{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:22:13Z","timestamp":1792466533320,"version":"4.5.0"},"reference-count":42,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2017.7521","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T09:12:14Z","timestamp":1512465134000},"source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive characterization of cancer genes in hepatocellular carcinoma genomes"],"prefix":"10.3892","author":[{"given":"Zhihao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Liver, Gallbladder and Pancreas Surgery, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"key20200714001831_b1-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"key20200714001831_b2-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1073274817729245","DOI":"10.1177\/1073274817729245","article-title":"Epidemiology of hepatocellular carcinoma and intrahepatic cholangiocarcinoma","volume":"24","author":"Massarweh","year":"2017","journal-title":"Cancer Control"},{"key":"key20200714001831_b3-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1158\/1055-9965.EPI-11-0643","article-title":"International trends in liver cancer incidence rates","volume":"20","author":"Center","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20200714001831_b4-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.semcancer.2013.07.003","article-title":"Obesity, insulin resistance, NASH and hepatocellular carcinoma","volume":"23","author":"Yu","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"key20200714001831_b5-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.soc.2013.10.001","article-title":"Epidemiology and risk factors of biliary tract and primary liver tumors","volume":"23","author":"Augustine","year":"2014","journal-title":"Surg Oncol Clin N Am"},{"key":"key20200714001831_b6-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"key":"key20200714001831_b7-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1101\/gr.134635.111","article-title":"MuSiC: Identifying mutational significance in cancer genomes","volume":"22","author":"Dees","year":"2012","journal-title":"Genome Res"},{"key":"key20200714001831_b8-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/ng.3126","article-title":"Trans-ancestry mutational landscape of hepatocellular carcinoma genomes","volume":"46","author":"Totoki","year":"2014","journal-title":"Nat Genet"},{"key":"key20200714001831_b9-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1093\/nar\/gks743","article-title":"Functional impact bias reveals cancer drivers","volume":"40","author":"Gonzalez-Perez","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"Web Server Issue","key":"key20200714001831_b10-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"W452","DOI":"10.1093\/nar\/gks539","article-title":"SIFT web server: Predicting effects of amino acid substitutions on proteins","volume":"40","author":"Sim","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b11-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"key20200714001831_b12-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"e118","DOI":"10.1093\/nar\/gkr407","article-title":"Predicting the functional impact of protein mutations: Application to cancer genomics","volume":"39","author":"Reva","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b13-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1101\/gr.120477.111","article-title":"De novo discovery of mutated driver pathways in cancer","volume":"22","author":"Vandin","year":"2012","journal-title":"Genome Res"},{"key":"key20200714001831_b14-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Cancer Genome Atlas Research Network: Comprehensive and integrative genomic characterization of hepatocellular carcinoma","volume":"169","author":"Cancer Genome Atlas Research Network","year":"2017","journal-title":"Cell"},{"key":"key20200714001831_b15-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","article-title":"Deriving the consequences of genomic variants with the ensembl API and SNP effect predictor","volume":"26","author":"McLaren","year":"2010","journal-title":"Bioinformatics"},{"key":"key20200714001831_b16-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"key20200714001831_b17-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources","volume":"45","author":"The Gene Ontology Consortium","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b18-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: New perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b19-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b20-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13148-015-0121-1","article-title":"Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach","volume":"7","author":"Gao","year":"2015","journal-title":"Clin Epigenetics"},{"issue":"Database Issue","key":"key20200714001831_b21-ol-0-0-7521","first-page":"D991","article-title":"NCBI GEO: Archive for functional genomics data sets-Update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"key20200714001831_b22-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.7717\/peerj-cs.67","article-title":"OncoLnc: Linking TCGA survival data to mRNAs, miRNAs and lncRNAs","volume":"2","author":"Anaya","year":"2016","journal-title":"PeerJ Comput Sci"},{"key":"key20200714001831_b23-ol-0-0-7521","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-380866-0.60002-2","volume-title":"Epigenetics and Cancer, Part A","author":"Kulis","year":"2010"},{"key":"key20200714001831_b24-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/ng.2699","article-title":"Integrated molecular analysis of clear-cell renal cell carcinoma","volume":"45","author":"Sato","year":"2013","journal-title":"Nat Genet"},{"key":"key20200714001831_b25-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1182\/blood-2015-05-644591","article-title":"IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma","volume":"126","author":"Wang","year":"2015","journal-title":"Blood"},{"key":"key20200714001831_b26-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.canlet.2016.05.011","article-title":"CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma","volume":"378","author":"Betti","year":"2016","journal-title":"Cancer Lett"},{"key":"key20200714001831_b27-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"e91264","DOI":"10.1371\/journal.pone.0091264","article-title":"High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: Novel fusion partner and splice","volume":"9","author":"Nome","year":"2014","journal-title":"PLoS One"},{"key":"key20200714001831_b28-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1158\/1078-0432.CCR-15-0726","article-title":"Loss of SMAD4 promotes colorectal cancer progression by accumulation of myeloid-derived suppressor cells through the CCL15-CCR1 chemokine axis","volume":"22","author":"Inamoto","year":"2016","journal-title":"Clin Cancer Res"},{"key":"key20200714001831_b29-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1038\/onc.2014.428","article-title":"LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression","volume":"34","author":"Mura","year":"2015","journal-title":"Oncogene"},{"key":"key20200714001831_b30-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1245\/s10434-007-9541-2","article-title":"Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype","volume":"14","author":"Paik","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"key20200714001831_b31-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1038\/sj.bjc.6603482","article-title":"Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer","volume":"95","author":"Christoph","year":"2006","journal-title":"Br J Cancer"},{"key":"key20200714001831_b32-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.pharmthera.2015.06.001","article-title":"Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein","volume":"153","author":"Ishizawa","year":"2015","journal-title":"Pharmacol Ther"},{"key":"key20200714001831_b33-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/cas.12430","article-title":"Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma","volume":"105","author":"Yoshimura","year":"2014","journal-title":"Cancer Sci"},{"key":"key20200714001831_b34-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1097\/JTO.0000000000000485","article-title":"Overexpression of CRM1: A characteristic feature in a transformed phenotype of lung carcinogenesis and a molecular target for lung cancer adjuvant therapy","volume":"10","author":"Gao","year":"2015","journal-title":"J Thorac Oncol"},{"key":"key20200714001831_b35-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s12032-013-0726-1","article-title":"CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas","volume":"30","author":"Zhou","year":"2013","journal-title":"Med Oncol"},{"key":"key20200714001831_b36-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"4166","DOI":"10.1182\/blood-2012-08-447581","article-title":"Prognostic impact and targeting of CRM1 in acute myeloid leukemia","volume":"121","author":"Kojima","year":"2013","journal-title":"Blood"},{"key":"key20200714001831_b37-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"E315","DOI":"10.25011\/cim.v32i6.10668","article-title":"Prognostic value of CRM1 in pancreas cancer","volume":"32","author":"Huang","year":"2009","journal-title":"Clin Invest Med"},{"key":"key20200714001831_b38-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1182\/blood-2011-11-391748","article-title":"IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma","volume":"119","author":"Cairns","year":"2012","journal-title":"Blood"},{"key":"key20200714001831_b39-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/neup.12187","article-title":"IDH2 mutation in gliomas including novel mutation","volume":"35","author":"Koh","year":"2015","journal-title":"Neuropathology"},{"key":"key20200714001831_b40-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1182\/blood-2010-12-322479","article-title":"The prognostic significance of IDH2 mutations in AML depends on the location of the mutation","volume":"118","author":"Green","year":"2011","journal-title":"Blood"},{"key":"key20200714001831_b41-ol-0-0-7521","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1756-9966-33-32","article-title":"High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma","volume":"33","author":"Liu","year":"2014","journal-title":"J Exp Clin Cancer Res"},{"key":"key20200714001831_b42-ol-0-0-7521","first-page":"540236","article-title":"IDH mutations: Genotype-phenotype correlation and prognostic impact","volume":"2014","author":"Wang","year":"2014","journal-title":"Biomed Res Int"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:51:03Z","timestamp":1594687863000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2017.7521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,5]]},"references-count":42,"URL":"https:\/\/doi.org\/10.3892\/ol.2017.7521","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,5]]}}}