{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:54:15Z","timestamp":1769925255213,"version":"3.49.0"},"reference-count":38,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.3892\/or.2013.2853","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T11:23:21Z","timestamp":1384428201000},"page":"145-152","source":"Crossref","is-referenced-by-count":46,"title":["Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study"],"prefix":"10.3892","volume":"31","author":[{"given":"SHUAI","family":"LI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHIYANG","family":"HAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONG","family":"MA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUIPENG","family":"SONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIEMIN","family":"PEI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TONGSEN","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIABEI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DONGSHENG","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIANG","family":"FANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONGCHI","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIANXIN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"key20180107222941_b1-or-31-01-0145","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.1711390210","article-title":"Pathological aspects of cholangiocarcinoma","volume":"139","author":"Weinbren","year":"1983","journal-title":"J Pathol"},{"key":"key20180107222941_b2-or-31-01-0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ncpgasthep0389","article-title":"Cholangiocarcinoma","volume":"3","author":"Patel","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"key20180107222941_b3-or-31-01-0145","first-page":"711","article-title":"Tumors and tumor-like lesions of the liver and the biliary tract: aetiology, epidemiology and pathology","volume-title":"Pathology of the Liver","author":"Burt","year":"2002"},{"key":"key20180107222941_b4-or-31-01-0145","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/gut.48.6.816","article-title":"Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968\u20131998","volume":"48","author":"Taylor-Robinson","year":"2001","journal-title":"Gut"},{"key":"key20180107222941_b5-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1136\/gutjnl-2011-301748","article-title":"Guidelines for the diagnosis and treatment of cholangiocarcinoma","volume":"61","author":"Khan","year":"2012","journal-title":"Gut"},{"key":"key20180107222941_b6-or-31-01-0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-2007-1007302","article-title":"Recent advances in the management of cholangiocarcinomas","volume":"14","author":"Vauthey","year":"1994","journal-title":"Semin Liver Dis"},{"key":"key20180107222941_b7-or-31-01-0145","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hep.22310","article-title":"Cholangiocarcinoma: advances in pathogenesis, diagnosis and treatment","volume":"48","author":"Blechacz","year":"2008","journal-title":"Hepatology"},{"key":"key20180107222941_b8-or-31-01-0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-2004-828895","article-title":"Surgical management of cholangio- carcinoma","volume":"24","author":"Jarnagin","year":"2004","journal-title":"Semin Liver Dis"},{"key":"key20180107222941_b9-or-31-01-0145","first-page":"278","article-title":"Surgical therapy for hiliarcholangiocarcinoma: analysis of 198 cases","volume":"5","author":"Zhang","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"key20180107222941_b10-or-31-01-0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4254\/wjh.v2.i2.58","article-title":"Surgery and chemotherapy for intrahepatic cholangiocarcinoma","volume":"2","author":"Morise","year":"2010","journal-title":"World J Hepatol"},{"key":"key20180107222941_b11-or-31-01-0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S1072-7515(98)00207-5","article-title":"Treatment of hilar cholangiocarcinoma (Klatskin tumors) with hepatic resection or transplantation","volume":"187","author":"Iwatsuki","year":"1998","journal-title":"J Am Coll Surg"},{"key":"key20180107222941_b12-or-31-01-0145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/hep.20537","article-title":"Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy","volume":"41","author":"Sirica","year":"2005","journal-title":"Hepatology"},{"key":"key20180107222941_b13-or-31-01-0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1634\/theoncologist.9-1-43","article-title":"Diagnosis and treatment of cholangiocarcinoma","volume":"9","author":"Anderson","year":"2004","journal-title":"Oncologist"},{"key":"key20180107222941_b14-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.bcp.2006.02.009","article-title":"Molecular targets of dietary agents for prevention and therapy of cancer","volume":"71","author":"Aggarwal","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"key20180107222941_b15-or-31-01-0145","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bcp.2007.02.014","article-title":"Ins and outs of dietary phytochemicals in cancer chemoprevention","volume":"74","author":"Russo","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"key20180107222941_b16-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2174\/092986708784221403","article-title":"Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials","volume":"15","author":"Naithani","year":"2008","journal-title":"Curr Med Chem"},{"key":"key20180107222941_b17-or-31-01-0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jnutbio.2007.11.003","article-title":"The role of herbs and spices in cancer prevention","volume":"19","author":"Kaefer","year":"2008","journal-title":"J Nutr Biochem"},{"key":"key20180107222941_b18-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1017\/S1368980007668530","article-title":"Importance of functional foods in the Mediterranean diet","volume":"9","author":"Ortega","year":"2006","journal-title":"Public Health Nutr"},{"key":"key20180107222941_b19-or-31-01-0145","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gut.46.2.191","article-title":"Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E2 synthesis","volume":"46","author":"Bartoli","year":"2000","journal-title":"Gut"},{"key":"key20180107222941_b20-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0959-8049(00)00103-9","article-title":"The anti-oxidant\/anticancer potential of phenolic compounds isolated from olive oil","volume":"36","author":"Owen","year":"2000","journal-title":"Eur J Cancer"},{"key":"key20180107222941_b21-or-31-01-0145","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1753-4887.2010.00278.x","article-title":"Hydroxytyrosol: from laboratory investigations to future clinical trials","volume":"68","author":"Granados-Principal","year":"2010","journal-title":"Nutr Rev"},{"key":"key20180107222941_b22-or-31-01-0145","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/bbrc.2000.3875","article-title":"Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis","volume":"278","author":"Ragione","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107222941_b23-or-31-01-0145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00008469-200208000-00006","article-title":"Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis","volume":"11","author":"Fabiani","year":"2002","journal-title":"Eur J Cancer Prev"},{"key":"key20180107222941_b24-or-31-01-0145","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.freeradbiomed.2004.12.015","article-title":"Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells","volume":"38","author":"D\u2019Angelo","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20180107222941_b25-or-31-01-0145","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10616-009-9191-2","article-title":"Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells","volume":"59","author":"Han","year":"2009","journal-title":"Cytotechnology"},{"key":"key20180107222941_b26-or-31-01-0145","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/mnfr.200800269","article-title":"Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1\/2 and cyclin D1","volume":"53","author":"Corona","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"key20180107222941_b27-or-31-01-0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1620\/tjem.177.61","article-title":"Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1","volume":"177","author":"Saijyo","year":"1995","journal-title":"Tohoku J Exp Med"},{"key":"key20180107222941_b28-or-31-01-0145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2009.10.011","article-title":"Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis","volume":"36","author":"Autret","year":"2009","journal-title":"Mol Cell"},{"key":"key20180107222941_b29-or-31-01-0145","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","article-title":"Caspases: killer proteases","volume":"22","author":"Nicholson","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"key20180107222941_b30-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"key20180107222941_b31-or-31-01-0145","first-page":"2922","article-title":"The expanding role of mitochondria in apoptosis","volume":"15","author":"Wang","year":"2001","journal-title":"Genes Dev"},{"key":"key20180107222941_b32-or-31-01-0145","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0898-6568(98)00023-0","article-title":"Regulation of proliferation, differentiation and survival by the IL-3\/IL-5\/GM-CSF receptor family","volume":"10","author":"de Groot","year":"1998","journal-title":"Cell Signal"},{"key":"key20180107222941_b33-or-31-01-0145","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.coph.2006.11.012","article-title":"Inhibitors of stress-activated protein\/mitogen activated protein kinase pathways","volume":"7","author":"Malemud","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"key20180107222941_b34-or-31-01-0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.cellbio.19.111401.091942","article-title":"Regulation of MAP kinase signaling modules by scaffold proteins in mammals","volume":"19","author":"Morrison","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"key20180107222941_b35-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2004.08.003","article-title":"Stress kinase signaling in cancer: fact or fiction?","volume":"217","author":"Rennefahrt","year":"2005","journal-title":"Cancer Lett"},{"key":"key20180107222941_b36-or-31-01-0145","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.bcp.2003.11.009","article-title":"Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway","volume":"67","author":"Prouillet","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"key20180107222941_b37-or-31-01-0145","first-page":"413","article-title":"Apigenin inhibits growth and induces G2\/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells","volume":"21","author":"Yin","year":"2001","journal-title":"Anticancer Res"},{"key":"key20180107222941_b38-or-31-01-0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-211-73574-9_9","article-title":"Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway","volume":"72","author":"Wruck","year":"2007","journal-title":"J Neural Transm (Suppl)"}],"updated-by":[{"DOI":"10.3892\/or.2025.8918","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"record-id":"69036"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2013.2853\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:39:11Z","timestamp":1515364751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2013.2853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,11,14]]},"published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.3892\/or.2013.2853"],"URL":"https:\/\/doi.org\/10.3892\/or.2013.2853","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}