{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:16:58Z","timestamp":1791501418022,"version":"4.3.4"},"reference-count":38,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.3892\/ol.2017.6304","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T08:08:40Z","timestamp":1496390920000},"page":"1275-1280","source":"Crossref","is-referenced-by-count":13,"title":["Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review"],"prefix":"10.3892","volume":"14","author":[{"given":"Saad","family":"Alqahtani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Y.","family":"Alhefdhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Almalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyad","family":"Mahasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher","family":"Al-Tweigeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"key20180108115026_b1-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.det.2012.04.001","article-title":"Update on the recurrence state of melanoma incidence","volume":"30","author":"Little","year":"2012","journal-title":"Dematol Clin"},{"key":"key20180108115026_b2-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0305-7372(03)00105-1","article-title":"The management of brain metastasis","volume":"29","author":"Patchell","year":"2003","journal-title":"Cancer Treat Rev"},{"key":"key20180108115026_b3-ol-0-0-6304","volume-title":"Cutaneous Melanoma","author":"Balch","year":"2003","edition":"4th"},{"key":"key20180108115026_b4-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180108115026_b5-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0014-2964(78)90201-3","article-title":"The current causes of death in patients with malignant melanoma","volume":"14","author":"Budman","year":"1978","journal-title":"Eur J Cancer"},{"key":"key20180108115026_b6-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/cncr.25634","article-title":"Prognostic factors for survival in melanoma patients with brain metastases","volume":"117","author":"Davies","year":"2011","journal-title":"Cancer"},{"key":"key20180108115026_b7-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0002-9610(78)90171-X","article-title":"Metastatic pattern of malignant melanoma: A study of 216 autopsy cases","volume":"135","author":"Patel","year":"1978","journal-title":"Am J Surg"},{"key":"key20180108115026_b8-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jso.20592","article-title":"Metastatic melanoma in the breast: A report of 27 cases","volume":"94","author":"Ravdel","year":"2006","journal-title":"J Surg Oncol"},{"key":"key20180108115026_b9-ol-0-0-6304","first-page":"149","article-title":"Breast Metastasis from a melanoma","volume":"12","author":"Al Samaraee","year":"2012","journal-title":"Ochsner J"},{"key":"key20180108115026_b10-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(05)70937-5","article-title":"Cutaneous melanoma","volume":"365","author":"Thomson","year":"2005","journal-title":"Lancet"},{"key":"key20180108115026_b11-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/S0278-2391(03)00670-0","article-title":"Primary malignant melanoma of the oral mucosa","volume":"61","author":"Rapidis","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"key20180108115026_b12-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.tripleo.2011.02.040","article-title":"Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications","volume":"112","author":"Shen","year":"2011","journal-title":"Oral Surg Oral Med Oral pathol Oral Radiol Endod"},{"key":"key20180108115026_b13-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hed.10019","article-title":"Primary mucosal malignant melanoma of the head and neck","volume":"24","author":"Patel","year":"2002","journal-title":"Head Neck"},{"key":"key20180108115026_b14-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jso.23445","article-title":"Outcomes in patients with mucosal melanomas","volume":"108","author":"Keller","year":"2013","journal-title":"J Surg Oncol"},{"key":"key20180108115026_b15-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12105-014-0526-8","article-title":"Oral mucosal melanoma: Some pathobiological considerations and illustrative report of a case","volume":"9","author":"Tlholoe","year":"2015","journal-title":"Head Neck Pathol"},{"key":"key20180108115026_b16-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"44","DOI":"10.61172\/ndj.v19i1.140","article-title":"Primary oral malignant melanoma-a case report","volume":"19","author":"Kumar","year":"2011","journal-title":"Nig Dent J"},{"key":"key20180108115026_b17-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1017\/S0022215100137363","article-title":"Malignant melanoma arising in the frontal sinuses","volume":"111","author":"Jayaraj","year":"1997","journal-title":"J Laryngol Otol"},{"key":"key20180108115026_b18-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2273.1993.tb00806.x","article-title":"Malignant melanoma of the nasal cavity and paranasal sinuses","volume":"18","author":"Thompson","year":"1993","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"key20180108115026_b19-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1259\/0007-1285-64-768-1147","article-title":"Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses","volume":"64","author":"Gilligan","year":"1991","journal-title":"Br J Radiol"},{"key":"key20180108115026_b20-ol-0-0-6304","first-page":"170","article-title":"Brain metastases from malignant melanoma","volume":"13","author":"Chiarion-Sileni","year":"2003","journal-title":"Forum (Genova)"},{"key":"key20180108115026_b21-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/028418698430412","article-title":"Central nervous system metastases of cutaneous malignant melanoma-a population based study","volume":"37","author":"Cohn-Cedermark","year":"1998","journal-title":"Acta Oncol"},{"key":"key20180108115026_b22-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1200\/JCO.2007.12.7837","article-title":"Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free survival and overall survival benchmarks for future phase II trials","volume":"26","author":"Korn","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20180108115026_b23-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/CMR.0000000000000029","article-title":"The treatment of melanoma brain metastases before the advent of targeted therapies: Associations between therapeutic choice, clinical symptoms and outcome with survival","volume":"24","author":"Vecchio","year":"2014","journal-title":"Melanoma Res"},{"key":"key20180108115026_b24-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1200\/JCO.2004.11.044","article-title":"Temozolomide for treatment of brain metastases associated with metastatic melanoma: A phase II study","volume":"22","author":"Agarwala","year":"2004","journal-title":"J Clin Oncol"},{"key":"key20180108115026_b25-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00432-002-0323-8","article-title":"Temozolomide and whole brain radiation in melanoma metastatic to the brain: A phase II trial of the cytokine working group","volume":"128","author":"Margolin","year":"2002","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180108115026_b26-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"Fodi","year":"2010","journal-title":"N Engl J Med"},{"key":"key20180108115026_b27-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1470-2045(14)70012-9","article-title":"Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study","volume":"15","author":"McArthur","year":"2014","journal-title":"Lancet Oncol"},{"key":"key20180108115026_b28-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(15)60898-4","article-title":"Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicenter, double blind, phase 3 randomised controlled trial","volume":"386","author":"Long","year":"2015","journal-title":"Lancet"},{"key":"key20180108115026_b29-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ctrv.2016.03.003","article-title":"Survival of patients with metastatic melanoma and brain metastases in era of MAP-kinase inhibitors and immunologic checkpoint blockade antibodies: A systemic review","volume":"45","author":"Spagnolo","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"key20180108115026_b30-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0748-7983(03)00123-9","article-title":"Metastases to the breast","volume":"29","author":"Cabrero","year":"2003","journal-title":"Eur J Surg Oncol"},{"key":"key20180108115026_b31-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2214\/ajr.129.4.673","article-title":"Metastatic disease to the breast: Clinical, pathologic, and radiographic features","volume":"129","author":"Toombs","year":"1977","journal-title":"AM J Roentgenol"},{"key":"key20180108115026_b32-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/1097-0142(20011101)92:9<2259::AID-CNCR1571>3.0.CO;2-O","article-title":"Secondary neoplasms of the breast: A survey of the 20th century","volume":"92","author":"Georgiannos","year":"2001","journal-title":"Cancer"},{"key":"key20180108115026_b33-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000226826","article-title":"Metastases to the breast from extra-mammary malignancies","volume":"47","author":"Amichetti","year":"1990","journal-title":"Oncology"},{"key":"key20180108115026_b34-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jso.2930480208","article-title":"Metastases to the breast: Differential diagnosis from primary breast carcinoma","volume":"48","author":"Vergier","year":"1991","journal-title":"J Surg Oncol"},{"key":"key20180108115026_b35-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7863\/jum.2000.19.4.257","article-title":"Metastatic tumors to the breast: Mammographic and ultrasonographic findings","volume":"19","author":"Lee","year":"2000","journal-title":"J Ultrasound Med"},{"key":"key20180108115026_b36-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jso.2930500110","article-title":"Breast metastases from malignant melanoma","volume":"50","author":"Arora","year":"1992","journal-title":"J Surg Oncol"},{"key":"key20180108115026_b37-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2133.1997.tb03648.x","article-title":"Gender and cutaneous melanoma","volume":"136","author":"Miller","year":"1997","journal-title":"Br J Dermatol"},{"key":"key20180108115026_b38-ol-0-0-6304","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.critrevonc.2015.11.011","article-title":"Metastatic melanoma treatment: Combining old and new therapies","volume":"98","author":"Davey","year":"2016","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:46:51Z","timestamp":1692827211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.6304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,2]]},"published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.3892\/ol.2017.6304"],"URL":"https:\/\/doi.org\/10.3892\/ol.2017.6304","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}