{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:38:23Z","timestamp":1776886703375,"version":"3.51.2"},"reference-count":31,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.3892\/or.2015.3942","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:27:47Z","timestamp":1430198867000},"page":"3061-3068","source":"Crossref","is-referenced-by-count":32,"title":["Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2\/Bax"],"prefix":"10.3892","volume":"33","author":[{"given":"XIAOGUANG","family":"TIAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUANG","family":"ZENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XI","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZIZHONG","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"key20180107213637_b1-or-33-06-3061","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3892\/mmr.2014.2717","article-title":"Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113","volume":"11","author":"Shao","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180107213637_b2-or-33-06-3061","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3892\/ijo.2013.1873","article-title":"Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and \u03b1v\u03b26 integrin","volume":"42","author":"Li","year":"2013","journal-title":"Int J Oncol"},{"key":"key20180107213637_b3-or-33-06-3061","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3892\/ol.2014.2097","article-title":"Squamous cell carcinoma of the tongue in a female with advanced breast cancer: A case report of an elderly patient presenting with two types of cancer","volume":"8","author":"Addeo","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180107213637_b4-or-33-06-3061","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijo.2014.2752","article-title":"Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b\/27b cluster in bladder cancer","volume":"46","author":"Chiyomaru","year":"2015","journal-title":"Int J Oncol"},{"key":"key20180107213637_b5-or-33-06-3061","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3892\/or.2014.3638","article-title":"Epithelial-mesenchymal transition-associated microRNAs in colorectal cancer and drug-targeted therapies (Review)","volume":"33","author":"Jin","year":"2015","journal-title":"Oncol Rep"},{"key":"key20180107213637_b6-or-33-06-3061","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.oraloncology.2010.02.002","article-title":"MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines","volume":"46","author":"Yu","year":"2010","journal-title":"Oral Oncol"},{"key":"key20180107213637_b7-or-33-06-3061","doi-asserted-by":"crossref","first-page":"e86149","DOI":"10.1371\/journal.pone.0086149","article-title":"Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"key20180107213637_b8-or-33-06-3061","doi-asserted-by":"crossref","first-page":"415","DOI":"10.7150\/ijbs.8002","article-title":"Cantharidin exerts anti-hepatocellular carcinoma by miR-214 modulating macrophage polarization","volume":"10","author":"Lu","year":"2014","journal-title":"Int J Biol Sci"},{"key":"key20180107213637_b9-or-33-06-3061","doi-asserted-by":"crossref","first-page":"603925","DOI":"10.1155\/2011\/603925","article-title":"p53: The attractive tumor suppressor in the cancer research field","volume":"2011","author":"Ozaki","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"key20180107213637_b10-or-33-06-3061","doi-asserted-by":"crossref","DOI":"10.1007\/s13277-013-1410-y","article-title":"Alisertib (MLN8237), a selective Aurora-A kinase inhibitor, induces apoptosis in human tongue squamous cell carcinoma cell both in vitro and in vivo","author":"Qi","year":"2014","journal-title":"Tumour Biol"},{"key":"key20180107213637_b11-or-33-06-3061","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1269\/jrr.44.41","article-title":"Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene","volume":"44","author":"Yasumoto","year":"2003","journal-title":"J Radiat Res"},{"key":"key20180107213637_b12-or-33-06-3061","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3835(02)00265-3","article-title":"Squamous cell carcinoma of the tongue: The prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study","volume":"186","author":"Nagler","year":"2002","journal-title":"Cancer Lett"},{"key":"key20180107213637_b13-or-33-06-3061","first-page":"935","article-title":"Receptor-related mechanism of proliferation inhibilion and apoptosis induetion of human tongue squamous cell line Tca8113 by retinoids","volume":"25","author":"Niu","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"key20180107213637_b14-or-33-06-3061","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/paor.1999.0231","article-title":"Correlation of bcl-2 oncoprotein immunohistochemical expression with proliferation index and histopathologic parameters in colorectal neoplasia","volume":"5","author":"Saleh","year":"1999","journal-title":"Pathol Oncol Res"},{"key":"key20180107213637_b15-or-33-06-3061","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<913::AID-CNCR4>3.0.CO;2-A","article-title":"The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue","volume":"86","author":"Xie","year":"1999","journal-title":"Cancer"},{"key":"key20180107213637_b16-or-33-06-3061","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1016\/j.ejmech.2010.05.053","article-title":"Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells","volume":"45","author":"Yeh","year":"2010","journal-title":"Eur J Med Chem"},{"key":"key20180107213637_b17-or-33-06-3061","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/104063879801000113","article-title":"Cantharidin poisoning of emu chicks by ingestion of Pyrota insulata","volume":"10","author":"Barr","year":"1998","journal-title":"J Vet Diagn Invest"},{"key":"key20180107213637_b18-or-33-06-3061","article-title":"Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells","author":"Hsia","year":"2014","journal-title":"Environ Toxicol"},{"key":"key20180107213637_b19-or-33-06-3061","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.3892\/ol.2014.2611","article-title":"Cantharidin induces G2\/M phase arrest and apoptosis in human gastric cancer SGC-7901 and BGC-823 cells","volume":"8","author":"Zhang","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180107213637_b20-or-33-06-3061","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3892\/mmr.2013.1804","article-title":"Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K\/Akt signaling pathway","volume":"9","author":"Wang","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20180107213637_b21-or-33-06-3061","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3892\/ol.2014.2054","article-title":"Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old","volume":"7","author":"Fang","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180107213637_b22-or-33-06-3061","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3892\/ijo.2014.2428","article-title":"Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways","volume":"45","author":"Hsia","year":"2014","journal-title":"Int J Oncol"},{"key":"key20180107213637_b23-or-33-06-3061","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.intimp.2012.05.016","article-title":"Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p","volume":"13","author":"Su","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20180107213637_b24-or-33-06-3061","doi-asserted-by":"crossref","first-page":"e109347","DOI":"10.1371\/journal.pone.0109347","article-title":"Association of serum microRNA expression in hepatocellular carcinomas treated with transarterial chemoembolization and patient survival","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"key20180107213637_b25-or-33-06-3061","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.intimp.2012.04.002","article-title":"Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway","volume":"13","author":"Lee","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20180107213637_b26-or-33-06-3061","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1126\/science.8153613","article-title":"New tumor suppressor may rival p53","volume":"264","author":"Marx","year":"1994","journal-title":"Science"},{"key":"key20180107213637_b27-or-33-06-3061","first-page":"1243","article-title":"Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways","volume":"37","author":"Kuo","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180107213637_b28-or-33-06-3061","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mco.2013.189","article-title":"Lack of M30 expression correlates with factors reflecting tumor progression in rectal cancer with preoperative chemoradiotherapy","volume":"2","author":"Saigusa","year":"2014","journal-title":"Mol Clin Oncol"},{"key":"key20180107213637_b29-or-33-06-3061","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1349-7006.2010.01523.x","article-title":"Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2\/M cell-cycle arrest and apoptosis","volume":"101","author":"Li","year":"2010","journal-title":"Cancer Sci"},{"key":"key20180107213637_b30-or-33-06-3061","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tox.2006.03.012","article-title":"Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line","volume":"223","author":"Huan","year":"2006","journal-title":"Toxicology"},{"key":"key20180107213637_b31-or-33-06-3061","first-page":"330","article-title":"Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms","volume":"27","author":"Zhang","year":"2005","journal-title":"Zhonghua Zhong Liu Za Zhi"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.3942\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T01:44:13Z","timestamp":1566611053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.3942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,4,28]]},"published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.3892\/or.2015.3942"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.3942","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,28]]}}}