{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:42:53Z","timestamp":1791294173010,"version":"4.1.0"},"reference-count":23,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.3892\/or.2012.1981","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T10:56:49Z","timestamp":1345633009000},"page":"1585-1590","source":"Crossref","is-referenced-by-count":26,"title":["Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells"],"prefix":"10.3892","volume":"28","author":[{"given":"KOJI","family":"YAMANEGI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNKO","family":"YAMANE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KENTA","family":"KOBAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDEKI","family":"OHYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEIJI","family":"NAKASHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOKO","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAKI","family":"HATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SATORU","family":"FUKUNAGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROYUKI","family":"FUTANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HARUKI","family":"OKAMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOBUYUKI","family":"TERADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"key20180107215628_b1-or-28-05-1585","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1038\/onc.2008.267","article-title":"NK cells and cancer immunosurveillance","volume":"27","author":"Waldhauer","year":"2008","journal-title":"Oncogene"},{"key":"key20180107215628_b2-or-28-05-1585","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1038\/onc.2008.272","article-title":"NKG2D ligands in tumor immunity","volume":"27","author":"Nausch","year":"2008","journal-title":"Oncogene"},{"key":"key20180107215628_b3-or-28-05-1585","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.4049\/jimmunol.169.8.4098","article-title":"Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding","volume":"169","author":"Salih","year":"2002","journal-title":"J Immunol"},{"key":"key20180107215628_b4-or-28-05-1585","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.humimm.2006.02.008","article-title":"Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients","volume":"67","author":"Salih","year":"2006","journal-title":"Hum Immunol"},{"key":"key20180107215628_b5-or-28-05-1585","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1158\/0008-5472.CAN-05-2520","article-title":"Proteolytic release of soluble UL16-binding protein 2 from tumor cells","volume":"66","author":"Waldhauer","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107215628_b6-or-28-05-1585","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4049\/jimmunol.182.1.49","article-title":"Cutting edge: the metalloproteinase ADAM17\/TNF-\u03b1-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein","volume":"182","author":"Boutet","year":"2009","journal-title":"J Immunol"},{"key":"key20180107215628_b7-or-28-05-1585","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nature01112","article-title":"Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation","volume":"419","author":"Groh","year":"2002","journal-title":"Nature"},{"key":"key20180107215628_b8-or-28-05-1585","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1593\/neo.04316","article-title":"Downregulation and\/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma","volume":"6","author":"Raffaghello","year":"2004","journal-title":"Neoplasia"},{"key":"key20180107215628_b9-or-28-05-1585","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/ijc.22186","article-title":"Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing \u03b3\u03b4T cell cytotoxicity","volume":"119","author":"M\u00e4rten","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180107215628_b10-or-28-05-1585","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd1930","article-title":"Epigenetic therapy of cancer: past, present and future","volume":"5","author":"Yoo","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107215628_b11-or-28-05-1585","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2009.10.011","article-title":"Epigenetics and cancer treatment","volume":"625","author":"Kristensen","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"key20180107215628_b12-or-28-05-1585","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1158\/0008-5472.CAN-04-4252","article-title":"Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate","volume":"65","author":"Armeanu","year":"2005","journal-title":"Cancer Res"},{"key":"key20180107215628_b13-or-28-05-1585","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.canlet.2008.06.027","article-title":"Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells","volume":"272","author":"Schmudde","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180107215628_b14-or-28-05-1585","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00262-008-0645-8","article-title":"Sodium butyrate upregulates expression of NKG2D ligand MICA\/B in HeLa and HepG2 cell lines and increases their susceptibility to NK lysis","volume":"58","author":"Zhang","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"key20180107215628_b15-or-28-05-1585","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/leu.2008.354","article-title":"Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate","volume":"23","author":"Poggi","year":"2009","journal-title":"Leukemia"},{"key":"key20180107215628_b16-or-28-05-1585","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3892\/or_00001026","article-title":"Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA\/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity","volume":"24","author":"Yamanegi","year":"2010","journal-title":"Oncol Rep"},{"key":"key20180107215628_b17-or-28-05-1585","first-page":"1069","article-title":"Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression","volume":"40","author":"Cho","year":"2007","journal-title":"J Biochem Mol Biol"},{"key":"key20180107215628_b18-or-28-05-1585","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1756-9966-28-105","article-title":"Risedronate inhibits human osteosarcoma cell invasion","volume":"28","author":"Xin","year":"2009","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180107215628_b19-or-28-05-1585","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11010-010-0510-x","article-title":"Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer","volume":"343","author":"Lee","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"key20180107215628_b20-or-28-05-1585","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.surg.2010.10.007","article-title":"Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors","volume":"149","author":"Mitmarker","year":"2011","journal-title":"Surgery"},{"key":"key20180107215628_b21-or-28-05-1585","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cbi.2006.12.012","article-title":"Depsipeptide a histone deacetylase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549)","volume":"165","author":"Vinodhkumar","year":"2007","journal-title":"Chem Biol Interact"},{"key":"key20180107215628_b22-or-28-05-1585","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1158\/0008-5472.CAN-07-6768","article-title":"Tumor-associated MICA is shed by ADAM proteases","volume":"68","author":"Waldhauer","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107215628_b23-or-28-05-1585","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.0903789","article-title":"The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of a disintegrin and metalloproteinases","volume":"184","author":"Liu","year":"2010","journal-title":"J Immunol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2012.1981\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:56:38Z","timestamp":1515362198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2012.1981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,22]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,8,22]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.3892\/or.2012.1981"],"URL":"https:\/\/doi.org\/10.3892\/or.2012.1981","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,22]]}}}