{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:20:35Z","timestamp":1762867235847},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2017.7165","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T11:16:58Z","timestamp":1507634218000},"source":"Crossref","is-referenced-by-count":1,"title":["Familial genetic tuberous sclerosis complex associated with bilateral giant renal angiomyolipoma: A case report"],"prefix":"10.3892","author":[{"given":"Lina","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"key20200714000949_b1-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s12017-015-8354-x","article-title":"TSC1 R509X Mutation in a chinese family with tuberous sclerosis complex","volume":"17","author":"Zhang","year":"2015","journal-title":"Neuromolecular Med"},{"key":"key20200714000949_b2-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12881-015-0185-y","article-title":"Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated","volume":"16","author":"Cabrera-L\u00f3pez","year":"2015","journal-title":"BMC Med Genet"},{"key":"key20200714000949_b3-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1185\/03007995.2011.586687","article-title":"Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: Systematic review","volume":"27","author":"Hallett","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"key20200714000949_b4-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1001\/archneur.57.5.662","article-title":"National Institutes of Health consensus conference: Tuberous sclerosis complex","volume":"57","author":"Hyman","year":"2000","journal-title":"Arch Neurol"},{"key":"key20200714000949_b5-ol-0-0-7165","first-page":"229","article-title":"Tuberous sclerosis complex: Perioperative considerations","volume":"14","author":"Rabito","year":"2014","journal-title":"Ochsner J"},{"key":"key20200714000949_b6-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.4238\/2013.April.12.3","article-title":"Mutational analyses of the TSC1 and TSC2 genes in cases of tuberous sclerosis complex in Chinese Han children","volume":"12","author":"Wang","year":"2013","journal-title":"Genet Mol Res"},{"key":"key20200714000949_b7-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"International Tuberous Sclerosis Complex Consensus Group: Tuberous sclerosis complex diagnostic criteria update: Recommendations of the 2012 iinternational tuberous sclerosis complex consensus conference","volume":"49","author":"Northrup","year":"2013","journal-title":"Pediatr Neurol"},{"key":"key20200714000949_b8-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/sj.ejhg.5201402","article-title":"Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: Genotype-phenotype correlations and comparison of diagnostic DNA techniques in tuberous sclerosis complex","volume":"13","author":"Sancak","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"key20200714000949_b9-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"key20200714000949_b10-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/978-1-4419-6448-9_8","article-title":"Tuberous sclerosis complex and DNA repair","volume":"685","author":"Habib","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"key20200714000949_b11-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ng1494","article-title":"Dysregulation of the TSC-mTOR pathway in human disease","volume":"37","author":"Inoki","year":"2005","journal-title":"Nat Genet"},{"key":"key20200714000949_b12-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"F279","DOI":"10.1152\/ajprenal.00525.2013","article-title":"Tuberous sclerosis complex, mTOR, and the kidney: Report of an NIDDK-sponsored workshop","volume":"306","author":"Henske","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20200714000949_b13-ol-0-0-7165","first-page":"819","article-title":"Diagnosis and analysis of cases of tuberous sclerosis","volume":"10","author":"Yi","year":"2015","journal-title":"J Clin Exp Med"},{"key":"key20200714000949_b14-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2490-14-77","article-title":"Percutaneous cryoablation for tuberous sclerosis-associated renal angiomyolipoma with neoadjuvant mTOR inhibition","volume":"14","author":"Krummel","year":"2014","journal-title":"BMC Urol"},{"key":"key20200714000949_b15-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"404","DOI":"10.2174\/157015912804499537","article-title":"mTOR inhibitors in tuberous sclerosis complex","volume":"10","author":"Curatolo","year":"2012","journal-title":"Curr Neuropharmacol"},{"key":"key20200714000949_b16-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s11255-012-0292-z","article-title":"Nephron-sparing resection of angiomyolipoma after sirolimus pretreatment in patients with tuberous sclerosis","volume":"44","author":"Staehler","year":"2012","journal-title":"Int Urol Nephrol"},{"key":"key20200714000949_b17-ol-0-0-7165","first-page":"CD011272","article-title":"Rapamycin and rapalogs for tuberous sclerosis complex","volume":"7","author":"Sasongko","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key20200714000949_b18-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1100\/2011\/263137","article-title":"Giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin","volume":"11","author":"Peces","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"key20200714000949_b19-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1185\/03007995.2011.586687","article-title":"Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: Systematic review","volume":"27","author":"Hallett","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"key20200714000949_b20-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N Engl J Med"},{"key":"key20200714000949_b21-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1464-410X.2004.05046.x","article-title":"An epidemiological study of renal pathology in tuberous sclerosis complex","volume":"94","author":"O'Callaghan","year":"2004","journal-title":"BJU Int"},{"key":"key20200714000949_b22-ol-0-0-7165","first-page":"83","article-title":"Haemorrhage from angiomyolipoma of kidney during pregnancy-a diagnostic dilemma","volume":"94","author":"Mascarenhas","year":"2001","journal-title":"Ir Med J"},{"key":"key20200714000949_b23-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.gyobfe.2005.09.015","article-title":"Influence of pregnancy on renal angiomyolipoma","volume":"33","author":"Raft","year":"2005","journal-title":"Gynecol Obstet Fertil"},{"key":"key20200714000949_b24-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.urology.2008.01.067","article-title":"Hormone receptor expression in renal angiomyolipoma: Clinicopathologic correlation","volume":"72","author":"Boorjian","year":"2008","journal-title":"Urology"},{"key":"key20200714000949_b25-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler","year":"2013","journal-title":"Lancet"},{"key":"key20200714000949_b26-ol-0-0-7165","first-page":"211","article-title":"Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex","volume":"7","author":"Franz","year":"2013","journal-title":"Biologics"},{"key":"key20200714000949_b27-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.mce.2009.12.018","article-title":"Metabolic control of puberty onset: New players, new mechanisms","volume":"324","author":"Roa","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"key20200714000949_b28-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s11255-015-0936-x","article-title":"Use of oestrogen-containing medication is not associated with renal angiomyolipoma in tuberous sclerosis: Findings from a survey","volume":"47","author":"Sauter","year":"2015","journal-title":"Int Urol Nephrol"},{"key":"key20200714000949_b29-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1016\/S0929-6646(09)60353-3","article-title":"Malignant epithelioid angiomyolipoma of the kidney","volume":"106","author":"Huang","year":"2007","journal-title":"J Formos Med Assoc"},{"key":"key20200714000949_b30-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/0090-4295(75)90523-3","article-title":"Angiomyolipoma and renal cell carcinoma in same kidney","volume":"6","author":"Kavaney","year":"1975","journal-title":"Urology"},{"key":"key20200714000949_b31-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1093\/ndt\/gfm552","article-title":"Combined nephrectomy and pre-emptive renal transplantation in a tuberous sclerosis patient with angiomyolipoma, renal carcinoma and life-threatening abdominal haemorrhages","volume":"22","author":"Corsenca","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"key20200714000949_b32-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"key20200714000949_b33-ol-0-0-7165","first-page":"21","article-title":"Angiomyolipoma of kidney","volume":"15","author":"Eble","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"key20200714000949_b34-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40001-014-0046-8","article-title":"A giant renal angiomyolipoma (AML) in a patient with septo-optic dysplasia (SOD)","volume":"19","author":"Cichocki","year":"2014","journal-title":"Eur J Med Res"},{"key":"key20200714000949_b35-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"318","DOI":"10.4103\/1319-2442.109591","article-title":"Renal transplant in a tuberous sclerosis patient with bilateral giant renal angiomyolipomas and concurrent renal carcinoma","volume":"24","author":"Hussain","year":"2013","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"key20200714000949_b36-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"56","DOI":"10.4103\/2156-7514.122326","article-title":"Giant renal angiomyolipoma: Unusual cause of huge abdominal mass","volume":"3","author":"Taneja","year":"2013","journal-title":"J Clin Imaging Sci"},{"key":"key20200714000949_b37-ol-0-0-7165","first-page":"591","article-title":"Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis","volume":"10","author":"Miyoshi","year":"1998","journal-title":"Oncol Res"},{"key":"key20200714000949_b38-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1148\/radiol.2251011477","article-title":"Renal angiomyolipoma: Relationships between tumor size, aneurysm formation, and rupture","volume":"225","author":"Yamakado","year":"2002","journal-title":"Radiology"},{"key":"key20200714000949_b39-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4236\/oju.2012.22013","article-title":"Giant angiomyolipoma of the kidney presenting as anaemia-a rare presentation","volume":"2","author":"Mitra","year":"2012","journal-title":"Open J Urol"},{"key":"key20200714000949_b40-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","article-title":"Tuberous sclerosis","volume":"372","author":"Curatolo","year":"2008","journal-title":"Lancet"},{"key":"key20200714000949_b41-ol-0-0-7165","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3892\/etm.2014.2093","article-title":"Efficacy and safety of a mammalian target of rapamycin inhibitor in pediatric patients with tuberous sclerosis complex: A systematic review and meta-analysis","volume":"9","author":"Yang","year":"2015","journal-title":"Exp Ther Med"},{"key":"key20200714000949_b42-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa063564","article-title":"Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis","volume":"358","author":"Bissler","year":"2008","journal-title":"N Engl J Med"},{"key":"key20200714000949_b43-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1750-1172-7-87","article-title":"Assessing the effectiveness of rapamycin on angiomyolipoma in tuberous sclerosis: A two years trial","volume":"7","author":"Cabrera-L\u00f3pez","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"key20200714000949_b44-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.juro.2014.04.096","article-title":"Efficacy and safety of sirolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: A systematic review","volume":"192","author":"Peng","year":"2014","journal-title":"J Urol"},{"key":"key20200714000949_b45-ol-0-0-7165","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1056\/NEJMe0707153","article-title":"Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis","volume":"358","author":"Paul","year":"2008","journal-title":"N Engl J Med"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:45:47Z","timestamp":1594687547000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.7165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/ol.2017.7165","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]}}}