{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:53:46Z","timestamp":1791975226506,"version":"4.4.0"},"reference-count":43,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2025.15306","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:41:57Z","timestamp":1759311717000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Anticancer effects of the Kiperin Purple Collagen complex: Evidence from HCT116 and MIA PaCa\u20112 cell models"],"prefix":"10.3892","volume":"30","author":[{"given":"Lutfiye","family":"Batur","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, Istanbul 34015, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuneyd","family":"Yavas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, Istanbul 34015, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezih","family":"Hekim","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, Istanbul 34015, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"key20251111103833_b1-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1002\/cncr.33587","article-title":"The ever-increasing importance of cancer as a leading cause of premature death worldwide","volume":"127","author":"Bray","year":"2021","journal-title":"Cancer"},{"key":"key20251111103833_b2-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1001\/jamaoncol.2022.7826","article-title":"Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050","volume":"9","author":"Chen","year":"2023","journal-title":"JAMA Oncol"},{"key":"key20251111103833_b3-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1038\/s41591-022-02109-2","article-title":"Global and regional estimates of orphans attributed to maternal cancer mortality in 2020","volume":"28","author":"Guida","year":"2022","journal-title":"Nat Med"},{"key":"key20251111103833_b4-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"key":"key20251111103833_b5-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"2400370","DOI":"10.1002\/adtp.202400370","article-title":"Role of the extracellular matrix in cancer: Insights into tumor progression and therapy","volume":"8","author":"Desai","year":"2025","journal-title":"Adv Ther"},{"key":"key20251111103833_b6-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular matrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"key20251111103833_b7-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat Commun"},{"key":"key20251111103833_b8-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J Cell Sci"},{"key":"key20251111103833_b9-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1364\/AO.377105","article-title":"Assessment of anisotropy of collagen structures through spatial frequencies of Mueller matrix images for cervical pre-cancer detection","volume":"59","author":"Zaffar","year":"2020","journal-title":"Appl Opt"},{"key":"key20251111103833_b10-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"10509","DOI":"10.3390\/ijms231810509","article-title":"Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment","volume":"23","author":"Song","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20251111103833_b11-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"9663","DOI":"10.1007\/s11033-023-08809-3","article-title":"Cancer treatment therapies: Traditional to modern approaches to combat cancers","volume":"50","author":"Kaur","year":"2023","journal-title":"Mol Biol Rep"},{"key":"key20251111103833_b12-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/ajcn\/nqz001","article-title":"Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans","volume":"109","author":"Hiel","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"key20251111103833_b13-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"127266","DOI":"10.1016\/j.foodchem.2020.127266","article-title":"Elderberry (Sambucus nigra L.) as potential source of antioxidants: Characterization, optimization of extraction parameters and bioactive properties","volume":"330","author":"Dom\u00ednguez","year":"2020","journal-title":"Food Chem"},{"key":"key20251111103833_b14-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/fqsafe\/fyx031","article-title":"Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: Traditional uses, chemical constituents, and nutraceutical effects","volume":"2","author":"Srinivasan","year":"2018","journal-title":"Food Qual Saf"},{"key":"key20251111103833_b15-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3390\/nu13051397","article-title":"Magnesium for pain treatment in 2021? State of the art","volume":"13","author":"Morel","year":"2021","journal-title":"Nutrients"},{"key":"key20251111103833_b16-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2147\/CIA.S5797","article-title":"Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders: Results from two open-label human clinical studies","volume":"4","author":"Ruff","year":"2009","journal-title":"Clin Interv Aging"},{"key":"key20251111103833_b17-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3390\/nu16132060","article-title":"Exploring the therapeutic potential of bromelain: Applications, benefits, and mechanisms","volume":"16","author":"Kansakar","year":"2024","journal-title":"Nutrients"},{"key":"key20251111103833_b18-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1229243","DOI":"10.3389\/fnut.2023.1229243","article-title":"Vitamin C fortification: Need and recent trends in encapsulation technologies","volume":"10","author":"Maurya","year":"2023","journal-title":"Front Nutr"},{"key":"key20251111103833_b19-ol-30-6-15306","article-title":"List of restricted substances for food supplements","author":"Republic of T\u00fcrkiye Ministry of Agriculture and Forestry","year":"2025"},{"key":"key20251111103833_b20-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3390\/cimb47050364","article-title":"Kiperin double-hydrolyzed collagen as a potential anti-tumor agent: Effects on HCT116 colon carcinoma cells and oxidative stress modulation","volume":"47","author":"Batur","year":"2025","journal-title":"Curr Issues Mol Biol"},{"key":"key20251111103833_b21-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1002\/tox.24143","article-title":"PW06 suppresses cancer cell metastasis in human pancreatic carcinoma MIA PaCa-2 cells via the inhibitions of p-Akt\/mTOR\/NF-\u03baB and MMP2\/MMP9 signaling pathways in vitro","volume":"39","author":"Huang","year":"2024","journal-title":"Environ Toxicol"},{"key":"key20251111103833_b22-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2016.04.012","article-title":"The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116","volume":"254","author":"Abassi","year":"2016","journal-title":"Toxicol Lett"},{"key":"key20251111103833_b23-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1038\/s41598-023-29060-7","article-title":"Fetal bovine serum, an important factor affecting the reproducibility of cell experiments","volume":"13","author":"Liu","year":"2023","journal-title":"Sci Rep"},{"key":"key20251111103833_b24-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4161\/cam.36224","article-title":"An introduction to the wound healing assay using live-cell microscopy","volume":"8","author":"Jonkman","year":"2014","journal-title":"Cell Adh Migr"},{"key":"key20251111103833_b25-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.3390\/biomedicines13061430","article-title":"Kiperin postbiotic supplement-enhanced bacterial supernatants promote fibroblast function: Implications for regenerative medicine","volume":"13","author":"Batur","year":"2025","journal-title":"Biomedicines"},{"key":"key20251111103833_b26-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2174\/2212796812666180503151759","article-title":"Oxidative stress and heavy metal levels of Pholiota limonella mushroom collected from different regions","volume":"12","author":"Sevindik","year":"2018","journal-title":"Curr Chem Biol"},{"key":"key20251111103833_b27-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20251111103833_b28-ol-30-6-15306","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"key20251111103833_b29-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.cell.2011.12.033","article-title":"TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers","volume":"148","author":"Singh","year":"2012","journal-title":"Cell"},{"key":"key20251111103833_b30-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1200\/JCO.2014.60.0213","article-title":"Personalizing colon cancer adjuvant therapy: Selecting optimal treatments for individual patients","volume":"33","author":"Dienstmann","year":"2015","journal-title":"J Clin Oncol"},{"key":"key20251111103833_b31-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"108708","DOI":"10.1016\/j.biopha.2019.108708","article-title":"Collagen facilitates the colorectal cancer stemness and metastasis through an integrin\/PI3K\/AKT\/Snail signaling pathway","volume":"114","author":"Wu","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"key20251111103833_b32-ol-30-6-15306","article-title":"787 Targeting DNA damage response modulates antiphagocytic signals to convert radiotherapy into a systemic immunotherapy to treat metastatic colorectal cancer","volume":"12","author":"Turner","year":"2024","journal-title":"J Immuno Therapy Cancer"},{"key":"key20251111103833_b33-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"e103243","DOI":"10.1371\/journal.pone.0103243","article-title":"Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation","volume":"9","author":"Skowronki","year":"2014","journal-title":"PLoS One"},{"key":"key20251111103833_b34-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"13895","DOI":"10.1016\/j.ceramint.2021.01.256","article-title":"Doped and un-doped cerium oxide nanoparticles: Biosynthesis, characterization, and cytotoxic study","volume":"47","author":"Hamidian","year":"2021","journal-title":"Ceram Int"},{"key":"key20251111103833_b35-ol-30-6-15306","first-page":"395","article-title":"Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells","volume":"8","author":"Sato","year":"1993","journal-title":"Oncogene"},{"key":"key20251111103833_b36-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0046-8177(80)80031-1","article-title":"Collagen polymorphism in the lung: An immunochemical study of pulmonary fibrosis","volume":"11","author":"Madri","year":"1980","journal-title":"Hum Pathol"},{"key":"key20251111103833_b37-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3233\/JBR-180366","article-title":"Potential roles of berries in the prevention of breast cancer progression","volume":"8","author":"Reboredo-Rodr\u00edguez","year":"2018","journal-title":"J Berry Res"},{"key":"key20251111103833_b38-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.3945\/jn.111.140178","article-title":"Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple-negative breast tumors in nude mice","volume":"141","author":"Adams","year":"2011","journal-title":"J Nutr"},{"key":"key20251111103833_b39-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1007\/s13277-013-1511-7","article-title":"Collagen as a double-edged sword in tumor progression","volume":"35","author":"Fang","year":"2014","journal-title":"Tumour Biol"},{"key":"key20251111103833_b40-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"154164","DOI":"10.1155\/2015\/154164","article-title":"Impact of procyanidins from different berries on caspase 8 activation in colon cancer","volume":"2015","author":"Minker","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"key20251111103833_b41-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.ajpath.2013.06.026","article-title":"Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression","volume":"183","author":"Mammoto","year":"2013","journal-title":"Am J Pathol"},{"key":"key20251111103833_b42-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1158\/1541-7786.MCR-13-0236","article-title":"The pathobiology of collagens in glioma","volume":"11","author":"Payne","year":"2013","journal-title":"Mol Cancer Res"},{"key":"key20251111103833_b43-ol-30-6-15306","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12935-021-01982-0","article-title":"Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma","volume":"21","author":"Yin","year":"2021","journal-title":"Cancer Cell Int"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:38:37Z","timestamp":1762850317000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2025.15306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2025.15306","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}