{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:43:25Z","timestamp":1769384605064,"version":"3.49.0"},"reference-count":37,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.3892\/or.2015.4086","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T07:07:37Z","timestamp":1435302457000},"page":"1162-1168","source":"Crossref","is-referenced-by-count":27,"title":["Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells"],"prefix":"10.3892","volume":"34","author":[{"given":"YUHUI","family":"HUANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOTOFUMI","family":"KUMAZOE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAEHOON","family":"BAE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUHEI","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIKA","family":"TAKAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIORI","family":"HIDAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUYA","family":"YAMASHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOONHEE","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEONGSEON","family":"WON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOTOKI","family":"MURATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUNTARO","family":"TSUKAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROFUMI","family":"TACHIBANA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"key20180107211726_b1-or-34-03-1162","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","article-title":"Chronic myeloid leukaemia","volume":"385","author":"Apperley","year":"2015","journal-title":"Lancet"},{"key":"key20180107211726_b2-or-34-03-1162","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(07)61165-9","article-title":"Chronic myeloid leukaemia","volume":"370","author":"Hehlmann","year":"2007","journal-title":"Lancet"},{"key":"key20180107211726_b3-or-34-03-1162","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat Med"},{"key":"key20180107211726_b4-or-34-03-1162","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N Engl J Med"},{"key":"key20180107211726_b5-or-34-03-1162","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature07737","article-title":"Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia","volume":"458","author":"Zhao","year":"2009","journal-title":"Nature"},{"key":"key20180107211726_b6-or-34-03-1162","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI43605","article-title":"BCR-ABL kinase is dead; long live the CML stem cell","volume":"121","author":"Perl","year":"2011","journal-title":"J Clin Invest"},{"key":"key20180107211726_b7-or-34-03-1162","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/sj.bjc.6604140","article-title":"Possible protective effect of green tea intake on risk of adult leukaemia","volume":"98","author":"Zhang","year":"2008","journal-title":"Br J Cancer"},{"key":"key20180107211726_b8-or-34-03-1162","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10552-008-9217-7","article-title":"A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan","volume":"20","author":"Kuo","year":"2009","journal-title":"Cancer Causes Control"},{"key":"key20180107211726_b9-or-34-03-1162","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/aje\/kwp187","article-title":"Green tea consumption and hematologic malignancies in Japan: The Ohsaki study","volume":"170","author":"Naganuma","year":"2009","journal-title":"Am J Epidemiol"},{"key":"key20180107211726_b10-or-34-03-1162","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cncr.27719","article-title":"Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia","volume":"119","author":"Shanafelt","year":"2013","journal-title":"Cancer"},{"key":"key20180107211726_b11-or-34-03-1162","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2165\/11209370-000000000-00000","article-title":"Polyphenon E 10% ointment: In immunocompetent adults with external genital and perianal warts","volume":"13","author":"Hoy","year":"2012","journal-title":"Am J Clin Dermatol"},{"key":"key20180107211726_b12-or-34-03-1162","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.taap.2006.11.024","article-title":"Tea and cancer prevention: Molecular mechanisms and human relevance","volume":"224","author":"Yang","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20180107211726_b13-or-34-03-1162","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2141.2009.08040.x","article-title":"Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2","volume":"149","author":"Britschgi","year":"2010","journal-title":"Br J Haematol"},{"key":"key20180107211726_b14-or-34-03-1162","first-page":"787","article-title":"67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis","volume":"123","author":"Kumazoe","year":"2013","journal-title":"J Clin Invest"},{"key":"key20180107211726_b15-or-34-03-1162","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1182\/blood-2006-05-022814","article-title":"Specific killing of multiple myeloma cells by (-)-epigallocat-echin-3-gallate extracted from green tea: Biologic activity and therapeutic implications","volume":"108","author":"Shammas","year":"2006","journal-title":"Blood"},{"key":"key20180107211726_b16-or-34-03-1162","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/bjh.13135","article-title":"Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells","volume":"168","author":"Kumazoe","year":"2015","journal-title":"Br J Haematol"},{"key":"key20180107211726_b17-or-34-03-1162","first-page":"8118","article-title":"Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins","volume":"63","author":"Leone","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107211726_b18-or-34-03-1162","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1158\/1078-0432.CCR-04-2273","article-title":"Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species","volume":"11","author":"Nakazato","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180107211726_b19-or-34-03-1162","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1182\/blood-2003-08-2763","article-title":"VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia","volume":"104","author":"Lee","year":"2004","journal-title":"Blood"},{"issue":"Suppl","key":"key20180107211726_b20-or-34-03-1162","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.1194\/jlr.R800040-JLR200","article-title":"The challenge of lipid rafts","volume":"50","author":"Pike","year":"2009","journal-title":"J Lipid Res"},{"key":"key20180107211726_b21-or-34-03-1162","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1158\/0008-5472.CAN-07-0353","article-title":"Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells","volume":"67","author":"Rebillard","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107211726_b22-or-34-03-1162","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/BJ20111837","article-title":"Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase C\u03b4 and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells","volume":"443","author":"Tsukamoto","year":"2012","journal-title":"Biochem J"},{"key":"key20180107211726_b23-or-34-03-1162","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1529\/biophysj.106.092650","article-title":"Fretting about FRET: Correlation between kappa and R","volume":"92","author":"VanBeek","year":"2007","journal-title":"Biophys J"},{"key":"key20180107211726_b24-or-34-03-1162","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2183\/pjab.87.66","article-title":"Green tea polyphenol sensing","volume":"87","author":"Tachibana","year":"2011","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"key20180107211726_b25-or-34-03-1162","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1074\/jbc.274.12.7987","article-title":"Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs","volume":"274","author":"Micheau","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180107211726_b26-or-34-03-1162","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nsmb743","article-title":"A receptor for green tea polyphenol EGCG","volume":"11","author":"Tachibana","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"key20180107211726_b27-or-34-03-1162","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bbrc.2005.05.108","article-title":"Epigallocatechin-3-O- gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor","volume":"333","author":"Umeda","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107211726_b28-or-34-03-1162","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1074\/jbc.M707892200","article-title":"Green tea poly-phenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor","volume":"283","author":"Umeda","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180107211726_b29-or-34-03-1162","doi-asserted-by":"crossref","first-page":"32671","DOI":"10.1074\/jbc.M114.604983","article-title":"67-kDa laminin receptor-dependent protein phosphatase 2A (PP2A) activation elicits melanoma-specific antitumor activity overcoming drug resistance","volume":"289","author":"Tsukamoto","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180107211726_b30-or-34-03-1162","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1074\/jbc.M507851200","article-title":"Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo","volume":"281","author":"Humphries","year":"2006","journal-title":"J Biol Chem"},{"key":"key20180107211726_b31-or-34-03-1162","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1158\/0008-5472.CAN-07-2621","article-title":"FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling","volume":"68","author":"Hung","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107211726_b32-or-34-03-1162","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrc2641","article-title":"Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance","volume":"9","author":"Yang","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20180107211726_b33-or-34-03-1162","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1016\/j.febslet.2013.07.041","article-title":"Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis","volume":"587","author":"Kumazoe","year":"2013","journal-title":"FEBS Lett"},{"key":"key20180107211726_b34-or-34-03-1162","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180107211726_b35-or-34-03-1162","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1158\/0008-5472.CAN-07-0411","article-title":"The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells","volume":"67","author":"Adachi","year":"2007","journal-title":"Cancer Res"},{"issue":"Suppl 9","key":"key20180107211726_b36-or-34-03-1162","first-page":"S217","article-title":"Molecular targets of (\u2212)-epigallocatechin-3-gallate (EGCG): Specificity and interaction with membrane lipid rafts","volume":"59","author":"Patra","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"key20180107211726_b37-or-34-03-1162","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cellsig.2009.01.026","article-title":"Roles and regulation of secretory and lysosomal acid sphingomyelinase","volume":"21","author":"Jenkins","year":"2009","journal-title":"Cell Signal"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.4086\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:17:38Z","timestamp":1515359858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.4086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,6,26]]},"published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.3892\/or.2015.4086"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.4086","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}