{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:15:40Z","timestamp":1767888940744,"version":"3.49.0"},"reference-count":28,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.3892\/or.2015.4200","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T11:37:36Z","timestamp":1439465856000},"page":"2305-2310","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of Src family kinases overcomes anoikis resistance induced by spheroid formation and facilitates cisplatin-induced apoptosis in human mesothelioma cells"],"prefix":"10.3892","volume":"34","author":[{"given":"RYOJI","family":"EGUCHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUMIKO","family":"FUJITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIHARU","family":"TABATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROYASU","family":"OGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ICHIRO","family":"WAKABAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKASHI","family":"NAKANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIHIRO","family":"FUJIMORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"key20180107212159_b1-or-34-05-2305","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","volume":"366","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"key20180107212159_b2-or-34-05-2305","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1200\/JCO.2008.19.8523","article-title":"Malignant pleural mesothelioma","volume":"27","author":"Tsao","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180107212159_b3-or-34-05-2305","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0140-6736(08)60703-5","article-title":"Chemotherapy for malignant pleural mesothelioma","volume":"371","author":"Vogelzang","year":"2008","journal-title":"Lancet"},{"key":"key20180107212159_b4-or-34-05-2305","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11912-005-0048-3","article-title":"New therapeutic options for mesothelioma","volume":"7","author":"Goudar","year":"2005","journal-title":"Curr Oncol Rep"},{"key":"key20180107212159_b5-or-34-05-2305","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J Clin Oncol"},{"key":"key20180107212159_b6-or-34-05-2305","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.124.4.619","article-title":"Disruption of epithelial cell-matrix interactions induces apoptosis","volume":"124","author":"Frisch","year":"1994","journal-title":"J Cell Biol"},{"key":"key20180107212159_b7-or-34-05-2305","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1091\/mbc.4.9.953","article-title":"The extracellular matrix as a cell survival factor","volume":"4","author":"Meredith","year":"1993","journal-title":"Mol Biol Cell"},{"key":"key20180107212159_b8-or-34-05-2305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: The executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"key20180107212159_b9-or-34-05-2305","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/bst0320421","article-title":"Anoikis","volume":"32","author":"Valentijn","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"key20180107212159_b10-or-34-05-2305","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1040-8428(00)00081-0","article-title":"Autologous spheroid culture: A screening tool for human brain tumour invasion","volume":"36","author":"de Ridder","year":"2000","journal-title":"Crit Rev Oncol Hematol"},{"key":"key20180107212159_b11-or-34-05-2305","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.canlet.2008.05.029","article-title":"Anoikis resistance and tumor metastasis","volume":"272","author":"Simpson","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180107212159_b12-or-34-05-2305","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cellsig.2011.10.005","article-title":"Cell surface adhesion molecules and adhesion-initiated signaling: Understanding of anoikis resistance mechanisms and therapeutic opportunities","volume":"24","author":"Zhong","year":"2012","journal-title":"Cell Signal"},{"key":"key20180107212159_b13-or-34-05-2305","doi-asserted-by":"crossref","first-page":"C1109","DOI":"10.1152\/ajpcell.1997.273.4.C1109","article-title":"Three-dimensional cell cultures: From molecular mechanisms to clinical applications","volume":"273","author":"Mueller-Klieser","year":"1997","journal-title":"Am J Physiol"},{"key":"key20180107212159_b14-or-34-05-2305","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/cdd.2009.32","article-title":"Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates","volume":"16","author":"Daubriac","year":"2009","journal-title":"Cell Death Differ"},{"key":"key20180107212159_b15-or-34-05-2305","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.cellbio.13.1.513","article-title":"Cellular functions regulated by Src family kinases","volume":"13","author":"Thomas","year":"1997","journal-title":"Annu Rev Cell Dev Biol"},{"key":"key20180107212159_b16-or-34-05-2305","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrc1366","article-title":"A renaissance for SRC","volume":"4","author":"Yeatman","year":"2004","journal-title":"Nat Revc Cancer"},{"key":"key20180107212159_b17-or-34-05-2305","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/carcin\/bgs109","article-title":"Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells","volume":"33","author":"Eguchi","year":"2012","journal-title":"Carcinogenesis"},{"key":"key20180107212159_b18-or-34-05-2305","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/pmic.201300053","article-title":"Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system","volume":"13","author":"Arai","year":"2013","journal-title":"Proteomics"},{"key":"key20180107212159_b19-or-34-05-2305","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.cellsig.2013.05.008","article-title":"FK506 induces endothelial dysfunction through attenuation of Akt and ERK1\/2 independently of calcineurin inhibition and the caspase pathway","volume":"25","author":"Eguchi","year":"2013","journal-title":"Cell Signal"},{"key":"key20180107212159_b20-or-34-05-2305","first-page":"1289","article-title":"Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model","volume":"37","author":"Eguchi","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180107212159_b21-or-34-05-2305","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jcp.22397","article-title":"Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells","volume":"226","author":"Eguchi","year":"2011","journal-title":"J Cell Physiol"},{"key":"key20180107212159_b22-or-34-05-2305","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yexcr.2013.11.011","article-title":"Cell cycle arrest or survival signaling through \u03b1v integrins, activation of PKC and ERK1\/2 lead to anoikis resistance of ovarian cancer spheroids","volume":"320","author":"Carduner","year":"2014","journal-title":"Exp Cell Res"},{"key":"key20180107212159_b23-or-34-05-2305","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1158\/0008-5472.CAN-14-2740","article-title":"TUBB3\/\u03b2III-tubulin acts through the PTEN\/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer","volume":"75","author":"McCarroll","year":"2015","journal-title":"Cancer Res"},{"key":"key20180107212159_b24-or-34-05-2305","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.13.22.2905","article-title":"Cellular survival: A play in three Akts","volume":"13","author":"Datta","year":"1999","journal-title":"Genes Dev"},{"key":"key20180107212159_b25-or-34-05-2305","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.ejca.2006.03.007","article-title":"PI3-K\/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation","volume":"42","author":"Diaz-Montero","year":"2006","journal-title":"Eur J Cancer"},{"key":"key20180107212159_b26-or-34-05-2305","doi-asserted-by":"crossref","first-page":"13021","DOI":"10.1074\/jbc.M709698200","article-title":"Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids","volume":"283","author":"Barbone","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180107212159_b27-or-34-05-2305","doi-asserted-by":"crossref","first-page":"e84941","DOI":"10.1371\/journal.pone.0084941","article-title":"Ovarian cancer spheroid cells with stem cell-like properties contribute to tumor generation, metastasis and chemotherapy resistance through hypoxia-resistant metabolism","volume":"9","author":"Liao","year":"2014","journal-title":"PLoS One"},{"key":"key20180107212159_b28-or-34-05-2305","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/JTO.0b013e318248242c","article-title":"Phase II study of dasatinib in patients with previously treated malignant mesothelioma (cancer and leukemia group B 30601): a brief report","volume":"7","author":"Dudek","year":"2012","journal-title":"J Thorac Oncol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.4200\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:22:10Z","timestamp":1515360130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.4200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,13]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,8,13]]},"published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.3892\/or.2015.4200"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.4200","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,13]]}}}