{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:11:57Z","timestamp":1790403117080,"version":"4.1.0"},"reference-count":101,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2023.14129","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T12:48:27Z","timestamp":1698929307000},"source":"Crossref","is-referenced-by-count":6,"title":["Mechanistic insights into UHRF1\u2011mediated DNA methylation by structure\u2011based functional clarification of UHRF1 domains (Review)"],"prefix":"10.3892","volume":"26","author":[{"given":"Yiying","family":"Song","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Jinan Zhangqiu Hospital of Traditional Chinese Medicine, Jinan, Shandong 250200, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnosis, Shandong First Medical University, Jinan, Shandong 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"key20231122104309_b1-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrm2640","article-title":"Epigenetic inheritance during the cell cycle","volume":"10","author":"Probst","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20231122104309_b2-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"R415","DOI":"10.1530\/ERC-19-0093","article-title":"DNA methylation in thyroid cancer","volume":"26","author":"Zafon","year":"2019","journal-title":"Endocr Relat Cancer"},{"key":"key20231122104309_b3-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ijbiomac.2020.12.149","article-title":"Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA","volume":"170","author":"Abhishek","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"key20231122104309_b4-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.bcp.2013.10.002","article-title":"Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis","volume":"86","author":"Bronner","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"key20231122104309_b5-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ygyno.2015.11.017","article-title":"Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1\/PRMT5 complex in endometrial carcinoma","volume":"140","author":"Sheng","year":"2016","journal-title":"Gynecol Oncol"},{"key":"key20231122104309_b6-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/cncr.25531","article-title":"UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer","volume":"117","author":"Daskalos","year":"2011","journal-title":"Cancer"},{"key":"key20231122104309_b7-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ccr.2014.01.003","article-title":"UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma","volume":"25","author":"Mudbhary","year":"2014","journal-title":"Cancer Cell"},{"key":"key20231122104309_b8-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/mc.22270","article-title":"The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma","volume":"55","author":"Zhuo","year":"2016","journal-title":"Mol Carcinog"},{"key":"key20231122104309_b9-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jtho.2020.08.024","article-title":"UHRF1 is a novel druggable epigenetic target in malignant pleural mesothelioma","volume":"16","author":"Reardon","year":"2021","journal-title":"J Thorac Oncol"},{"key":"key20231122104309_b10-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"57821","DOI":"10.18632\/oncotarget.11067","article-title":"UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma","volume":"7","author":"Nakamura","year":"2016","journal-title":"Oncotarget"},{"key":"key20231122104309_b11-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"e11333","DOI":"10.1371\/journal.pone.0011333","article-title":"Disruption of Dnmt1\/PCNA\/UHRF1 interactions promotes tumorigenesis from human and mice glial cells","volume":"5","author":"Hervouet","year":"2010","journal-title":"PLoS One"},{"key":"key20231122104309_b12-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"39497","DOI":"10.18632\/oncotarget.17078","article-title":"Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome","volume":"8","author":"Kan","year":"2017","journal-title":"Oncotarget"},{"key":"key20231122104309_b13-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/ni.2886","article-title":"The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells","volume":"15","author":"Obata","year":"2014","journal-title":"Nat Immunol"},{"key":"key20231122104309_b14-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1172\/JCI96121","article-title":"UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease","volume":"128","author":"Elia","year":"2018","journal-title":"J Clin Invest"},{"key":"key20231122104309_b15-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"7601","DOI":"10.1038\/sj.onc.1208053","article-title":"ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain","volume":"23","author":"Unoki","year":"2004","journal-title":"Oncogene"},{"key":"key20231122104309_b16-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1091\/mbc.e05-03-0194","article-title":"Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth","volume":"16","author":"Jenkins","year":"2005","journal-title":"Mol Biol Cell"},{"key":"key20231122104309_b17-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.bcp.2009.05.035","article-title":"Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis","volume":"78","author":"Unoki","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"key20231122104309_b18-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/sj.bjc.6601068","article-title":"ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells","volume":"89","author":"Mousli","year":"2003","journal-title":"Br J Cancer"},{"key":"key20231122104309_b19-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/sj.bjc.6605123","article-title":"UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer","volume":"101","author":"Unoki","year":"2009","journal-title":"Br J Cancer"},{"key":"key20231122104309_b20-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1053\/j.gastro.2005.08.012","article-title":"Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma","volume":"129","author":"Crnogorac-Jurcevic","year":"2005","journal-title":"Gastroenterology"},{"key":"key20231122104309_b21-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.humpath.2005.07.016","article-title":"Cell cycle and\/or proliferation markers: What is the best method to discriminate cervical high-grade lesions?","volume":"36","author":"Lorenzato","year":"2005","journal-title":"Hum Pathol"},{"key":"key20231122104309_b22-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/s41419-022-05515-z","article-title":"UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis"},{"key":"key20231122104309_b23-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.ccell.2023.05.005","article-title":"Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity","volume":"41","author":"Fang","year":"2023","journal-title":"Cancer Cell"},{"key":"key20231122104309_b24-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.bbrc.2012.11.087","article-title":"Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1","volume":"430","author":"Achour","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20231122104309_b25-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.bcp.2009.12.015","article-title":"Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1","volume":"79","author":"Alhosin","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"key20231122104309_b26-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1756-9966-30-41","article-title":"Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties","volume":"30","author":"Alhosin","year":"2011","journal-title":"J Exp Clin Cancer Res"},{"key":"key20231122104309_b27-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1756-9966-32-30","article-title":"Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation","volume":"32","author":"Krifa","year":"2013","journal-title":"J Exp Clin Cancer Res"},{"key":"key20231122104309_b28-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.cellsig.2010.08.015","article-title":"Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis","volume":"23","author":"Abusnina","year":"2011","journal-title":"Cell Signal"},{"key":"key20231122104309_b29-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1007\/s11033-013-2559-6","article-title":"Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma","volume":"40","author":"Yang","year":"2013","journal-title":"Mol Biol Rep"},{"key":"key20231122104309_b30-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.str.2017.12.016","article-title":"An intramolecular interaction of uhrf1 reveals dual control for its histone association","volume":"26","author":"Gao","year":"2018","journal-title":"Structure"},{"key":"key20231122104309_b31-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.ccell.2019.03.003","article-title":"Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties","volume":"35","author":"Kong","year":"2019","journal-title":"Cancer Cell"},{"key":"key20231122104309_b32-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.pharmthera.2007.06.003","article-title":"The UHRF family: Oncogenes that are drugable targets for cancer therapy in the near future?","volume":"115","author":"Bronner","year":"2007","journal-title":"Pharmacol Therap"},{"key":"key20231122104309_b33-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/genes10010065","article-title":"Coordinated dialogue between UHRF1 and DNMT1 to ensure faithful inheritance of methylated DNA patterns","volume":"10","author":"Bronner","year":"2019","journal-title":"Genes (Basel)"},{"key":"key20231122104309_b34-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature14465","article-title":"Human body epigenome maps reveal noncanonical DNA methylation variation","volume":"523","author":"Schultz","year":"2015","journal-title":"Nature"},{"key":"key20231122104309_b35-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/s41422-020-0359-9","article-title":"Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration","volume":"30","author":"Ming","year":"2020","journal-title":"Cell Res"},{"key":"key20231122104309_b36-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"e17101","DOI":"10.7554\/eLife.17101","article-title":"Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1","volume":"5","author":"Harrison","year":"2016","journal-title":"ELife"},{"key":"key20231122104309_b37-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"549","DOI":"10.2147\/OTT.S192234","article-title":"Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies","volume":"12","author":"Xue","year":"2019","journal-title":"Onco Targets Ther"},{"key":"key20231122104309_b38-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.molcel.2014.04.004","article-title":"Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate","volume":"54","author":"Gelato","year":"2014","journal-title":"Mol Cell"},{"key":"key20231122104309_b39-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"6012","DOI":"10.1021\/acs.biochem.5b00419","article-title":"Site-selective monitoring of the interaction of the SRA domain of UHRF1 with target DNA sequences labeled with 2-aminopurine","volume":"54","author":"Greiner","year":"2015","journal-title":"Biochemistry"},{"key":"key20231122104309_b40-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nature07280","article-title":"The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix","volume":"455","author":"Hashimoto","year":"2008","journal-title":"Nature"},{"key":"key20231122104309_b41-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nature07273","article-title":"Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1","volume":"455","author":"Avvakumov","year":"2008","journal-title":"Nature"},{"key":"key20231122104309_b42-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nature07249","article-title":"Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism","volume":"455","author":"Arita","year":"2008","journal-title":"Nature"},{"key":"key20231122104309_b43-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s11427-022-2155-0","article-title":"H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination","volume":"65","author":"Zhang","year":"2022","journal-title":"Sci China Life Sci"},{"key":"key20231122104309_b44-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3390\/genes9120600","article-title":"The growing complexity of UHRF1-mediated maintenance DNA methylation","volume":"9","author":"Xie","year":"2018","journal-title":"Genes (Basel)"},{"key":"key20231122104309_b45-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.molcel.2017.07.012","article-title":"Methylation of DNA ligase 1 by G9a\/GLP recruits UHRF1 to replicating DNA and regulates DNA methylation","volume":"67","author":"Ferry","year":"2017","journal-title":"Mol Cell"},{"key":"key20231122104309_b46-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.str.2018.11.012","article-title":"Structure of the UHRF1 tandem tudor domain bound to a methylated non-histone protein, LIG1, reveals rules for binding and regulation","volume":"27","author":"Kori","year":"2019","journal-title":"Structure"},{"key":"key20231122104309_b47-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1093\/nar\/gky104","article-title":"Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation","volume":"46","author":"Li","year":"2018","journal-title":"Nucl Acids Res"},{"key":"key20231122104309_b48-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ncb2579","article-title":"Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass","volume":"14","author":"Povlsen","year":"2012","journal-title":"Nat Cell Biol"},{"key":"key20231122104309_b49-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.1016\/j.jmb.2017.10.014","article-title":"Ubiquitome analysis reveals PCNA-associated factor 15 (PAF15) as a specific ubiquitination target of UHRF1 in embryonic stem cells","volume":"429","author":"Karg","year":"2017","journal-title":"J Mol Biol"},{"key":"key20231122104309_b50-ol-26-6-14129","first-page":"2315","article-title":"Double monoubiquitination modifies the molecular recognition properties of p15(PAF) promoting binding to the reader module of Dnmt1","volume":"14","author":"Gonz\u00e1lez-Maga\u00f1a","year":"2019","journal-title":"ACS Chem Biol"},{"key":"key20231122104309_b51-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"e79013","DOI":"10.7554\/eLife.79013","article-title":"The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5","volume":"12","author":"Miyashita","year":"2023","journal-title":"Elife"},{"key":"key20231122104309_b52-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.bcp.2013.10.002","article-title":"Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis","volume":"86","author":"Bronner","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"key20231122104309_b53-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"116500","DOI":"10.1016\/j.bmc.2021.116500","article-title":"Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1","volume":"52","author":"Kori","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"key20231122104309_b54-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1177\/2472555218766278","article-title":"Discovery of small-molecule antagonists of the H3K9me3 binding to UHRF1 tandem tudor domain","volume":"23","author":"Senisterra","year":"2018","journal-title":"SLAS Discov"},{"key":"key20231122104309_b55-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"e4760","DOI":"10.1002\/pro.4760","article-title":"Refined read-out: The hUHRF1 Tandem-Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2\/3","volume":"32","author":"Choudalakis","year":"2023","journal-title":"Protein Sci"},{"key":"key20231122104309_b56-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"12527","DOI":"10.1093\/nar\/gkac1082","article-title":"Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger","volume":"50","author":"Hata","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"key20231122104309_b57-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13072-020-0328-z","article-title":"Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions","volume":"13","author":"Jain","year":"2020","journal-title":"Epigenetics Chromatin"},{"key":"key20231122104309_b58-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"9061","DOI":"10.1093\/nar\/gkr613","article-title":"Handpicking epigenetic marks with PHD fingers","volume":"39","author":"Musselman","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key20231122104309_b59-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jmb.2011.11.012","article-title":"UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail","volume":"415","author":"Xie","year":"2012","journal-title":"J Mol Biol"},{"key":"key20231122104309_b60-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nature08397","article-title":"Cooperative binding of two acetylation marks on a histone tail by a single bromodomain","volume":"461","author":"Morini\u00e8re","year":"2009","journal-title":"Nature"},{"key":"key20231122104309_b61-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.molcel.2011.07.006","article-title":"PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression","volume":"43","author":"Rajakumara","year":"2011","journal-title":"Mol Cell"},{"key":"key20231122104309_b62-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1074\/jbc.M112.415398","article-title":"Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein","volume":"288","author":"Cheng","year":"2013","journal-title":"J Biol Chem"},{"key":"key20231122104309_b63-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/nsmb.2391","article-title":"Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation","volume":"19","author":"Rothbart","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"key20231122104309_b64-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"12950","DOI":"10.1073\/pnas.1203701109","article-title":"Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1","volume":"109","author":"Arita","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20231122104309_b65-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1101\/gad.220467.113","article-title":"Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation","volume":"27","author":"Rothbart","year":"2013","journal-title":"Genes Dev"},{"key":"key20231122104309_b66-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/157489211793980024","article-title":"Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers","volume":"6","author":"Unoki","year":"2011","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"key20231122104309_b67-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"8907","DOI":"10.1074\/jbc.RA119.008008","article-title":"Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1","volume":"294","author":"Du","year":"2019","journal-title":"J Biol Chem"},{"key":"key20231122104309_b68-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"15724","DOI":"10.1074\/jbc.RA119.010160","article-title":"The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation","volume":"294","author":"Vaughan","year":"2019","journal-title":"J Biol Chem"},{"key":"key20231122104309_b69-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13046-016-0453-5","article-title":"Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer","volume":"35","author":"Alhosin","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"key20231122104309_b70-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"107958","DOI":"10.1016\/j.celrep.2020.107958","article-title":"Acetylation of UHRF1 regulates hemi--methylated DNA binding and maintenance of Genome-wide DNA methylation","volume":"32","author":"Hahm","year":"2020","journal-title":"Cell Rep"},{"key":"key20231122104309_b71-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/sj.onc.1210855","article-title":"The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression","volume":"27","author":"Achour","year":"2008","journal-title":"Oncogene"},{"key":"key20231122104309_b72-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1074\/jbc.M113.528893","article-title":"The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism","volume":"289","author":"Bashtrykov","year":"2014","journal-title":"J Biol Chem"},{"key":"key20231122104309_b73-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/s41388-019-1032-y","article-title":"UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation\/acetylation is critical for the proliferation of colon cancer cells","volume":"39","author":"Taniue","year":"2020","journal-title":"Oncogene"},{"key":"key20231122104309_b74-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12032-022-01720-0","article-title":"UHRF1 modulates breast cancer cell growth via estrogen signaling","volume":"39","author":"Luo","year":"2022","journal-title":"Med Oncol"},{"key":"key20231122104309_b75-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"928884","DOI":"10.3389\/fgene.2022.928884","article-title":"Structural-guided identification of small molecule inhibitor of UHRF1 methyltransferase activity","volume":"13","author":"Awal","year":"2022","journal-title":"Front Gene"},{"key":"key20231122104309_b76-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"13363","DOI":"10.1002\/chem.201902605","article-title":"A molecular tool targeting the base-flipping activity of human UHRF1","volume":"25","author":"Zaayter","year":"2019","journal-title":"Chemistry"},{"key":"key20231122104309_b77-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"106616","DOI":"10.1016\/j.bioorg.2023.106616","article-title":"Inhibitors of UHRF1 base flipping activity showing cytotoxicity against cancer cells","volume":"137","author":"Ciaco","year":"2023","journal-title":"Bioorg Chem"},{"key":"key20231122104309_b78-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/s41422-022-00735-6","article-title":"Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia","volume":"32","author":"Hu","year":"2022","journal-title":"Cell Res"},{"key":"key20231122104309_b79-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"key":"key20231122104309_b80-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/513481a","article-title":"Chemistry: Chemical con artists foil drug discovery","volume":"513","author":"Baell","year":"2014","journal-title":"Nature"},{"key":"key20231122104309_b81-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"24300","DOI":"10.1074\/jbc.M111.234104","article-title":"Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein","volume":"286","author":"Nady","year":"2011","journal-title":"J Biol Chem"},{"key":"key20231122104309_b82-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.molcel.2018.09.029","article-title":"A bifunctional role for the UHRF1 UBL domain in the control of hemi-methylated DNA-dependent histone ubiquitylation","volume":"72","author":"DaRosa","year":"2018","journal-title":"Mol Cell"},{"key":"key20231122104309_b83-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.molcel.2018.09.028","article-title":"Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin","volume":"72","author":"Foster","year":"2018","journal-title":"Mol Cell"},{"key":"key20231122104309_b84-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/genes12050622","article-title":"Thymoquinone is a multitarget single epidrug that inhibits the UHRF1 protein complex","volume":"12","author":"Abdullah","year":"2021","journal-title":"Genes (Basel)"},{"key":"key20231122104309_b85-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1007\/s10637-011-9734-1","article-title":"Anti-neoplastic agent thymoquinone induces degradation of \u03b1 and \u03b2 tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts","volume":"30","author":"Alhosin","year":"2012","journal-title":"Invest New Drugs"},{"key":"key20231122104309_b86-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"175522","DOI":"10.1016\/j.ejphar.2023.175522","article-title":"Diosgenin inhibits prostate cancer progression by inducing UHRF1 protein degradation","volume":"942","author":"Peng","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"key20231122104309_b87-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature12488","article-title":"Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication","volume":"502","author":"Nishiyama","year":"2013","journal-title":"Nature"},{"key":"key20231122104309_b88-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/cr.2015.72","article-title":"DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination","volume":"25","author":"Qin","year":"2015","journal-title":"Cell Res"},{"key":"key20231122104309_b89-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"e0162521","DOI":"10.1128\/mBio.01625-21","article-title":"UHRF1 suppresses HIV-1 transcription and promotes HIV-1 latency by competing with p-TEFb for ubiquitination-proteasomal degradation of tat","volume":"12","author":"Liang","year":"2021","journal-title":"mBio"},{"key":"key20231122104309_b90-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1038\/onc.2017.96","article-title":"PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311","volume":"36","author":"Yang","year":"2017","journal-title":"Oncogene"},{"key":"key20231122104309_b91-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1091\/mbc.e11-06-0487","article-title":"UHRF1 phosphorylation by cyclin A2\/cyclin-dependent kinase 2 is required for zebrafish embryogenesis","volume":"23","author":"Chu","year":"2012","journal-title":"Mol Biol Cell"},{"key":"key20231122104309_b92-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.celrep.2015.07.046","article-title":"An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Rep"},{"key":"key20231122104309_b93-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"11197","DOI":"10.1038\/ncomms11197","article-title":"Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition","volume":"7","author":"Fang","year":"2016","journal-title":"Nat Commun"},{"key":"key20231122104309_b94-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1038\/cr.2011.176","article-title":"S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res"},{"key":"key20231122104309_b95-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/cas.12052","article-title":"Diagnostic and prognostic value of plasma and tissue ubiquitin-like, containing PHD and RING finger domains 1 in breast cancer patients","volume":"104","author":"Geng","year":"2013","journal-title":"Cancer Sci"},{"key":"key20231122104309_b96-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1091\/mbc.02-02-0023","article-title":"Gene expression patterns in human liver cancers","volume":"13","author":"Chen","year":"2002","journal-title":"Mol Biol Cell"},{"key":"key20231122104309_b97-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/cas.12689","article-title":"Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis","volume":"106","author":"Zhu","year":"2015","journal-title":"Cancer Sci"},{"key":"key20231122104309_b98-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1097\/PAS.0000000000001840","article-title":"UHRF1 Immunohistochemical staining separates benign reactive spindle cell mesothelial proliferations from sarcomatoid mesotheliomas","volume":"46","author":"Yang","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"key20231122104309_b99-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1101\/gr.208108.116","article-title":"Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells","volume":"27","author":"Cai","year":"2017","journal-title":"Genome Res"},{"key":"key20231122104309_b100-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13148-019-0668-3","article-title":"UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells","volume":"11","author":"Niinuma","year":"2019","journal-title":"Clin Epigenetics"},{"key":"key20231122104309_b101-ol-26-6-14129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41389-022-00446-y","article-title":"AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer","volume":"12","author":"Fu","year":"2023","journal-title":"Oncogenesis"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:52:41Z","timestamp":1700643161000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2023.14129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":101,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2023.14129","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,2]]},"article-number":"542"}}