{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:06Z","timestamp":1787509866254,"version":"build-2736575974"},"reference-count":38,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.3892\/or.2014.3564","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T11:13:08Z","timestamp":1414062788000},"page":"33-39","source":"Crossref","is-referenced-by-count":101,"title":["L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: A double-blind, randomized, placebo-controlled trial"],"prefix":"10.3892","volume":"33","author":[{"given":"TAKAE","family":"TSUJIMOTO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIFUMI","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAFUMI","family":"WASA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUKINORI","family":"TAKENAKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSUMU","family":"NAKAHARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TASTUYA","family":"TAKAGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAMIKO","family":"TSUGANE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORIYUKI","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUHISA","family":"MAEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDENORI","family":"INOHARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ETSUKO","family":"UEJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOSHINORI","family":"ITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"key20180107213443_b1-or-33-01-0033","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1093\/jnci\/91.24.2065","article-title":"Radiotherapy and concurrent chemotherapy: a strategy that improves locoregional control and survival in oropharyngeal cancer","volume":"91","author":"Forastiere","year":"1999","journal-title":"J Nat Cancer Inst"},{"key":"key20180107213443_b2-or-33-01-0033","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ijrobp.2005.10.010","article-title":"Compromised local control due to treatment interruptions and late treatment breaks in early glottis cancer: population-based outcomes study supporting need for intensified treatment schedules","volume":"64","author":"Groome","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180107213443_b3-or-33-01-0033","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semradonc.2008.09.006","article-title":"Strategies for managing radiation-induced mucositis in head and neck cancer","volume":"19","author":"Rosenthal","year":"2009","journal-title":"Semin Radiat Oncol"},{"key":"key20180107213443_b4-or-33-01-0033","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.22484","article-title":"Updated clinical practice guidelines for the prevention and treatment of mucositis","volume":"109","author":"Keefe","year":"2007","journal-title":"Cancer"},{"key":"key20180107213443_b5-or-33-01-0033","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejca.2007.09.014","article-title":"Guideline for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoetic stem cell transplant patients","volume":"44","author":"Quinn","year":"2008","journal-title":"Eur J Cancer"},{"key":"key20180107213443_b6-or-33-01-0033","doi-asserted-by":"crossref","first-page":"661.e1","DOI":"10.1016\/j.jcrc.2010.03.011","article-title":"Role of glutamine administration on cellular immunity after total parenteral nutrition enriched with glutamine in patients with systemic inflammatory response syndrome","volume":"25","author":"Cetinbas","year":"2010","journal-title":"J Crit Care"},{"key":"key20180107213443_b7-or-33-01-0033","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/ajcn\/75.5.789","article-title":"Protective nutrients and functional foods for the gastrointestinal tract","volume":"75","author":"Duggan","year":"2002","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 9","key":"key20180107213443_b8-or-33-01-0033","doi-asserted-by":"crossref","first-page":"2505S","DOI":"10.1093\/jn\/131.9.2505S","article-title":"Glutamine and the bowel","volume":"131","author":"Reeds","year":"2001","journal-title":"J Nutr"},{"issue":"Suppl 1","key":"key20180107213443_b9-or-33-01-0033","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1053\/j.gastro.2005.11.049","article-title":"Glutamine: do the data support the cause for glutamine supplementation in humans?","volume":"130","author":"Alpers","year":"2006","journal-title":"Gastroenterology"},{"key":"key20180107213443_b10-or-33-01-0033","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1753-4887.1990.tb02967.x","article-title":"Is glutamine a conditionally essential amino acid?","volume":"48","author":"Lacey","year":"1990","journal-title":"Nutr Rev"},{"key":"key20180107213443_b11-or-33-01-0033","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0305-7372(03)00133-6","article-title":"Prevention of chemotherapy and radiation toxicity with glutamine","volume":"29","author":"Savarese","year":"2003","journal-title":"Cancer Treat Rev"},{"key":"key20180107213443_b12-or-33-01-0033","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0360-3016(99)00402-2","article-title":"Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial","volume":"46","author":"Huang","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180107213443_b13-or-33-01-0033","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0022-2143(96)90082-7","article-title":"Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study","volume":"127","author":"Skubitz","year":"1996","journal-title":"J Lab Clin Med"},{"key":"key20180107213443_b14-or-33-01-0033","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0261-5614(95)80014-X","article-title":"A pilot study of oral glutamine supplementation in patients receiving bone marrow transplants","volume":"14","author":"Jebb","year":"1995","journal-title":"Clin Nutr"},{"key":"key20180107213443_b15-or-33-01-0033","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/1097-0142(19941115)74:10<2879::AID-CNCR2820741022>3.0.CO;2-H","article-title":"Parenteral glutamine dipeptide supplementation does not ameliorate chemotherapy-induced toxicity","volume":"74","author":"van Zaanen","year":"1994","journal-title":"Cancer"},{"key":"key20180107213443_b16-or-33-01-0033","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/bjc.1994.385","article-title":"5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation","volume":"70","author":"Jebb","year":"1994","journal-title":"Br J Cancer"},{"key":"key20180107213443_b17-or-33-01-0033","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/(SICI)1097-0142(19981001)83:7<1433::AID-CNCR22>3.0.CO;2-4","article-title":"Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy","volume":"83","author":"Anderson","year":"1998","journal-title":"Cancer"},{"issue":"Suppl 4","key":"key20180107213443_b18-or-33-01-0033","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1177\/014860719001400402","article-title":"Glutamine metabolism and its physiologic importance","volume":"14","author":"Smith","year":"1990","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key20180107213443_b19-or-33-01-0033","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-4889(87)90153-4","article-title":"Effects on preformed proline and proline amino acid precursors (including glutamine) on collagen synthesis in human fibroblast cultures","volume":"930","author":"Bellon","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"key20180107213443_b20-or-33-01-0033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0167-4889(95)00093-8","article-title":"Glutamine increases collagen gene transcription in cultured human fibroblasts","volume":"1268","author":"Bellon","year":"1995","journal-title":"Biochem Biophys Acta"},{"key":"key20180107213443_b21-or-33-01-0033","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0022-4804(92)90275-5","article-title":"The effect of glutamine-enriched TPN on gut immune cellularity","volume":"52","author":"Alverdy","year":"1992","journal-title":"J Surg Res"},{"key":"key20180107213443_b22-or-33-01-0033","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00280-007-0463-2","article-title":"Glutamine and alanyl-glutamine accelerate the recovery from 5-fluorouracil-induced experimental oral mucositis in hamster","volume":"61","author":"Leitao","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"key20180107213443_b23-or-33-01-0033","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/0148607110362694","article-title":"Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy","volume":"34","author":"Nose","year":"2010","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key20180107213443_b24-or-33-01-0033","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.lungcan.2008.06.015","article-title":"Prevention of acute radiation-induced esophagitis with glutamine in non-small cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parameters","volume":"63","author":"Topkan","year":"2009","journal-title":"Lung Cancer"},{"key":"key20180107213443_b25-or-33-01-0033","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.ijrobp.2006.03.042","article-title":"Double-blinded, placebo-controlled trial on intravenous L-alanyl-L-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head- and-neck cancer","volume":"65","author":"Cerchietti","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180107213443_b26-or-33-01-0033","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/gut.48.1.28","article-title":"Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomized trial","volume":"48","author":"Daniele","year":"2001","journal-title":"Gut"},{"key":"key20180107213443_b27-or-33-01-0033","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1200\/JCO.2010.32.4095","article-title":"Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study","volume":"29","author":"Le","year":"2011","journal-title":"J Clin Oncol"},{"key":"key20180107213443_b28-or-33-01-0033","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/sj.bmt.1705084","article-title":"A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study","volume":"36","author":"Aquino","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"key20180107213443_b29-or-33-01-0033","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00520-005-0790-y","article-title":"A randomized, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients","volume":"13","author":"Blijevens","year":"2005","journal-title":"Support Care Cancer"},{"key":"key20180107213443_b30-or-33-01-0033","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/sj.bmt.1704363","article-title":"Glutamine parenteral supplementation in stem cell transplant","volume":"33","author":"Piccirillo","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"key20180107213443_b31-or-33-01-0033","first-page":"476","article-title":"A randomized double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies - three years\u2019 follow-up","volume":"52","author":"Sykorova","year":"2005","journal-title":"Neoplasm"},{"key":"key20180107213443_b32-or-33-01-0033","doi-asserted-by":"crossref","first-page":"821","DOI":"10.7326\/0003-4819-116-10-821","article-title":"Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation: a randomized double-blind, controlled study","volume":"116","author":"Ziegler","year":"1992","journal-title":"Ann Intern Med"},{"key":"key20180107213443_b33-or-33-01-0033","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1177\/0148607193017005422","article-title":"Patients receiving glutamine-supplemented intravenous feedings report an improvement in mood","volume":"17","author":"Young","year":"1993","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key20180107213443_b34-or-33-01-0033","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/0148607193017005407","article-title":"Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (a randomized, double-blind study)","volume":"17","author":"Schloerb","year":"1993","journal-title":"JPEN J Pareter Enteral Nutr"},{"key":"key20180107213443_b35-or-33-01-0033","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/014860710002400261","article-title":"Effect of oral glutamine supplementation during bone marrow transplantation","volume":"24","author":"Coghlin Dickson","year":"2002","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key20180107213443_b36-or-33-01-0033","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/jcp.20339","article-title":"Molecular mechanisms of glutamine action","volume":"204","author":"Curi","year":"2005","journal-title":"J Cell Physiol"},{"issue":"Suppl 9","key":"key20180107213443_b37-or-33-01-0033","doi-asserted-by":"crossref","first-page":"S1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer"},{"key":"key20180107213443_b38-or-33-01-0033","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.2042-7158.1974.tb10672.x","article-title":"Inhibitory effect of L-glutamine on the aspirin-induced gastric lesions in the rat","volume":"26","author":"Okabe","year":"1974","journal-title":"Pharm Pharmacol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2014.3564\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:02:58Z","timestamp":1565953378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2014.3564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,23]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,10,23]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.3892\/or.2014.3564"],"URL":"https:\/\/doi.org\/10.3892\/or.2014.3564","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,23]]}}}