{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:30:24Z","timestamp":1791138624043,"version":"4.1.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.3892\/or.2015.3830","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T07:42:46Z","timestamp":1425454966000},"page":"2411-2419","source":"Crossref","is-referenced-by-count":29,"title":["Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1"],"prefix":"10.3892","volume":"33","author":[{"given":"KI-EUN","family":"HWANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNG-SUK","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU-RI","family":"HWANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SU-JIN","family":"KWON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DO-SIM","family":"PARK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BYONG-KI","family":"CHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BYOUNG-RYUN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KWON-HA","family":"YOON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EUN-TAIK","family":"JEONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAK-RYUL","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"key20180107213109_b1-or-33-05-2411","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"key20180107213109_b2-or-33-05-2411","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1200\/JCO.2004.02.109","article-title":"Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small-cell lung cancer","volume":"22","author":"Hotta","year":"2004","journal-title":"J Clin Oncol"},{"key":"key20180107213109_b3-or-33-05-2411","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/14728210903074563","article-title":"Malignant pleural mesothelioma: Current treatments and emerging drugs","volume":"14","author":"Belli","year":"2009","journal-title":"Expert Opin Emerg Drugs"},{"key":"key20180107213109_b4-or-33-05-2411","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J Clin Oncol"},{"key":"key20180107213109_b5-or-33-05-2411","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1200\/JCO.2007.15.0375","article-title":"Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer","volume":"26","author":"Scagliotti","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20180107213109_b6-or-33-05-2411","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3904\/kjim.2010.25.3.294","article-title":"Pemetrexed versus gefitinib versus erlotinib in previously treated patients with non-small cell lung cancer","volume":"25","author":"Hong","year":"2010","journal-title":"Korean J Intern Med"},{"key":"key20180107213109_b7-or-33-05-2411","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/1535-7163.MCT-06-0343","article-title":"Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications","volume":"6","author":"Chattopadhyay","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"key20180107213109_b8-or-33-05-2411","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-4598-11-25","article-title":"Molecular mechanism implicated in pemetrexed-induced apoptosis in human melanoma cells","volume":"11","author":"Buqu\u00e9","year":"2012","journal-title":"Mol Cancer"},{"key":"key20180107213109_b9-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.chembiol.2008.09.009","article-title":"Mechanisms and molecular probes of sirtuins","volume":"15","author":"Smith","year":"2008","journal-title":"Chem Biol"},{"key":"key20180107213109_b10-or-33-05-2411","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1158\/0008-5472.CAN-07-0085","article-title":"SIRT1 is significantly elevated in mouse and human prostate cancer","volume":"67","author":"Huffman","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107213109_b11-or-33-05-2411","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature06500","article-title":"DBC1 is a negative regulator of SIRT1","volume":"451","author":"Kim","year":"2008","journal-title":"Nature"},{"key":"key20180107213109_b12-or-33-05-2411","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.08.011","article-title":"Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses","volume":"123","author":"Chen","year":"2005","journal-title":"Cell"},{"key":"key20180107213109_b13-or-33-05-2411","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1126\/science.1116801","article-title":"Suppressing cancer: The importance of being senescent","volume":"309","author":"Campisi","year":"2005","journal-title":"Science"},{"key":"key20180107213109_b14-or-33-05-2411","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/sj.onc.1209049","article-title":"Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells","volume":"25","author":"Ota","year":"2006","journal-title":"Oncogene"},{"key":"key20180107213109_b15-or-33-05-2411","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1006\/excr.1998.4380","article-title":"The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis","volume":"247","author":"Wolf","year":"1999","journal-title":"Exp Cell Res"},{"key":"key20180107213109_b16-or-33-05-2411","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"key20180107213109_b17-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0140-6736(09)61497-5","article-title":"Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study","volume":"374","author":"Ciuleanu","year":"2009","journal-title":"Lancet"},{"key":"key20180107213109_b18-or-33-05-2411","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/sj.leu.2404599","article-title":"Pemetrexed acts as an antimyeloma agent by provoking cell cycle blockade and apoptosis","volume":"21","author":"Ramirez","year":"2007","journal-title":"Leukemia"},{"key":"key20180107213109_b19-or-33-05-2411","first-page":"3671","article-title":"Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma","volume":"59","author":"Tonkinson","year":"1999","journal-title":"Cancer Res"},{"key":"key20180107213109_b20-or-33-05-2411","doi-asserted-by":"crossref","first-page":"e97888","DOI":"10.1371\/journal.pone.0097888","article-title":"Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"key20180107213109_b21-or-33-05-2411","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/mc.21842","article-title":"Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated\/p53-dependent and -independent signaling pathways","volume":"52","author":"Yang","year":"2013","journal-title":"Mol Carcinog"},{"key":"key20180107213109_b22-or-33-05-2411","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1081\/CNV-120002155","article-title":"Mitochondrial DNA alterations in cancer","volume":"20","author":"Copeland","year":"2002","journal-title":"Cancer Invest"},{"key":"key20180107213109_b23-or-33-05-2411","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4046\/trd.2005.59.1.30","article-title":"Combination treatment with arsenic trioxide and sulindac induces apoptosis of NCI-H157 human lung carcinoma cells via ROS generation with mitochondrial dysfunction","volume":"59","author":"Kim","year":"2005","journal-title":"Tuberc Respir Dis"},{"key":"key20180107213109_b24-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"key20180107213109_b25-or-33-05-2411","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/35083620","article-title":"Endonuclease G is an apoptotic DNase when released from mitochondria","volume":"412","author":"Li","year":"2001","journal-title":"Nature"},{"key":"key20180107213109_b26-or-33-05-2411","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"key":"key20180107213109_b27-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1042\/bst0241028","article-title":"Control of cell proliferation by reactive oxygen species","volume":"24","author":"Burdon","year":"1996","journal-title":"Biochem Soc Trans"},{"key":"key20180107213109_b28-or-33-05-2411","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"key20180107213109_b29-or-33-05-2411","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/jps.20874","article-title":"Oxidative stress and apoptosis: Impact on cancer therapy","volume":"96","author":"Ozben","year":"2007","journal-title":"J Pharm Sci"},{"key":"key20180107213109_b30-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1083\/jcb.141.6.1423","article-title":"The regulation of reactive oxygen species production during programmed cell death","volume":"141","author":"Tan","year":"1998","journal-title":"J Cell Biol"},{"key":"key20180107213109_b31-or-33-05-2411","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2007.08.030","article-title":"Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity","volume":"28","author":"Kim","year":"2007","journal-title":"Mol Cell"},{"key":"key20180107213109_b32-or-33-05-2411","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"key20180107213109_b33-or-33-05-2411","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1126\/science.1165946","article-title":"Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1","volume":"323","author":"Westerheide","year":"2009","journal-title":"Science"},{"key":"key20180107213109_b34-or-33-05-2411","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/1947601913484497","article-title":"Stress inducibility of SIRT1 and its role in cytoprotection and cancer","volume":"4","author":"Raynes","year":"2013","journal-title":"Genes Cancer"},{"key":"key20180107213109_b35-or-33-05-2411","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1074\/jbc.M110.208173","article-title":"Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization","volume":"286","author":"Kawai","year":"2011","journal-title":"J Biol Chem"},{"key":"key20180107213109_b36-or-33-05-2411","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.3830\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T16:38:49Z","timestamp":1566405529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.3830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,3,4]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.3892\/or.2015.3830"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.3830","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}