{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:25:36Z","timestamp":1776475536051,"version":"3.51.2"},"reference-count":28,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.3892\/ol_00000115","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T12:14:30Z","timestamp":1275653670000},"page":"657-662","source":"Crossref","is-referenced-by-count":27,"title":["Role and mechanism of hypoxia-inducible factor-1 in cell growth and apoptosis of breast cancer cell line MDA-MB-231"],"prefix":"10.3892","volume":"1","author":[{"given":"YONGHONG","family":"SHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIAOMIAO","family":"CHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FANG","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOHUI","family":"OUYANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONGFENG","family":"JIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUA","family":"DU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"key20180108105138_b1-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"key20180108105138_b2-ol-01-04-0657","first-page":"1527","article-title":"Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer","volume":"20","author":"Volm","year":"2000","journal-title":"Anticancer Res"},{"key":"key20180108105138_b3-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-3835(02)00053-8","article-title":"Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions","volume":"181","author":"Zhong","year":"2002","journal-title":"Cancer Lett"},{"key":"key20180108105138_b4-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/jcp.2003.012963","article-title":"Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours","volume":"57","author":"Jubb","year":"2004","journal-title":"J Clin Pathol"},{"key":"key20180108105138_b5-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.humpath.2007.02.010","article-title":"Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma","volume":"38","author":"Osada","year":"2007","journal-title":"Hum Pathol"},{"key":"key20180108105138_b6-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1158\/1078-0432.CCR-0946-03","article-title":"Prognostic impact of hypoxia-inducible factors 1{alpha} and 2{alpha} in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression","volume":"10","author":"Yoshimura","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180108105138_b7-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1302\/0301-620X.90B3.19806","article-title":"Expression of hypoxia-inducible factor-1{alpha} and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours","volume":"90B","author":"Kubo","year":"2008","journal-title":"J Bone Joint Surg Br"},{"key":"key20180108105138_b8-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.02-0445fje","article-title":"Widespread, hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs","volume":"17","author":"Wiesener","year":"2003","journal-title":"FASEB J"},{"key":"key20180108105138_b9-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/cdd.2008.21","article-title":"The role of hypoxia-inducible factors in tumorigenesis","volume":"15","author":"Rankin","year":"2008","journal-title":"Cell Death Differ"},{"key":"key20180108105138_b10-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1182\/blood-2003-06-1859","article-title":"Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells","volume":"103","author":"Ameri","year":"2004","journal-title":"Blood"},{"key":"key20180108105138_b11-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/path.1734","article-title":"In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K\/Akt and MEK1\/ERK pathways","volume":"205","author":"Shi","year":"2005","journal-title":"J Pathol"},{"key":"key20180108105138_b12-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W","article-title":"Expression of hypoxia-inducible factor 1 alpha in brain tumors \u2013 association with angiogenesis, invasion, and progression","volume":"88","author":"Zagzag","year":"2000","journal-title":"Cancer"},{"key":"key20180108105138_b13-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1158\/1078-0432.CCR-06-2692","article-title":"Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo","volume":"15","author":"Gillespie","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key20180108105138_b14-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1038\/sj.onc.1210008","article-title":"Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance","volume":"26","author":"Kilic","year":"2007","journal-title":"Oncogene"},{"key":"key20180108105138_b15-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1158\/0008-5472.CAN-03-2301","article-title":"Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1{alpha}","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res"},{"key":"key20180108105138_b16-ol-01-04-0657","first-page":"395","article-title":"Role of hypoxia-inducible factor-1{alpha} in hypoxia-induced apoptosis of primary alveolar epithelial type II cells","volume":"32","author":"Krick","year":"2005","journal-title":"Cell Mol Biol"},{"key":"key20180108105138_b17-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00240-4","article-title":"Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth","volume":"3","author":"Mack","year":"2003","journal-title":"Cancer Cell"},{"key":"key20180108105138_b18-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1124\/mol.106.028076","article-title":"Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1{alpha}","volume":"70","author":"Lim","year":"2006","journal-title":"Mol Pharmacol"},{"key":"key20180108105138_b19-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1128\/MCB.25.12.4853-4862.2005","article-title":"Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling","volume":"25","author":"Emerling","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180108105138_b20-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-005-9017-9","article-title":"Anti-apoptotic action by hypoxia inducible factor 1-alpha in human pituitary adenoma cell line, HP-75 in hypoxic condition","volume":"78","author":"Yoshida","year":"2006","journal-title":"J Neurooncol"},{"key":"key20180108105138_b21-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.gt.3303103","article-title":"Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes","volume":"15","author":"Takahashi","year":"2008","journal-title":"Gene Ther"},{"key":"key20180108105138_b22-ol-01-04-0657","first-page":"154","article-title":"Effects of hypoxia inducible factor-1alpha (HIF-1alpha) on the growth and adhesion in tongue squamous cell carcinoma cells","volume":"129","author":"Song","year":"2009","journal-title":"Indian J Med Res"},{"key":"key20180108105138_b23-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1091\/mbc.E05-01-0080","article-title":"Impaired akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157","volume":"16","author":"Yang","year":"2005","journal-title":"Mol Biol Cell"},{"key":"key20180108105138_b24-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1059108","article-title":"Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death","volume":"292","author":"Wei","year":"2001","journal-title":"Science"},{"key":"key20180108105138_b25-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0006-291X(03)00615-6","article-title":"Mechanisms of cytochrome c release by proapoptotic BCL-2 family members","volume":"304","author":"Scorrano","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108105138_b26-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/MCB.19.12.8469","article-title":"BCL-2 is phosphorylated and inactivated by an ASK1\/Jun N-Terminal protein kinase pathway normally activated at G2\/M","volume":"19","author":"Amamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key20180108105138_b27-ol-01-04-0657","doi-asserted-by":"crossref","first-page":"7255","DOI":"10.1158\/1078-0432.CCR-05-0274","article-title":"Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms","volume":"11","author":"Kondo","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180108105138_b28-ol-01-04-0657","first-page":"1851","article-title":"Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway","volume":"56","author":"Blagosklonny","year":"1996","journal-title":"Cancer Res"}],"container-title":["Oncology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ol_00000115\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T20:47:53Z","timestamp":1559162873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ol_00000115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.3892\/ol_00000115"],"URL":"https:\/\/doi.org\/10.3892\/ol_00000115","relation":{},"ISSN":["1792-1074","1792-1082"],"issn-type":[{"value":"1792-1074","type":"print"},{"value":"1792-1082","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}