{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:31:04Z","timestamp":1791099064972,"version":"4.1.0"},"reference-count":29,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.3892\/or.2013.2652","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T04:57:40Z","timestamp":1375419460000},"page":"1906-1912","source":"Crossref","is-referenced-by-count":22,"title":["Exome capture sequencing reveals new insights into hepatitis B virus-induced hepatocellular carcinoma at the early stage of tumorigenesis"],"prefix":"10.3892","volume":"30","author":[{"given":"YONG","family":"CHEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIJUAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HEXIANG","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XINGXIANG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YINGREN","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,8,2]]},"reference":[{"key":"key20180107223320_b1-or-30-04-1906","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","volume":"132","author":"El-Serag","year":"2007","journal-title":"Gastroenterology"},{"key":"key20180107223320_b2-or-30-04-1906","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180107223320_b3-or-30-04-1906","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","article-title":"The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide","volume":"45","author":"Perz","year":"2006","journal-title":"J Hepatol"},{"key":"key20180107223320_b4-or-30-04-1906","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000218339","article-title":"Hepatocellular carcinoma - epidemiological trends and risk factors","volume":"27","author":"Sch\u00fctte","year":"2009","journal-title":"Dig Dis"},{"key":"key20180107223320_b5-or-30-04-1906","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1204040","article-title":"Exploring the genomes of cancer cells: progress and promise","volume":"331","author":"Stratton","year":"2011","journal-title":"Science"},{"key":"key20180107223320_b6-or-30-04-1906","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nature07943","article-title":"The cancer genome","volume":"458","author":"Stratton","year":"2009","journal-title":"Nature"},{"key":"key20180107223320_b7-or-30-04-1906","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrg2841","article-title":"Advances in understanding cancer genomes through second-generation sequencing","volume":"11","author":"Meyerson","year":"2010","journal-title":"Nat Rev Genet"},{"key":"key20180107223320_b8-or-30-04-1906","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ng.2295","article-title":"Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma","volume":"44","author":"Sung","year":"2012","journal-title":"Nat Genet"},{"key":"key20180107223320_b9-or-30-04-1906","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/ng.903","article-title":"Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma","volume":"43","author":"Li","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107223320_b10-or-30-04-1906","doi-asserted-by":"crossref","first-page":"12042","DOI":"10.1073\/pnas.1108715108","article-title":"Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data","volume":"108","author":"Tao","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107223320_b11-or-30-04-1906","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ng.804","article-title":"High-resolution characterization of a hepatocellular carcinoma genome","volume":"43","author":"Totoki","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107223320_b12-or-30-04-1906","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"key20180107223320_b13-or-30-04-1906","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"key20180107223320_b14-or-30-04-1906","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1101\/gr.129684.111","article-title":"VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Res"},{"key":"key20180107223320_b15-or-30-04-1906","doi-asserted-by":"crossref","first-page":"e46688","DOI":"10.1371\/journal.pone.0046688","article-title":"Predicting the functional effect of amino acid substitutions and indels","volume":"7","author":"Choi","year":"2012","journal-title":"PLoS One"},{"key":"key20180107223320_b16-or-30-04-1906","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: predicting amino acid changes that affect protein function","volume":"31","author":"Ng","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key20180107223320_b17-or-30-04-1906","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/sj.onc.1210279","article-title":"TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer","volume":"26","author":"Hussain","year":"2007","journal-title":"Oncogene"},{"key":"key20180107223320_b18-or-30-04-1906","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-0030-1247134","article-title":"Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma","volume":"30","author":"Imbeaud","year":"2010","journal-title":"Semin Liver Dis"},{"key":"key20180107223320_b19-or-30-04-1906","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/humu.10176","article-title":"TP53 and liver carcinogenesis","volume":"21","author":"Staib","year":"2003","journal-title":"Hum Mutat"},{"key":"key20180107223320_b20-or-30-04-1906","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1478-3231.2003.00869.x","article-title":"Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis","volume":"23","author":"Kew","year":"2003","journal-title":"Liver Int"},{"key":"key20180107223320_b21-or-30-04-1906","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20180107223320_b22-or-30-04-1906","first-page":"1635","article-title":"p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China","volume":"52","author":"Scorsone","year":"1992","journal-title":"Cancer Res"},{"key":"key20180107223320_b23-or-30-04-1906","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/350429a0","article-title":"Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa","volume":"350","author":"Bressac","year":"1991","journal-title":"Nature"},{"key":"key20180107223320_b24-or-30-04-1906","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/carcin\/bgq118","article-title":"Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein","volume":"31","author":"Gouas","year":"2010","journal-title":"Carcinogenesis"},{"key":"key20180107223320_b25-or-30-04-1906","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1469-1809.2002.00121.x","article-title":"Multifunctional zinc finger proteins in development and disease","volume":"66","author":"Ladomery","year":"2002","journal-title":"Ann Hum Genet"},{"key":"key20180107223320_b26-or-30-04-1906","first-page":"891","article-title":"Transcription factors: structure, function, and implication in malignant growth","volume":"15","author":"Papavassiliou","year":"1995","journal-title":"Anticancer Res"},{"key":"key20180107223320_b27-or-30-04-1906","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1038\/sj.onc.1203178","article-title":"Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: evidence for increased tumor cell apoptosis in vivo","volume":"18","author":"Hans","year":"1999","journal-title":"Oncogene"},{"key":"key20180107223320_b28-or-30-04-1906","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000327946","article-title":"FLNA and PGK1 are two potential markers for progression in hepatocellular carcinoma","volume":"27","author":"Ai","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"key20180107223320_b29-or-30-04-1906","doi-asserted-by":"crossref","first-page":"11476","DOI":"10.1158\/0008-5472.CAN-07-1653","article-title":"Adaptation versus selection: the origins of metastatic behavior","volume":"67","author":"Scheel","year":"2007","journal-title":"Cancer Res"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2013.2652\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T17:42:30Z","timestamp":1515346950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2013.2652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,2]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,8,2]]},"published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.3892\/or.2013.2652"],"URL":"https:\/\/doi.org\/10.3892\/or.2013.2652","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,2]]}}}