestamp":1515428434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.5997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,4,5]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.3892\/ol.2017.5997"],"URL":"https:\/\/doi.org\/10.3892\/ol.2017.5997","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]}}}