{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:20:12Z","timestamp":1784866812616,"version":"3.55.0"},"reference-count":41,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2023.13941","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T12:24:36Z","timestamp":1688473476000},"source":"Crossref","is-referenced-by-count":7,"title":["Novel single nucleotide polymorphism biomarkers to predict opioid effects for cancer pain"],"prefix":"10.3892","volume":"26","author":[{"given":"Yoshihiko","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Genome Biology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Biostatics, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Tsurutani","sequence":"additional","affiliation":[{"name":"Advanced Cancer Translational Research Institute, Showa University, Tokyo 142\u20118555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nakura","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Makimura","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Ohtake","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takegawa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Haratani","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Takahama","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Tanizaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Genome Biology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589\u20118511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"key20230807130246_b1-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"iv166","DOI":"10.1093\/annonc\/mdy152","article-title":"Management of cancer pain in adult patients: ESMO clinical practice guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann Oncol"},{"key":"key20230807130246_b2-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"628","DOI":"10.6004\/jnccn.2018.0044","article-title":"NCCN frameworks for resource stratification of nccn guidelines: Adult cancer pain and palliative care","volume":"16","author":"Swarm","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"key20230807130246_b3-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/S1470-2045(12)70040-2","article-title":"Use of opioid analgesics in the treatment of cancer pain: Evidence-based recommendations from the EAPC","volume":"13","author":"Caraceni","year":"2012","journal-title":"Lancet Oncol"},{"key":"key20230807130246_b4-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/phar.1986","article-title":"Review of opioid pharmacogenetics and considerations for pain management","volume":"37","author":"Owusu Obeng","year":"2017","journal-title":"Pharmacotherapy"},{"key":"key20230807130246_b5-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2147\/TCRM.S262843","article-title":"Safe use of opioids in chronic kidney disease and hemodialysis patients: Tips and tricks for non-pain specialists","volume":"16","author":"Coluzzi","year":"2020","journal-title":"Ther Clin Risk Manag"},{"key":"key20230807130246_b6-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/clpt.1990.85","article-title":"Morphine and oxycodone hydrochloride in the management of cancer pain","volume":"47","author":"Kalso","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"key20230807130246_b7-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0304-3959(03)00160-X","article-title":"Controlled-release oxycodone relieves neuropathic pain: A randomized controlled trial in painful diabetic neuropathy","volume":"105","author":"Watson","year":"2003","journal-title":"Pain"},{"key":"key20230807130246_b8-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/107327481502200408","article-title":"Clinical implications of opioid pharmacogenomics in patients with cancer","volume":"22","author":"Bell","year":"2015","journal-title":"Cancer Control"},{"key":"key20230807130246_b9-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pain.2005.03.032","article-title":"The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients","volume":"116","author":"Rakv\u00e5g","year":"2005","journal-title":"Pain"},{"key":"key20230807130246_b10-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1744-8069-4-64","article-title":"Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain","volume":"4","author":"Rakv\u00e5g","year":"2008","journal-title":"Mol Pain"},{"key":"key20230807130246_b11-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.pain.2006.10.023","article-title":"Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene","volume":"130","author":"Reyes-Gibby","year":"2007","journal-title":"Pain"},{"key":"key20230807130246_b12-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1093\/oncolo\/oyac233","article-title":"Morphine versus oxycodone for cancer pain using a catechol-O-methyltransferase genotype biomarker: A multicenter, randomized, open-label, phase III clinical trial (RELIEF Study)","volume":"28","author":"Matsuoka","year":"2023","journal-title":"Oncologist"},{"key":"key20230807130246_b13-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/cpt.2149","article-title":"Clinical pharmacogenetics implementation consortium guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy","volume":"110","author":"Crews","year":"2021","journal-title":"Clin Pharmacol Ther"},{"key":"key20230807130246_b14-ol-26-2-13941","first-page":"1393","article-title":"Expression changes in arrestin \u03b2 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients","volume":"27","author":"Matsuoka","year":"2012","journal-title":"Oncol Rep"},{"key":"key20230807130246_b15-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12529-017-9644-5","article-title":"Expectation of a decrease in pain affects the prognosis of pain in cancer patients: A prospective cohort study of response to morphine","volume":"24","author":"Matsuoka","year":"2017","journal-title":"Int J Behav Med"},{"key":"key20230807130246_b16-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3892\/br.2017.963","article-title":"Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer","volume":"7","author":"Matsuoka","year":"2017","journal-title":"Biomed Rep"},{"key":"key20230807130246_b17-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.6004\/jnccn.2010.0076","article-title":"Adult cancer pain","volume":"8","author":"Swarm","year":"2010","journal-title":"J Natl Compr Canc Netw"},{"key":"key20230807130246_b18-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12017-007-8017-7","article-title":"Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease","volume":"10","author":"Ag\u00fandez","year":"2008","journal-title":"Neuromolecular Med"},{"key":"key20230807130246_b19-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/j.pain.2014.05.032","article-title":"TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population","volume":"155","author":"Cook-Sather","year":"2014","journal-title":"Pain"},{"key":"key20230807130246_b20-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"e1000086","DOI":"10.1371\/journal.pgen.1000086","article-title":"Pain genes","volume":"4","author":"Foulkes","year":"2008","journal-title":"PLoS Genet"},{"key":"key20230807130246_b21-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: Is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"key20230807130246_b22-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"480739","DOI":"10.1155\/2013\/480739","article-title":"Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain","volume":"2013","author":"Ramesh","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20230807130246_b23-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.peptides.2012.08.005","article-title":"Central administration of oxytocin reduces hyperalgesia in mice: Implication for cannabinoid and opioid systems","volume":"38","author":"Russo","year":"2012","journal-title":"Peptides"},{"key":"key20230807130246_b24-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1111\/bph.12532","article-title":"Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics","volume":"171","author":"Sousa-Valente","year":"2014","journal-title":"Br J Pharmacol"},{"key":"key20230807130246_b25-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"e0198625","DOI":"10.1371\/journal.pone.0198625","article-title":"SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study","volume":"13","author":"Zhang","year":"2018","journal-title":"PLoS One"},{"key":"key20230807130246_b26-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"864319","DOI":"10.1155\/2013\/864319","article-title":"Pharmacogenetics of chronic pain and its treatment","volume":"2013","author":"Sv\u011btl\u00edk","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20230807130246_b27-ol-26-2-13941","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0212s60","article-title":"SNP genotyping using the sequenom MassARRAY iPLEX platform","author":"Gabriel","year":"2009","journal-title":"Curr Protoc Hum Genet"},{"key":"key20230807130246_b28-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1373\/clinchem.2016.264986","article-title":"Analgesia and opioids: A pharmacogenetics shortlist for implementation in clinical practice","volume":"63","author":"Matic","year":"2017","journal-title":"Clin Chem"},{"key":"key20230807130246_b29-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"e84244","DOI":"10.1371\/journal.pone.0084244","article-title":"Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding","volume":"8","author":"Shiotani","year":"2013","journal-title":"PLoS One"},{"key":"key20230807130246_b30-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1186\/s12885-017-3664-z","article-title":"Selection of opioids for cancer-related pain using a biomarker: A randomized, multi-institutional, open-label trial (RELIEF study)","volume":"17","author":"Matsuoka","year":"2017","journal-title":"BMC Cancer"},{"key":"key20230807130246_b31-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1476-5381.2012.02139.x","article-title":"Differential activation of the \u00b5-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model","volume":"168","author":"Nakamura","year":"2013","journal-title":"Br J Pharmacol"},{"key":"key20230807130246_b32-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.pain.2007.03.022","article-title":"Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain","volume":"132","author":"Nielsen","year":"2007","journal-title":"Pain"},{"key":"key20230807130246_b33-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.pain.2011.01.040","article-title":"Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients","volume":"152","author":"Klepstad","year":"2011","journal-title":"Pain"},{"key":"key20230807130246_b34-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.4049\/jimmunol.174.3.1525","article-title":"A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes","volume":"174","author":"Chang","year":"2005","journal-title":"J Immunol"},{"key":"key20230807130246_b35-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.12659\/MSM.905942","article-title":"Impact of tag single nucleotide polymorphisms (SNPs) in CCL11 gene on risk of subtypes of ischemic stroke in xinjiang han populations","volume":"23","author":"Liang","year":"2017","journal-title":"Med Sci Monit"},{"key":"key20230807130246_b36-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.gene.2018.02.053","article-title":"Association of CCL11 promoter polymorphisms with schizophrenia in a Korean population","volume":"656","author":"Kang","year":"2018","journal-title":"Gene"},{"key":"key20230807130246_b37-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/imm.13172","article-title":"The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain","volume":"159","author":"Pawlik","year":"2020","journal-title":"Immunology"},{"key":"key20230807130246_b38-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"781310","DOI":"10.3389\/fimmu.2021.781310","article-title":"Blockade of CC chemokine receptor type 3 diminishes pain and enhances opioid analgesic potency in a model of neuropathic pain","volume":"12","author":"Pawlik","year":"2021","journal-title":"Front Immunol"},{"key":"key20230807130246_b39-ol-26-2-13941","first-page":"e25430","article-title":"Radiomodulation in mixed, complex cancer pain by triple target irradiation in the brain: A preliminary experience","volume":"14","author":"Lovo","year":"2022","journal-title":"Cureus"},{"key":"key20230807130246_b40-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"e669","DOI":"10.1097\/PR9.0000000000000669","article-title":"Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain: A cross-sectional pilot study","volume":"3","author":"Richards","year":"2018","journal-title":"Pain Rep"},{"key":"key20230807130246_b41-ol-26-2-13941","doi-asserted-by":"publisher","first-page":"5029","DOI":"10.2174\/1381612821666150831141931","article-title":"Chemokines and their receptors: Potential therapeutic targets for bone cancer pain","volume":"21","author":"Zhou","year":"2015","journal-title":"Curr Pharm Des"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T10:06:59Z","timestamp":1691402819000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2023.13941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,4]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2023.13941","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"article-number":"355"}}