{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:14:33Z","timestamp":1759882473989,"version":"build-2065373602"},"reference-count":68,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2025.15276","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:10:21Z","timestamp":1758193821000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Anticancer effects of thymoquinone on prostate cancer cells and natural killer cell activity"],"prefix":"10.3892","volume":"30","author":[{"given":"Nouf","family":"Aldarmahi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Tarbiah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuha","family":"Alkhattabi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Alshaibi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"key20251007110403_b1-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"509","DOI":"10.2307\/3349375","article-title":"The epidemiological transition: A theory of the epidemiology of population change","volume":"49","author":"Omran","year":"1971","journal-title":"Millbank Mem Fund Q"},{"volume-title":"World","author":"Ferlay","key":"key20251007110403_b2-ol-30-5-15276"},{"key":"key20251007110403_b3-ol-30-5-15276","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"key20251007110403_b4-ol-30-5-15276","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"key20251007110403_b5-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1002\/cam4.1885","article-title":"Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients","volume":"8","author":"Panigrahi","year":"2019","journal-title":"Cancer Med"},{"key":"key20251007110403_b6-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of prostate cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J Oncol"},{"key":"key20251007110403_b7-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"8152","DOI":"10.1200\/JCO.2005.03.1492","article-title":"Role of diet in prostate cancer development and progression","volume":"23","author":"Chan","year":"2005","journal-title":"J Clin Oncol"},{"key":"key20251007110403_b8-ol-30-5-15276","first-page":"8542","article-title":"Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study","volume":"63","author":"Platz","year":"2003","journal-title":"Cancer Res"},{"key":"key20251007110403_b9-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","article-title":"Top 10 challenges in cancer immunotherapy","volume":"52","author":"Hegde","year":"2020","journal-title":"Immunity"},{"key":"key20251007110403_b10-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1189\/jlb.5VMR1116-491RR","article-title":"Myeloid-derived cells in prostate cancer progression: Phenotype and prospective therapies","volume":"102","author":"Lopez-Bujanda","year":"2017","journal-title":"J Leukoc Biol"},{"key":"key20251007110403_b11-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1158\/2159-8290.CD-11-0130","article-title":"Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets","volume":"1","author":"Beltran","year":"2011","journal-title":"Cancer Discov"},{"key":"key20251007110403_b12-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: Impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"key20251007110403_b13-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41571-018-0142-8","article-title":"Cancer immunoediting and resistance to T cell-based immunotherapy","volume":"16","author":"O'Donnell","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"key20251007110403_b14-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"key20251007110403_b15-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/S1470-2045(16)30498-3","article-title":"Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: A randomised, phase 2 cohort of the open-label KEYNOTE-021 study","volume":"17","author":"Langer","year":"2016","journal-title":"Lancet Oncol"},{"key":"key20251007110403_b16-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"186","DOI":"10.21037\/tlcr.2017.03.04","article-title":"Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors","volume":"6","author":"Patel","year":"2017","journal-title":"Transl Lung Cancer Res"},{"key":"key20251007110403_b17-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2005.10.011","article-title":"Natural killer cells in human health and disease","volume":"118","author":"Orange","year":"2006","journal-title":"Clin Immunol"},{"key":"key20251007110403_b18-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat Immunol"},{"key":"key20251007110403_b19-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1034\/j.1600-0528.2002.017416.x","article-title":"Innate and adaptive lymphoid cells in the human liver","volume":"174","author":"Doherty","year":"2000","journal-title":"Immunol Rev"},{"key":"key20251007110403_b20-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nrc2618","article-title":"Microenvironmental regulation of metastasis","volume":"9","author":"Joyce","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20251007110403_b21-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"16606","DOI":"10.1073\/pnas.0407522101","article-title":"Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs","volume":"101","author":"Ferlazzo","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20251007110403_b22-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.4049\/jimmunol.178.8.4947","article-title":"CD56brightCD16- killer Ig-like receptor-NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation","volume":"178","author":"Romagnani","journal-title":"J Immunol"},{"key":"key20251007110403_b23-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol"},{"key":"key20251007110403_b24-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-1-0716-0203-4_9","article-title":"Immunomodulation of NK cell activity","volume":"2097","author":"Domaica","year":"2020","journal-title":"Methods Mol Biol"},{"key":"key20251007110403_b25-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"20847","DOI":"10.1073\/pnas.0906481106","article-title":"Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity","volume":"106","author":"Balsamo","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20251007110403_b26-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"874","DOI":"10.4014\/jmb.1801.01074","article-title":"Improved anti-cancer effect of curcumin on breast cancer cells by increasing the activity of natural killer cells","volume":"28","author":"Lee","year":"2018","journal-title":"J Microbiol Biotechnol"},{"key":"key20251007110403_b27-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.3390\/cells9061382","article-title":"Anti-PSMA CAR-engineered NK-92 cells: An off-the-shelf cell therapy for prostate cancer","volume":"9","author":"Montagner","year":"2020","journal-title":"Cells"},{"key":"key20251007110403_b28-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"e108925","DOI":"10.1371\/journal.pone.0108925","article-title":"Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: Mechanism of immune evasion","volume":"9","author":"Lundholm","year":"2014","journal-title":"PLoS One"},{"key":"key20251007110403_b29-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"676198","DOI":"10.1155\/2011\/676198","article-title":"Natural killer cells in human cancer: From biological functions to clinical applications","volume":"2011","author":"Levy","year":"2011","journal-title":"Biomed Res Int"},{"key":"key20251007110403_b30-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"731175","DOI":"10.3389\/fonc.2021.731175","article-title":"Targeting Tim-3 in cancer with resistance to PD-1\/PD-L1 blockade","volume":"11","author":"Tian","year":"2021","journal-title":"Front Oncol"},{"key":"key20251007110403_b31-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"862416","DOI":"10.3389\/fonc.2022.862416","article-title":"Myeloid-derived suppressor cells as key players and promising therapy targets in prostate cancer","volume":"12","author":"Siemi\u0144ska","year":"2022","journal-title":"Front Oncol"},{"key":"key20251007110403_b32-ol-30-5-15276","first-page":"293","article-title":"Immune checkpoint inhibitors and prostate cancer: A new frontier?","volume":"10","author":"Modena","year":"2016","journal-title":"Oncol Rev"},{"key":"key20251007110403_b33-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1073\/pnas.1822001116","article-title":"PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer","volume":"116","author":"Kamada","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20251007110403_b34-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.3390\/cancers12113285","article-title":"The immune checkpoint PD-1 in natural killer cells: Expression, function and targeting in tumour immunotherapy","volume":"12","author":"Quatrini","year":"2020","journal-title":"Cancers (Basel)"},{"key":"key20251007110403_b35-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jaim.2016.07.004","article-title":"Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive","volume":"7","author":"Majdalawieh","year":"2016","journal-title":"J Ayurveda Integr Med"},{"key":"key20251007110403_b36-ol-30-5-15276","first-page":"801","article-title":"Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): A complementary drug with historical and clinical significance","volume":"67","author":"Dajani","year":"2016","journal-title":"J Physiol Pharmacol"},{"key":"key20251007110403_b37-ol-30-5-15276","first-page":"1","article-title":"The Role of Nigella sativa and Its Active Component Thymoquinone in Cancer Prevention and Treatment: A Review Article","volume":"1","author":"Bay\u0131r","year":"2021","journal-title":"Eurasian J Med Biol Sci"},{"key":"key20251007110403_b38-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/j.1365-2621.2006.01417.x","article-title":"Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): An overview","volume":"42","author":"Ramadan","year":"2007","journal-title":"Int J Food Sci Technol"},{"key":"key20251007110403_b39-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/bab.1619","article-title":"The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells","volume":"65","author":"AlShaibi","year":"2018","journal-title":"Biotechnol Appl Biochem"},{"key":"key20251007110403_b40-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1142\/S0192415X1100941X","article-title":"Anticancer activity of Nigella sativa (black seed)-a review","volume":"39","author":"Randhawa","year":"2011","journal-title":"Am J Chin Med"},{"key":"key20251007110403_b41-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.drudis.2013.08.021","article-title":"Thymoquinone: Fifty years of success in the battle against cancer models","volume":"19","author":"Schneider-Stock","year":"2014","journal-title":"Drug Discov Today"},{"key":"key20251007110403_b42-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"51907","DOI":"10.18632\/oncotarget.17206","article-title":"Thymoquinone, as an anticancer molecule: From basic research to clinical investigation","volume":"8","author":"Khan","year":"2017","journal-title":"Oncotarget"},{"key":"key20251007110403_b43-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"19580","DOI":"10.18632\/oncotarget.3973","article-title":"Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition","volume":"6","author":"Khan","year":"2015","journal-title":"Oncotarget"},{"key":"key20251007110403_b44-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jep.2010.06.030","article-title":"Nigella sativa modulates splenocyte proliferation, Th1\/Th2 cytokine profile, macrophage function and NK anti-tumor activity","volume":"131","author":"Majdalawieh","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"key20251007110403_b45-ol-30-5-15276","first-page":"1","article-title":"Modulation of gene expression by thymoquinone conjugated zinc oxide nanoparticles arrested cell cycle, DNA damage and increased apoptosis in triple negative breast cancer cell line MDA-MB-231","volume":"47","author":"Sjs","year":"2022","journal-title":"Drug Dev Ind Pharm"},{"key":"key20251007110403_b46-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"9218640","DOI":"10.1155\/2022\/9218640","article-title":"Studying the anticancer effects of thymoquinone on breast cancer cells through natural killer cell activity","volume":"2022","author":"Alshaibi","year":"2022","journal-title":"Biomed Res Int"},{"key":"key20251007110403_b47-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"e0233466","DOI":"10.1371\/journal.pone.0233466","article-title":"Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets","volume":"15","author":"Murphy","year":"2020","journal-title":"PLoS One"},{"key":"key20251007110403_b48-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3892\/or.2012.2165","article-title":"Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-\u03baB pathway","volume":"29","author":"Peng","year":"2013","journal-title":"Oncol Rep"},{"key":"key20251007110403_b49-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1128\/JVI.03002-13","article-title":"Therapeutic depletion of natural killer cells controls persistent infection","volume":"88","author":"Waggoner","year":"2014","journal-title":"J Virol"},{"key":"key20251007110403_b50-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"6593","DOI":"10.1182\/blood-2009-01-201467","article-title":"NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses","volume":"113","author":"Krebs","year":"2009","journal-title":"Blood"},{"key":"key20251007110403_b51-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.3390\/ijms23042305","article-title":"PI3K-AKT pathway modulation by thymoquinone limits tumor growth and glycolytic metabolism in colorectal cancer","volume":"23","author":"Karim","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20251007110403_b52-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.2147\/JIR.S358632","article-title":"Experimental and theoretical insights on chemopreventive effect of the liposomal thymoquinone against benzo [a] pyrene-induced lung cancer in swiss albino mice","volume":"15","author":"Khan","year":"2022","journal-title":"J Inflamm Res"},{"key":"key20251007110403_b53-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.canlet.2021.03.025","article-title":"Regulation of nuclear factor-KappaB (NF-\u03baB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?","volume":"509","author":"Mirzaei","year":"2021","journal-title":"Cancer Lett"},{"key":"key20251007110403_b54-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8+ T cells: Foot soldiers of the immune system","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"key20251007110403_b55-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"e23078","DOI":"10.1002\/jbt.23078","article-title":"Suppressive effects of thymoquinone on the initiation stage of diethylnitrosamine hepatocarcinogenesis in rats","volume":"36","author":"Ibrahim","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"key":"key20251007110403_b56-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1002\/tox.23317","article-title":"Erk phosphorylation reduces the thymoquinone toxicity in human hepatocarcinoma","volume":"36","author":"Zhang","year":"2021","journal-title":"Environ Toxicol"},{"key":"key20251007110403_b57-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"103117","DOI":"10.1016\/j.dnarep.2021.103117","article-title":"Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage","volume":"103","author":"Zhang","year":"2021","journal-title":"DNA Repair (Amst)"},{"key":"key20251007110403_b58-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"e23008","DOI":"10.1002\/jbt.23008","article-title":"Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line","volume":"36","author":"Narayanan","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"key":"key20251007110403_b59-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"109022","DOI":"10.1016\/j.cbi.2020.109022","article-title":"Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt\/\u03b2-catenin signaling pathway","volume":"320","author":"Zhang","year":"2020","journal-title":"Chem Biol Interact"},{"key":"key20251007110403_b60-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1084\/jem.192.10.1403","article-title":"Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation","volume":"192","author":"Sutton","year":"2000","journal-title":"J Exp Med"},{"key":"key20251007110403_b61-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","article-title":"NK cells for cancer immunotherapy","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"key20251007110403_b62-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.molimm.2004.07.034","article-title":"Activation of NK cell cytotoxicity","volume":"42","author":"Smyth","year":"2005","journal-title":"Mol Immunol"},{"author":"Kingdom of Saudi Arabia, Saudi Health Council, National Cancer Center, Saudi Cancer Registry","key":"key20251007110403_b63-ol-30-5-15276","article-title":"Cancer Incididence Report Saudi Arabia 2020"},{"key":"key20251007110403_b64-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev.immunol.26.021607.090404","article-title":"Death by a thousand cuts: Granzyme pathways of programmed cell death","volume":"26","author":"Chowdhury","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"key20251007110403_b65-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0092-8674(86)90007-3","article-title":"Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity","volume":"44","author":"Young","year":"1986","journal-title":"Cell"},{"key":"key20251007110403_b66-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"S124","DOI":"10.4049\/jimmunol.200.Supp.124.5","article-title":"Thymoquinone enhanced the tumoricidal activity of NK cells against lung cancer","volume":"200","author":"Singh","year":"2018","journal-title":"J Immunol"},{"key":"key20251007110403_b67-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-07-2088","article-title":"Targeting nuclear factor-\u03baB activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis","volume":"6","author":"Sethi","year":"2008","journal-title":"Mol Cancer Res"},{"key":"key20251007110403_b68-ol-30-5-15276","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.1007\/s11033-023-08363-y","article-title":"Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: A review","volume":"50","author":"Sadeghi","year":"2023","journal-title":"Mol Biol Rep"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:04:28Z","timestamp":1759824268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2025.15276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,18]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2025.15276","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"type":"print","value":"1792-1074"},{"type":"electronic","value":"1792-1082"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}