{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:09:57Z","timestamp":1791284997729,"version":"4.1.0"},"reference-count":29,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.3892\/or.2015.3845","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T13:48:05Z","timestamp":1425908885000},"page":"2261-2268","source":"Crossref","is-referenced-by-count":103,"title":["Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: An in vitro and in vivo study"],"prefix":"10.3892","volume":"33","author":[{"given":"LEI","family":"YUAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUN","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QINGYANG","family":"MENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIULEI","family":"XI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIULIN","family":"ZHUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI","family":"JIANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUSONG","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BO","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JING","family":"FANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUOHAO","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"key20180107213139_b1-or-33-05-2261","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3322\/canjclin.52.2.72","article-title":"Cancer anorexia-cachexia syndrome: Current issues in research and management","volume":"52","author":"Inui","year":"2002","journal-title":"CA Cancer J Clin"},{"key":"key20180107213139_b2-or-33-05-2261","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00075197-200005000-00003","article-title":"Cancer cachexia: From experimental models to patient management","volume":"3","author":"Costelli","year":"2000","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"key20180107213139_b3-or-33-05-2261","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: Mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"key20180107213139_b4-or-33-05-2261","doi-asserted-by":"crossref","first-page":"168407","DOI":"10.1155\/2014\/168407","article-title":"Inflammation based regulation of cancer cachexia","volume":"2014","author":"Onesti","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20180107213139_b5-or-33-05-2261","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1200\/JCO.2012.44.2020","article-title":"Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia","volume":"31","author":"Ando","year":"2013","journal-title":"J Clin Oncol"},{"key":"key20180107213139_b6-or-33-05-2261","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1158\/1078-0432.CCR-11-2133","article-title":"Suppression of skeletal muscle turnover in cancer cachexia: Evidence from the transcriptome in sequential human muscle biopsies","volume":"18","author":"Gallagher","year":"2012","journal-title":"Clin Cancer Res"},{"key":"key20180107213139_b7-or-33-05-2261","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/bmj.315.7117.1219","article-title":"ABC of palliative care. Anorexia, cachexia, and nutrition","volume":"315","author":"Bruera","year":"1997","journal-title":"BMJ"},{"key":"key20180107213139_b8-or-33-05-2261","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biopha.2013.08.005","article-title":"Malnutrition, anorexia and cachexia in cancer patients: A mini-review on pathogenesis and treatment","volume":"67","author":"Nicolini","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"key20180107213139_b9-or-33-05-2261","first-page":"479","article-title":"Tumour growth and nitrogen metabolism in the host (Review)","volume":"14","author":"Argil\u00e9s","year":"1999","journal-title":"Int J Oncol"},{"key":"key20180107213139_b10-or-33-05-2261","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00075197-200105000-00003","article-title":"What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?","volume":"4","author":"Jagoe","year":"2001","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"key20180107213139_b11-or-33-05-2261","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1152\/ajpendo.00039.2012","article-title":"JAK\/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia","volume":"303","author":"Bonetto","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20180107213139_b12-or-33-05-2261","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/SPC.0000000000000091","article-title":"Role of interleukin-6 in cachexia: Therapeutic implications","volume":"8","author":"Narsale","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"key":"key20180107213139_b13-or-33-05-2261","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20180107213139_b14-or-33-05-2261","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/mus.20611","article-title":"Ubiquitin ligase gene expression in healthy volunteers with 20-day bedrest","volume":"34","author":"Ogawa","year":"2006","journal-title":"Muscle Nerve"},{"key":"key20180107213139_b15-or-33-05-2261","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1113\/jphysiol.2006.118042","article-title":"Alterations in mRNA expression and protein products following spinal cord injury in humans","volume":"579","author":"Urso","year":"2007","journal-title":"J Physiol"},{"key":"key20180107213139_b16-or-33-05-2261","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1096\/fj.05-5249fje","article-title":"Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1","volume":"20","author":"L\u00e9ger","year":"2006","journal-title":"FASEB J"},{"key":"key20180107213139_b17-or-33-05-2261","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/thx.2009.133827","article-title":"Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD","volume":"65","author":"Doucet","year":"2010","journal-title":"Thorax"},{"key":"key20180107213139_b18-or-33-05-2261","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.mad.2006.07.005","article-title":"Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle","volume":"127","author":"Clavel","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"key20180107213139_b19-or-33-05-2261","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1210\/en.2004-0406","article-title":"Role of the insulin-like growth factor I decline in the induction of atrogin-1\/MAFbx during fasting and diabetes","volume":"145","author":"Dehoux","year":"2004","journal-title":"Endocrinology"},{"key":"key20180107213139_b20-or-33-05-2261","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","article-title":"Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression","volume":"18","author":"Lecker","year":"2004","journal-title":"FASEB J"},{"key":"key20180107213139_b21-or-33-05-2261","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/01.SLA.0000055225.96357.71","article-title":"Increased muscle proteasome activity correlates with disease severity in gastric cancer patients","volume":"237","author":"Bossola","year":"2003","journal-title":"Ann Surg"},{"key":"key20180107213139_b22-or-33-05-2261","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1096\/fasebj.12.10.871","article-title":"Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha","volume":"12","author":"Li","year":"1998","journal-title":"FASEB J"},{"key":"key20180107213139_b23-or-33-05-2261","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/iub.1066","article-title":"Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells","volume":"64","author":"Zhou","year":"2012","journal-title":"IUBMB Life"},{"key":"key20180107213139_b24-or-33-05-2261","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.biocel.2004.10.017","article-title":"Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss","volume":"37","author":"Khal","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107213139_b25-or-33-05-2261","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/mus.23945","article-title":"Gastric cancer does not affect the expression of atrophy-related genes in human skeletal muscle","volume":"49","author":"D\u2019Orlando","year":"2014","journal-title":"Muscle Nerve"},{"key":"key20180107213139_b26-or-33-05-2261","first-page":"921","article-title":"Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice","volume":"55","author":"Yasumoto","year":"1995","journal-title":"Cancer Res"},{"key":"key20180107213139_b27-or-33-05-2261","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ijc.10338","article-title":"Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26\/clone 20 adenocarcinoma","volume":"99","author":"Iizuka","year":"2002","journal-title":"Int J Cancer"},{"issue":"Suppl 9","key":"key20180107213139_b28-or-33-05-2261","first-page":"S251","article-title":"Crossroads of cytokine signaling - the chase to stop muscle cachexia","volume":"59","author":"Pajak","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"key20180107213139_b29-or-33-05-2261","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.04-2364com","article-title":"TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1\/MAFbx in skeletal muscle","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.3845\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T19:53:31Z","timestamp":1566417211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.3845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,3,9]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.3892\/or.2015.3845"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.3845","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}