{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:56:34Z","timestamp":1789721794311,"version":"4.0.1"},"reference-count":40,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.3892\/ol.2017.6120","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T11:13:56Z","timestamp":1493896436000},"page":"47-54","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma"],"prefix":"10.3892","volume":"14","author":[{"given":"Juan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Bai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou-Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"key20180108115756_b1-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fertnstert.2012.10.048","article-title":"Biomarkers in uterine leiomyoma","volume":"99","author":"Levy","year":"2013","journal-title":"Fertil Steril"},{"key":"key20180108115756_b2-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ajog.2015.07.044","article-title":"The medical management of abnormal uterine bleeding in reproductive-aged women","volume":"214","author":"Bradley","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"key20180108115756_b3-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humupd\/dmv030","article-title":"Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth","volume":"21","author":"Commandeur","year":"2015","journal-title":"Hum Reprod Update"},{"key":"key20180108115756_b4-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/humrep\/deh407","article-title":"Uterine leiomyoma and menstrual cycle characteristics in a population-based cohort study","volume":"19","author":"Marino","year":"2004","journal-title":"Hum Reprod"},{"key":"key20180108115756_b5-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.fertnstert.2014.07.1238","article-title":"Fibroid growth and medical options for treatment","volume":"102","author":"Chabbert-Buffet","year":"2014","journal-title":"Fertil Steril"},{"key":"key20180108115756_b6-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.fertnstert.2014.06.041","article-title":"With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice?","volume":"102","author":"Donnez","year":"2014","journal-title":"Fertil Steril"},{"key":"key20180108115756_b7-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.1208930","article-title":"MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas","volume":"334","author":"Makinen","year":"2011","journal-title":"Science"},{"key":"key20180108115756_b8-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMoa1302736","article-title":"Characterization of uterine leiomyomas by whole-genome sequencing","volume":"369","author":"Mehine","year":"2013","journal-title":"N Engl J Med"},{"key":"key20180108115756_b9-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/ijc.27424","article-title":"MED12 mutations in uterine fibroids-their relationship to cytogenetic subgroups","volume":"131","author":"Markowski","year":"2012","journal-title":"Int J Cancer"},{"key":"key20180108115756_b10-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/humu.22612","article-title":"Mutations in exon 1 highlight the role of MED12 in uterine leiomyomas","volume":"35","author":"K\u00e4mpj\u00e4rvi","year":"2014","journal-title":"Hum Mutat"},{"key":"key20180108115756_b11-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/molehr\/gau055","article-title":"Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma","volume":"20","author":"Di Tommaso","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"key20180108115756_b12-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.fertnstert.2014.06.040","article-title":"MED12 mutation frequency in unselected sporadic uterine leiomyomas","volume":"102","author":"Heinonen","year":"2014","journal-title":"Fertil Steril"},{"key":"key20180108115756_b13-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ng.3037","article-title":"Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma","volume":"46","author":"Lim","year":"2014","journal-title":"Nat Genet"},{"key":"key20180108115756_b14-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.3409","article-title":"Genomic landscapes of breast fibroepithelial tumors","volume":"47","author":"Tan","year":"2015","journal-title":"Nat Genet"},{"key":"key20180108115756_b15-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.18632\/oncotarget.2753","article-title":"Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia","volume":"6","author":"K\u00e4mpj\u00e4rvi","year":"2015","journal-title":"Oncotarget"},{"key":"key20180108115756_b16-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ng.2279","article-title":"Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer","volume":"44","author":"Barbieri","year":"2012","journal-title":"Nat Genet"},{"key":"key20180108115756_b17-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pros.23092","article-title":"Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms","volume":"76","author":"K\u00e4mpj\u00e4rvi","year":"2016","journal-title":"Prostate"},{"key":"key20180108115756_b18-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/bjc.2012.428","article-title":"Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer","volume":"107","author":"K\u00e4mpj\u00e4rvi","year":"2012","journal-title":"Br J Cancer"},{"key":"key20180108115756_b19-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.1767009","article-title":"The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function","volume":"23","author":"Knuesel","year":"2009","journal-title":"Genes Dev"},{"key":"key20180108115756_b20-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1172\/JCI81534","article-title":"Med12 gain-of-function mutation causes leiomyomas and genomic instability","volume":"125","author":"Mittal","year":"2015","journal-title":"J Clin Invest"},{"key":"key20180108115756_b21-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N Engl J Med"},{"key":"key20180108115756_b22-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2010.10.038","article-title":"IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders","volume":"402","author":"Zou","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108115756_b23-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","article-title":"Mutations in GNA11 in uveal melanoma","volume":"363","author":"van Raamsdonk","year":"2010","journal-title":"N Engl J Med"},{"key":"key20180108115756_b24-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"D67","DOI":"10.1093\/nar\/gkv1276","article-title":"GenBank","volume":"44","author":"Clark","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"key20180108115756_b25-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"e113699","DOI":"10.1371\/journal.pone.0113699","article-title":"Elevated serum polybrominated diphenyl ethers and alteration of thyroid hormones in children from Guiyu, China","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"key20180108115756_b26-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1159\/000369488","article-title":"Analysis of the discriminative methods for diagnosis of benign and malignant solitary pulmonary nodules based on serum markers","volume":"37","author":"Wang","year":"2014","journal-title":"Oncol Res Treat"},{"key":"key20180108115756_b27-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/00071668.2012.719147","article-title":"Changes in plasma gonadotrophins, 17\u03b2-oestradiol, progesterone, prolactin, thyroxine and triiodothyronine concentrations in female Japanese quail (Coturnix coturnix japonica) of a heavy body weight line during photo-induced ovarian growth and regression","volume":"53","author":"Henare","year":"2012","journal-title":"Br Poult Sci"},{"key":"key20180108115756_b28-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/his.12039","article-title":"Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours","volume":"62","author":"Matsubara","year":"2013","journal-title":"Histopathology"},{"key":"key20180108115756_b29-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/PGP.0000000000000255","article-title":"Frequency and spectrum of MED12 exon 2 mutations in multiple versus solitary uterine leiomyomas from Russian patients","volume":"35","author":"Osinovskaya","year":"2016","journal-title":"Int J Gynecol Pathol"},{"key":"key20180108115756_b30-ol-0-0-6120","first-page":"2441","article-title":"Somatic mutational analysis of MED12 exon 2 in uterine leiomyomas of Iranian women","volume":"5","author":"Shahbazi","year":"2015","journal-title":"Am J Cancer Res"},{"key":"key20180108115756_b31-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s13277-015-3943-8","article-title":"The study of MED12 gene mutations in uterine leiomyomas from Iranian patients","volume":"37","author":"Sadeghi","year":"2016","journal-title":"Tumour Biol"},{"key":"key20180108115756_b32-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1093\/hmg\/ddv177","article-title":"Clonally related uterine leiomyomas are common and display branched tumor evolution","volume":"24","author":"Mehine","year":"2015","journal-title":"Hum Mol Genet"},{"key":"key20180108115756_b33-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1089\/gtmb.2014.0273","article-title":"High-resolution melting analysis of MED12 mutations in uterine leiomyomas in Chinese patients","volume":"19","author":"Wang","year":"2015","journal-title":"Genet Test Mol Biomarkers"},{"key":"key20180108115756_b34-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00438-014-0938-x","article-title":"Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids","volume":"290","author":"Halder","year":"2015","journal-title":"Mol Genet Genomics"},{"key":"key20180108115756_b35-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1002\/cncr.28900","article-title":"Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma","volume":"120","author":"Zhang","year":"2014","journal-title":"Cancer"},{"key":"key20180108115756_b36-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/modpathol.2013.243","article-title":"MED12 and HMGA2 mutations: Two independent genetic events in uterine leiomyoma and leiomyosarcoma","volume":"27","author":"Bertsch","year":"2014","journal-title":"Mod Pathol"},{"key":"key20180108115756_b37-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ejhg.2013.33","article-title":"MED12 exon 2 mutations in histopathological uterine leiomyoma variants","volume":"21","author":"Makinen","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"key20180108115756_b38-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3892\/ol.2015.3118","article-title":"MED12 mutation in patients with hysteromyoma","volume":"9","author":"Ye","year":"2015","journal-title":"Oncol Lett"},{"key":"key20180108115756_b39-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2013.08.005","article-title":"MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors","volume":"45","author":"Schwetye","year":"2014","journal-title":"Hum Pathol"},{"key":"key20180108115756_b40-ol-0-0-6120","doi-asserted-by":"crossref","first-page":"e33251","DOI":"10.1371\/journal.pone.0033251","article-title":"Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas","volume":"7","author":"McGuire","year":"2012","journal-title":"PLoS One"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T20:32:37Z","timestamp":1515443557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.6120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,5,4]]},"published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.3892\/ol.2017.6120"],"URL":"https:\/\/doi.org\/10.3892\/ol.2017.6120","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]}}}