{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:06:38Z","timestamp":1761217598985},"reference-count":41,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.3892\/or.2013.2353","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T09:25:57Z","timestamp":1363771557000},"page":"2318-2324","source":"Crossref","is-referenced-by-count":24,"title":["Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells"],"prefix":"10.3892","volume":"29","author":[{"given":"JUNG-IL","family":"CHAE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOUNG-JOO","family":"JEON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUNG-HYUN","family":"SHIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"key20180107215132_b1-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1378\/chest.125.3.1103","article-title":"Asbestos and the pleura: a review","volume":"125","author":"Cugell","year":"2004","journal-title":"Chest"},{"key":"key20180107215132_b2-or-29-06-2318","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1200\/JCO.2008.19.8523","article-title":"Malignant pleural mesothelioma","volume":"27","author":"Tsao","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180107215132_b3-or-29-06-2318","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1165\/ajrcmb.17.6.f141","article-title":"Asbestos, the mesothelial cell and malignancy: a matter of life or death","volume":"17","author":"Broaddus","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180107215132_b4-or-29-06-2318","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2486\/indhealth.39.65","article-title":"Asbestos-related lung cancer and mesothelioma in Japan","volume":"39","author":"Morinaga","year":"2001","journal-title":"Ind Health"},{"key":"key20180107215132_b5-or-29-06-2318","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1164\/ajrccm.153.2.8564122","article-title":"Mineral fiber content of lungs in patients with mesothelioma seeking compensation in Quebec","volume":"153","author":"Dufresne","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"key20180107215132_b6-or-29-06-2318","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/sonc.2002.30237","article-title":"The epidemiology of mesothelioma","volume":"29","author":"Britton","year":"2002","journal-title":"Semin Oncol"},{"key":"key20180107215132_b7-or-29-06-2318","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s11912-002-0012-4","article-title":"Current surgical management of malignant pleural mesothelioma","volume":"4","author":"Zellos","year":"2002","journal-title":"Curr Oncol Rep"},{"key":"key20180107215132_b8-or-29-06-2318","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-010-9235-2","article-title":"Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals","volume":"29","author":"Gupta","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"key20180107215132_b9-or-29-06-2318","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2003.08.026","article-title":"Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production","volume":"992","author":"Liou","year":"2003","journal-title":"Brain Res"},{"key":"key20180107215132_b10-or-29-06-2318","doi-asserted-by":"crossref","first-page":"35501","DOI":"10.1074\/jbc.M302967200","article-title":"Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo","volume":"278","author":"Bai","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180107215132_b11-or-29-06-2318","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.3748\/wjg.v10.i23.3459","article-title":"Honokiol: a potent chemotherapy candidate for human colorectal carcinoma","volume":"10","author":"Chen","year":"2004","journal-title":"World J Gastroenterol"},{"key":"key20180107215132_b12-or-29-06-2318","first-page":"1529","article-title":"Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest","volume":"30","author":"Wolf","year":"2007","journal-title":"Int J Oncol"},{"key":"key20180107215132_b13-or-29-06-2318","doi-asserted-by":"crossref","first-page":"e1096","DOI":"10.1371\/journal.pone.0001096","article-title":"Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth","volume":"2","author":"Sheu","year":"2007","journal-title":"PLoS One"},{"key":"key20180107215132_b14-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1182\/blood-2005-01-0346","article-title":"Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis","volume":"106","author":"Ishitsuka","year":"2005","journal-title":"Blood"},{"key":"key20180107215132_b15-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0006-2952(02)00894-8","article-title":"Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells","volume":"63","author":"Yang","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"key20180107215132_b16-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/cncr.22551","article-title":"Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells","volume":"109","author":"Shigemura","year":"2007","journal-title":"Cancer"},{"key":"key20180107215132_b17-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2005.01.013","article-title":"Sp1: regulation of gene expression by phosphorylation","volume":"348","author":"Chu","year":"2005","journal-title":"Gene"},{"key":"key20180107215132_b18-or-29-06-2318","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1038\/sj.onc.1209696","article-title":"Overexpression of Sp1 transcription factor induces apoptosis","volume":"25","author":"Deniaud","year":"2006","journal-title":"Oncogene"},{"key":"key20180107215132_b19-or-29-06-2318","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.aanat.2010.07.010","article-title":"The role of Sp1 and Sp3 in normal and cancer cell biology","volume":"192","author":"Li","year":"2010","journal-title":"Ann Anat"},{"key":"key20180107215132_b20-or-29-06-2318","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2174\/157340611796799203","article-title":"Targeting Sp1 transcription factors in prostate cancer therapy","volume":"7","author":"Sankpal","year":"2011","journal-title":"Med Chem"},{"key":"key20180107215132_b21-or-29-06-2318","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.yexcr.2010.04.027","article-title":"Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth","volume":"316","author":"Jutooru","year":"2010","journal-title":"Exp Cell Res"},{"key":"key20180107215132_b22-or-29-06-2318","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrc723","article-title":"Natural products in cancer chemotherapy: past, present and future","volume":"2","author":"Mann","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107215132_b23-or-29-06-2318","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2008.11.029","article-title":"Down-regulation of c-Src\/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells","volume":"277","author":"Park","year":"2009","journal-title":"Cancer Lett"},{"key":"key20180107215132_b24-or-29-06-2318","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.3748\/wjg.v10.i15.2205","article-title":"Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO","volume":"10","author":"Wang","year":"2004","journal-title":"World J Gastroenterol"},{"key":"key20180107215132_b25-or-29-06-2318","doi-asserted-by":"crossref","first-page":"e21573","DOI":"10.1371\/journal.pone.0021573","article-title":"Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells","volume":"6","author":"Arora","year":"2011","journal-title":"PLoS One"},{"key":"key20180107215132_b26-or-29-06-2318","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbagen.2012.03.009","article-title":"Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia","volume":"1820","author":"Ishikawa","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key20180107215132_b27-or-29-06-2318","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/jcp.22954","article-title":"Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1","volume":"227","author":"Rajendran","year":"2012","journal-title":"J Cell Physiol"},{"key":"key20180107215132_b28-or-29-06-2318","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/154065804322966315","article-title":"Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays","volume":"2","author":"Riss","year":"2004","journal-title":"Assay Drug Dev Technol"},{"key":"key20180107215132_b29-or-29-06-2318","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2012.04.110","article-title":"Screening of anti-cancer agent using zebrafish: comparison with the MTT assay","volume":"422","author":"Li","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107215132_b30-or-29-06-2318","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2407-2-35","article-title":"Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?","volume":"2","author":"Chiefari","year":"2002","journal-title":"BMC Cancer"},{"key":"key20180107215132_b31-or-29-06-2318","first-page":"461","article-title":"Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer","volume":"25","author":"Hosoi","year":"2004","journal-title":"Int J Oncol"},{"key":"key20180107215132_b32-or-29-06-2318","first-page":"6371","article-title":"Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer","volume":"9","author":"Wang","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20180107215132_b33-or-29-06-2318","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1158\/1078-0432.CCR-03-0628","article-title":"Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer","volume":"10","author":"Yao","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180107215132_b34-or-29-06-2318","first-page":"1546","article-title":"Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma","volume":"60","author":"Zannetti","year":"2000","journal-title":"Cancer Res"},{"key":"key20180107215132_b35-or-29-06-2318","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.advenzreg.2007.11.016","article-title":"Nuclear organization and chromatin dynamics - Sp1, Sp3 and histone deacetylases","volume":"48","author":"Davie","year":"2008","journal-title":"Adv Enzyme Regul"},{"key":"key20180107215132_b36-or-29-06-2318","first-page":"21","article-title":"The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1","volume":"30","author":"Lee","year":"2012","journal-title":"Int J Mol Med"},{"key":"key20180107215132_b37-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4161\/cc.10.8.15326","article-title":"HIF-1\u03b1 depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs","volume":"10","author":"Culver","year":"2011","journal-title":"Cell Cycle"},{"key":"key20180107215132_b38-or-29-06-2318","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1172\/JCI115474","article-title":"Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo","volume":"88","author":"Blume","year":"1991","journal-title":"J Clin Invest"},{"key":"key20180107215132_b39-or-29-06-2318","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2407-11-371","article-title":"Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors","volume":"11","author":"Chintharlapalli","year":"2011","journal-title":"BMC Cancer"},{"key":"key20180107215132_b40-or-29-06-2318","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/BC.2008.039","article-title":"p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter","volume":"389","author":"Pietrzak","year":"2008","journal-title":"Biol Chem"},{"key":"key20180107215132_b41-or-29-06-2318","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.4161\/cc.7.18.6671","article-title":"Regulation of Sp1 by cell cycle-related proteins","volume":"7","author":"Tapias","year":"2008","journal-title":"Cell Cycle"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2013.2353\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:51:44Z","timestamp":1515361904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2013.2353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,20]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,3,20]]},"published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.3892\/or.2013.2353"],"URL":"https:\/\/doi.org\/10.3892\/or.2013.2353","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,20]]}}}