{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:26:58Z","timestamp":1788838018581,"version":"build-2803163510"},"reference-count":53,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3892\/or.2012.1817","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T17:36:03Z","timestamp":1337276163000},"page":"640-646","source":"Crossref","is-referenced-by-count":21,"title":["Synergistic effect of malathion and estrogen on mammary gland carcinogenesis"],"prefix":"10.3892","volume":"28","author":[{"given":"GLORIA M.","family":"CALAF","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLOS","family":"ECHIBUR\u00da-CHAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,5,17]]},"reference":[{"key":"key20180107215726_b1-or-28-02-0640","first-page":"381","article-title":"Mechanisms of estrogenic and antiestrogenic regulation of growth of human breast carcinoma","volume-title":"Hormonal Manipulation of Cancer: Peptides, Growth Factors, and New (Anti) Steroidal Agents","author":"Dickson","year":"1987"},{"key":"key20180107215726_b2-or-28-02-0640","first-page":"20","article-title":"Steroid receptors and other prognostic factors in primary breast cancer","volume":"18","author":"Clark","year":"1989","journal-title":"Semin Oncol"},{"key":"key20180107215726_b3-or-28-02-0640","first-page":"4987","article-title":"Dissociation between steroid receptor expression and cell proliferation in the human breast","volume":"57","author":"Clarke","year":"1997","journal-title":"Cancer Res"},{"key":"key20180107215726_b4-or-28-02-0640","first-page":"1","article-title":"Epidemiology and risk factors","volume-title":"Breast Cancer: Diagnosis and Management","author":"Henderson","year":"1984"},{"key":"key20180107215726_b5-or-28-02-0640","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.8381558","article-title":"Hormonal chemoprevention of cancer in women","volume":"259","author":"Henderson","year":"1993","journal-title":"Science"},{"key":"key20180107215726_b6-or-28-02-0640","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.278.5340.1068","article-title":"Environment and cancer: who are susceptible?","volume":"278","author":"Perera","year":"1997","journal-title":"Science"},{"key":"key20180107215726_b7-or-28-02-0640","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1289\/ehp.93101386","article-title":"Functional toxicology: a new approach to detect biologically active xenobiotics","volume":"101","author":"McLachlan","year":"1995","journal-title":"Environ Health Perspect"},{"key":"key20180107215726_b8-or-28-02-0640","first-page":"131","article-title":"Anticholinesterase agents","volume-title":"The Pharmacological Basis of Therapeutics","author":"Taylor","year":"1990"},{"key":"key20180107215726_b9-or-28-02-0640","first-page":"1615","article-title":"Nonmetallic environmental toxicants: air pollutants, solvents and vapors, and pesticides","volume-title":"The Pharmacological Basis of Therapeutics","author":"Klaasen","year":"1990"},{"key":"key20180107215726_b10-or-28-02-0640","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1432-1033.1987.tb13662.x","article-title":"Modes of attachment of acetylcholinesterase to the surface membrane","volume":"170","author":"Silman","year":"1987","journal-title":"Eur J Biochem"},{"key":"key20180107215726_b11-or-28-02-0640","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jnci\/80.1.2","article-title":"Rising incidence of breast cancer","volume":"80","author":"Krieger","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b12-or-28-02-0640","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF02106571","article-title":"Exposure, susceptibility, and breast cancer risk: a hypothesis regarding exogenous carcinogens, breast tissue development, and social gradients, including black\/white differences, in breast cancer incidence","volume":"13","author":"Krieger","year":"1989","journal-title":"Breast Cancer Res Treat"},{"key":"key20180107215726_b13-or-28-02-0640","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/oxfordjournals.epirev.a036115","article-title":"Reproductive factors and breast cancer","volume":"15","author":"Kelsey","year":"1993","journal-title":"Epidemiol Rev"},{"key":"key20180107215726_b14-or-28-02-0640","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.pu.17.050196.000403","article-title":"Epidemiology and prevention of breast cancer","volume":"17","author":"Kelsey","year":"1996","journal-title":"Annu Rev Public Health"},{"key":"key20180107215726_b15-or-28-02-0640","first-page":"4595","article-title":"The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture","volume":"36","author":"Lippman","year":"1976","journal-title":"Cancer Res"},{"key":"key20180107215726_b16-or-28-02-0640","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-4613-1733-3_6","article-title":"Control of human breast cancer by estrogen, growth factors, and oncogenes","volume":"40","author":"Dickson","year":"1988","journal-title":"Cancer Treat Res"},{"key":"key20180107215726_b17-or-28-02-0640","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/bjc.1988.44","article-title":"The dose-effect relationship between \u2018unopposed\u2019 oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk","volume":"57","author":"Key","year":"1988","journal-title":"Br J Cancer"},{"key":"key20180107215726_b18-or-28-02-0640","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1093\/carcin\/17.11.2279","article-title":"Estrogens and breast cancer","volume":"17","author":"Feigelson","year":"1996","journal-title":"Carcinogenesis"},{"key":"key20180107215726_b19-or-28-02-0640","first-page":"7","article-title":"The epidemiology of breast cancer","volume":"1","author":"Bernstein","year":"1998","journal-title":"LOWAC J"},{"key":"key20180107215726_b20-or-28-02-0640","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jnci\/87.3.190","article-title":"A prospective study of endogenous estrogens and breast cancer in postmenopausal women","volume":"87","author":"Toniolo","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b21-or-28-02-0640","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/jnci\/86.14.1076","article-title":"Estrogen metabolism and excretion in Oriental and Caucasian women","volume":"86","author":"Adlercreutz","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b22-or-28-02-0640","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/jnci\/88.5.291","article-title":"Serum sex hormone levels after menopause and subsequent breast cancer","volume":"88","author":"Berrino","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b23-or-28-02-0640","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/bjc.1990.316","article-title":"Serum oestrogen levels in postmenopausal women: comparison of American whites and Japanese in Japan","volume":"62","author":"Shimizu","year":"1990","journal-title":"Br J Cancer"},{"key":"key20180107215726_b24-or-28-02-0640","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00053183","article-title":"Serum hormone levels in pre-menopausal Chinese women in Shanghai and white women in Los Angeles: results from two breast cancer case-control studies","volume":"1","author":"Bernstein","year":"1990","journal-title":"Cancer Causes Control"},{"key":"key20180107215726_b25-or-28-02-0640","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/bjc.1990.56","article-title":"Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls","volume":"61","author":"Bernstein","year":"1990","journal-title":"Br J Cancer"},{"key":"key20180107215726_b26-or-28-02-0640","first-page":"1","article-title":"Estrogen-induced tumors of the kidney. III Growth characteristics in the Syrian hamster","volume":"1","author":"Kirkman","year":"1959","journal-title":"Natl Cancer Inst Monogr"},{"key":"key20180107215726_b27-or-28-02-0640","first-page":"5200","article-title":"Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney","volume":"43","author":"Li","year":"1983","journal-title":"Cancer Res"},{"key":"key20180107215726_b28-or-28-02-0640","first-page":"279","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","author":"International Agency for Research on Cancer (IARC)","year":"1979"},{"key":"key20180107215726_b29-or-28-02-0640","first-page":"280","volume-title":"IARC Monographs on the Evolution of Carcinogenic Risks to Humans","author":"International Agency for Research on Cancer (IARC)","year":"1987"},{"key":"key20180107215726_b30-or-28-02-0640","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1073\/pnas.94.20.10937","article-title":"Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators","volume":"94","author":"Cavalieri","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107215726_b31-or-28-02-0640","first-page":"107","article-title":"Estrogen-DNA damage in mouse skin H-ras gene is mutated by error prone repair","volume":"41","author":"Chakravarti","year":"2000","journal-title":"Proc Am Assoc Cancer Res"},{"key":"key20180107215726_b32-or-28-02-0640","first-page":"166","article-title":"The synergism between radiation and estrogen in the production of mammary cancer in the rat","volume":"31","author":"Segaloff","year":"1971","journal-title":"Cancer Res"},{"key":"key20180107215726_b33-or-28-02-0640","first-page":"177","article-title":"Catechol estrogens as biomarkers for mammary gland cancer","volume":"39","author":"Calaf","year":"2011","journal-title":"Int J Oncol"},{"key":"key20180107215726_b34-or-28-02-0640","article-title":"IARC Monographs on the Evolution of Carcinogenic Risks to Humans","volume-title":"Hormonal Contraception and Postmenopausal Hormone Therapy","author":"International Agency for Research on Cancer (IARC)","year":"1999"},{"key":"key20180107215726_b35-or-28-02-0640","first-page":"1006","article-title":"Demonstration of a direct carcinogenic effect of estradiol on Leydig cells of the mouse","volume":"40","author":"Huseby","year":"1980","journal-title":"Cancer Res"},{"key":"key20180107215726_b36-or-28-02-0640","first-page":"1","article-title":"Pathological changes in female C3H mice continuously fed diets containing diethylstilbestrol or 17beta-estradiol","volume":"1","author":"Highman","year":"1978","journal-title":"J Environ Pathol Toxicol"},{"key":"key20180107215726_b37-or-28-02-0640","first-page":"81","article-title":"Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17beta-estradiol","volume":"4","author":"Highman","year":"1980","journal-title":"J Environ Pathol Toxicol"},{"key":"key20180107215726_b38-or-28-02-0640","first-page":"653","article-title":"Osseous changes and osteosacomas in mice continuously fed diets containing diethylstilbestrol or 17beta-estradiol","volume":"67","author":"Highman","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b39-or-28-02-0640","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/0014-2964(80)90031-6","article-title":"Long-term effects of progesterone or diethylstilbestrol with or without estrogen after maturity on mammary tumorigenesis in mice","volume":"16","author":"Nagasawa","year":"1980","journal-title":"Eur J Cancer"},{"key":"key20180107215726_b40-or-28-02-0640","first-page":"699","article-title":"Protective effects of progesterone and tamoxifen in estrogen-induced mammary carcinogenesis in ovariectomized W\/Fu rats","volume":"76","author":"Inoh","year":"1985","journal-title":"Jpn J Cancer Res"},{"key":"key20180107215726_b41-or-28-02-0640","first-page":"766","article-title":"Spontaneous and estrogen-produced tumors in Nb rats and their behavior after transplantation","volume":"35","author":"Noble","year":"1975","journal-title":"Cancer Res"},{"key":"key20180107215726_b42-or-28-02-0640","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/carcin\/18.8.1595","article-title":"Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma","volume":"18","author":"Shull","year":"1997","journal-title":"Carcinogenesis"},{"key":"key20180107215726_b43-or-28-02-0640","first-page":"3415","article-title":"Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins","volume":"45","author":"Welsch","year":"1985","journal-title":"Cancer Res"},{"key":"key20180107215726_b44-or-28-02-0640","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF00346048","article-title":"Estrogen-induced tumorigenesis in hamsters: roles for hormonal and carcinogenic activities","volume":"55","author":"Li","year":"1984","journal-title":"Arch Toxicol"},{"key":"key20180107215726_b45-or-28-02-0640","first-page":"1858","article-title":"Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism","volume":"46","author":"Li","year":"1987","journal-title":"Fed Proc"},{"key":"key20180107215726_b46-or-28-02-0640","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1073\/pnas.0437929100","article-title":"Critical role of oxidative stress in estrogen-induced carcinogenesis","volume":"100","author":"Bhat","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107215726_b47-or-28-02-0640","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0165-1110(90)90018-7","article-title":"Genotoxic effects of estrogens","volume":"238","author":"Liehr","year":"1990","journal-title":"Mutat Res"},{"key":"key20180107215726_b48-or-28-02-0640","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute of Animal Laboratory Resources","year":"1996"},{"key":"key20180107215726_b49-or-28-02-0640","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000419251","article-title":"Mammary tumorigenesis","volume":"33","author":"Russo","year":"1991","journal-title":"Prog Exp Tumor Res"},{"key":"key20180107215726_b50-or-28-02-0640","first-page":"231","article-title":"An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions","volume":"55","author":"Wellings","year":"1975","journal-title":"J Natl Cancer Inst"},{"key":"key20180107215726_b51-or-28-02-0640","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1289\/ehp.01109471","article-title":"A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition","volume":"109","author":"Cabello","year":"2001","journal-title":"Environ Health Perspect"},{"key":"key20180107215726_b52-or-28-02-0640","article-title":"Malignant transformation of rat kidney induced by environmental substances and estrogen","author":"Alfaro-Lira","journal-title":"Int J Environ Res Public Health"},{"key":"key20180107215726_b53-or-28-02-0640","first-page":"603","article-title":"Rat lung cancer induced by malathion and estrogen","volume":"33","author":"Echiburu-Chau","year":"2008","journal-title":"Int J Oncol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2012.1817\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:57:44Z","timestamp":1515362264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2012.1817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,17]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5,17]]},"published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.3892\/or.2012.1817"],"URL":"https:\/\/doi.org\/10.3892\/or.2012.1817","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,17]]}}}