{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:03:23Z","timestamp":1792886603028,"version":"4.5.0"},"reference-count":21,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2022.13225","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T16:40:30Z","timestamp":1644424830000},"source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of the expression of fatty acid synthase and <i>O<\/i>\u2011GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches"],"prefix":"10.3892","volume":"23","author":[{"given":"Sadia","family":"Raab","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, UMR 8576\u2011UGSF\u2011Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Very","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, UMR 8576\u2011UGSF\u2011Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Duch\u00eane","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, Inserm, CHU Lille, UMR 9020\u2011U1277, CANTHER\u2011Cancer Heterogeneity, Plasticity and Resistance to Therapies, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rybarczyk","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologique, CHU Amiens\u2011Picardie, F\u201180000 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jonckheere","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, Inserm, CHU Lille, UMR 9020\u2011U1277, CANTHER\u2011Cancer Heterogeneity, Plasticity and Resistance to Therapies, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"El Yazidi\u2011belkoura","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, UMR 8576\u2011UGSF\u2011Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CNRS, UMR 8576\u2011UGSF\u2011Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F\u201159000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"key20220311105719_b1-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0163-7827(02)00067-X","article-title":"Structural and functional organization of the animal fatty acid synthase","volume":"42","author":"Smith","year":"2003","journal-title":"Prog Lipid Res"},{"key":"key20220311105719_b2-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/S0006-291X(03)00265-1","article-title":"Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains","volume":"302","author":"Swinnen","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"key20220311105719_b3-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrc2222","article-title":"Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis","volume":"7","author":"Menendez","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"key20220311105719_b4-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0003-9861(02)00578-7","article-title":"Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene","volume":"409","author":"Hanover","year":"2003","journal-title":"Arch Biochem Biophys"},{"key":"key20220311105719_b5-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fendo.2013.00099","article-title":"O-GlcNAcylation: A New cancer hallmark?","volume":"4","author":"Fardini","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20220311105719_b6-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1016\/j.jmb.2016.04.035","article-title":"The nutrient-dependent O-GlcNAc modification controls the expression of liver fatty acid synthase","volume":"428","author":"Baldini","year":"2016","journal-title":"J Mol Biol"},{"key":"key20220311105719_b7-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1007\/s00018-021-03857-z","article-title":"Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells","volume":"78","author":"Raab","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"key20220311105719_b8-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.tcb.2014.03.003","article-title":"Regulation of mTORC1 by amino acids","volume":"24","author":"Bar-Peled","year":"2014","journal-title":"Trends Cell Biol"},{"key":"key20220311105719_b9-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1158\/1541-7786.MCR-14-0536","article-title":"mTOR\/MYC axis regulates O-GlcNAc transferase expression and O-GlcNAcylation in breast cancer","volume":"13","author":"Sodi","year":"2015","journal-title":"Mol Cancer Res"},{"key":"key20220311105719_b10-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10863-018-9747-y","article-title":"Cross regulation between mTOR signaling and O-GlcNAcylation","volume":"50","author":"Very","year":"2018","journal-title":"J Bioenerg Biomembr"},{"key":"key20220311105719_b11-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3390\/cells8121584","article-title":"Targeting mTOR and metabolism in cancer. Lessons and innovations","volume":"8","author":"Magaway","year":"2019","journal-title":"Cells"},{"key":"key20220311105719_b12-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13045-019-0754-1","article-title":"Targeting mTOR for cancer therapy","volume":"12","author":"Hua","year":"2019","journal-title":"J Hematol Oncol"},{"key":"key20220311105719_b13-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20220311105719_b14-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fonc.2016.00006","article-title":"O-GlcNAcylation and the metabolic shift in high-proliferating cells: All the evidence suggests that sugars dictate the flux of lipid biogenesis in tumor processes","volume":"6","author":"Baldini","year":"2016","journal-title":"Front Oncol"},{"key":"key20220311105719_b15-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3390\/ijms16010924","article-title":"Lipid metabolism, apoptosis and cancer therapy","volume":"16","author":"Huang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"key20220311105719_b16-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1080\/14728222.2017.1381087","article-title":"Fatty acid synthase (FASN) as a therapeutic target in breast cancer","volume":"21","author":"Menendez","year":"2017","journal-title":"Expert Opin Ther Targets"},{"key":"key20220311105719_b17-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fendo.2016.00046","article-title":"Silencing the nucleocytoplasmic O-GlcNAc transferase reduces proliferation, adhesion, and migration of cancer and fetal human colon cell lines","volume":"7","author":"Steenackers","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20220311105719_b18-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1038\/onc.2010.41","article-title":"Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1","volume":"29","author":"Caldwell","year":"2010","journal-title":"Oncogene"},{"key":"key20220311105719_b19-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1096\/fj.13-243535","article-title":"O-GlcNAcylation stabilizes \u03b2-catenin through direct competition with phosphorylation at threonine 41","volume":"28","author":"Olivier-Van Stichelen","year":"2014","journal-title":"FASEB"},{"key":"key20220311105719_b20-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s12032-011-9912-1","article-title":"O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation","volume":"29","author":"Zhu","year":"2012","journal-title":"Med Oncol"},{"key":"key20220311105719_b21-ol-23-04-13225","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1158\/1535-7163.MCT-13-0314","article-title":"Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+\/calmodulin-dependent protein kinase II","volume":"12","author":"Meng","year":"2013","journal-title":"Mol Cancer Ther"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T08:57:29Z","timestamp":1646989049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2022.13225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2,3]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2022.13225","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"article-number":"105"}}