{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:21:46Z","timestamp":1781353306636,"version":"3.54.1"},"reference-count":40,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2021.13062","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T06:21:18Z","timestamp":1632378078000},"source":"Crossref","is-referenced-by-count":12,"title":["Long non\u2011coding RNA XIST accelerates hepatic carcinoma progression by targeting the microRNA\u2011320a\/PIK3CA axis"],"prefix":"10.3892","volume":"22","author":[{"given":"Lina","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangliang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonglei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Lianyungang No.\u00a01 People's Hospital, Lianyungang, Jiangsu 222002, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"key20211011111851_b1-ol-0-0-13062","first-page":"703","article-title":"Diagnostic value of glypican-3 in alpha fetoprotein negative hepatocellular carcinoma patients","volume":"13","author":"Li","year":"2013","journal-title":"Afr Health Sci"},{"key":"key20211011111851_b2-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cld.2015.01.007","article-title":"Surgical resection and liver transplantation for hepatocellular carcinoma","volume":"19","author":"Akoad","year":"2015","journal-title":"Clin Liver Dis"},{"key":"key20211011111851_b3-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/jjco\/hym025","article-title":"Effectiveness of hepatic resection for early-stage hepatocellular carcinoma in cirrhotic patients: Subgroup analysis according to Milan criteria","volume":"37","author":"Yamamoto","year":"2007","journal-title":"Jpn J Clin Oncol"},{"key":"key20211011111851_b4-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1186\/s12885-016-2749-4","article-title":"Advanced hepatocellular carcinoma with hepatic vein tumor thrombosis and renal dysfunction after hepatic arterial infusion chemotherapy effectively treated by liver resection with active veno-venous bypass: Report of a case","volume":"16","author":"Itoh","year":"2016","journal-title":"BMC Cancer"},{"key":"key20211011111851_b5-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1146\/annurev.pharmtox.45.120403.095906","article-title":"Hepatic fibrosis: Molecular mechanisms and drug targets","volume":"45","author":"Lotersztajn","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key20211011111851_b6-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"57379","DOI":"10.18632\/oncotarget.10545","article-title":"LncRNAs in pancreatic cancer","volume":"7","author":"Huang","year":"2016","journal-title":"Oncotarget"},{"key":"key20211011111851_b7-ol-0-0-13062","first-page":"584","article-title":"Advances in research on circulating miRNAs and lncRNAs in early diagnosis and treatment of lung cancer","volume":"35","author":"Xu","year":"2015","journal-title":"Tumor"},{"key":"key20211011111851_b8-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13046-015-0136-7","article-title":"Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge","volume":"34","author":"Deng","year":"2015","journal-title":"J Exp Clin Cancer Res"},{"key":"key20211011111851_b9-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.phymed.2015.05.071","article-title":"Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer","volume":"22","author":"Zamani","year":"2015","journal-title":"Phytomedicine"},{"key":"key20211011111851_b10-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1158\/0008-5472.CAN-14-3721","article-title":"Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma","volume":"75","author":"Li","year":"2015","journal-title":"Cancer Res"},{"key":"key20211011111851_b11-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.1038\/sj.onc.1210266","article-title":"Riboregulator H19 induction of MDR1-associated drug resistance in human hepatocellular carcinoma cells","volume":"26","author":"Tsang","year":"2007","journal-title":"Oncogene"},{"key":"key20211011111851_b12-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"94358","DOI":"10.18632\/oncotarget.21719","article-title":"LncRNA XIST acts as a tumor suppressor in prostate cancer through sponging miR-23a to modulate RKIP expression","volume":"8","author":"Du","year":"2017","journal-title":"Oncotarget"},{"key":"key20211011111851_b13-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3892\/or.2017.5751","article-title":"lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP","volume":"38","author":"Tang","year":"2017","journal-title":"Oncol Rep"},{"key":"key20211011111851_b14-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1158\/1535-7163.MCT-15-0470","article-title":"High XIST and low 53BP1 expression predict poor outcome after high-dose alkylating chemotherapy in patients with a BRCA1-like breast cancer","volume":"15","author":"Schouten","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20211011111851_b15-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.bbrc.2016.08.030","article-title":"Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression","volume":"478","author":"Fang","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"key20211011111851_b16-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12935-019-0909-8","article-title":"lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4","volume":"19","author":"Zhang","year":"2019","journal-title":"Cancer Cell Int"},{"key":"key20211011111851_b17-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"4458","DOI":"10.1002\/jcb.26540","article-title":"LncRNA XIST functions as a molecular sponge of miR-194-5p to regulate MAPK1 expression in hepatocellular carcinoma cell","volume":"119","author":"Kong","year":"2018","journal-title":"J Cell Biochem"},{"key":"key20211011111851_b18-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/nprot.2006.236","article-title":"Quantification of mRNA using real-time RT-PCR","volume":"1","author":"Nolan","year":"2006","journal-title":"Nat Protoc"},{"key":"key20211011111851_b19-ol-0-0-13062","first-page":"450","article-title":"Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival","volume":"8","author":"Inagawa","year":"2002","journal-title":"Clin Cancer Res"},{"key":"key20211011111851_b20-ol-0-0-13062","first-page":"259","article-title":"Advances in research on prediction for early postoperative metastasis and recurrence in patients with hepatocellular carcinoma","volume":"13","author":"Li","year":"2013","journal-title":"Chin Med Abstracts"},{"key":"key20211011111851_b21-ol-0-0-13062","article-title":"X-Chromosome Inactivation and Long Non-Coding RNAs","author":"Lee"},{"key":"key20211011111851_b22-ol-0-0-13062","first-page":"1403","article-title":"Expression and clinical significance of long non-coding RNA XIST in tissue and plasma of gastric cancer","volume":"38","author":"Li","year":"2017","journal-title":"Acad J Sec Mil Med Univ"},{"key":"key20211011111851_b23-ol-0-0-13062","first-page":"1507","article-title":"Knockdown of lncRNA XIST suppresses osteosarcoma progression by inactivating AKT\/mTOR signaling pathway by sponging miR-375-3p","volume":"12","author":"Sun","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"key20211011111851_b24-ol-0-0-13062","first-page":"696","article-title":"Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p","volume":"22","author":"Song","year":"2017","journal-title":"J BUON"},{"key":"key20211011111851_b25-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/aps.2017.3","article-title":"The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer","volume":"38","author":"Zhang","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"key20211011111851_b26-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"BSR20170696","DOI":"10.1042\/BSR20170696","article-title":"LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway","volume":"37","author":"Du","year":"2017","journal-title":"Biosci Rep"},{"key":"key20211011111851_b27-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"e12525","DOI":"10.1111\/cpr.12525","article-title":"LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-\u03baB\/NLRP3 inflammasome pathway","volume":"52","author":"Ma","year":"2019","journal-title":"Cell Prolif"},{"key":"key20211011111851_b28-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"e1112","DOI":"10.1002\/mgg3.1112","article-title":"LncRNA XIST modulates HIF-1A\/AXL signaling pathway by inhibiting miR-93-5p in colorectal cancer","volume":"8","author":"Yang","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"key20211011111851_b29-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/hep.510280114","article-title":"Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis","volume":"28","author":"Macdonald","year":"1998","journal-title":"Hepatology"},{"key":"key20211011111851_b30-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"6750","DOI":"10.1002\/jcp.26383","article-title":"LncRNA MALAT1 induces colon cancer development by regulating miR-129-5p\/HMGB1 axis","volume":"233","author":"Wu","year":"2017","journal-title":"J Cell Physiol"},{"key":"key20211011111851_b31-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"e69230","DOI":"10.1371\/journal.pone.0069230","article-title":"Characterization of MicroRNA expression profiles and the discovery of novel MicroRNAs involved in cancer during human embryonic development","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"key20211011111851_b32-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1289\/ehp.11841","article-title":"RDX induces aberrant expression of MicroRNAs in Mouse brain and liver","volume":"117","author":"Zhang","year":"2009","journal-title":"Environ Health Perspect"},{"key":"key20211011111851_b33-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1002\/ijc.29544","article-title":"Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma","volume":"137","author":"Wen","year":"2015","journal-title":"Int J Cancer"},{"key":"key20211011111851_b34-ol-0-0-13062","first-page":"234","article-title":"GNAI1 suppresses tumor cell migration and invasion and is post-transcriptionally regulated by Mir-320a\/c\/d in hepatocellular carcinoma","volume":"9","author":"Yao","year":"2012","journal-title":"Cancer Biol Med"},{"key":"key20211011111851_b35-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/biom10010020","article-title":"Suppression of hepatocellular carcinoma progression through FOXM1 and EMT inhibition via hydroxygenkwanin-induced miR-320a expression","volume":"10","author":"Chou","year":"2019","journal-title":"Biomolecules"},{"key":"key20211011111851_b36-ol-0-0-13062","first-page":"2305","article-title":"The expression of miR-320a on hepatocellular carcinoma and the effect of apoptosis and migration on SMMC-7721 cell line","volume":"5","author":"Lv","year":"2018","journal-title":"Genomics Appl Biol"},{"key":"key20211011111851_b37-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"20181","DOI":"10.1016\/S0021-9258(19)47043-9","article-title":"Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae","volume":"264","author":"Auger","year":"1989","journal-title":"J Biol Chem"},{"key":"key20211011111851_b38-ol-0-0-13062","doi-asserted-by":"publisher","DOI":"10.21236\/ADA485346","article-title":"Targeting breast cancers featuring activating mutations in PIK3CA by generating a lethal dose of PIP3","author":"Zhao","year":"2008"},{"key":"key20211011111851_b39-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2012.10.021","article-title":"Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes","volume":"92","author":"Orloff","year":"2013","journal-title":"Am J Hum Genet"},{"key":"key20211011111851_b40-ol-0-0-13062","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/jpi.12194","article-title":"Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE\/NF-K B\/JNK signaling pathway in aging mouse model","volume":"58","author":"Ali","year":"2015","journal-title":"J Pineal Res"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T11:31:44Z","timestamp":1633951904000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2021.13062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,23]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2021.13062","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]},"article-number":"801"}}