{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:04Z","timestamp":1787067904002,"version":"build-2736575974"},"reference-count":43,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2022.13395","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T01:20:51Z","timestamp":1655860851000},"source":"Crossref","is-referenced-by-count":13,"title":["Effects of dihydroartemisinin combined with cisplatin on proliferation, apoptosis and migration of HepG2 cells"],"prefix":"10.3892","volume":"24","author":[{"given":"Qi","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"key20220803125953_b1-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"key20220803125953_b2-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ijpharm.2015.02.027","article-title":"A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma","volume":"483","author":"Wang","year":"2015","journal-title":"Int J Pharm"},{"key":"key20220803125953_b3-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"12","DOI":"10.21037\/cco-20-113","article-title":"Hepatocellular carcinoma, novel therapies on the horizon","volume":"10","author":"El Dika","year":"2021","journal-title":"Chin Clin Oncol"},{"key":"key20220803125953_b4-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"188314","DOI":"10.1016\/j.bbcan.2019.188314","article-title":"Challenges in liver cancer and possible treatment approaches","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"key20220803125953_b5-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"2962580","DOI":"10.1155\/2019\/2962580","article-title":"Epithelial mesenchymal and endothelial mesenchymal transitions in hepatocellular carcinoma: A review","volume":"2019","author":"Gurzu","year":"2019","journal-title":"Biomed Res Int"},{"key":"key20220803125953_b6-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/bs.acr.2020.12.001","article-title":"Systemic therapy of liver cancer","volume":"149","author":"Demir","year":"2021","journal-title":"Adv Cancer Res"},{"key":"key20220803125953_b7-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.fct.2019.04.012","article-title":"Natural products: An upcoming therapeutic approach to cancer","volume":"128","author":"Dutta","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"key20220803125953_b8-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: The first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg Chem"},{"key":"key20220803125953_b9-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1021\/cr020010d","article-title":"Biochemical modulation of cisplatin mechanisms of action: Enhancement of antitumor activity and circumvention of drug resistance","volume":"103","author":"Fuertes","year":"2003","journal-title":"Chem Rev"},{"key":"key20220803125953_b10-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ejphar.2017.05.063","article-title":"Cisplatin induced arrhythmia; electrolyte imbalance or disturbance of the SA node?","volume":"811","author":"Oun","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"key20220803125953_b11-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int"},{"key":"key20220803125953_b12-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"111079","DOI":"10.1016\/j.fct.2019.111079","article-title":"Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents","volume":"136","author":"Santos","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"key20220803125953_b13-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3892\/or.2013.2279","article-title":"Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation","volume":"29","author":"Astolfi","year":"2013","journal-title":"Oncol Rep"},{"key":"key20220803125953_b14-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cell.2011.08.024","article-title":"Artemisinin: Discovery from the Chinese herbal garden","volume":"146","author":"Miller","year":"2011","journal-title":"Cell"},{"key":"key20220803125953_b15-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"107658","DOI":"10.1016\/j.pharmthera.2020.107658","article-title":"The birth of artemisinin","volume":"216","author":"Ma","year":"2020","journal-title":"Pharmacol Ther"},{"key":"key20220803125953_b16-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"509","DOI":"10.2174\/156802606776743129","article-title":"From artemisinin to new artemisinin antimalarials: Biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements","volume":"6","author":"Haynes","year":"2006","journal-title":"Curr Top Med Chem"},{"key":"key20220803125953_b17-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"603","DOI":"10.7150\/ijbs.50364","article-title":"Dihydroartemisinin: A potential natural anticancer drug","volume":"17","author":"Dai","year":"2021","journal-title":"Int J Biol Sci"},{"key":"key20220803125953_b18-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3892\/ol.2020.11955","article-title":"Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy","volume":"20","author":"Chen","year":"2020","journal-title":"Oncol Lett"},{"key":"key20220803125953_b19-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"e0171840","DOI":"10.1371\/journal.pone.0171840","article-title":"Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"key20220803125953_b20-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.toxlet.2009.10.012","article-title":"Increase the cisplatin cytotoxicity and cisplatin-induced DNA damage in HepG2 cells by XRCC1 abrogation related mechanisms","volume":"192","author":"Zhang","year":"2010","journal-title":"Toxicol Lett"},{"key":"key20220803125953_b21-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1039\/c9mt00049f","article-title":"Unexpected therapeutic effects of cisplatin","volume":"11","author":"Raudenska","year":"2019","journal-title":"Metallomics"},{"key":"key20220803125953_b22-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.3390\/ijms22158199","article-title":"Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment","volume":"22","author":"Kiss","year":"2021","journal-title":"Int J Mol Sci"},{"key":"key20220803125953_b23-ol-24-02-13395","first-page":"1237","article-title":"Identification of cisplatin sensitizers through high-throughput combinatorial screening","volume":"53","author":"Sun","year":"2018","journal-title":"Int J Oncol"},{"key":"key20220803125953_b24-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40659-019-0243-6","article-title":"Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells","volume":"52","author":"Liu","year":"2019","journal-title":"Biol Res"},{"key":"key20220803125953_b25-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.ejmech.2017.12.039","article-title":"Natural compounds and combination therapy in colorectal cancer treatment","volume":"144","author":"Rejhov\u00e1","year":"2018","journal-title":"Eur J Med Chem"},{"key":"key20220803125953_b26-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1186\/s12885-019-5891-y","article-title":"Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo","volume":"19","author":"Abe","year":"2019","journal-title":"BMC Cancer"},{"key":"key20220803125953_b27-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat Med"},{"key":"key20220803125953_b28-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1586\/17512433.2014.907523","article-title":"Novel anti-malarial combinations and their toxicity","volume":"7","author":"Angus","year":"2014","journal-title":"Expert Rev Clin Pharmacol"},{"key":"key20220803125953_b29-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"14134","DOI":"10.1002\/anie.201907388","article-title":"Programmed release of dihydroartemisinin for synergistic cancer therapy using a CaCO3 mineralized metal-organic framework","volume":"58","author":"Wan","year":"2019","journal-title":"Angew Chem Int Ed Engl"},{"key":"key20220803125953_b30-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.lfs.2017.11.008","article-title":"Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells","volume":"192","author":"Im","year":"2018","journal-title":"Life Sci"},{"key":"key20220803125953_b31-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.2147\/OTT.S297785","article-title":"Dihydroartemisinin as a sensitizing agent in cancer therapies","volume":"14","author":"Li","year":"2021","journal-title":"Onco Targets Ther"},{"key":"key20220803125953_b32-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.3892\/ol.2016.5187","article-title":"In vitro and in vivo inhibition of tumor cell viability by combined dihydroartemisinin and doxorubicin treatment, and the underlying mechanism","volume":"12","author":"Tai","year":"2016","journal-title":"Oncol Lett"},{"key":"key20220803125953_b33-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.3892\/mmr.2017.6989","article-title":"Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt\/mTOR\/STAT3 pathway","volume":"16","author":"Jin","year":"2017","journal-title":"Mol Med Rep"},{"key":"key20220803125953_b34-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.3390\/ijms23031532","article-title":"Pharmacological effects of cisplatin combination with natural products in cancer chemotherapy","volume":"23","author":"Dasari","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20220803125953_b35-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1021\/acs.chemrestox.9b00204","article-title":"Advances in toxicological research of the anticancer drug cisplatin","volume":"32","author":"Qi","year":"2019","journal-title":"Chem Res Toxicol"},{"key":"key20220803125953_b36-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2478\/raon-2019-0018","article-title":"Cisplatin and beyond: Molecular mechanisms of action and drug resistance development in cancer chemotherapy","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol Oncol"},{"key":"key20220803125953_b37-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fphar.2020.00343","article-title":"The drug-resistance mechanisms of five platinum-based antitumor agents","volume":"11","author":"Zhou","year":"2020","journal-title":"Front Pharmacol"},{"key":"key20220803125953_b38-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3892\/ijmm.2012.1176","article-title":"Involvement of the mitochondrial pathway and Bim\/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro","volume":"31","author":"Mao","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20220803125953_b39-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3390\/nano8100804","article-title":"Nanostructured dihydroartemisinin plus epirubicin liposomes enhance treatment efficacy of breast cancer by inducing autophagy and apoptosis","volume":"8","author":"Hu","year":"2018","journal-title":"Nanomaterials (Basel)"},{"key":"key20220803125953_b40-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1177\/15353702211038511","article-title":"Cyclin D1b induces changes in the macrophage phenotype resulting in promotion of tumor metastasis","volume":"246","author":"Wang","year":"2021","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20220803125953_b41-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"827","DOI":"10.7150\/ijbs.32460","article-title":"Overexpression of microRNA-9 enhances cisplatin sensitivity in hepatocellular carcinoma by regulating EIF5A2-mediated epithelial-mesenchymal transition","volume":"16","author":"Bao","year":"2020","journal-title":"Int J Biol Sci"},{"key":"key20220803125953_b42-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3390\/molecules21070965","article-title":"Targeting epithelial-mesenchymal transition (EMT) to overcome drug resistance in cancer","volume":"21","author":"Du","year":"2016","journal-title":"Molecules"},{"key":"key20220803125953_b43-ol-24-02-13395","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T06:00:01Z","timestamp":1659506401000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2022.13395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,22]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2022.13395","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,22]]},"article-number":"275"}}