{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:43:34Z","timestamp":1792478614326,"version":"4.5.0"},"reference-count":89,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Lett"],"DOI":"10.3892\/ol.2026.15883","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:40:01Z","timestamp":1790250001000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Research progress of pancreatic cancer based on ferroptosis\u2011cuproptosis interaction (Review)"],"prefix":"10.3892","volume":"32","author":[{"given":"Wenqing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Ding","sequence":"additional","affiliation":[{"name":"Graduate Student Department, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijiao","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"key20261020093305_b1-ol-32-5-15883","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"key20261020093305_b2-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: A review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"key20261020093305_b3-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"key20261020093305_b4-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"key20261020093305_b5-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"key20261020093305_b6-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"key20261020093305_b7-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"key20261020093305_b8-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","article-title":"Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway","volume":"11","author":"Dai","year":"2020","journal-title":"Nat Commun"},{"key":"key20261020093305_b9-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"key20261020093305_b10-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"key20261020093305_b11-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"Kremer","year":"2021","journal-title":"Nat Commun"},{"key":"key20261020093305_b12-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res"},{"key":"key20261020093305_b13-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41419-024-06592-y","article-title":"HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells","volume":"15","author":"Luo","year":"2024","journal-title":"Cell Death Dis"},{"key":"key20261020093305_b14-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41419-022-05082-3","article-title":"Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3\/GPX4 signalling","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"key20261020093305_b15-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.chembiol.2021.01.006","article-title":"MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells","volume":"28","author":"Kuang","year":"2021","journal-title":"Cell Chem Biol"},{"key":"key20261020093305_b16-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1182\/blood-2006-02-003681","article-title":"The steap proteins are metalloreductases","volume":"108","author":"Ohgami","year":"2006","journal-title":"Blood"},{"key":"key20261020093305_b17-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.bbamcr.2012.02.011","article-title":"Charting the travels of copper in eukaryotes from yeast to mammals","volume":"1823","author":"Nevitt","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key20261020093305_b18-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"6836","DOI":"10.1073\/pnas.111057298","article-title":"The copper transporter CTR1 provides an essential function in mammalian embryonic development","volume":"98","author":"Kuo","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20261020093305_b19-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.4143\/crt.2015.282","article-title":"Serum concentrations of selenium and copper in patients diagnosed with pancreatic cancer","volume":"48","author":"Lener","year":"2016","journal-title":"Cancer Res Treat"},{"key":"key20261020093305_b20-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"46334","DOI":"10.1021\/acsami.1c13091","article-title":"Tetrahedral framework nucleic acid delivered RNA therapeutics significantly attenuate pancreatic cancer progression via inhibition of CTR1-dependent copper absorption","volume":"13","author":"Song","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"key20261020093305_b21-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41586-021-04025-w","article-title":"SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells","volume":"599","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"key20261020093305_b22-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"29579","DOI":"10.1038\/s41598-024-81317-x","article-title":"NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism","volume":"14","author":"Liu","year":"2024","journal-title":"Sci Rep"},{"key":"key20261020093305_b23-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1016\/j.ymthe.2025.09.004","article-title":"Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC","volume":"33","author":"Yu","year":"2025","journal-title":"Mol Ther"},{"key":"key20261020093305_b24-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: Potential targets for medical interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J Amino Acids"},{"key":"key20261020093305_b25-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1080\/15548627.2024.2410619","article-title":"USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2\/NRF2-SQSTM1\/p62-KEAP1 axis dependent on the KRAS signaling pathway","volume":"21","author":"Chen","year":"2025","journal-title":"Autophagy"},{"key":"key20261020093305_b26-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1080\/15548627.2021.1990672","article-title":"Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice","volume":"18","author":"Wang","year":"2022","journal-title":"Autophagy"},{"key":"key20261020093305_b27-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol Cell"},{"key":"key20261020093305_b28-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"e132747","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"key20261020093305_b29-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cbpa.2017.11.003","article-title":"Protein lipoylation: An evolutionarily conserved metabolic regulator of health and disease","volume":"42","author":"Rowland","year":"2018","journal-title":"Curr Opin Chem Biol"},{"key":"key20261020093305_b30-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","article-title":"Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death","volume":"82","author":"Cobine","year":"2022","journal-title":"Mol Cell"},{"key":"key20261020093305_b31-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: From transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"key20261020093305_b32-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat Commun"},{"key":"key20261020093305_b33-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.cell.2012.01.058","article-title":"Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism","volume":"149","author":"Ying","year":"2012","journal-title":"Cell"},{"key":"key20261020093305_b34-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"key":"key20261020093305_b35-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.bbamcr.2011.11.002","article-title":"Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis","volume":"1823","author":"Shi","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key20261020093305_b36-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nature17393","article-title":"Reductive carboxylation supports redox homeostasis during anchorage-independent growth","volume":"532","author":"Jiang","year":"2016","journal-title":"Nature"},{"key":"key20261020093305_b37-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"110391","DOI":"10.1016\/j.celrep.2022.110391","article-title":"Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation","volume":"38","author":"Li","year":"2022","journal-title":"Cell Rep"},{"key":"key20261020093305_b38-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20261020093305_b39-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nature24637","article-title":"NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis","volume":"551","author":"Alvarez","year":"2017","journal-title":"Nature"},{"key":"key20261020093305_b40-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1242\/dmm.009019","article-title":"Biogenesis of iron-sulfur clusters in mammalian cells: New insights and relevance to human disease","volume":"5","author":"Rouault","year":"2012","journal-title":"Dis Models Mech"},{"key":"key20261020093305_b41-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/j.bbamcr.2012.05.010","article-title":"Mammalian iron metabolism and its control by iron regulatory proteins","volume":"1823","author":"Anderson","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key20261020093305_b42-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat Cell Biol"},{"key":"key20261020093305_b43-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"key20261020093305_b44-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"key20261020093305_b45-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"a031435","DOI":"10.1101\/cshperspect.a031435","article-title":"KRAS: The critical driver and therapeutic target for pancreatic cancer","volume":"8","author":"Waters","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key20261020093305_b46-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/cancers12010164","article-title":"Ferroptosis in cancer cell biology","volume":"12","author":"Bebber","year":"2020","journal-title":"Cancers (Basel)"},{"key":"key20261020093305_b47-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/cdd.2014.34","article-title":"Novel signaling axis for ROS generation during K-ras-induced cellular transformation","volume":"21","author":"Park","year":"2014","journal-title":"Cell Death Differ"},{"key":"key20261020093305_b48-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nature13611","article-title":"Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function","volume":"514","author":"Viale","year":"2014","journal-title":"Nature"},{"key":"key20261020093305_b49-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature13180","article-title":"Copper is required for oncogenic BRAF signalling and tumorigenesis","volume":"509","author":"Brady","year":"2014","journal-title":"Nature"},{"key":"key20261020093305_b50-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s41587-020-0707-9","article-title":"Mitochondrial copper depletion suppresses triple-negative breast cancer in mice","volume":"39","author":"Cui","year":"2021","journal-title":"Nat Biotechnol"},{"key":"key20261020093305_b51-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"key20261020093305_b52-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"key20261020093305_b53-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","article-title":"Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein","volume":"16","author":"Dai","year":"2020","journal-title":"Autophagy"},{"key":"key20261020093305_b54-ol-32-5-15883","first-page":"1","article-title":"Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study","volume":"6","author":"Brewer","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20261020093305_b55-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1128\/MCB.05722-11","article-title":"A novel role for copper in Ras\/mitogen-activated protein kinase signaling","volume":"32","author":"Turski","year":"2012","journal-title":"Mol Cell Biol"},{"key":"key20261020093305_b56-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"939956","DOI":"10.3389\/fgene.2022.939956","article-title":"A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity","volume":"13","author":"Liu","year":"2022","journal-title":"Front Genet"},{"key":"key20261020093305_b57-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: An update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20261020093305_b58-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"\u00d6hlund","year":"2017","journal-title":"J Exp Med"},{"key":"key20261020093305_b59-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.3390\/cancers14163994","article-title":"Heterogeneity of cancer-associated fibroblasts and the tumor immune microenvironment in pancreatic cancer","volume":"14","author":"Shinkawa","year":"2022","journal-title":"Cancers"},{"key":"key20261020093305_b60-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","article-title":"IL1-induced JAK\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma","volume":"9","author":"Biffi","year":"2019","journal-title":"Cancer Discov"},{"key":"key20261020093305_b61-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.2147\/JIR.S506964","article-title":"The dual roles of STAT3 in ferroptosis: Mechanism, regulation and therapeutic potential","volume":"18","author":"Xie","year":"2025","journal-title":"J Inflammation Res"},{"key":"key20261020093305_b62-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"e70611","DOI":"10.1111\/jcmm.70611","article-title":"Copper homeostasis, emerging central players in cancer immunotherapy","volume":"29","author":"Chen","year":"2025","journal-title":"J Cell Mol Med"},{"key":"key20261020093305_b63-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"841814","DOI":"10.3389\/fmolb.2022.841814","article-title":"Selective targeting of cancer cells by copper ionophores: An overview","volume":"9","author":"Oliveri","year":"2022","journal-title":"Front Mol Biosci"},{"key":"key20261020093305_b64-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.3390\/cancers13184552","article-title":"Metallothionein 2A expression in cancer-associated fibroblasts and cancer cells promotes esophageal squamous cell carcinoma progression","volume":"13","author":"Shimizu","year":"2021","journal-title":"Cancers"},{"key":"key20261020093305_b65-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.bbrc.2016.12.148","article-title":"Copper chaperone Atox1 plays role in breast cancer cell migration","volume":"483","author":"Blockhuys","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"key20261020093305_b66-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nature19084","article-title":"Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion","volume":"536","author":"Sousa","year":"2016","journal-title":"Nature"},{"key":"key20261020093305_b67-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.7150\/thno.89805","article-title":"Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer","volume":"14","author":"Zhu","year":"2024","journal-title":"Theranostics"},{"key":"key20261020093305_b68-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"100960","DOI":"10.1016\/j.drup.2023.100960","article-title":"Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs","volume":"68","author":"Qi","year":"2023","journal-title":"Drug Resist Updat"},{"key":"key20261020093305_b69-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/S0360-3016(00)00803-8","article-title":"Pancreatic tumors show high levels of hypoxia","volume":"48","author":"Koong","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20261020093305_b70-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.cmet.2008.12.012","article-title":"Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency","volume":"9","author":"Shah","year":"2009","journal-title":"Cell Metab"},{"key":"key20261020093305_b71-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1172\/JCI31370","article-title":"Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)","volume":"117","author":"Peyssonnaux","year":"2007","journal-title":"J Clin Invest"},{"key":"key20261020093305_b72-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1182\/blood-2004-10-3980","article-title":"Copper-dependent activation of hypoxia-inducible factor (HIF)-1: Implications for ceruloplasmin regulation","volume":"105","author":"Martin","year":"2005","journal-title":"Blood"},{"key":"key20261020093305_b73-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1517\/14728222.2016.1151003","article-title":"Lysyl oxidase isoforms and potential therapeutic opportunities for fibrosis and cancer","volume":"20","author":"Trackman","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"key20261020093305_b74-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nrc2438","article-title":"Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response","volume":"8","author":"Dewhirst","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"key20261020093305_b75-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.molcel.2026.03.007","article-title":"The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer","volume":"86","author":"Hubbi","year":"2026","journal-title":"Mol Cell"},{"key":"key20261020093305_b76-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"key20261020093305_b77-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"key":"key20261020093305_b78-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"6836","DOI":"10.1073\/pnas.1817473116","article-title":"ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis","volume":"116","author":"Shanbhag","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20261020093305_b79-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"ra56","DOI":"10.1126\/scisignal.2004870","article-title":"Memo is a copper-dependent redox protein with an essential role in migration and metastasis","volume":"7","author":"MacDonald","year":"2014","journal-title":"Sci Signaling"},{"key":"key20261020093305_b80-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"9518","DOI":"10.1158\/0008-5472.CAN-07-0175","article-title":"Dynamics of the immune reaction to pancreatic cancer from inception to invasion","volume":"67","author":"Clark","year":"2007","journal-title":"Cancer Res"},{"key":"key20261020093305_b81-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"e003430","DOI":"10.1136\/jitc-2021-003430","article-title":"Immunogenic ferroptosis and where to find it?","volume":"9","author":"Demuynck","year":"2021","journal-title":"J Immunother Cancer"},{"key":"key20261020093305_b82-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","article-title":"The release and activity of HMGB1 in ferroptosis","volume":"510","author":"Wen","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"key20261020093305_b83-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.1021\/jacsau.4c00712","article-title":"Signaling mechanism of cuproptosis activating cGAS-STING immune pathway","volume":"4","author":"Zhu","year":"2024","journal-title":"JACS Au"},{"key":"key20261020093305_b84-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.imbio.2014.09.011","article-title":"Macrophage iron homeostasis and polarization in the context of cancer","volume":"220","author":"Jung","year":"2015","journal-title":"Immunobiology"},{"key":"key20261020093305_b85-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab"},{"key":"key20261020093305_b86-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.cell.2016.04.009","article-title":"Effector T cells abrogate Stroma-mediated chemoresistance in ovarian cancer","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"key20261020093305_b87-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"1904197","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv Mater"},{"key":"key20261020093305_b88-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13046-025-03409-4","article-title":"Novel Pt@PCN-Cu-induced cuproptosis amplifies \u03b1PD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation","volume":"44","author":"Wang","year":"2025","journal-title":"J Exp Clin Cancer Res"},{"key":"key20261020093305_b89-ol-32-5-15883","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.gendis.2022.05.033","article-title":"A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression","volume":"10","author":"Jin","year":"2023","journal-title":"Genes Dis"}],"container-title":["Oncology Letters"],"original-title":[],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:33:14Z","timestamp":1792477994000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ol.2026.15883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":89,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,24]]}},"URL":"https:\/\/doi.org\/10.3892\/ol.2026.15883","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}