{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T21:16:03Z","timestamp":1781385363250,"version":"3.54.1"},"reference-count":25,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.3892\/or.2014.3531","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T08:34:27Z","timestamp":1412584467000},"page":"2735-2743","source":"Crossref","is-referenced-by-count":23,"title":["Mitotic rate is a more reliable unfavorable prognosticator than ulceration for early cutaneous melanoma: A 5-year survival analysis"],"prefix":"10.3892","volume":"32","author":[{"given":"PIOTR","family":"DONIZY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MACIEJ","family":"KACZOROWSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAREK","family":"LESKIEWICZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCIN","family":"ZIETEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MALGORZATA","family":"PIENIAZEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CYPRIAN","family":"KOZYRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AGNIESZKA","family":"HALON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAFAL","family":"MATKOWSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"key20180107210443_b1-or-32-06-2735","article-title":"GLOBOCAN 2012 Cancer Incidence and Mortality Worldwide","volume-title":"IARC CancerBase V1.0","author":"Ferlay","year":"2013"},{"key":"key20180107210443_b2-or-32-06-2735","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanomas of the skin","volume":"29","author":"Clark","year":"1969","journal-title":"Cancer Res"},{"key":"key20180107210443_b3-or-32-06-2735","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000658-197011000-00017","article-title":"Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma","volume":"172","author":"Breslow","year":"1970","journal-title":"Ann Surg"},{"key":"key20180107210443_b4-or-32-06-2735","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000658-197812000-00004","article-title":"A multifactorial analysis of melanoma: prognostic histopathological features comparing Clark\u2019s and Breslow\u2019s staging methods","volume":"188","author":"Balch","year":"1978","journal-title":"Ann Surg"},{"key":"key20180107210443_b5-or-32-06-2735","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1200\/JCO.2001.19.16.3622","article-title":"Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b6-or-32-06-2735","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b7-or-32-06-2735","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1200\/JCO.2001.19.16.3635","article-title":"Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b8-or-32-06-2735","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1200\/JCO.2010.31.5812","article-title":"Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database","volume":"29","author":"Thompson","year":"2011","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b9-or-32-06-2735","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1245\/ASO.2005.04.027","article-title":"Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas","volume":"12","author":"Kesmodel","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"key20180107210443_b10-or-32-06-2735","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1200\/JCO.2009.27.1627","article-title":"Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases","volume":"28","author":"Balch","year":"2010","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b11-or-32-06-2735","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/cncr.11196","article-title":"Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma: an analysis of 3661 patients from a single center","volume":"97","author":"Azzola","year":"2003","journal-title":"Cancer"},{"key":"key20180107210443_b12-or-32-06-2735","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.0303-6987.2005.00310.x","article-title":"The importance of mitotic rate as a prognostic factor for localized cutaneous melanoma","volume":"32","author":"Barnhill","year":"2005","journal-title":"J Cutan Pathol"},{"key":"key20180107210443_b13-or-32-06-2735","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1245\/ASO.2004.07.014","article-title":"The prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-up","volume":"11","author":"Francken","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"key20180107210443_b14-or-32-06-2735","first-page":"87","article-title":"The biology of melanoma prognostic factors","volume":"10","author":"Spatz","year":"2010","journal-title":"Discov Med"},{"key":"key20180107210443_b15-or-32-06-2735","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/cncr.10326","article-title":"Prognostic factors in patients with thick cutaneous melanoma (>4 mm)","volume":"94","author":"Zettersten","year":"2002","journal-title":"Cancer"},{"key":"key20180107210443_b16-or-32-06-2735","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00008390-200506000-00005","article-title":"Prognostic factors in localized invasive cutaneous melanoma: high value of mitotic rate, vascular invasion and microscopic satellitosis","volume":"15","author":"Nagore","year":"2005","journal-title":"Melanoma Res"},{"key":"key20180107210443_b17-or-32-06-2735","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1245\/s10434-012-2265-y","article-title":"Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma","volume":"19","author":"Murali","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"key20180107210443_b18-or-32-06-2735","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1200\/JCO.2011.37.8539","article-title":"Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma","volume":"30","author":"Azimi","year":"2012","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b19-or-32-06-2735","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1200\/JCO.2013.50.1114","article-title":"Clinicopathologic predictors of sentinel lymph node metastasis in thin melanoma","volume":"31","author":"Han","year":"2013","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b20-or-32-06-2735","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1200\/JCO.2004.03.075","article-title":"Impact of ulceration in stages I to III cutaneous melanoma as staged by the American Joint Committee on Cancer Staging System: an analysis of the German Central Malignant Melanoma Registry","volume":"22","author":"Eigentler","year":"2004","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b21-or-32-06-2735","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0959-8049(03)00325-3","article-title":"Interobserver reproducibility of ulceration assessment in primary cutaneous melanomas","volume":"39","author":"Spatz","year":"2003","journal-title":"Eur J Cancer"},{"key":"key20180107210443_b22-or-32-06-2735","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1200\/JCO.2006.08.9755","article-title":"Tumor-infiltrating lymphocytes predict sentinel lymph node positivity in patients with cutaneous melanoma","volume":"25","author":"Taylor","year":"2007","journal-title":"J Clin Oncol"},{"key":"key20180107210443_b23-or-32-06-2735","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2391::AID-CNCR14>3.0.CO;2-I","article-title":"Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?","volume":"85","author":"Ostmeier","year":"1999","journal-title":"Cancer"},{"key":"key20180107210443_b24-or-32-06-2735","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/archderm.144.4.462","article-title":"Lymphatic invasion identified by monoclonal antibody D2\u201340, younger age, and ulceration: predictors of sentinel lymph node involvement in primary cutaneous melanoma","volume":"144","author":"Niakosari","year":"2008","journal-title":"Arch Dermatol"},{"key":"key20180107210443_b25-or-32-06-2735","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1002\/1097-0142(19800615)45:12<3012::AID-CNCR2820451223>3.0.CO;2-O","article-title":"The prognostic significance of ulceration of cutaneous melanoma","volume":"45","author":"Balch","year":"1980","journal-title":"Cancer"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2014.3531\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:04:51Z","timestamp":1515359091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2014.3531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,6]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,10,6]]},"published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.3892\/or.2014.3531"],"URL":"https:\/\/doi.org\/10.3892\/or.2014.3531","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,6]]}}}