{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:14:50Z","timestamp":1770549290510,"version":"3.49.0"},"reference-count":48,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2023.13899","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T17:36:39Z","timestamp":1686072999000},"source":"Crossref","is-referenced-by-count":6,"title":["Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system <i>in\u00a0vitro<\/i>"],"prefix":"10.3892","volume":"26","author":[{"given":"Mariko","family":"Kogami","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine,\u00a0Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki 300\u20110395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine,\u00a0Tokyo Medical University, Tokyo 160\u20110023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki 300\u20110395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutetsu","family":"Aoshiba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki 300\u20110395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"key20230622100517_b1-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1172\/JCI200420468","article-title":"PPARalpha governs glycerol metabolism","volume":"114","author":"Patsouris","year":"2004","journal-title":"J Clin Invest"},{"key":"key20230622100517_b2-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"55","DOI":"10.12688\/f1000research.5827.2","article-title":"Fenofibrate in cancer: Mechanisms involved in anticancer activity","volume":"4","author":"Koltai","year":"2015","journal-title":"F1000Res"},{"key":"key20230622100517_b3-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2217\/cer-2016-0076","article-title":"Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis","volume":"6","author":"Abdel Magid","year":"2017","journal-title":"J Comp Eff Res"},{"key":"key20230622100517_b4-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.2337\/db13-0800","article-title":"An update on the molecular actions of fenofibrate and its clinical effects on diabetic retinopathy and other microvascular end points in patients with diabetes","volume":"62","author":"Noonan","year":"2013","journal-title":"Diabetes"},{"key":"key20230622100517_b5-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.7150\/jca.24488","article-title":"Anticancer roperties of fenofibrate: A repurposing use","volume":"9","author":"Lian","year":"2018","journal-title":"J Cancer"},{"key":"key20230622100517_b6-ol-26-1-13899","first-page":"560","article-title":"Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers","volume":"60","author":"Vlase","year":"2010","journal-title":"Arzneimittelforschung"},{"key":"key20230622100517_b7-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"660490","DOI":"10.3389\/fphar.2021.660490","article-title":"The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models","volume":"12","author":"Davies","year":"2021","journal-title":"Front Pharmacol"},{"key":"key20230622100517_b8-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/cancers11010077","article-title":"Fenofibrate augments the sensitivity of drug-resistant prostate cancer cells to docetaxel","volume":"11","author":"Luty","year":"2019","journal-title":"Cancers (Basel)"},{"key":"key20230622100517_b9-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.phrs.2019.03.025","article-title":"Molecular targets of fenofibrate in the cardiovascular-renal axis: A unifying perspective of its pleiotropic benefits","volume":"144","author":"Balakumar","year":"2019","journal-title":"Pharmacol Res"},{"key":"key20230622100517_b10-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1080\/02713683.2018.1501072","article-title":"Fenofibrate ameliorates oxidative stress-induced retinal microvascular dysfunction in diabetic rats","volume":"43","author":"Li","year":"2018","journal-title":"Curr Eye Res"},{"key":"key20230622100517_b11-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"e0188596","DOI":"10.1371\/journal.pone.0188596","article-title":"Effects of peroxisome proliferator activated receptors (PPAR)-\u03b3 and -\u03b1 agonists on cochlear protection from oxidative stress","volume":"12","author":"Sekulic-Jablanovic","year":"2017","journal-title":"PLOS One"},{"key":"key20230622100517_b12-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3390\/antiox9080712","article-title":"Protective effect of fenofibrate on oxidative stress-induced apoptosis in retinal-choroidal vascular endothelial cells: Implication for diabetic retinopathy treatment","volume":"9","author":"Hsu","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"key20230622100517_b13-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"8895376","DOI":"10.1155\/2021\/8895376","article-title":"Fenofibrate protects cardiomyocytes from hypoxia\/reperfusion- and high glucose-induced detrimental effects","volume":"2021","author":"Cortes-Lopez","year":"2021","journal-title":"PPAR Res"},{"key":"key20230622100517_b14-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2131\/jts.41.339","article-title":"Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways","volume":"41","author":"Thongnuanjan","year":"2016","journal-title":"J Toxicol Sci"},{"key":"key20230622100517_b15-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.taap.2018.06.010","article-title":"Protective roles of fenofibrate against cisplatin-induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction","volume":"353","author":"Kim","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20230622100517_b16-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: Molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"key20230622100517_b17-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20230622100517_b18-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/0021-9150(96)05859-5","article-title":"Pharmacodynamic activity of lipoprotein lipase and hepatic lipase, and pharmacokinetic parameters measured in normolipidaemic subjects receiving ciprofibrate (100 or 200 mg\/day) or micronised fenofibrate (200 mg\/day) therapy for 23 days","volume":"124","author":"Desager","year":"1996","journal-title":"Atherosclerosis"},{"key":"key20230622100517_b19-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.canlet.2011.12.025","article-title":"Use of the \u03b3-H2AX assay to monitor DNA damage and repair in translational cancer research","volume":"327","author":"Ivashkevich","year":"2012","journal-title":"Cancer Lett"},{"key":"key20230622100517_b20-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1038\/onc.2008.307","article-title":"Bcl-2 family proteins and cancer","volume":"27","author":"Yip","year":"2008","journal-title":"Oncogene"},{"key":"key20230622100517_b21-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"e1027","DOI":"10.1038\/cddis.2013.550","article-title":"Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70","volume":"5","author":"Endo","year":"2014","journal-title":"Cell Death Dis"},{"key":"key20230622100517_b22-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/ijc.22132","article-title":"Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA","volume":"120","author":"Berndtsson","year":"2007","journal-title":"Int J Cancer"},{"key":"key20230622100517_b23-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2019.01.014","article-title":"Hypercapnic tumor microenvironment confers chemoresistance to lung cancer cells by reprogramming mitochondrial metabolism in vitro","volume":"134","author":"Kikuchi","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"key20230622100517_b24-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3390\/antiox11030501","article-title":"Superoxide radicals in the execution of cell death","volume":"11","author":"Fujii","year":"2022","journal-title":"Antioxidants(Basel)"},{"key":"key20230622100517_b25-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1002\/jcp.29219","article-title":"Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms","volume":"235","author":"Shaw","year":"2020","journal-title":"J Cell Physiol"},{"key":"key20230622100517_b26-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"1378175","DOI":"10.1155\/2017\/1378175","article-title":"Collaborative power of Nrf2 and PPAR\u03b3 activators against metabolic and drug-Induced oxidative injury","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"key20230622100517_b27-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key20230622100517_b28-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fonc.2017.00085","article-title":"The KEAP1-NRF2 system in cancer","volume":"7","author":"Taguchi","year":"2017","journal-title":"Front Oncol"},{"key":"key20230622100517_b29-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"e0135257","DOI":"10.1371\/journal.pone.0135257","article-title":"Cancer cell growth is differentially affected by constitutive activation of NRF2 by KEAP1 deletion and pharmacological activation of NRF2 by the synthetic triterpenoid, RTA 405","volume":"10","author":"Probst","year":"2015","journal-title":"PLoS One"},{"key":"key20230622100517_b30-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbrc.2008.07.137","article-title":"Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues","volume":"373","author":"Wang","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20230622100517_b31-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"20340","DOI":"10.1074\/jbc.M412081200","article-title":"Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: Direct cross-talk between phase I and II drug-metabolizing enzymes","volume":"280","author":"Miao","year":"2005","journal-title":"J Biol Chem"},{"key":"key20230622100517_b32-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopen.2018.05.001","article-title":"AhR signaling pathways and regulatory functions","volume":"7","author":"Larigot","year":"2018","journal-title":"Biochim Open"},{"key":"key20230622100517_b33-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.bbrc.2007.10.084","article-title":"PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects","volume":"364","author":"Villard","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20230622100517_b34-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00109-021-02163-2","article-title":"Pharmacological blockage of the AHR-CYP1A1 axis: A call for in vivo evidence","volume":"100","author":"Coelho","year":"2022","journal-title":"J Mol Med (Berl)"},{"key":"key20230622100517_b35-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2133\/dmpk.DMPK-11-RG-054","article-title":"Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR","volume":"26","author":"Terashima","year":"2011","journal-title":"Drug Metab Pharmacokinet"},{"key":"key20230622100517_b36-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"6316","DOI":"10.1038\/s41598-019-42838-y","article-title":"Potent and PPAR\u03b1-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro","volume":"9","author":"Majeed","year":"2013","journal-title":"Sci Rep"},{"key":"key20230622100517_b37-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1002\/2211-5463.13247","article-title":"Fenofibrate inhibits TGF-\u03b2-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro","volume":"11","author":"Kikuchi","year":"2021","journal-title":"FEBS Open Bio"},{"key":"key20230622100517_b38-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2018.05.002","article-title":"Antioxidant response elements: Discovery, classes, regulation and potential applications","volume":"17","author":"Raghunath","year":"2018","journal-title":"Redox Biol"},{"key":"key20230622100517_b39-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.bbrc.2015.08.056","article-title":"Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation","volume":"465","author":"Park","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key20230622100517_b40-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4330\/wjc.v5.i6.164","article-title":"Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system","volume":"5","author":"Kim","year":"2013","journal-title":"World J Cardiol"},{"key":"key20230622100517_b41-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0014-5793(96)01487-1","article-title":"C\/EBP alpha is a major activator for the transcription of rat Cu\/Zn superoxide dismutase gene in liver cell","volume":"401","author":"Kim","year":"1997","journal-title":"FEBS Lett"},{"key":"key20230622100517_b42-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cardiores.2007.06.027","article-title":"Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage","volume":"76","author":"Ding","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20230622100517_b43-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1210\/me.2002-0020","article-title":"Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter","volume":"16","author":"Girnun","year":"2002","journal-title":"Mol Endocrinol"},{"key":"key20230622100517_b44-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"7188","DOI":"10.1128\/MCB.00915-07","article-title":"NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis","volume":"27","author":"Shin","year":"2007","journal-title":"Mol Cell Biol"},{"key":"key20230622100517_b45-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key20230622100517_b46-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"214","DOI":"10.31083\/j.fbl2707214","article-title":"Fenofibrate attenuates radiation-induced oxidative damage to the skin through fatty acid binding protein 4 (FABP4)","volume":"27","author":"Sun","year":"2022","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20230622100517_b47-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ejphar.2012.10.012","article-title":"Differential effects of low-dose fenofibrate treatment in diabetic rats with early onset nephropathy and established nephropathy","volume":"698","author":"Kadian","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"key20230622100517_b48-ol-26-1-13899","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/molecules22010031","article-title":"Fenofibrate therapy restores antioxidant protection and improves myocardial insulin resistance in a rat model of metabolic syndrome and myocardial ischemia: The role of angiotensin II","volume":"22","author":"Ibarra-Lara","year":"2016","journal-title":"Molecules"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T19:27:39Z","timestamp":1687462059000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2023.13899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,6,6]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2023.13899","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"article-number":"313"}}