{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:22:35Z","timestamp":1788481355436,"version":"build-2803163510"},"reference-count":44,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.3892\/or.2013.2429","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T05:20:17Z","timestamp":1366953617000},"page":"313-319","source":"Crossref","is-referenced-by-count":16,"title":["Overexpression of Numb suppresses tumor cell growth and enhances sensitivity to cisplatin in epithelioid malignant pleural mesothelioma"],"prefix":"10.3892","volume":"30","author":[{"given":"YANMENG","family":"KANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MINGJIE","family":"DING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUANGYAN","family":"TIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAISHENG","family":"GUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUNYAN","family":"WAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHOUHONG","family":"YAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BIN","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANJIE","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"key20180109222835_b1-or-30-01-0313","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.bjc.6690105","article-title":"The European mesothelioma epidemic","volume":"79","author":"Peto","year":"1999","journal-title":"Br J Cancer"},{"key":"key20180109222835_b2-or-30-01-0313","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2486\/indhealth.45.379","article-title":"Malignant mesothelioma: global incidence and relationship with asbestos","volume":"45","author":"Bianchi","year":"2007","journal-title":"Ind Health"},{"key":"key20180109222835_b3-or-30-01-0313","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","volume":"366","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"key20180109222835_b4-or-30-01-0313","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature03100","article-title":"Tissue repair and stem cell renewal in carcinogenesis","volume":"432","author":"Beachy","year":"2004","journal-title":"Nature"},{"key":"key20180109222835_b5-or-30-01-0313","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0092-8674(89)90849-0","article-title":"numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos","volume":"58","author":"Uemura","year":"1989","journal-title":"Cell"},{"key":"key20180109222835_b6-or-30-01-0313","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0092-8674(94)90112-0","article-title":"Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells","volume":"76","author":"Rhyu","year":"1994","journal-title":"Cell"},{"key":"key20180109222835_b7-or-30-01-0313","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cell.2008.01.038","article-title":"Stem cells and niches: mechanisms that promote stem cell maintenance throughout life","volume":"132","author":"Morrison","year":"2008","journal-title":"Cell"},{"key":"key20180109222835_b8-or-30-01-0313","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nn1924","article-title":"Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors","volume":"10","author":"Ra\u0161in","year":"2007","journal-title":"Nat Neurosci"},{"key":"key20180109222835_b9-or-30-01-0313","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.devcel.2007.05.003","article-title":"Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3","volume":"13","author":"Nishimura","year":"2007","journal-title":"Dev Cell"},{"key":"key20180109222835_b10-or-30-01-0313","doi-asserted-by":"crossref","first-page":"23196","DOI":"10.1074\/jbc.M302827200","article-title":"Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain","volume":"278","author":"McGill","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180109222835_b11-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/ncb1510","article-title":"Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination","volume":"8","author":"Di Marcotullio","year":"2006","journal-title":"Nat Cell Biol"},{"key":"key20180109222835_b12-or-30-01-0313","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature06412","article-title":"NUMB controls p53 tumour suppressor activity","volume":"451","author":"Colaluca","year":"2008","journal-title":"Nature"},{"key":"key20180109222835_b13-or-30-01-0313","first-page":"26","article-title":"NUMB-ing down cancer by more than just a NOTCH","volume":"1815","author":"Pece","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key20180109222835_b14-or-30-01-0313","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1038\/onc.2010.215","article-title":"EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer","volume":"29","author":"Singh","year":"2010","journal-title":"Oncogene"},{"key":"key20180109222835_b15-or-30-01-0313","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"key20180109222835_b16-or-30-01-0313","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1111\/j.1600-0854.2008.00816.x","article-title":"Endocytosis and cancer: an \u2018insider\u2019 network with dangerous liaisons","volume":"9","author":"Lanzetti","year":"2008","journal-title":"Traffic"},{"key":"key20180109222835_b17-or-30-01-0313","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molonc.2009.05.005","article-title":"At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression","volume":"3","author":"Vaccari","year":"2009","journal-title":"Mol Oncol"},{"key":"key20180109222835_b18-or-30-01-0313","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.devcel.2007.10.007","article-title":"The PAR proteins: fundamental players in animal cell polarization","volume":"13","author":"Goldstein","year":"2007","journal-title":"Dev Cell"},{"key":"key20180109222835_b19-or-30-01-0313","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.1038\/onc.2008.340","article-title":"Par complex in cancer: a regulator of normal cell polarity joins the dark side","volume":"27","author":"Aranda","year":"2008","journal-title":"Oncogene"},{"key":"key20180109222835_b20-or-30-01-0313","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1083\/jcb.200406140","article-title":"Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis","volume":"167","author":"Pece","year":"2004","journal-title":"J Cell Biol"},{"key":"key20180109222835_b21-or-30-01-0313","doi-asserted-by":"crossref","first-page":"22293","DOI":"10.1073\/pnas.0907781106","article-title":"Alterations of the Notch pathway in lung cancer","volume":"106","author":"Westhoff","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180109222835_b22-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/ng1632","article-title":"Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster","volume":"37","author":"Caussinus","year":"2005","journal-title":"Nat Genet"},{"key":"key20180109222835_b23-or-30-01-0313","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccr.2009.08.015","article-title":"Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model","volume":"16","author":"Bric","year":"2009","journal-title":"Cancer Cell"},{"key":"key20180109222835_b24-or-30-01-0313","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/039463200702000414","article-title":"Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas","volume":"20","author":"Maiorano","year":"2007","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20180109222835_b25-or-30-01-0313","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2004.11.008","article-title":"Medulloblastoma: developmental mechanisms out of control","volume":"11","author":"Marino","year":"2005","journal-title":"Trends Mol Med"},{"key":"key20180109222835_b26-or-30-01-0313","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1440-1789.2008.00907.x","article-title":"Characterization of Numb expression in astrocytomas","volume":"28","author":"Yan","year":"2008","journal-title":"Neuropathology"},{"key":"key20180109222835_b27-or-30-01-0313","article-title":"Pathology & Genetics","volume-title":"Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis","year":"2004"},{"key":"key20180109222835_b28-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/labinvest.3780328","article-title":"Ki-67-Mcm6, a new MoAb specific to Mcm6: comparison of the distribution profile of Mcm6 and Ki-67 antigen","volume":"81","author":"Heidebrecht","year":"2008","journal-title":"Lab Invest"},{"key":"key20180109222835_b29-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"key20180109222835_b30-or-30-01-0313","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.humpath.2006.12.013","article-title":"Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma","volume":"38","author":"Kleinberg","year":"2007","journal-title":"Hum Pathol"},{"key":"key20180109222835_b31-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/modpathol.3800478","article-title":"Immunocytochemical detection of XIAP in body cavity effusions and washes","volume":"18","author":"Wu","year":"2005","journal-title":"Mod Pathol"},{"key":"key20180109222835_b32-or-30-01-0313","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/path.2121","article-title":"Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma","volume":"211","author":"Gordon","year":"2007","journal-title":"J Pathol"},{"key":"key20180109222835_b33-or-30-01-0313","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/path.2120","article-title":"Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-\u03b1 in malignant pleural mesothelioma","volume":"211","author":"Gordon","year":"2007","journal-title":"J Pathol"},{"key":"key20180109222835_b34-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00432-011-1030-0","article-title":"BIRC5 promoter SNPs do not affect nuclear survivin expression and survival of malignant pleural mesothelioma patients","volume":"137","author":"Hmeljak","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180109222835_b35-or-30-01-0313","first-page":"5315","article-title":"IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs","volume":"58","author":"Tamm","year":"1998","journal-title":"Cancer Res"},{"key":"key20180109222835_b36-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1073\/pnas.96.4.1457","article-title":"Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation","volume":"96","author":"Kobayashi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180109222835_b37-or-30-01-0313","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ijrobp.2006.12.018","article-title":"Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests","volume":"67","author":"Kim","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180109222835_b38-or-30-01-0313","first-page":"687","article-title":"Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides","volume":"1","author":"Xia","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"key20180109222835_b39-or-30-01-0313","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ctrv.2006.09.006","article-title":"Molecular mechanisms of resistance and toxicity associated with platinating agents","volume":"33","author":"Rabik","year":"2007","journal-title":"Cancer Treat Rev"},{"key":"key20180109222835_b40-or-30-01-0313","first-page":"663","article-title":"Cisplatin and platinum drugs at the molecular level (Review)","volume":"10","author":"Boulikas","year":"2003","journal-title":"Oncol Rep"},{"key":"key20180109222835_b41-or-30-01-0313","first-page":"1229","article-title":"Defects in apoptotic signal transduction in cisplatin-resistant non-small cell lung cancer cells","volume":"13","author":"Ikuta","year":"2005","journal-title":"Oncol Rep"},{"key":"key20180109222835_b42-or-30-01-0313","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/ijc.11585","article-title":"Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo","volume":"108","author":"Okouoyo","year":"2003","journal-title":"Int J Cancer"},{"key":"key20180109222835_b43-or-30-01-0313","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00432-004-0556-9","article-title":"Resistance to chemotherapy-induced apoptosis via decreased caspase-3 activity and overexpression of antiapoptotic proteins in ovarian cancer","volume":"130","author":"Yang","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180109222835_b44-or-30-01-0313","first-page":"513","article-title":"Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer","volume":"63","author":"Mueller","year":"2003","journal-title":"Cancer Res"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2013.2429\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T19:07:13Z","timestamp":1515524833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2013.2429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,4,26]]},"published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.3892\/or.2013.2429"],"URL":"https:\/\/doi.org\/10.3892\/or.2013.2429","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]}}}