{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:48:57Z","timestamp":1771375737568,"version":"3.50.1"},"reference-count":47,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2019.11111","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T11:30:50Z","timestamp":1574163050000},"source":"Crossref","is-referenced-by-count":5,"title":["Histone deacetylase inhibitors differentially regulate c\u2011Myc expression in retinoblastoma cells"],"prefix":"10.3892","author":[{"given":"Na","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panyang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihui","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keming","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"key20200714095940_b1-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/S0140-6736(11)61137-9","article-title":"Retinoblastoma","volume":"379","author":"Dimaras","year":"2012","journal-title":"Lancet"},{"key":"key20200714095940_b2-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/s41388-017-0050-x","article-title":"The management of retinoblastoma","volume":"37","author":"Fabian","year":"2018","journal-title":"Oncogene"},{"key":"key20200714095940_b3-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1136\/bjo.2008.150292","article-title":"The epidemiological challenge of the most frequent eye cancer: Retinoblastoma, an issue of birth and death","volume":"93","author":"Kivela","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"key20200714095940_b4-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: Statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200714095940_b5-ol-0-0-11111","first-page":"75","article-title":"Expression and function of myc family genes","volume":"2","author":"Zimmerman","year":"1990","journal-title":"Crit Rev Oncog"},{"key":"key20200714095940_b6-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","article-title":"MYC oncogenes and human neoplastic disease","volume":"18","author":"Nesbit","year":"1999","journal-title":"Oncogene"},{"key":"key20200714095940_b7-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrc1014","article-title":"Neuroblastoma: Biological insights into a clinical enigma","volume":"3","author":"Brodeur","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key20200714095940_b8-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3816\/CLM.2005.n.021","article-title":"Adult Burkitt's lymphoma","volume":"6","author":"Bociek","year":"2005","journal-title":"Clin Lymphoma"},{"key":"key20200714095940_b9-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"e497","DOI":"10.14694\/EdBook_AM.2014.34.e497","article-title":"Taking on challenging targets: Making MYC druggable","author":"Horiuchi","year":"2014","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"key20200714095940_b10-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"a014357","DOI":"10.1101\/cshperspect.a014357","article-title":"An overview of MYC and its interactome","volume":"4","author":"Conacci-Sorrell","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key20200714095940_b11-ol-0-0-11111","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1016-8478(23)13212-2","article-title":"c-myc expression: Keep the noise down!","volume":"20","author":"Chung","year":"2005","journal-title":"Mol Cells"},{"key":"key20200714095940_b12-ol-0-0-11111","first-page":"2868","article-title":"Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT","volume":"6","author":"Kitagawa","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20200714095940_b13-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.neo.2014.05.009","article-title":"5-aza-2\u2032- deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia","volume":"16","author":"Grandjenette","year":"2004","journal-title":"Neoplasia"},{"key":"key20200714095940_b14-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"82658","DOI":"10.18632\/oncotarget.12308","article-title":"Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1\u03b1, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation","volume":"7","author":"Long","year":"2016","journal-title":"Oncotarget"},{"key":"key20200714095940_b15-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.bbrc.2004.09.130","article-title":"Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1\/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells","volume":"324","author":"Li","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714095940_b16-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/excr.1999.4686","article-title":"Function of the c-Myc oncogenic transcription factor","volume":"253","author":"Dang","year":"1999","journal-title":"Exp Cell Res"},{"key":"key20200714095940_b17-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbrc.2013.10.034","article-title":"C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells","volume":"441","author":"Guo","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200714095940_b18-ol-0-0-11111","first-page":"773","article-title":"Regulation of cell cycle duration by c-myc levels","volume":"4","author":"Karn","year":"1989","journal-title":"Oncogene"},{"key":"key20200714095940_b19-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1071489","article-title":"Sustained loss of a neoplastic phenotype by brief inactivation of MYC","volume":"297","author":"Jain","year":"2002","journal-title":"Science"},{"key":"key20200714095940_b20-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"615","DOI":"10.4161\/cbt.11.7.14688","article-title":"c-Myc induction of programmed cell death may contribute to carcinogenesis: A perspective inspired by several concepts of chemical carcinogenesis","volume":"11","author":"Wang","year":"2011","journal-title":"Cancer Biol Ther"},{"key":"key20200714095940_b21-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"10213","DOI":"10.1158\/0008-5472.CAN-10-2720","article-title":"Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose","volume":"70","author":"Okuyama","year":"2010","journal-title":"Cancer Res"},{"key":"key20200714095940_b22-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Liva","year":"2001","journal-title":"Methods"},{"key":"key20200714095940_b23-ol-0-0-11111","first-page":"1119","article-title":"Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells","volume":"10","author":"Futamura","year":"1995","journal-title":"Oncogene"},{"key":"key20200714095940_b24-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1158\/0008-5472.CAN-10-2259","article-title":"Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels","volume":"71","author":"Kretzner","year":"2011","journal-title":"Cancer Res"},{"key":"key20200714095940_b25-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1158\/1078-0432.CCR-15-2388","article-title":"c-Myc modulation & acetylation is a key HDAC inhibitor target in cancer","volume":"23","author":"Nebbioso","year":"2017","journal-title":"Clin Cancer Res"},{"key":"key20200714095940_b26-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/emboj.2009.139","article-title":"Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells","volume":"28","author":"Napoli","year":"2009","journal-title":"EMBO J"},{"key":"key20200714095940_b27-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1002\/1873-3468.13521","article-title":"HDAC2-dependent miRNA signature in acute myeloid leukemia","volume":"593","author":"Conte","year":"2019","journal-title":"FEBS Lett"},{"key":"key20200714095940_b28-ol-0-0-11111","first-page":"1213","article-title":"HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer","volume":"7","author":"Shan","year":"2017","journal-title":"Am J Cancer Res"},{"key":"key20200714095940_b29-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sj.bjc.6604199","article-title":"Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy","volume":"98","author":"Weichert","year":"2008","journal-title":"Br J Cancer"},{"key":"key20200714095940_b30-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1158\/1541-7786.MCR-12-0332","article-title":"Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer","volume":"11","author":"Kim","year":"2013","journal-title":"Mol Cancer Res"},{"key":"key20200714095940_b31-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3892\/ol.2016.5436","article-title":"HDAC2 regulates cell proliferation, cell cycle progression and cell apoptosis in esophageal squamous cell carcinoma EC9706 cells","volume":"13","author":"Li","year":"2017","journal-title":"Oncol Lett"},{"key":"key20200714095940_b32-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.biopha.2016.09.030","article-title":"HDAC2 promotes the migration and invasion of non-small cell lung cancer cells via upregulation of fibronectin","volume":"84","author":"Li","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"key20200714095940_b33-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/jjco\/hyw096","article-title":"HDAC2 overexpression is a poor prognostic factor of breast cancer patients with increased multidrug resistance-associated protein expression who received anthracyclines therapy","volume":"46","author":"Zhao","year":"2016","journal-title":"Jpn J Clin Oncol"},{"key":"key20200714095940_b34-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1093\/emboj\/cdg315","article-title":"The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2","volume":"22","author":"Kr\u00e4mer","year":"2003","journal-title":"EMBO J"},{"key":"key20200714095940_b35-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.toxlet.2013.10.035","article-title":"Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells","volume":"224","author":"Kwieci\u0144ska","year":"2014","journal-title":"Toxicol Lett"},{"key":"key20200714095940_b36-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1111\/j.1582-4934.2008.00436.x","article-title":"The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo","volume":"13","author":"Jones","year":"2009","journal-title":"J Cell Mol Med"},{"key":"key20200714095940_b37-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.biocel.2008.08.019","article-title":"Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status","volume":"41","author":"Travaglini","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"key20200714095940_b38-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nm1161","article-title":"Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells","volume":"11","author":"Nebbioso","year":"2005","journal-title":"Nat Med"},{"key":"key20200714095940_b39-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"e28103","DOI":"10.1371\/journal.pone.0028103","article-title":"Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1\/S cell cycle proteins","volume":"6","author":"Noh","year":"2011","journal-title":"PLoS One"},{"key":"key20200714095940_b40-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-015-0201-7","article-title":"Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma","volume":"3","author":"Ecker","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"key20200714095940_b41-ol-0-0-11111","first-page":"151","article-title":"Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: Defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines","volume":"2","author":"Glaser","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"key20200714095940_b42-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1073\/pnas.85.7.2210","article-title":"Human retinoblastoma susceptibility gene: Genomic organization and analysis of heterozygous intragenic deletion mutants","volume":"85","author":"Bookstein","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200714095940_b43-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00418-014-1285-z","article-title":"Re-characterization of established human retinoblastoma cell lines","volume":"143","author":"Busch","year":"2015","journal-title":"Histochem Cell Biol"},{"key":"key20200714095940_b44-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/73432","article-title":"Systematic variation in gene expression patterns in human cancer cell lines","volume":"24","author":"Ross","year":"2000","journal-title":"Nat Genet"},{"key":"key20200714095940_b45-ol-0-0-11111","first-page":"1915","article-title":"Constitutive c-Myc expression in an IL-3 dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis","volume":"6","author":"Askew","year":"1991","journal-title":"Oncogene"},{"key":"key20200714095940_b46-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","article-title":"Induction of apoptosis in fibroblasts by c-Myc protein","volume":"69","author":"Evan","year":"1992","journal-title":"Cell"},{"key":"key20200714095940_b47-ol-0-0-11111","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1002\/j.1460-2075.1994.tb06630.x","article-title":"c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines","volume":"13","author":"Harrington","year":"1994","journal-title":"EMBO J"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T06:19:32Z","timestamp":1722061172000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2019.11111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":47,"URL":"https:\/\/doi.org\/10.3892\/ol.2019.11111","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,19]]}}}