{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:08Z","timestamp":1771550708813,"version":"3.50.1"},"reference-count":33,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.3892\/or.2014.3648","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T08:47:00Z","timestamp":1417769220000},"page":"974-980","source":"Crossref","is-referenced-by-count":30,"title":["miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism"],"prefix":"10.3892","volume":"33","author":[{"given":"JING","family":"CAO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAO","family":"GUO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QINGSHAN","family":"DONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIANQIANG","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANFENG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"key20180107213403_b1-or-33-02-0974","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1590\/S0103-64402011000600013","article-title":"Oral tongue squamous cell carcinoma (OTSCC): alcohol and tobacco consumption versus non-consumption. A study in a Portuguese population","volume":"22","author":"Albuquerque","year":"2011","journal-title":"Braz Dent J"},{"key":"key20180107213403_b2-or-33-02-0974","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2334\/josnusd.52.267","article-title":"Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection","volume":"52","author":"Marocchio","year":"2010","journal-title":"J Oral Sci"},{"key":"key20180107213403_b3-or-33-02-0974","first-page":"197","article-title":"Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity","volume":"24","author":"Pettus","year":"2009","journal-title":"Histol Histopathol"},{"key":"key20180107213403_b4-or-33-02-0974","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0002-9610(97)00282-1","article-title":"Clinicopathological analysis of local spread of carcinoma of the tongue","volume":"175","author":"Yuen","year":"1998","journal-title":"Am J Surg"},{"key":"key20180107213403_b5-or-33-02-0974","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/hed.10094","article-title":"Prognostic factors of clinically stage I and II oral tongue carcinoma - a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features","volume":"24","author":"Po Wing Yuen","year":"2002","journal-title":"Head Neck"},{"key":"key20180107213403_b6-or-33-02-0974","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"key20180107213403_b7-or-33-02-0974","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrc3166","article-title":"Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy","volume":"11","author":"Kasinski","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"key20180107213403_b8-or-33-02-0974","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/emmm.201100209","article-title":"MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review","volume":"4","author":"Iorio","year":"2012","journal-title":"EMBO Mol Med"},{"key":"key20180107213403_b9-or-33-02-0974","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1158\/1078-0432.CCR-07-0666","article-title":"Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue","volume":"14","author":"Wong","year":"2008","journal-title":"Clin Cancer Res"},{"key":"key20180107213403_b10-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.febslet.2011.04.018","article-title":"MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11","volume":"585","author":"Liu","year":"2011","journal-title":"FEBS Lett"},{"key":"key20180107213403_b11-or-33-02-0974","doi-asserted-by":"crossref","first-page":"e69963","DOI":"10.1371\/journal.pone.0069963","article-title":"Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"key20180107213403_b12-or-33-02-0974","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/jama.2013.284664","article-title":"MicroRNA biomarkers in whole blood for detection of pancreatic cancer","volume":"311","author":"Schultz","year":"2014","journal-title":"JAMA"},{"key":"key20180107213403_b13-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1245\/s10434-010-1359-7","article-title":"Identification of differentially expressed microRNA in parathyroid tumors","volume":"18","author":"Rahbari","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"key20180107213403_b14-or-33-02-0974","doi-asserted-by":"crossref","first-page":"e16264","DOI":"10.1371\/journal.pone.0016264","article-title":"Role of microRNA-26b in glioma development and its mediated regulation on EphA2","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"key20180107213403_b15-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMoa0901282","article-title":"MicroRNA expression, survival, and response to interferon in liver cancer","volume":"361","author":"Ji","year":"2009","journal-title":"N Engl J Med"},{"key":"key20180107213403_b16-or-33-02-0974","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10555-011-9298-8","article-title":"Cyclooxygenase- and lipoxygenase-mediated DNA damage","volume":"30","author":"Speed","year":"2011","journal-title":"Cancer Metastasis Rev"},{"key":"key20180107213403_b17-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2174\/138945011795677764","article-title":"Biology of Cox-2: an application in cancer therapeutics","volume":"12","author":"Khan","year":"2011","journal-title":"Curr Drug Targets"},{"key":"key20180107213403_b18-or-33-02-0974","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180107213403_b19-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s11033-012-2222-7","article-title":"MiR-26a regulates cell cycle and anoikis of human esophageal adenocarcinoma cells through Rb1-E2F1 signaling pathway","volume":"40","author":"Zhang","year":"2013","journal-title":"Mol Biol Rep"},{"key":"key20180107213403_b20-or-33-02-0974","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/092986708783497247","article-title":"Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug","volume":"15","author":"Suleyman","year":"2008","journal-title":"Curr Med Chem"},{"key":"key20180107213403_b21-or-33-02-0974","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.oooo.2013.12.410","article-title":"Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer","volume":"117","author":"Morita","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"key20180107213403_b22-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.joms.2013.04.015","article-title":"Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma","volume":"71","author":"Kono","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"key20180107213403_b23-or-33-02-0974","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3892\/ijo.2012.1529","article-title":"Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma","volume":"41","author":"Morita","year":"2012","journal-title":"Int J Oncol"},{"key":"key20180107213403_b24-or-33-02-0974","doi-asserted-by":"crossref","first-page":"S360","DOI":"10.1007\/s12032-010-9737-3","article-title":"COX-2 gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway","volume":"28","author":"Wang","year":"2011","journal-title":"Med Oncol"},{"key":"key20180107213403_b25-or-33-02-0974","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/modpathol.3800244","article-title":"COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma","volume":"18","author":"Kyzas","year":"2005","journal-title":"Mod Pathol"},{"key":"key20180107213403_b26-or-33-02-0974","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2867-13-7","article-title":"MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer","volume":"13","author":"Li","year":"2013","journal-title":"Cancer Cell Int"},{"key":"key20180107213403_b27-or-33-02-0974","first-page":"558","article-title":"MiRNA-26b inhibits cellular proliferation by targeting CDK8 in breast cancer","volume":"7","author":"Li","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"key20180107213403_b28-or-33-02-0974","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s13277-012-0454-8","article-title":"Circulating miRNA is a novel marker for head and neck squamous cell carcinoma","volume":"33","author":"Hsu","year":"2012","journal-title":"Tumour Biol"},{"key":"key20180107213403_b29-or-33-02-0974","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cca.2010.12.026","article-title":"Cyclooxygenase-2 in oncogenesis","volume":"412","author":"Rizzo","year":"2011","journal-title":"Clin Chim Acta"},{"key":"key20180107213403_b30-or-33-02-0974","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1734-1140(10)70262-0","article-title":"COX-2 as a target for cancer chemotherapy","volume":"62","author":"Ghosh","year":"2010","journal-title":"Pharmacol Rep"},{"key":"key20180107213403_b31-or-33-02-0974","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hed.10108","article-title":"Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer","volume":"24","author":"Lin","year":"2002","journal-title":"Head Neck"},{"key":"key20180107213403_b32-or-33-02-0974","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1734-1140(10)70262-0","article-title":"COX-2 as a target for cancer chemotherapy","volume":"62","author":"Ghosh","year":"2010","journal-title":"Pharmacol Rep"},{"key":"key20180107213403_b33-or-33-02-0974","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-642-30331-9_5","article-title":"COX-2 active agents in the chemoprevention of colorectal cancer","volume":"191","author":"Kraus","year":"2013","journal-title":"Recent Results Cancer Res"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2014.3648\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:34:35Z","timestamp":1515360875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2014.3648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,12,5]]},"published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.3892\/or.2014.3648"],"URL":"https:\/\/doi.org\/10.3892\/or.2014.3648","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}