{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:09:25Z","timestamp":1790230165257,"version":"4.1.0"},"reference-count":68,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2019.11042","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T08:12:38Z","timestamp":1572855158000},"source":"Crossref","is-referenced-by-count":9,"title":["Identification of potential hub genes associated with the pathogenesis and prognosis of pancreatic duct adenocarcinoma using bioinformatics meta\u2011analysis of multi\u2011platform datasets"],"prefix":"10.3892","author":[{"given":"Yufan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinquan","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646099, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"key20200714092423_b1-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"key20200714092423_b2-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"key20200714092423_b3-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1056\/NEJMra0901557","article-title":"Pancreatic cancer","volume":"362","author":"Hidalgo","year":"2010","journal-title":"N Engl J Med"},{"key":"key20200714092423_b4-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.12659\/MSM.906313","article-title":"Possible Molecular markers for the diagnosis of pancreatic ductal adenocarcinoma","volume":"24","author":"Shen","year":"2018","journal-title":"Med Sci Monit"},{"key":"key20200714092423_b5-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.21873\/anticanres.12914","article-title":"Proteomic identification of FLT3 and PCBP3 as potential prognostic biomarkers for pancreatic cancer","volume":"38","author":"Ger","year":"2018","journal-title":"Anticancer Res"},{"key":"key20200714092423_b6-ol-0-0-11042","first-page":"2453","article-title":"Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis","volume":"16","author":"Tang","year":"2018","journal-title":"Oncol Lett"},{"key":"key20200714092423_b7-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ccell.2017.07.007","article-title":"Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma","volume":"32","author":"Cancer Genome Atlas Research Network:; and Cancer Genome Atlas Research Network","year":"2017","journal-title":"Cancer Cell"},{"key":"key20200714092423_b8-ol-0-0-11042","article-title":"Methods for robust rank aggregation","author":"Kolde","year":"2013"},{"key":"key20200714092423_b9-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","article-title":"Robust rank aggregation for gene list integration and meta-analysis","volume":"28","author":"Kolde","year":"2012","journal-title":"Bioinformatics"},{"key":"key20200714092423_b10-ol-0-0-11042","first-page":"2016","article-title":"Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia","volume":"55","author":"Badea","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"key20200714092423_b11-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ccr.2009.07.016","article-title":"FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt","volume":"16","author":"Pei","year":"2009","journal-title":"Cancer Cell"},{"key":"key20200714092423_b12-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1053\/j.gastro.2013.10.010","article-title":"MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression","volume":"146","author":"Frampton","year":"2014","journal-title":"Gastroenterology"},{"key":"key20200714092423_b13-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1186\/s12885-016-2540-6","article-title":"Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma","volume":"16","author":"Janky","year":"2016","journal-title":"BMC Cancer"},{"key":"key20200714092423_b14-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1158\/0008-5472.CAN-15-2841","article-title":"A Novel MIF signaling pathway drives the malignant character of pancreatic cancer by targeting NR3C2","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res"},{"key":"key20200714092423_b15-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat Genet"},{"key":"key20200714092423_b16-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"53165","DOI":"10.18632\/oncotarget.10242","article-title":"Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"key20200714092423_b17-ol-0-0-11042","first-page":"ncrna3030024","article-title":"Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma","volume":"3","author":"Sutaria","year":"2017","journal-title":"Noncoding RNA"},{"key":"key20200714092423_b18-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-60761-987-1_18","article-title":"Software for visualization and analysis of biological networks","volume":"696","author":"Kohl","year":"2011","journal-title":"Methods Mol Biol"},{"key":"key20200714092423_b19-ol-0-0-11042","first-page":"450","article-title":"Expression profiles analysis identifies a novel three-mRNA signature to predict overall survival in oral squamous cell carcinoma","volume":"8","author":"Zhao","year":"2018","journal-title":"Am J Cancer Res"},{"key":"key20200714092423_b20-ol-0-0-11042","doi-asserted-by":"crossref","first-page":"21281","DOI":"10.18632\/oncotarget.15068","article-title":"Genome-scale analysis identifies GJB2 and ERO1LB as prognosis markers in patients with pancreatic cancer","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"key20200714092423_b21-ol-0-0-11042","doi-asserted-by":"crossref","first-page":"52571","DOI":"10.18632\/oncotarget.16732","article-title":"Integrated expression profiles analysis reveals novel predictive biomarker in pancreatic ductal adenocarcinoma","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"key20200714092423_b22-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"a004903","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome-an inventory of extracellular matrix constituents and functions","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20200714092423_b23-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200714092423_b24-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fonc.2015.00224","article-title":"Targeting ECM disrupts cancer progression","volume":"5","author":"Venning","year":"2015","journal-title":"Front Oncol"},{"key":"key20200714092423_b25-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1007\/s13277-013-1511-7","article-title":"Collagen as a double-edged sword in tumor progression","volume":"35","author":"Fang","year":"2014","journal-title":"Tumour Biol"},{"key":"key20200714092423_b26-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1158\/1541-7786.MCR-13-0535","article-title":"Insidious changes in stromal matrix fuel cancer progression","volume":"12","author":"Miles","year":"2014","journal-title":"Mol Cancer Res"},{"key":"key20200714092423_b27-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.15252\/embr.201439246","article-title":"The extracellular matrix modulates the hallmarks of cancer","volume":"15","author":"Pickup","year":"2014","journal-title":"EMBO Rep"},{"key":"key20200714092423_b28-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/00006676-198701000-00003","article-title":"Distribution of extracellular matrix proteins in pancreatic ductal adenocarcinoma and its influence on tumor cell proliferation in vitro","volume":"2","author":"Mollenhauer","year":"1987","journal-title":"Pancreas"},{"key":"key20200714092423_b29-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1158\/1078-0432.CCR-03-0825","article-title":"Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma","volume":"10","author":"Armstrong","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20200714092423_b30-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/S0016-5085(03)01203-4","article-title":"Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways","volume":"125","author":"Vaquero","year":"2003","journal-title":"Gastroenterology"},{"key":"key20200714092423_b31-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1158\/0008-5472.CAN-05-2804","article-title":"Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells","volume":"66","author":"Koenig","year":"2006","journal-title":"Cancer Res"},{"key":"key20200714092423_b32-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/sj.bjc.6603088","article-title":"The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines","volume":"94","author":"Grzesiak","year":"2006","journal-title":"Br J Cancer"},{"key":"key20200714092423_b33-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.canlet.2015.12.027","article-title":"Matrix control of pancreatic cancer: New insights into fibronectin signaling","volume":"381","author":"Topalovski","year":"2016","journal-title":"Cancer Lett"},{"key":"key20200714092423_b34-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2017.12.007","article-title":"NKp46 receptor-mediated interferon-\u04af production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis","volume":"48","author":"Glasner","year":"2018","journal-title":"Immunity"},{"key":"key20200714092423_b35-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12957-019-1574-z","article-title":"Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma","volume":"17","author":"Hu","year":"2019","journal-title":"World J Surg Oncol"},{"key":"key20200714092423_b36-ol-0-0-11042","first-page":"900","article-title":"Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells","volume":"58","author":"Shibata","year":"1998","journal-title":"Cancer Res"},{"key":"key20200714092423_b37-ol-0-0-11042","first-page":"246","article-title":"Metalloproteinases in tumor progression: The contribution of MMP-9","volume":"14","author":"Himelstein","year":"1994-1995","journal-title":"Invasion Metastasis"},{"key":"key20200714092423_b38-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/BF02574483","article-title":"Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials","volume":"9","author":"Bloomston","year":"2002","journal-title":"Ann Surg Oncol"},{"key":"key20200714092423_b39-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jconrel.2016.08.016","article-title":"Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer","volume":"239","author":"Grunwald","year":"2016","journal-title":"J Control Release"},{"key":"key20200714092423_b40-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"5880","DOI":"10.1158\/0008-5472.CAN-09-4341","article-title":"Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: Implications for antiangiogenic therapy","volume":"70","author":"Agarwal","year":"2010","journal-title":"Cancer Res"},{"key":"key20200714092423_b41-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tcb.2018.08.006","article-title":"Recognizing the molecular multifunctionality and interactome of TIMP-1","volume":"29","author":"Grunwald","year":"2019","journal-title":"Trends Cell Biol"},{"issue":"(Suppl 1)","key":"key20200714092423_b42-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1038\/onc.2009.199","article-title":"Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer","volume":"28","author":"Hirsch","year":"2009","journal-title":"Oncogene"},{"key":"key20200714092423_b43-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","article-title":"Epidermal growth factor receptor (EGFR) signaling in cancer","volume":"366","author":"Normanno","year":"2006","journal-title":"Gene"},{"key":"key20200714092423_b44-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","article-title":"The ErbB signaling network: Receptor heterodimerization in development and cancer","volume":"19","author":"Olayioye","year":"2000","journal-title":"EMBO J"},{"key":"key20200714092423_b45-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1038\/nm.3388","article-title":"The quest to overcome resistance to EGFR-targeted therapies in cancer","volume":"19","author":"Chong","year":"2013","journal-title":"Nat Med"},{"key":"key20200714092423_b46-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ctrv.2008.11.007","article-title":"Treatment of advanced pancreatic cancer: From gemcitabine single agent to combinations and targeted therapy","volume":"35","author":"Rivera","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"key20200714092423_b47-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"8653","DOI":"10.1007\/s13277-014-2131-6","article-title":"MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma","volume":"35","author":"Wang","year":"2014","journal-title":"Tumour Biol"},{"key":"key20200714092423_b48-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1530\/rep.1.00234","article-title":"EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways","volume":"128","author":"Qiu","year":"2004","journal-title":"Reproduction"},{"key":"key20200714092423_b49-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0006-291X(02)00741-6","article-title":"Both tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 activate Ras but through different pathways","volume":"296","author":"Wang","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714092423_b50-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"59441","DOI":"10.18632\/oncotarget.11118","article-title":"TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: A potential novel approach to the treatment of metastatic colorectal cancer","volume":"7","author":"Tarpgaard","year":"2016","journal-title":"Oncotarget"},{"key":"key20200714092423_b51-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/1869","article-title":"Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites","volume":"5","author":"Curry","year":"1998","journal-title":"Nat Struct Biol"},{"key":"key20200714092423_b52-ol-0-0-11042","first-page":"9361","article-title":"Cachexia and pancreatic cancer: Are there treatment options?","volume":"20","author":"Mueller","year":"2014","journal-title":"World J Gastroenterol"},{"key":"key20200714092423_b53-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/01635581.2013.804580","article-title":"Cachexia in patients with chronic pancreatitis and pancreatic cancer: Impact on survival and outcome","volume":"65","author":"Bachmann","year":"2013","journal-title":"Nutr Cancer"},{"key":"key20200714092423_b54-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1586\/erm.10.73","article-title":"Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1","volume":"10","author":"Mengele","year":"2010","journal-title":"Expert Rev Mol Diagn"},{"key":"key20200714092423_b55-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1091\/mbc.e12-04-0306","article-title":"Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer","volume":"24","author":"Asuthkar","year":"2013","journal-title":"Mol Biol Cell"},{"key":"key20200714092423_b56-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.biocel.2009.03.004","article-title":"Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK\/p38 signaling","volume":"41","author":"Xue","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"key20200714092423_b57-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1158\/0008-5472.CAN-15-0390","article-title":"Early epigenetic downregulation of microRNA-192 expression promotes pancreatic cancer progression","volume":"76","author":"Botla","year":"2016","journal-title":"Cancer Res"},{"key":"key20200714092423_b58-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/jop.12677","article-title":"LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2","volume":"47","author":"Ding","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"key20200714092423_b59-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1038\/bjc.2013.607","article-title":"Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma","volume":"109","author":"Kinoshita","year":"2013","journal-title":"Br J Cancer"},{"key":"key20200714092423_b60-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1038\/s41598-018-21216-0","article-title":"LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET\/Akt signals","volume":"8","author":"Jung","year":"2018","journal-title":"Sci Rep"},{"key":"key20200714092423_b61-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"e55714","DOI":"10.1371\/journal.pone.0055714","article-title":"Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"key20200714092423_b62-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0304-3835(03)00390-2","article-title":"Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas","volume":"199","author":"Ohike","year":"2003","journal-title":"Cancer Lett"},{"key":"key20200714092423_b63-ol-0-0-11042","first-page":"86","article-title":"Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas","volume":"7","author":"Kashima","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"key20200714092423_b64-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/modpathol.3800772","article-title":"Prognostic significance of maspin in pancreatic ductal adenocarcinoma: Tissue microarray analysis of 223 surgically resected cases","volume":"20","author":"Cao","year":"2007","journal-title":"Mod Pathol"},{"key":"key20200714092423_b65-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13000-016-0512-4","article-title":"Expression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma","volume":"11","author":"Wang","year":"2016","journal-title":"Diagn Pathol"},{"key":"key20200714092423_b66-ol-0-0-11042","first-page":"119","article-title":"The multiple roles of amphiregulin in human cancer","volume":"1816","author":"Busser","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key20200714092423_b67-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cellsig.2018.01.019","article-title":"Secreted frizzled related protein 4 (sFRP4) update: A brief review","volume":"45","author":"Pawar","year":"2018","journal-title":"Cell Signal"},{"key":"key20200714092423_b68-ol-0-0-11042","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1038\/s41598-017-02256-4","article-title":"Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines","volume":"7","author":"Deshmukh","year":"2017","journal-title":"Sci Rep"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T09:59:15Z","timestamp":1594720755000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.11042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":68,"URL":"https:\/\/doi.org\/10.3892\/ol.2019.11042","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]}}}