{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:16:53Z","timestamp":1792023413390,"version":"4.4.0"},"reference-count":39,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.3892\/or.2014.3098","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T11:27:46Z","timestamp":1395228466000},"page":"2438-2446","source":"Crossref","is-referenced-by-count":33,"title":["Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia"],"prefix":"10.3892","volume":"31","author":[{"given":"YINGHUA","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUXIA","family":"PAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINGCI","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YINTAO","family":"SHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIANMIN","family":"LUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"key20180107222607_b1-or-31-05-2438","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","article-title":"Fused transcript of abl and bcr genes in chronic myelogenous leukaemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"key":"key20180107222607_b2-or-31-05-2438","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.3460176","article-title":"The chronic myelogenous leukemia-specific P210 protein is the product of the BCR\/ABL hybrid gene","volume":"233","author":"Ben-Neriah","year":"1986","journal-title":"Science"},{"key":"key20180107222607_b3-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2008-03-144790","article-title":"Molecular biology of bcr-abl1-positive chronic myeloid leukemia","volume":"113","author":"Quintas-Cardama","year":"2009","journal-title":"Blood"},{"key":"key20180107222607_b4-or-31-05-2438","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","article-title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013","volume":"122","author":"Baccarani","year":"2013","journal-title":"Blood"},{"key":"key20180107222607_b5-or-31-05-2438","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJM199909023411016","article-title":"Chronic myeloid leukemia","volume":"341","author":"Nash","year":"1999","journal-title":"N Engl J Med"},{"key":"key20180107222607_b6-or-31-05-2438","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J Clin Invest"},{"key":"key20180107222607_b7-or-31-05-2438","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s13238-010-0016-z","article-title":"Molecular and cellular bases of chronic myeloid leukemia","volume":"1","author":"Chen","year":"2010","journal-title":"Protein Cell"},{"key":"key20180107222607_b8-or-31-05-2438","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/156800911793743619","article-title":"Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - is it all BCR-ABL?","volume":"11","author":"Rumpold","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"key20180107222607_b9-or-31-05-2438","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.0510423103","article-title":"Gene expression changes associated with progression and response in chronic myeloid leukemia","volume":"103","author":"Radich","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107222607_b10-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1126\/science.8096088","article-title":"SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases","volume":"259","author":"Feng","year":"1993","journal-title":"Science"},{"key":"key20180107222607_b11-or-31-05-2438","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1600-065X.2008.00760.x","article-title":"SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels","volume":"228","author":"Lorenz","year":"2009","journal-title":"Immunol Rev"},{"key":"key20180107222607_b12-or-31-05-2438","first-page":"461","article-title":"Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic myelogenous leukemia","volume":"27","author":"Li","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180107222607_b13-or-31-05-2438","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.4049\/jimmunol.162.6.3220","article-title":"Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1","volume":"162","author":"Dong","year":"1999","journal-title":"J Immunol"},{"key":"key20180107222607_b14-or-31-05-2438","first-page":"122","article-title":"Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice","volume":"25","author":"Tapley","year":"1997","journal-title":"Exp Hematol"},{"key":"key20180107222607_b15-or-31-05-2438","first-page":"6390","article-title":"Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias\/lymphomas","volume":"62","author":"Oka","year":"2002","journal-title":"Cancer Res"},{"key":"key20180107222607_b16-or-31-05-2438","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1182\/blood-2003-06-2007","article-title":"SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak\/STAT pathway","volume":"103","author":"Chim","year":"2004","journal-title":"Blood"},{"key":"key20180107222607_b17-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0002-9440(10)64629-9","article-title":"Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter","volume":"157","author":"Zhang","year":"2000","journal-title":"Am J Pathol"},{"key":"key20180107222607_b18-or-31-05-2438","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1182\/blood-2011-03-341073","article-title":"SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia","volume":"118","author":"Esposito","year":"2011","journal-title":"Blood"},{"key":"key20180107222607_b19-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/sj.leu.2402214","article-title":"Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation","volume":"15","author":"Bruecher-Encke","year":"2001","journal-title":"Leukemia"},{"key":"key20180107222607_b20-or-31-05-2438","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1073\/pnas.93.14.6898","article-title":"The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1","volume":"93","author":"Kharbanda","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107222607_b21-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.leu.2404189","article-title":"BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry","volume":"20","author":"Hamilton","year":"2006","journal-title":"Leukemia"},{"key":"key20180107222607_b22-or-31-05-2438","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2141.2009.08066.x","article-title":"BCR-ABL1 tyrosine kinase activity at diagnosis, as determined via the pCrkL\/CrkL ratio, is predictive of clinical outcome in chronic myeloid leukaemia","volume":"149","author":"Lucas","year":"2010","journal-title":"Br J Haematol"},{"key":"key20180107222607_b23-or-31-05-2438","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"key20180107222607_b24-or-31-05-2438","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/bmt.2011.194","article-title":"Prognostic factors for outcomes in allogeneic transplantation for CML in the imatinib era: a CIBMTR analysis","volume":"47","author":"Khoury","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"key20180107222607_b25-or-31-05-2438","first-page":"1251","article-title":"The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury","volume":"22","author":"Chong","year":"2007","journal-title":"Histol Histopathol"},{"key":"key20180107222607_b26-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J Cell Sci"},{"key":"key20180107222607_b27-or-31-05-2438","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1182\/blood-2009-10-248211","article-title":"High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia","volume":"117","author":"Warsch","year":"2011","journal-title":"Blood"},{"key":"key20180107222607_b28-or-31-05-2438","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1038\/sj.onc.1204834","article-title":"Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation","volume":"20","author":"Xie","year":"2001","journal-title":"Oncogene"},{"key":"key20180107222607_b29-or-31-05-2438","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1158\/0008-5472.CAN-06-0025","article-title":"Janus kinase 2: a critical target in chronic myelogenous leukemia","volume":"66","author":"Samanta","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107222607_b30-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/onc.2009.7","article-title":"Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients","volume":"28","author":"Samanta","year":"2009","journal-title":"Oncogene"},{"key":"key20180107222607_b31-or-31-05-2438","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/leu.2010.287","article-title":"Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia","volume":"25","author":"Samanta","year":"2011","journal-title":"Leukemia"},{"key":"key20180107222607_b32-or-31-05-2438","first-page":"128","article-title":"Mutation analysis of hematopoietic cell phosphatase gene in acute leukemia","volume":"12","author":"Luo","year":"2004","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"key20180107222607_b33-or-31-05-2438","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/path.2178","article-title":"Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shp1) is associated with progression of chronic myeloid leukaemia","volume":"212","author":"Amin","year":"2007","journal-title":"J Pathol"},{"key":"key20180107222607_b34-or-31-05-2438","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/jcp.2006.036715","article-title":"Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma","volume":"60","author":"Chim","year":"2007","journal-title":"J Clin Pathol"},{"key":"key20180107222607_b35-or-31-05-2438","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1073\/pnas.0501959102","article-title":"STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107222607_b36-or-31-05-2438","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood-2006-04-017434","article-title":"Loss of SHP1 enhances JAK3\/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma","volume":"108","author":"Han","year":"2006","journal-title":"Blood"},{"key":"key20180107222607_b37-or-31-05-2438","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccr.2005.10.015","article-title":"The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR\/ABL-regulated SET protein","volume":"8","author":"Neviani","year":"2005","journal-title":"Cancer Cell"},{"key":"key20180107222607_b38-or-31-05-2438","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00400-1","article-title":"The function of the protein tyrosine phosphatase SHP-1 in cancer","volume":"306","author":"Wu","year":"2003","journal-title":"Gene"},{"key":"key20180107222607_b39-or-31-05-2438","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1182\/asheducation-2007.1.384","article-title":"The biology of CML blast crisis","volume":"2007","author":"Radich","year":"2007","journal-title":"Hematology"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2014.3098\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T09:09:42Z","timestamp":1689066582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2014.3098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,19]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,3,19]]},"published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.3892\/or.2014.3098"],"URL":"https:\/\/doi.org\/10.3892\/or.2014.3098","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,19]]}}}