{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:37:59Z","timestamp":1790786279398,"version":"4.1.0"},"reference-count":63,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2018.9023","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:07:50Z","timestamp":1529996870000},"source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2011inflammatory and antitumor action of hydrogen via reactive oxygen species (Review)"],"prefix":"10.3892","author":[{"given":"Ye","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"key20200714083342_b1-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat Med"},{"key":"key20200714083342_b2-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bbrc.2008.08.020","article-title":"Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30\/GNL knockout mice","volume":"375","author":"Sato","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714083342_b3-ol-0-0-9023","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122113","article-title":"Molecular characterization of epithelial ovarian cancer: Implications for diagnosis and treatment","volume":"17","author":"Rojas","year":"2016","journal-title":"Int J Mol Sci"},{"key":"key20200714083342_b4-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00280-008-0924-2","article-title":"Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice","volume":"64","author":"Nakashima-Kamimura","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"key20200714083342_b5-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.mad.2005.03.026","article-title":"Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing","volume":"126","author":"James","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"key20200714083342_b6-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/ki.2009.421","article-title":"Oral hydrogen water prevents chronic allograft nephropathy in rats","volume":"77","author":"Cardinal","year":"2010","journal-title":"Kidney Int"},{"key":"key20200714083342_b7-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3164\/jcbn.09-100","article-title":"Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study","volume":"46","author":"Nakao","year":"2010","journal-title":"J Clin Biochem Nutr"},{"key":"key20200714083342_b8-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1080\/10715760902870603","article-title":"Hydrogen-rich saline protects against intestinal ischemia\/reperfusion injury in rats","volume":"43","author":"Zheng","year":"2009","journal-title":"Free Radic Res"},{"key":"key20200714083342_b9-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2045-9912-3-13","article-title":"Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: Initial clinical studies","volume":"3","author":"Nagatani","year":"2013","journal-title":"Med Gas Res"},{"key":"key20200714083342_b10-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2045-9912-2-14","article-title":"Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers","volume":"2","author":"Ono","year":"2012","journal-title":"Med Gas Res"},{"key":"key20200714083342_b11-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"8051","DOI":"10.1038\/s41598-018-26388-3","article-title":"Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques","volume":"8","author":"Zhu","year":"2018","journal-title":"Sci Rep"},{"key":"key20200714083342_b12-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1167\/iovs.10-6167","article-title":"Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model","volume":"52","author":"Kubota","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200714083342_b13-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1167\/iovs.09-4089","article-title":"Protection of the retina by rapid diffusion of hydrogen: Administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury","volume":"51","author":"Oharazawa","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200714083342_b14-ol-0-0-9023","first-page":"125","article-title":"Animal cancer tests and cancer prevention","author":"Ames","year":"1992","journal-title":"J Natl Cancer Inst Monogr"},{"key":"key20200714083342_b15-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/oxfordjournals.bmb.a072628","article-title":"Oxidative mechanisms in carcinogenesis","volume":"49","author":"Guyton","year":"1993","journal-title":"Br Med Bull"},{"key":"key20200714083342_b16-ol-0-0-9023","first-page":"5127","article-title":"DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion","volume":"50","author":"Schulte-Hermann","year":"1990","journal-title":"Cancer Res"},{"key":"key20200714083342_b17-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0891-5849(91)90077-G","article-title":"An overview of the relationship between oxidative stress and chemical carcinogenesis","volume":"10","author":"Trush","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"key20200714083342_b18-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1126\/science.2981433","article-title":"Prooxidant states and tumor promotion","volume":"227","author":"Cerutti","year":"1985","journal-title":"Science"},{"key":"key20200714083342_b19-ol-0-0-9023","doi-asserted-by":"crossref","first-page":"459","DOI":"10.33549\/physiolres.931844","article-title":"Some current insights into oxidative stress","volume":"59","author":"Durackov\u00e1","year":"2010","journal-title":"Physiol Res"},{"key":"key20200714083342_b20-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0304-3835(00)00545-0","article-title":"Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity","volume":"159","author":"Zhang","year":"2000","journal-title":"Cancer Lett"},{"key":"key20200714083342_b21-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"key20200714083342_b22-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrc1046","article-title":"Radical causes of cancer","volume":"3","author":"Hussain","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key20200714083342_b23-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1152\/physrev.00010.2014","article-title":"Paradoxical roles of antioxidant enzymes: Basic mechanisms and health implications","volume":"96","author":"Lei","year":"2016","journal-title":"Physiol Rev"},{"key":"key20200714083342_b24-ol-0-0-9023","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res"},{"key":"key20200714083342_b25-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/bjc.1997.363","article-title":"Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells","volume":"76","author":"Miyajima","year":"1997","journal-title":"Br J Cancer"},{"key":"key20200714083342_b26-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/carcin\/21.5.909","article-title":"Dietary antioxidant depletion: Enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice","volume":"21","author":"Salganik","year":"2000","journal-title":"Carcinogenesis"},{"key":"key20200714083342_b27-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/bcr315","article-title":"Hypoxia and oxidative stress in breast cancer. Oxidative stress: Its effects on the growth, metastatic potential and response to therapy of breast cancer","volume":"3","author":"Brown","year":"2001","journal-title":"Breast Cancer Res"},{"key":"key20200714083342_b28-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11010-010-0437-2","article-title":"Oxidant\/anti-oxidant dynamics in patients with advanced cervical cancer: Correlation with treatment response","volume":"341","author":"Sharma","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"key20200714083342_b29-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3748\/wjg.v9.i3.446","article-title":"Protective effect of ascorbic acid in experimental gastric cancer: Reduction of oxidative stress","volume":"9","author":"Oliveira","year":"2003","journal-title":"World J Gastroenterol"},{"key":"key20200714083342_b30-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.jhep.2004.07.030","article-title":"Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc\/TGF-alpha transgenic mouse model of liver cancer","volume":"41","author":"Calvisi","year":"2004","journal-title":"J Hepatol"},{"key":"key20200714083342_b31-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10937400701436460","article-title":"Inflammation and lung cancer: Roles of reactive oxygen\/nitrogen species","volume":"11","author":"Azad","year":"2008","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"key20200714083342_b32-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1586\/14737140.8.11.1751","article-title":"Reactive oxygen species: An Achilles' heel of melanoma?","volume":"8","author":"Fruehauf","year":"2008","journal-title":"Expert Rev Anticancer Ther"},{"key":"key20200714083342_b33-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/cbf.1127","article-title":"Oxidant\/antioxidant parameters and their relationship with medical treatment in multiple myeloma","volume":"23","author":"Kuku","year":"2005","journal-title":"Cell Biochem Funct"},{"key":"key20200714083342_b34-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.taap.2010.02.012","article-title":"Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells","volume":"244","author":"Sumi","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20200714083342_b35-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.freeradbiomed.2008.01.022","article-title":"Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma","volume":"44","author":"van de Wetering","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"key20200714083342_b36-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/cncr.22386","article-title":"Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile","volume":"109","author":"Bahar","year":"2007","journal-title":"Cancer"},{"key":"key20200714083342_b37-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1093\/carcin\/bgn167","article-title":"Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells","volume":"29","author":"Chan","year":"2008","journal-title":"Carcinogenesis"},{"key":"key20200714083342_b38-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1158\/0008-5472.CAN-15-0744","article-title":"Fibulin-5 blocks microenvironmental ROS in pancreatic cancer","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res"},{"key":"key20200714083342_b39-ol-0-0-9023","first-page":"301","article-title":"Oxidative stress in prostate cancer","author":"Shan","year":"2011","journal-title":"Oxidative Stress Cancer Biol Ther"},{"key":"key20200714083342_b40-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"8683","DOI":"10.1073\/pnas.0812688106","article-title":"Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma","volume":"106","author":"Ma","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200714083342_b41-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.4161\/cbt.7.12.7067","article-title":"Cancer cell killing via ROS: To increase or decrease, that is the question","volume":"7","author":"Wang","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"key20200714083342_b42-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"S289","DOI":"10.2307\/3433929","article-title":"The role of oxidative stress in chemical carcinogenesis","volume":"106","author":"Klaunig","year":"1998","journal-title":"Environ Health Perspect"},{"key":"key20200714083342_b43-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0006-2952(98)00227-5","article-title":"Reactive oxygen intermediates as mediators of programmed cell death in plants and animals","volume":"57","author":"Jabs","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"key20200714083342_b44-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrc.2015.2","article-title":"DNA damage and the balance between survival and death in cancer biology","volume":"16","author":"Roos","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"key20200714083342_b45-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bbrc.2008.05.165","article-title":"Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury","volume":"373","author":"Hayashida","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714083342_b46-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1111\/j.1600-6143.2008.02359.x","article-title":"Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury","volume":"8","author":"Buchholz","year":"2008","journal-title":"Am J Transplant"},{"key":"key20200714083342_b47-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"P18","DOI":"10.1186\/1753-6561-5-S8-P18","article-title":"Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles","volume":"5","author":"Shirahata","year":"2011","journal-title":"BMC Proc"},{"key":"key20200714083342_b48-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3727\/096504008786991620","article-title":"Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression","volume":"17","author":"Saitoh","year":"2008","journal-title":"Oncol Res"},{"key":"key20200714083342_b49-ol-0-0-9023","first-page":"1463","article-title":"Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death","volume":"24","author":"Asada","year":"2010","journal-title":"Oncol Rep"},{"key":"key20200714083342_b50-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/1462-2920.13498","article-title":"Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum","volume":"19","author":"Ren","year":"2017","journal-title":"Environ Microbiol"},{"key":"key20200714083342_b51-ol-0-0-9023","first-page":"3653","article-title":"Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells","volume":"41","author":"Zhang","year":"2018","journal-title":"Int J Mol Med"},{"key":"key20200714083342_b52-ol-0-0-9023","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.148","article-title":"Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs","author":"Varga","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"key20200714083342_b53-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.jhep.2010.08.011","article-title":"The protective role of hydrogen-rich saline in experimental liver injury in mice","volume":"54","author":"Sun","year":"2011","journal-title":"J Hepatol"},{"key":"key20200714083342_b54-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3109\/10715762.2015.1038257","article-title":"Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury","volume":"49","author":"Hattori","year":"2015","journal-title":"Free Radic Res"},{"key":"key20200714083342_b55-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40733-018-0040-y","article-title":"Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice","volume":"4","author":"Zhang","year":"2018","journal-title":"Asthma Res Pract"},{"key":"key20200714083342_b56-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.bbrc.2007.07.088","article-title":"Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia\/reperfusion through reducing oxidative stress","volume":"361","author":"Fukuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714083342_b57-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/SHK.0b013e3181cdc4ae","article-title":"Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release","volume":"34","author":"Xie","year":"2010","journal-title":"Shock"},{"key":"key20200714083342_b58-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.bbrc.2008.10.156","article-title":"Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice","volume":"377","author":"Ohsawa","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714083342_b59-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3164\/jcbn.10-19","article-title":"Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice","volume":"46","author":"Gu","year":"2010","journal-title":"J Clin Biochem Nutr"},{"key":"key20200714083342_b60-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"e7247","DOI":"10.1371\/journal.pone.0007247","article-title":"Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease","volume":"4","author":"Fujita","year":"2009","journal-title":"PLoS One"},{"key":"key20200714083342_b61-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1259\/bjr\/25604811","article-title":"Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT","volume":"83","author":"Kitamura","year":"2010","journal-title":"Br J Radiol"},{"key":"key20200714083342_b62-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2174\/092986709787002790","article-title":"Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: Therapeutic implications","volume":"16","author":"Zhao","year":"2009","journal-title":"Curr Med Chem"},{"key":"key20200714083342_b63-ol-0-0-9023","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2045-9912-1-11","article-title":"Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors","volume":"1","author":"Kang","year":"2011","journal-title":"Med Gas Res"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T10:37:54Z","timestamp":1661510274000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2018.9023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":63,"URL":"https:\/\/doi.org\/10.3892\/ol.2018.9023","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,26]]}}}