{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:31:41Z","timestamp":1762252301142},"reference-count":46,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.3892\/or.2015.4385","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T08:36:58Z","timestamp":1446539818000},"page":"243-252","source":"Crossref","is-referenced-by-count":11,"title":["Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer"],"prefix":"10.3892","volume":"35","author":[{"given":"JIE","family":"WU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANBO","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHUN","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONG","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIUMIN","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JICHENG","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUFENG","family":"XIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"TAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"key20180107211340_b1-or-35-01-0243","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","article-title":"Modes of p53 regulation","volume":"137","author":"Kruse","year":"2009","journal-title":"Cell"},{"key":"key20180107211340_b2-or-35-01-0243","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cell.2005.10.043","article-title":"A global map of p53 transcription-factor binding sites in the human genome","volume":"124","author":"Wei","year":"2006","journal-title":"Cell"},{"key":"key20180107211340_b3-or-35-01-0243","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature12634","article-title":"Mutational landscape and significance across 12 major cancer types","volume":"502","author":"Kandoth","year":"2013","journal-title":"Nature"},{"key":"key20180107211340_b4-or-35-01-0243","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2014.01.021","article-title":"Mutant p53 in cancer: New functions and therapeutic opportunities","volume":"25","author":"Muller","year":"2014","journal-title":"Cancer Cell"},{"key":"key20180107211340_b5-or-35-01-0243","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2641","article-title":"p53 mutations in cancer","volume":"15","author":"Muller","year":"2013","journal-title":"Nat Cell Biol"},{"key":"key20180107211340_b6-or-35-01-0243","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-94-017-9211-0_8","article-title":"Mutant p53 and the response to chemotherapy and radiation","volume":"85","author":"Tchelebi","year":"2014","journal-title":"Subcell Biochem"},{"key":"key20180107211340_b7-or-35-01-0243","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrclinonc.2010.174","article-title":"Translating p53 into the clinic","volume":"8","author":"Cheok","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"key20180107211340_b8-or-35-01-0243","doi-asserted-by":"crossref","first-page":"a001222","DOI":"10.1101\/cshperspect.a001222","article-title":"p53-based cancer therapy","volume":"2","author":"Lane","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20180107211340_b9-or-35-01-0243","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1016\/j.febslet.2014.03.011","article-title":"Keep-ING balance: Tumor suppression by epigenetic regulation","volume":"588","author":"Tallen","year":"2014","journal-title":"FEBS Lett"},{"key":"key20180107211340_b10-or-35-01-0243","first-page":"2373","article-title":"p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity","volume":"63","author":"Shiseki","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107211340_b11-or-35-01-0243","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.febslet.2004.06.010","article-title":"ING4 induces G2\/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells","volume":"570","author":"Zhang","year":"2004","journal-title":"FEBS Lett"},{"key":"key20180107211340_b12-or-35-01-0243","doi-asserted-by":"crossref","first-page":"34677","DOI":"10.1074\/jbc.M606296200","article-title":"Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility","volume":"281","author":"Unoki","year":"2006","journal-title":"J Biol Chem"},{"key":"key20180107211340_b13-or-35-01-0243","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.canlet.2008.05.050","article-title":"Adeno-virus-mediated ING4 expression suppresses lung carcinoma cell growth via induction of cell cycle alteration and apoptosis and inhibition of tumor invasion and angiogenesis","volume":"271","author":"Xie","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180107211340_b14-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CMR.0b013e32831bc42f","article-title":"Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14","volume":"19","author":"Cai","year":"2009","journal-title":"Melanoma Res"},{"key":"key20180107211340_b15-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.yexcr.2013.05.004","article-title":"Autophagy contributes to ING4-induced glioma cell death","volume":"319","author":"Gong","year":"2013","journal-title":"Exp Cell Res"},{"key":"key20180107211340_b16-or-35-01-0243","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/cgt.2010.67","article-title":"Enhanced antitumor activity by combining an adenovirus harboring ING4 with cisplatin for hepatocarcinoma cells","volume":"18","author":"Xie","year":"2011","journal-title":"Cancer Gene Ther"},{"key":"key20180107211340_b17-or-35-01-0243","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2011.11.003","article-title":"Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and (125)I radiation therapy on pancreatic cancer","volume":"316","author":"Zhao","year":"2012","journal-title":"Cancer Lett"},{"key":"key20180107211340_b18-or-35-01-0243","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/cgt.2012.50","article-title":"Enhanced radiosensitivity of non-small-cell lung cancer (NSCLC) by adenovirus-mediated ING4 gene therapy","volume":"19","author":"Ling","year":"2012","journal-title":"Cancer Gene Ther"},{"key":"key20180107211340_b19-or-35-01-0243","doi-asserted-by":"crossref","first-page":"16251","DOI":"10.1073\/pnas.0407158101","article-title":"A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer","volume":"101","author":"Kim","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211340_b20-or-35-01-0243","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1158\/0008-5472.CAN-06-3870","article-title":"Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1","volume":"67","author":"Shen","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107211340_b21-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1093\/carcin\/bgn086","article-title":"Role of ING4 in human melanoma cell migration, invasion and patient survival","volume":"29","author":"Li","year":"2008","journal-title":"Carcinogenesis"},{"key":"key20180107211340_b22-or-35-01-0243","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature02329","article-title":"The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis","volume":"428","author":"Garkavtsev","year":"2004","journal-title":"Nature"},{"key":"key20180107211340_b23-or-35-01-0243","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1128\/MCB.00697-08","article-title":"The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes","volume":"28","author":"Nozell","year":"2008","journal-title":"Mol Cell Biol"},{"key":"key20180107211340_b24-or-35-01-0243","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1073\/pnas.0502716102","article-title":"The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)","volume":"102","author":"Ozer","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211340_b25-or-35-01-0243","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1182\/blood-2007-02-074617","article-title":"The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: Involvement in myeloma-induced angiogenesis","volume":"110","author":"Colla","year":"2007","journal-title":"Blood"},{"key":"key20180107211340_b26-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/onc.2013.135","article-title":"Inhibitor of growth 4 induces NF\u03baB\/p65 ubiquitin-dependent degradation","volume":"33","author":"Hou","year":"2014","journal-title":"Oncogene"},{"key":"key20180107211340_b27-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.febslet.2013.04.004","article-title":"ING4 inhibits the translation of proto-oncogene MYC by interacting with AUF1","volume":"587","author":"Lu","year":"2013","journal-title":"FEBS Lett"},{"key":"key20180107211340_b28-or-35-01-0243","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180107211340_b29-or-35-01-0243","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1016\/S1470-2045(13)70173-6","article-title":"Is cancer gene therapy an empty suit?","volume":"14","author":"Brenner","year":"2013","journal-title":"Lancet Oncol"},{"key":"key20180107211340_b30-or-35-01-0243","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1389201023378445","article-title":"Viral-mediated gene transfer for cancer treatment","volume":"3","author":"Wilson","year":"2002","journal-title":"Curr Pharm Biotechnol"},{"key":"key20180107211340_b31-or-35-01-0243","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cell.2008.03.025","article-title":"Acetylation is indispensable for p53 activation","volume":"133","author":"Tang","year":"2008","journal-title":"Cell"},{"key":"key20180107211340_b32-or-35-01-0243","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/cbr.2011.1047","article-title":"Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells","volume":"26","author":"Xie","year":"2011","journal-title":"Cancer Biother Radiopharm"},{"key":"key20180107211340_b33-or-35-01-0243","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1089\/1043034041361181","article-title":"Conditionally replication-competent adenoviral vectors with enhanced infectivity for use in gene therapy of melanoma","volume":"15","author":"Liu","year":"2004","journal-title":"Hum Gene Ther"},{"key":"key20180107211340_b34-or-35-01-0243","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses","volume":"95","author":"He","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211340_b35-or-35-01-0243","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3748\/wjg.v7.i5.702","article-title":"Experimental study on antitumor effect of arsenic trioxide in combination with cisplatin or doxorubicin on hepatocellular carcinoma","volume":"7","author":"Wang","year":"2001","journal-title":"World J Gastroenterol"},{"key":"key20180107211340_b36-or-35-01-0243","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0955-0674(03)00003-6","article-title":"Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation","volume":"15","author":"Brooks","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"key20180107211340_b37-or-35-01-0243","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bbrc.2005.04.023","article-title":"Nuclear localization signal of ING4 plays a key role in its binding to p53","volume":"331","author":"Zhang","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107211340_b38-or-35-01-0243","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature03094","article-title":"G1 cell-cycle control and cancer","volume":"432","author":"Massagu\u00e9","year":"2004","journal-title":"Nature"},{"key":"key20180107211340_b39-or-35-01-0243","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: Critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"key20180107211340_b40-or-35-01-0243","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.molcel.2008.12.016","article-title":"ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation","volume":"33","author":"Hung","year":"2009","journal-title":"Mol Cell"},{"key":"key20180107211340_b41-or-35-01-0243","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"key20180107211340_b42-or-35-01-0243","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1172\/JCI70212","article-title":"Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer","volume":"123","author":"Welti","year":"2013","journal-title":"J Clin Invest"},{"key":"key20180107211340_b43-or-35-01-0243","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11684-012-0176-8","article-title":"Progress in tumor vascular normalization for anticancer therapy: Challenges and perspectives","volume":"6","author":"Shang","year":"2012","journal-title":"Front Med"},{"key":"key20180107211340_b44-or-35-01-0243","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.14.1.34","article-title":"Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha","volume":"14","author":"Ravi","year":"2000","journal-title":"Genes Dev"},{"key":"key20180107211340_b45-or-35-01-0243","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1073\/pnas.0911082107","article-title":"P53-induced micro-RNA-107 inhibits HIF-1 and tumor angiogenesis","volume":"107","author":"Yamakuchi","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211340_b46-or-35-01-0243","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1126391","article-title":"p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase","volume":"313","author":"Teodoro","year":"2006","journal-title":"Science"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.4385\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T02:06:45Z","timestamp":1653444405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.4385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,3]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.3892\/or.2015.4385"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.4385","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}