{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:46:18Z","timestamp":1789847178988,"version":"4.0.1"},"reference-count":41,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2026.15538","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:16:37Z","timestamp":1773839797000},"page":"1-15","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of induction chemotherapy combined with standard chemoradiotherapy vs. standard chemoradiotherapy monotherapy in locally advanced cervical cancer:\u00a0 A systematic review and meta\u2011analysis"],"prefix":"10.3892","volume":"31","author":[{"given":"Xinyu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Radiation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyou","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Pizhou County People's Hospital, Xuzhou, Jiangsu 221399, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Pizhou County People's Hospital, Xuzhou, Jiangsu 221399, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Radiation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"key20260505102818_b1-ol-31-5-15538","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"key20260505102818_b2-ol-31-5-15538","first-page":"221","article-title":"Cancer incidence and mortality in China, 2022","volume":"46","author":"Zheng","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi (Chinese)"},{"key":"key20260505102818_b3-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1700737","DOI":"10.2807\/1560-7917.ES.2018.23.41.1700737","article-title":"The impact of 10 years of human papillomavirus (HPV) vaccination in Australia: What additional disease burden will a nonavalent vaccine prevent?","volume":"23","author":"Patel","year":"2018","journal-title":"Euro Surveill"},{"key":"key20260505102818_b4-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"102467","DOI":"10.1016\/j.ctrv.2022.102467","article-title":"HPV vaccination and HPV-related malignancies: Impact, strategies and optimizations toward global immunization coverage","volume":"111","author":"Giannone","year":"2022","journal-title":"Cancer Treat Rev"},{"key":"key20260505102818_b5-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S1470-2045(18)30836-2","article-title":"Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020\u201399: A modelling study","volume":"20","author":"Simms","year":"2019","journal-title":"Lancet Oncol"},{"key":"key20260505102818_b6-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1080\/13697137.2018.1439917","article-title":"Innovative approaches to cervical cancer screening in low- and middle-income countries","volume":"21","author":"Toliman","year":"2018","journal-title":"Climacteric"},{"key":"key20260505102818_b7-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1200\/JCO.2000.18.8.1606","article-title":"Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix","volume":"18","author":"Peters","year":"2000","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b8-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1200\/JCO.1999.17.5.1339","article-title":"Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study","volume":"17","author":"Whitney","year":"1999","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b9-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1056\/NEJM199904153401501","article-title":"Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer","volume":"340","author":"Morris","year":"1999","journal-title":"N Engl J Med"},{"key":"key20260505102818_b10-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1056\/NEJM199904153401502","article-title":"Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer","volume":"340","author":"Rose","year":"1999","journal-title":"N Engl J Med"},{"key":"key20260505102818_b11-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1056\/NEJM199904153401503","article-title":"Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma","volume":"340","author":"Keys","year":"1999","journal-title":"N Engl J Med"},{"key":"key20260505102818_b12-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ygyno.2017.01.033","article-title":"Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: A systematic review and meta-analysis","volume":"145","author":"Datta","year":"2017","journal-title":"Gynecol Oncol"},{"key":"key20260505102818_b13-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1056\/NEJM199904153401509","article-title":"Improved treatment for cervical cancer-concurrent chemotherapy and radiotherapy","volume":"340","author":"Thomas","year":"1999","journal-title":"N Engl J Med"},{"key":"key20260505102818_b14-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1136\/ijgc-2024-005419","article-title":"Efficacy of cumulative cisplatin dose on survival in patients with locally advanced cervical cancer treated with definitive chemoradiotherapy: multicenter study by Turkish Oncology Group","volume":"34","author":"Akyildiz","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"key20260505102818_b15-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.1200\/JCO.2008.16.4368","article-title":"Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: A systematic review and meta-analysis of individual patient data from 18 randomized trials","volume":"26","author":"Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b16-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s43657-024-00158-w","article-title":"Stratification by mutational landscape reveals differential immune infiltration and predicts the recurrence and clinical outcome of cervical cancer","volume":"5","author":"Gao","year":"2025","journal-title":"Phenomics"},{"key":"key20260505102818_b17-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.joim.2022.06.004","article-title":"Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle","volume":"20","author":"Pal","year":"2022","journal-title":"J Integr Med"},{"key":"key20260505102818_b18-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/S1470-2045(23)00147-X","article-title":"Adjuvant chemotherapy following chemoradiotherapy as primary treatment for locally advanced cervical cancer versus chemoradiotherapy alone (OUTBACK): An international, open-label, randomised, phase 3 trial","volume":"24","author":"Mileshkin","year":"2023","journal-title":"Lancet Oncol"},{"key":"key20260505102818_b19-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1200\/JCO.2017.75.9985","article-title":"Neoadjuvant chemotherapy followed by radical surgery versus concomitant chemotherapy and radiotherapy in patients with stage IB2, IIA, or IIB squamous cervical cancer: A randomized controlled trial","volume":"36","author":"Gupta","year":"2018","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b20-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/IGC.0000000000000663","article-title":"Neoadjuvant chemotherapy followed by chemoradiation in cervical carcinoma: A review","volume":"26","author":"de Azevedo","year":"2016","journal-title":"Int J Gynecol Cancer"},{"key":"key20260505102818_b21-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1016\/S0959-8049(03)00425-8","article-title":"Neoadjuvant chemotherapy for locally advanced cervical cancer: A systematic review and meta-analysis of individual patient data from 21 randomised trials","volume":"39","author":"Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis Collaboration","year":"2003","journal-title":"Eur J Cancer"},{"key":"key20260505102818_b22-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.1200\/JCO.2007.12.3133","article-title":"Neoadjuvant cisplatin chemotherapy before chemoradiation: A flawed paradigm?","volume":"25","author":"Glynne-Jones","year":"2007","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b23-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/bjc.2013.230","article-title":"A phase II study of weekly neoadjuvant chemotherapy followed by radical chemoradiation for locally advanced cervical cancer","volume":"108","author":"McCormack","year":"2013","journal-title":"Br J Cancer"},{"key":"key20260505102818_b24-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/S0140-6736(24)01438-7","article-title":"Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): An international, multicentre, randomised phase 3 trial","volume":"404","author":"McCormack","year":"2024","journal-title":"Lancet"},{"key":"key20260505102818_b25-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"115375","DOI":"10.1016\/j.ejca.2025.115375","article-title":"Induction chemotherapy followed by chemoradiation in locally advanced cervical cancer: Quality of life outcomes of the GCIG INTERLACE trial","volume":"220","author":"Eminowicz","year":"2025","journal-title":"Eur J Cancer"},{"key":"key20260505102818_b26-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12885-023-10517-x","article-title":"Neoadjuvant chemotherapy with weekly cisplatin and paclitaxel followed by chemoradiation for locally advanced cervical cancer","volume":"23","author":"Li","year":"2023","journal-title":"BMC Cancer"},{"key":"key20260505102818_b27-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.21873\/anticanres.11441","article-title":"Dose-dense paclitaxel- and carboplatin-based neoadjuvant chemotherapy followed by surgery or concurrent chemo-radiotherapy in cervical cancer: A preliminary analysis","volume":"37","author":"Gadducci","year":"2017","journal-title":"Anticancer Res"},{"key":"key20260505102818_b28-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1136\/ijgc-2023-004863","article-title":"Neoadjuvant chemotherapy prior to radical hysterectomy in locally advanced cervical cancer: A systematic review and meta-analysis","volume":"34","author":"Borghi","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"key20260505102818_b29-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/ijgo.12611","article-title":"Cancer of the cervix uteri","volume":"143","author":"Bhatla","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"key20260505102818_b30-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"key20260505102818_b31-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"key20260505102818_b32-ol-31-5-15538","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/9781119536604.ch14","article-title":"Completing \u2018Summary of findings\u2019 tables and grading the certainty of the evidence","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Sch\u00fcnemann","year":"2019"},{"key":"key20260505102818_b33-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s13224-019-01236-0","article-title":"Comparative study of neoadjuvant chemotherapy followed by definitive chemoradiotherapy versus definitive chemoradiotherapy alone in locally advanced carcinoma of cervix","volume":"69","author":"Tripathi","year":"2019","journal-title":"J Obstet Gynecol India"},{"key":"key20260505102818_b34-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"114","DOI":"10.22159\/ajpcr.2022.v15i7.44947","article-title":"Treatment outcome and toxicity of neoadjuvant chemotherapy followed by concomitant chemoradiotherapy versus concomitant chemoradiation alone in locally advanced cervical carcinoma: A comparative study","volume":"15","author":"Banerjee","year":"2022","journal-title":"Asian J Pharm Clin Res"},{"key":"key20260505102818_b35-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.3802\/jgo.2024.35.e10","article-title":"Improving the efficacy and safety of concurrent chemoradiotherapy by neoadjuvant chemotherapy: A randomized controlled study of locally advanced cervical cancer with a large tumor","volume":"35","author":"Li","year":"2023","journal-title":"J Gynecol Oncol"},{"key":"key20260505102818_b36-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"353","DOI":"10.4103\/ijmpo.ijmpo_14_18","article-title":"A prospective randomized comparison of concurrent chemoradiation with neoadjuvant and adjuvant chemotherapy with concurrent chemoradiation alone for locally advanced carcinoma cervix","volume":"40","author":"Singh","year":"2019","journal-title":"Indian J Med Paediatr Oncol"},{"key":"key20260505102818_b37-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1200\/JCO.19.00674","article-title":"Neoadjuvant chemotherapy with cisplatin and gemcitabine followed by chemoradiation versus chemoradiation for locally advanced cervical cancer: A randomized phase II trial","volume":"37","author":"da Costa","year":"2019","journal-title":"J Clin Oncol"},{"key":"key20260505102818_b38-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"842","DOI":"10.3390\/cancers14030842","article-title":"Dose-intense cisplatin-based neoadjuvant chemotherapy increases survival in advanced cervical cancer: An up-to-date meta-analysis","volume":"14","author":"Nguyen","year":"2022","journal-title":"Cancers (Basel)"},{"key":"key20260505102818_b39-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ygyno.2003.09.015","article-title":"Phase II trial of neoadjuvant paclitaxel and cisplatin in uterine cervical cancer","volume":"92","author":"Park","year":"2004","journal-title":"Gynecol Oncol"},{"key":"key20260505102818_b40-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ygyno.2007.09.022","article-title":"Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer","volume":"108","author":"Kim","year":"2008","journal-title":"Gynecol Oncol"},{"key":"key20260505102818_b41-ol-31-5-15538","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12943-021-01317-7","article-title":"Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades","volume":"20","author":"Li","year":"2021","journal-title":"Mol Cancer"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:28:21Z","timestamp":1777966101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2026.15538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3,18]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2026.15538","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]}}}