{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:42:47Z","timestamp":1762850567757,"version":"build-2065373602"},"reference-count":40,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2025.15298","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:14:41Z","timestamp":1758716081000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Impact of SAMHD1 and phosphorylated ATM levels on the progression and prognosis of patients with soft tissue sarcoma"],"prefix":"10.3892","volume":"30","author":[{"given":"Yun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical School, Jeonbuk National University, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"key20251111103813_b1-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.6004\/jnccn.2020.0058","article-title":"NCCN guidelines insights: soft tissue sarcoma, version 1.2021","volume":"18","author":"von Mehren","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"key20251111103813_b2-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12889-018-5131-4","article-title":"Strengthening health data on a rare and heterogeneous disease: Sarcoma incidence and histological subtypes in Germany","volume":"18","author":"Ressing","year":"2018","journal-title":"BMC Public Health"},{"key":"key20251111103813_b3-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1038\/s41467-022-30453-x","article-title":"Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets","volume":"13","author":"Nacev","year":"2022","journal-title":"Nat Commun"},{"key":"key20251111103813_b4-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.3390\/cancers16162875","article-title":"Advances in soft tissue and bone sarcoma","volume":"16","author":"Rutland","year":"2024","journal-title":"Cancers (Basel)"},{"key":"key20251111103813_b5-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: Signaling, repair and the cancer connection","volume":"27","author":"Khanna","year":"2001","journal-title":"Nat Genet"},{"key":"key20251111103813_b6-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.3390\/ijms24054741","article-title":"DNA damage and its role in cancer therapeutics","volume":"24","author":"Moon","year":"2023","journal-title":"Int J Mol Sci"},{"key":"key20251111103813_b7-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41573-024-01060-w","article-title":"DNA damage response inhibitors in cancer therapy: Lessons from the past, current status and future implications","volume":"24","author":"Drew","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"key20251111103813_b8-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.tranon.2015.04.004","article-title":"Expression of DNA damage response molecules PARP1, \u03b3H2AX, BRCA1, and BRCA2 predicts poor survival of breast carcinoma patients","volume":"8","author":"Park","year":"2015","journal-title":"Trans Oncol"},{"key":"key20251111103813_b9-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3390\/ijms23010523","article-title":"ATM: Functions of ATM kinase and its relevance to hereditary tumors","volume":"23","author":"Ueno","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20251111103813_b10-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1093\/nar\/gkab051","article-title":"SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining","volume":"49","author":"Akimova","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"key20251111103813_b11-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00109-021-02131-w","article-title":"SAMHD1 in cancer: Curse or cure?","volume":"100","author":"Schott","year":"2022","journal-title":"J Mol Med (Berl)"},{"key":"key20251111103813_b12-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1186\/s12967-022-03844-3","article-title":"SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma","volume":"20","author":"Li","year":"2022","journal-title":"J Transl Med"},{"key":"key20251111103813_b13-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3892\/ol.2022.13423","article-title":"Expression of SAMHD1 and its mutation on prognosis of colon cancer","volume":"24","author":"Zhang","year":"2022","journal-title":"Oncol Lett"},{"key":"key20251111103813_b14-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s13402-023-00862-1","article-title":"SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer","volume":"47","author":"Guti\u00e9rrez-Chamorro","year":"2024","journal-title":"Cell Oncol (Dordr)"},{"key":"key20251111103813_b15-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"e0163193","DOI":"10.1371\/journal.pone.0163193","article-title":"Individual and combined expression of DNA damage response molecules PARP1, \u03b3H2AX, BRCA1, and BRCA2 predict shorter survival of soft tissue sarcoma patients","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"key20251111103813_b16-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000500822","article-title":"Expression and relationship of SAMHD1 with other apoptotic and autophagic genes in acute myeloid leukemia patients","volume":"143","author":"Jiang","year":"2020","journal-title":"Acta Haematol"},{"key":"key20251111103813_b17-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1186\/s12885-023-11294-3","article-title":"Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer","volume":"23","author":"Xun","year":"2023","journal-title":"BMC Cancer"},{"key":"key20251111103813_b18-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3390\/genes12050727","article-title":"The ATM gene in breast cancer: Its relevance in clinical practice","volume":"12","author":"Stucci","year":"2021","journal-title":"Genes (Basel)"},{"key":"key20251111103813_b19-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"e20220829","DOI":"10.1084\/jem.20220829","article-title":"Deficiency for SAMHD1 activates MDA5 in a cGAS\/STING-dependent manner","volume":"220","author":"Schumann","year":"2023","journal-title":"J Exp Med"},{"key":"key20251111103813_b20-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"key20251111103813_b21-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"e0134678","DOI":"10.1371\/journal.pone.0134678","article-title":"Prognostic significance of nuclear phospho-ATM expression in melanoma","volume":"10","author":"Bhandaru","year":"2015","journal-title":"PLoS One"},{"key":"key20251111103813_b22-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.3390\/ijms15045388","article-title":"Tug of war between survival and death: Exploring ATM function in cancer","volume":"15","author":"Stagni","year":"2014","journal-title":"Int J Mol Sci"},{"key":"key20251111103813_b23-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41586-018-0050-1","article-title":"SAMHD1 acts at stalled replication forks to prevent interferon induction","volume":"557","author":"Coquel","year":"2018","journal-title":"Nature"},{"key":"key20251111103813_b24-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.celrep.2017.08.008","article-title":"SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination","volume":"20","author":"Daddacha","year":"2017","journal-title":"Cell Rep"},{"key":"key20251111103813_b25-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1038\/s41467-022-34578-x","article-title":"SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks","volume":"13","author":"Kapoor-Vazirani","year":"2022","journal-title":"Nat Commun"},{"key":"key20251111103813_b26-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"10446","DOI":"10.1038\/s41598-025-93629-7","article-title":"SAMHD1 dysfunction impairs DNA damage response and increases sensitivity to PARP inhibition in chronic lymphocytic leukemia","volume":"15","author":"Rodr\u00edguez-S\u00e1nchez","year":"2025","journal-title":"Sci Rep"},{"key":"key20251111103813_b27-ol-30-6-15298","article-title":"Soft tissue and bone tumours","volume-title":"WHO Classification of Tumours Editorial","author":"World Health Organization (WHO)","year":"2020","edition":"5th Edition"},{"key":"key20251111103813_b28-ol-30-6-15298","first-page":"59","article-title":"Histologic grading of adult soft tissue sarcomas","volume":"82","author":"Coindre","year":"1998","journal-title":"Verh Dtsch Ges Pathol"},{"key":"key20251111103813_b29-ol-30-6-15298","first-page":"251","article-title":"AJCC Cancer Staging Manual","author":"Byrd","year":"2017","edition":"Eighth Edition"},{"key":"key20251111103813_b30-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1182\/blood-2013-04-490847","article-title":"SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage","volume":"123","author":"Clifford","year":"2014","journal-title":"Blood"},{"key":"key20251111103813_b31-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3892\/ol.2021.12712","article-title":"Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs","volume":"21","author":"Chen","year":"2021","journal-title":"Oncol Lett"},{"key":"key20251111103813_b32-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"zcae007","DOI":"10.1093\/narcan\/zcae007","article-title":"SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients","volume":"6","author":"Daddacha","year":"2024","journal-title":"NAR Cancer"},{"key":"key20251111103813_b33-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/bjh.17352","article-title":"Expression of the novel tumour suppressor sterile alpha motif and HD domain-containing protein 1 is an independent adverse prognostic factor in classical Hodgkin lymphoma","volume":"193","author":"Xagoraris","year":"2021","journal-title":"Br J Haematol"},{"key":"key20251111103813_b34-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"key20251111103813_b35-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: A review","volume":"11","author":"Rothblum-Oviatt","year":"2016","journal-title":"Orphanet J Rare Dis"},{"key":"key20251111103813_b36-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1200\/JCO.2014.56.5101","article-title":"Incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: A report from the French national registry of primary immune deficiencies","volume":"33","author":"Suarez","year":"2015","journal-title":"J Clin Oncol"},{"key":"key20251111103813_b37-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"102808","DOI":"10.1016\/j.ctrv.2024.102808","article-title":"Targeting the ATM pathway in cancer: Opportunities, challenges and personalized therapeutic strategies","volume":"129","author":"Lee","year":"2024","journal-title":"Cancer Treat Rev"},{"key":"key20251111103813_b38-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1002\/ijc.27488","article-title":"The role of ATM and 53BP1 as predictive markers in cervical cancer","volume":"131","author":"Roossink","year":"2012","journal-title":"Int J Cancer"},{"key":"key20251111103813_b39-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/cr.2013.110","article-title":"Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition","volume":"23","author":"Maunakea","year":"2013","journal-title":"Cell Res"},{"key":"key20251111103813_b40-ol-30-6-15298","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: Making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol Cell"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:38:20Z","timestamp":1762850300000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2025.15298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,9,24]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2025.15298","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"type":"print","value":"1792-1074"},{"type":"electronic","value":"1792-1082"}],"subject":[],"published":{"date-parts":[[2025,9,24]]}}}