{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:51:25Z","timestamp":1765295485164},"reference-count":26,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2024.14533","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:49:44Z","timestamp":1719398984000},"source":"Crossref","is-referenced-by-count":2,"title":["Effects of \u03b1\u2011solanine on human head and neck squamous cell carcinoma cells and human umbilical vein endothelial cells <i>in vitro<\/i>"],"prefix":"10.3892","volume":"28","author":[{"given":"Armin","family":"Von Fournier","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Totta","family":"Kasemo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Hackenberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agmal","family":"Scherzad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"key20240709110446_b1-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.1021\/jf061471t","article-title":"Potato glycoalkaloids and metabolites: Roles in the plant and in the diet","volume":"54","author":"Friedman","year":"2006","journal-title":"J Agric Food Chem"},{"key":"key20240709110446_b2-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1021\/acs.jafc.5b00818","article-title":"Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes","volume":"63","author":"Friedman","year":"2015","journal-title":"J Agric Food Chem"},{"key":"key20240709110446_b3-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3923\/ijp.2019.301.310","article-title":"Toxicity, teratogenicity and anti-cancer activity of \u03b1-solanine: A perspective on anti-cancer potential","volume":"15","author":"Ord\u00f3\u00f1ez V\u00e1squez","year":"2019","journal-title":"Int J Pharmacol"},{"key":"key20240709110446_b4-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/tera.1420150103","article-title":"Teratogenicity studies on late blighted potatoes in nonhuman primates (Macaca mulatta and Saguinus labiatus)","volume":"15","author":"Allen","year":"1977","journal-title":"Teratology"},{"key":"key20240709110446_b5-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1080\/01635581.2020.1803932","article-title":"Alpha solanine: A novel natural bioactive molecule with anticancer effects in multiple human malignancies","volume":"73","author":"Hassan","year":"2021","journal-title":"Nutr Cancer"},{"key":"key20240709110446_b6-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.21037\/tcr-20-3094","article-title":"A narrative review of the antitumor studies of solanine","volume":"10","author":"Luo","year":"2021","journal-title":"Transl Cancer Res"},{"key":"key20240709110446_b7-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.3892\/ol.2016.4167","article-title":"Solanine-induced reactive oxygen species inhibit the growth of human hepatocellular carcinoma HepG2 cells","volume":"11","author":"Meng","year":"2016","journal-title":"Oncol Lett"},{"key":"key20240709110446_b8-ol-28-2-14533","first-page":"1387","article-title":"\u03b1-Solanine inhibits growth and metastatic potential of human colorectal cancer cells","volume":"43","author":"Yan","year":"2020","journal-title":"Oncol Rep"},{"key":"key20240709110446_b9-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"805926","DOI":"10.1155\/2014\/805926","article-title":"Solanine induces mitochondria-mediated apoptosis in human pancreatic cancer cells","volume":"2014","author":"Sun","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20240709110446_b10-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.2174\/1871520619666190930123520","article-title":"Synergistic effect of \u03b1-solanine and cisplatin induces apoptosis and enhances cell cycle arrest in human hepatocellular carcinoma cells","volume":"19","author":"El-Daly","year":"2019","journal-title":"Anticancer Agents Med Chem"},{"key":"key20240709110446_b11-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"key20240709110446_b12-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1097-0142(197201)29:1<117::AID-CNCR2820290119>3.0.CO;2-R","article-title":"A new human cell line (FaDu) from a hypopharyngeal carcinoma","volume":"29","author":"Rangan","year":"1972","journal-title":"Cancer"},{"key":"key20240709110446_b13-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3892\/or.2015.4383","article-title":"The differentiation of hMSCs counteracts their migration capability and pro-angiogenic effects in vitro","volume":"35","author":"Scherzed","year":"2016","journal-title":"Oncol Rep"},{"key":"key20240709110446_b14-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"key20240709110446_b15-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.tiv.2015.01.018","article-title":"Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes","volume":"29","author":"Scherzad","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"key20240709110446_b16-ol-28-2-14533","first-page":"e51312","article-title":"Endothelial cell tube formation assay for the in vitro study of angiogenesis","author":"DeCicco-Skinner","year":"2014","journal-title":"J Vis Exp"},{"key":"key20240709110446_b17-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet"},{"key":"key20240709110446_b18-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"975","DOI":"10.21037\/atm.2020.03.164","article-title":"Translating KEYNOTE-048 into practice recommendations for head and neck cancer","volume":"8","author":"Szturz","year":"2020","journal-title":"Ann Transl Med"},{"key":"key20240709110446_b19-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"11896","DOI":"10.3390\/molecules190811896","article-title":"\u03b1-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and mMPs expression","volume":"19","author":"Shen","year":"2014","journal-title":"Molecules"},{"key":"key20240709110446_b20-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/nu10060672","article-title":"\u03b1-Chaconine and \u03b1-Solanine inhibit RL95-2 endometrium cancer cell proliferation by reducing expression of Akt (Ser473) and ER\u03b1 (Ser167)","volume":"10","author":"Karaboga Arslan","year":"2018","journal-title":"Nutrients"},{"key":"key20240709110446_b21-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1248\/bpb.33.1685","article-title":"\u03b1-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2\/9 activities","volume":"33","author":"Lu","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"key20240709110446_b22-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jep.2007.09.023","article-title":"Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein","volume":"115","author":"Ji","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"key20240709110446_b23-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.fct.2005.11.007","article-title":"Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1\/2 phosphorylation","volume":"44","author":"Yang","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"key20240709110446_b24-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1002\/cam4.916","article-title":"Inhibition of prostate cancer growth by solanine requires the suppression of cell cycle proteins and the activation of ROS\/P38 signaling pathway","volume":"5","author":"Pan","year":"2016","journal-title":"Cancer Med"},{"key":"key20240709110446_b25-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"e1860","DOI":"10.1038\/cddis.2015.219","article-title":"\u03b1-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt\/mTOR pathway","volume":"6","author":"Hasanain","year":"2015","journal-title":"Cell Death Dis"},{"key":"key20240709110446_b26-ol-28-2-14533","doi-asserted-by":"publisher","first-page":"e87868","DOI":"10.1371\/journal.pone.0087868","article-title":"Antitumor efficacy of \u03b1-solanine against pancreatic cancer in vitro and in vivo","volume":"9","author":"Lv","year":"2014","journal-title":"PLoS One"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:06:04Z","timestamp":1720512364000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2024.14533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,26]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2024.14533","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"article-number":"400"}}